PRP19

Pre-mRNA-processing factor 19

527 amino acids

Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair.

Belongs to the WD repeat PRP19 family.

57.817 kDa

MICAISGEVPDEPVVSKKSGLLFERRLVERYIEDHGKCPVTKEELTMDDIVAVKTNKVVKPRQLQAASIPGLLGMFQNEWDAIMLSSFALEQQLHTARQELSHALYQHDAACRVIARLKKERDEARALLAQAERQIPASMAGAAPTAVVSNGKRAFEDEVGPDGKKIRPGINPVMIDELTECNTMLSAHRKKRQVPPTLASIDAIERYTQISSHPLHKTNKPGILSMDIHPSKDIIATGGIDTNAVLFDRPSGQILCTLTGHSKKITSLKFVPRDELFVTGSADKTVKIWQGSEEGNYNCIHTLKDHTAEVEAVTVHATQKYFVTASKDNTWCFYDIPSGSCLTQVGESSGQEGYTSASFHPDGLILGTGTTEAVVKIWDVKTQSNVAKFEGHVGPVTAMSFSENGYFLATAALDGVKLWDLRKLRNFRTISPYDSDTPTNSVEFDFSGSYLAVGGSDTRVYQVANVKLEWNLVKTLPDLSGTGKVTNVKFGTDAKYIAVGSMDRNLRIFGHPGEDDQMDDAKPSEE

prp19

Pre-mRNA-processing factor 19

514 amino acids

Probable ubiquitin-protein ligase mainly involved in pre-mRNA splicing and DNA repair. Core component of the Prp19 complex/PRP19C/Nineteen complex/NTC which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.

Belongs to the WD repeat PRP19 family.

56.811 kDa

MICAISGSTTEEPVISTKTGNVYEKRLIEKYIDTNGKEPTTGEPLGLSDLITVKIGKTVKPRPTTATSIPSMLQLFQNEWDSLMLETFTLKQQHETVRQELAHSMYQYDAACRVIARLVKERDAARSALANARNIVQQQQQQTNNNNNNNNNKDVEMSSASTPSSSEDNLLDSTIYKRIAEKSEELIKTRKERTHQSLAEPDAIKQFKVSANVETDCQIKSLEVNSQDNNLIAMGGINGNVYVYSRETNELCTAIKGTSSAPINKVLFAPNNTIVSAGSDAVIRVVKGGESPSKKTYTQYKSTYQFAHKASVTDISLHVLGDYIISSSLDKSLNMYDIVNGTHLTSFGQSQQLCYTSVAFHPDGMFFAAGTQNGVVKIFDLKSKVNSFNFQGLSTAVNCISFSENGYYLTAADNNTVKLFDLRKAATKNSPDIQTITLDNQQIKSINFDYSSQYLGVASSNQINLYSCKSKQKPPISSIHSIDSDCLDFKWARPNSNFFVTSSSSKNIVNIFSN

PRP19

Pre-mRNA-processing factor 19

503 amino acids

Probable ubiquitin-protein ligase involved in pre-mRNA splicing. Acts as a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. It is also probably involved in DNA repair.

Belongs to the WD repeat PRP19 family.

56.57 kDa

MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP

prp19

Pre-mRNA-processing factor 19

488 amino acids

Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair.

Belongs to the WD repeat PRP19 family.

54.191 kDa

MFCSISGETPKEPVISRVSGNVYEKRLIEQVIRETSKDPVTQQECTLEDLVPVKVPDFVRPRPPSATSLPALLSLFQEEWDSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTKERDEAREALAKFSDNIGTVSSKTIEVQEVEMGESDDQLKTSLRSTVEKTFQELSSKRKRTKLQPKWATDDAVSQLLQATPSTILENLETESTTSFFPSPENSSFVLCLHKDELLCLDIQSNSTLKIFEGSALACCWLTSSKIAVATADAISIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEKCYIFSLKSQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRLG