pry-1

Axin-like protein pry-1

625 amino acids

Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity (By similarity).

70.334 kDa

MESGPSSHLDWARSLEAVLSDRTALDLFQKWLMEYSLPQYLDLYFAIRAFERMTLEGKPEKNQLSKSIYCKFLSSRTGNCEAIPKHFKAPIGEKIRHGIDLEDRAFSHCSSFVVDFLRRQHEEFVRSDEFIEALNKVRLRPLFPKPTVILQMSSSTDSSSSHQNTIRKSGSSKRTATQLTAEALLKTKHDRHTKFGELKLEKMYPSARQPYVCNATTSHNDSAVSSSFSGDAPGAHRSNRLRHLREEQAHQNRDTATVPRVEKQQASSAADQPFDHATENGRRGFSMEITKKLLRHLDKVKMNEEMERRIDDIEECRYTTIDMVNGTEADVDMGGIDEDEELDDYLKMKMTDDSQKGSQNRSPKGPNSGEKEKDGVSKNATFSPAPPPPRDSPRGLISSHLHHHSIHHNTIRPPRRTSKEYPLDISLSRNQYPRHHQIDTNRSLMSQSMCVPGPSYSSASSTFSRDSFAPSPMLKGFAGAPGSSKSSQMYDSSGIGSMAPSAFSATSSLDYKEKRHRKSLPNHHSMMSNSLTTPRKHHKIGKSLSNLITLSYVGSDKIPVVTHVPYDGPMTLAEFKRHFALPTGGQQLFFKTDCEDGSAPFQLLLVRDEHTLLPVFEGRIAAEIR

pry-1

Axin-like protein pry-1

586 amino acids

Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.

66.002 kDa

METHLGWARSLEAVLSDRSALDAFQEWLIEYSSPQYLDLFFAIRAYERMALEGKPEKSQLSKSIYSKFLSSRTGNCEAIPKHFRAPIGEKLRHGTELEDRVFSHCSNFVQEFLRRQHEEFVGSEEFIEAFNKMSSTTADQLPGGSAHHSSHQNTMRRSSGTTSRKSAAQIATQLTAEALLKSKHDRHSKLGETKLEKMYPPTRQPYVCNATTSHNDSAVSSTFSGDTPEAHRMHSNRLRHIRDEQARENHGTMTLPRVEKASVDGQQWDHSSESGRRNFAMEITRKLLRHIDKVKLNDEMEKRIDDIEECRYTTIDMVNGTEPNDDLGKIDEDEELDDYLKMKMTDDSQKGSTNRSPKGPAGEPNKSGEGSKNTTLSPTNRAPAQLHNTIRVPRRKDYPRDTSASLKSHRHHQIDTNRMMSQSMCAPSYSSASSSYSRDSFAPAPTTRVNFAPGSSKSSQFYDSSGIGSMAPSAFSATSSLDYKDRRQHRKAPTPKKHSKIGKNLSNLITISYLGTDKIPVVTHVPNDGPMTLAEFKRHFALPNGAHQLFFKTECEDGSAPFQLLLIKDEHHLLPVFEGRIAAELR