prvA

Extracellular serine protease

448 amino acids

This enzyme is a chymotrypsin-like serine protease. Degrades a variety of substrates present in the skin and hoof of the sheep, including elastin, keratin, fibrinogen and collagen. It seems to play an important role in the pathogenesis of sheep footrot.

Belongs to the peptidase S17 family.

48.154 kDa

single

MKLSHLSLAIISAITLAACGGGNDDKPMPQDPDNGALVEQRNEAIKKKATAYLEDKDGKAPALTKDEEATLSQIDENLFNEYKKKQKELENQASDDEVDPTKTGVVGNLDLGKQASQGTTQYVRGTKSSFDAENNPKEVSSATAILGVEAKTQNPWLTNIVLARKVRADGTVSIMQYLGNDGSDAADFTNVKSLQAQNDHNVVKFSDLKTNKPLDEAKLEAQKKQVDLIIKLYEKIDSSEITTEEKEELEKFVALKEELNAIDIKSPEGYVGLDEKAHKLFSETGASGSDDIIFGDDVPTNNSVLGTADTGSGAIPPVKPIYTSGKPGADATGAGALGLVGMNFKVGGTQEAIQGTEEKSQSSTRVFGRQYNTQSRAERKFNSYADAAVLALSSEKDLANAIAGITDQSELANITADMKNAKINYHLAVKPQKLDYVQYGRVTGNLDP