Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Function
Cleaves human complement component C3. May enable P.gingivalis to evade complement-mediated killing during the immune response. Plays an important role in soft tissue infections and is a virulence factor.
Similarity
Belongs to the peptidase C25 family.
Sequence
MHPSTMRCMHLRPVTMHPTSRMLCWKRRLRPKGVRSPEAIRGRIQGTWRQKTVDLPAGTEICCFPSLPKAPICSTSTLMRLRSKTNAKRADFTETFESSTHGEAPAEWTTIDADGDGQGWLCLSSGQLDWLTAHGGTNVVSSFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEADGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKKCVNVTVNSTQFNPVKNLKAQPDGGDVVLKWEAPSAKKTEGSREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSDLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIKEGLTETTYRDAGLSAQSHEYCVEVKYTAGVSPKVCVDYIPDGVEDVTVQKPHTLTVVGKTITVSWQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEETRYQVNLSWTRRLCADTSKHRSVIVSEYESVARPPFKEVGRLRFYAYYSNILLKQFVPKSCMKRLSYYLPHCKKGSFLRFPRSSTVITVCQFSWLEYLPVTQGVAGSSPVHTAKIRSCVEIVFRHSSIFVCYRSTGKYNYRMRLFNMLGKNFLRTKQKCLSLLRSAWDIGIKLVLFQEGRYMESPGQSDEERRTTIDFYGNGRYLLFRHSELLVENGYQVKAVVTMLGTKPMGRGHKVSPSMVKLYAQELGLPILQPDNLNEESFLDELRTYQPHLQIVVAFRMLPRSVWQMPPMGTINLHGSLLPMYRGAAPIQPRDTPWRYGKRELPPSASGMR