PROS1

Vitamin K-dependent protein S

676 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

75.123 kDa

MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS

PROS1

Vitamin K-dependent protein S

675 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

75.133 kDa

MRVLGGRTGTLLACLALVLPVLEANFLSRQHASQVLIRRRRANTLLEETKKGNLERECIEELCNKEEAREIFENNPETEYFYPKYLGCLGSFRAGLFTAARLSTNAYPDLRSCVNAISDQCNPLPCNEDGFMTCKDGQATFTCICKSGWQGEKCESDINECKDPVNINGGCSQICENTPGSYHCSCKNGFVMLSNKKDCKDVDECVLKPSICGTAVCKNIPGDFECECAEGYKYNPVSKSCDDVDECAENLCAQLCVNYPGGYSCYCDGKKGFKLAQDQKSCEAVPVCLPLDLDKNYELLYLAEQFVGVVLYLKFRLPETTRFSAEFDFRTYDSEGVILYAESSDHSAWFLIALREGKIEIQFKNEKTTKMTTGGKVINDGLWHMVSVEELEQSISVKIAKEAVMNINKPGSLFKPTNGFLETKVYFAGVPRKMENALIRPINPRLDGCIRGWNLMNQGTSGVKEIIQEKQNKHCLVNVEKGSYYPGTGVAQFSINYKNESNPEAWQINVSLNIRPSAGTGVMLALVSDNTVPFALSLVDSATEKLQDILVSVESMVIGRIEAISLCSDQQTFLEIRVNRNNLELSTQLRKDSFHSEDFQRQFAILDEAMKGTVVTYLGGLPDVPFSATPVNAFYQGCMEVNINGVQVDLDEAISKHNDIRAHSCPSVWQKTKHT

Pros1

Vitamin K-dependent protein S

675 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

74.934 kDa

MRVLSARFRVLLACLALVIPVSETNFLSKERASQVLVRKRRANTLFEETMKGNLERECIEELCNKEEAREVFENNPETDYFYPKYLGCLGAFRVGSFHAARQSANAYPDLRSCVKAISDQCDPIPCNEDGYLACQDGQAAFTCFCKPGWQGDRCQYDVNECKDPSNVNGGCSQICDNTPGSYHCSCKRGFAMLPNKKDCKDLDECALKPSVCGTAVCKNIPGDFECECPDGYRYDPSSKSCKDVDECSENMCAQLCVNFPGGYSCYCDGKKGFKLAQDQKSCEGIPVCLSLDLDKNYELLYLAEQFAGVVLYLKFRLPDITRFSAEFDFRTYDSEGIILYAESLDHSNWLLIALRDGKIEVQFKNEFSTQITTGGNVINNGIWNMVSVEELDDSVSIKIAKEAVMNINKLGSLFKPTDGFLDTKIYFAGLPRKVESALIKPINPRLDGCIRGWNLMKQGALGAKEIIEGKQNKHCFLNVEKGSYYPGSGIAQFSIDYNNVTNAEGWQMNVTLNIRPSTGTGVMLALVSGGTVPFALSLVDSRSGTSQDIVVFVENSVVARLEAVSLCSDQQSQLKCNVNRNGLELWTPLRKDVIYSKDLQRQLAVLDKAMKRTVATYLGGIPDISFSATPVNAFYSGCMEVNINGVQLDLDEAISKHKDIRAHSCPSVRKIQKNF

Pros1

Vitamin K-dependent protein S

675 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

74.627 kDa

MRVLSVRFRVLLACLALVLPNSETNFLSKERASQVLVRKRRANTLLEETKKGNLERECIEELCNKEEAREVFENNPETDYFYPKYLGCLGAFRVGAFSAARQSANAYPDLRSCVNAIPDQCDPMPCNEDGYLSCKDGQGAFTCICKPGWQGDKCQFDINECKDPSNINGGCSQTCDNTPGSYHCSCKIGFAMLTNKKDCKDVDECSLKPSVCGTAVCKNIPGDFECECPNGYRYDPSSKSCKDVDECSENTCAQLCVNYPGGYSCYCDGKKGFKLAQDQRSCEGIPVCLSLDLDKNYELLYLAEQFAGVVLYLKFRLPDITRFSAEFDFRTYDSEGIILYAESLDHSNWLLIALREGKIEVQFKNEFSTQITTGGNVINNGIWNMVSVEELDDSVSIKIAKEAVMNINKLGSLFKPTDGFLDTKIYFAGLPRKVESALIKPINPRLDGCIRGWNLMKQGALGAKEIVEGKQNKHCFLTVEKGSYYPGSGIAQFSIDYNNVTNAEGWQINVTLNIRPSTGTGVMLALVSGDTVPFALSLVDSGSGTSQDILVFVENSVAAHLEAITLCSEQPSQLKCNINRNGLELWTPVRKDVIYSKDLQRQLAILDKTMKGTVATYLGGVPDISFSATPVNAFYSGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVRKIQKNF

PROS1

Vitamin K-dependent protein S

649 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

72.402 kDa

single

SKQQASQVLVRKRRANSMLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQSGLFTAARQSTDAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGERCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKSGFVMLSNKKDCKDVDECSLKPNMCGTAVCKNIPGDFECECPEGYRYNLKSKSCEDVDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEAVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSQGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDIINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAEFHIDYNNGSNAEGWHINVTLNIRPSTGTGVMLALVSSNNTVPFAVSLVDSTSEKSQDIVISVENTVIYRIQALSLCSYQRSHLEFRVNRNNLELLTPLKIETISQEELQTQLAILDKAMKGKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVELDLDEAISKHNDIRAHSCPSVWKKTKNS

PROS1

Vitamin K-dependent protein S

646 amino acids

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

71.969 kDa

single

GHASQVLVRKRRANSMLEETKKGNLERECIEELCNKEEAREVFENDPETDYFYPKYLGCLGSFRAKLFTATRRSANGYPDLRSCVNAIPDQCNPLPCSEEGYLNCKDGQATFTCICKPGWQGEKCEIDINECKDPTNINGGCSQICDNTAGSYHCSCKSGFVMLANEKDCKDMDECSVKPSVCGTAVCKNTPGDFECECSEGYRYNPTAKSCEDIDECSENMCAQLCVNYPGGYSCYCDGKKGFKLAQDKKSCEAVPVCLPLDLDKNYQLLYLAEQFVGAVLYLKFHLPEITRFSAEFDFRTYDSEGVILYAESLDHSTWFLIALRQGKIEIQFKNDYAAQITTGGQVINDGLWNMVSVEELEHSVSIKIAQEPVMNINKPGSLFKPTNGFLETKVYFAGLPRKVENALIRPINPRLDGCMRGWNLMKQGASGVKEIIQQKQKKHCLVTVEKGSYYPGSGIAQFHIDYNNLSYVEDWQVNVTLNIRPSTGTGVMLTLVSGNTLPFALSLVQSTSETSQDILVSVENRVIYQLESISLCSGQQSQLEFSVSRNHLELSTPLVKDVIYSEDLQRHLAVLDEAMKGTVTTYLGGLPEVPFNATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWNDKTNS

proS1

Proline--tRNA ligase 1

581 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.191 kDa

MITRLSHLFLRTLRDDPADAEVPSHKLLVRAGYVRRIAPGVYSWLPLGLRVLREVERVVREEMNGIGAQEISLPALLPREPYEASNRWTEYGDGLFRLKDRKGGDYLLGPTHEELFALTVKGEYNSYKDFPVTLYQVQTKYRDEERPRAGILRGREFVMKDSYSFDLTDEGLTASYRAHRDAYERIFSRLGVKYVIVSATSGAMGGSASEEFLAESEIGEDTYVRCLESGYAANVEAVKTLAPEAVPFDGLPAAKVHDTPDTPTIATLVDWANGADLGWTVTAADTLKNILVKTRQPGGKWELLGIGVPGDREVDDKRLGASLEPAEFELLTEADFAANPFLVKGYIGPKALQANGVRYLVDPRIVDGTSWITGADEPGKHVVGLVAGRDFTPDGTIEAAEVRDGDPSPDGAGALVAARGIEIGHVFQLGRKYTDVFSVDVLGENGKPVRPTMGSYGVGVSRLVAVIAEQHHDEKGLRWPAEVSPADVHVVIANKDETAREGAEGLAAELDKAGLEVILDDRKASPGVKFKDSELLGVPLVVVVGRGWGEGKVEVRDRFTGESREVAAESALSEIVKAVRG

proS1

Proline--tRNA ligase 1

575 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

62.611 kDa

MHAVRYTQAFIPTLKEAPADAQVASHKLLVRAGFIRQLGAGIYDYLPLAKRSLTKIEAIVREEMNAIGGQEFFLPALHPAEIWKESGRWEVMGDNMFRLKDRKGGDYGLGMTHEEIFTAIARDELRSYRQLPQVWYQIQTKFRDEPRPKSGLLRVRQFTMKDAYSFDVDRAGLDKSYEDQRQAYEKIFTRCGLDFVAVQAHSGSMGGSESSEFMVRTDAGEDLVAACPRCRYAANTETATSRVAAEADGPGLAAPEKFPTPGVVTIEALEQAPHSVPARRQLKTLVYMADERPVIAVVRGDQELNEAKLQTATGAQVVRPAHAEEIPPLMGAHAGSLGAVRFTRARVVVDPSLADRKDMVTGANEDGFHLRGVDVRRDLLAHGATLAELRTVKAGEGCPRCDGALEVFKALEVGHIFKLGTKYSESMKATVLDAGGKQVPIVMGSYGIGVERILAAAIELHHDDNGIVFPMAIAPFHATVLTLGPEPELRKAAEEVVAALGKEGVEVLFDDRDERAGVKFKDADLLGIPIRVAVGKKGLAAGNVEWKLRRGGAVELVPLGEVARKAAEAVRAATT

proS1

Proline--tRNA ligase 1

571 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

64.4 kDa

MKMSKMFMPTLKEIPADAEITSHQLMVRSGMIKKMTSGVYNQLPMGLRVFKKIEQIIREELNKKDCQEILCAALLPSELWKESGRWTAMGEEMFRLKDRTEREYCLGPTHEEAFTDIIRQEITSYKQLPLNLYQIQVKYRDERRPRFGVMRTKTFTMKDAYSFDVDDKGLDKSYQDMFDAYVSIFDRCGLENSPVQADSGAIGGSTSAEFMVKSEVGEDEVVFCSGCDYAANVERAESCNLASQKEEMKELEEVHTPGAATIKELEEFLKTSPDKFAKTLVYEADGKTVVVVVRGDREVNEIKVSNAIGSVIEFALATDDVVRKVTNAEVGFAGPIGINADYVFIDKEIVEQRNIVVGANKTEYHIKNANYGRDFEGIVGDFRNVQEGDKCIVCGKPLEIARGVEVGHIFKLGTKYSESMNANFIDKDGKSKPIVMGCYGIGVERTAAAIIEQHNDEKGIIWPLSVAPYHVVIVPANMKNEEQISIAENIYNDLQAMGVEVLLDDRDERIGVKFNDSELIGIPMRITVGKNINEGKVEFKLRHKEDKEIIDIEEINEKVKAEFIRNNVRLG

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.179 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.179 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.122 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKALEKVATPDQKAIEEVSAFLNIEAEKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVTGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.19 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKALEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKALLNWEVGSLGPINVTGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.193 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEIKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

566 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

63.193 kDa

MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEIKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK

proS1

Proline--tRNA ligase 1

564 amino acids

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.

61.194 kDa

MAQVQRMSRLMVKTLRDDPADAETLNHKLLVRADYVRRTAAGIWSWLPLGKKVLENVARVVREEMDAMGGQEVLLPALLPKEPYEATGRWEEYGPELFRLKDRKGAEYLLGPTHEEIFTQLVKDQCSSYKDLPVILYQIQAKYRDEARPRAGILRGREFLMKDSYSFDTADEGLAQSYALHREAYIKIFNRLGLDHRIVSAVSGAMGGSASEEFLAPAPAGEDTFVDCPACDYAANTEAVTFVAPAVESVEHPAVEELDTPDTPTIESLAEYLGVPASATLKNLLVKADGEIVAVGVPGDREVDLGKLGEHLAPAVVELVTAEDFEGRDDLVRGYVGPQGLEKVRYIADPRVAPGTAWITGANKINTHAKNVVAGRDFEVDDYLDVVVVEEGDPCPSCGTGLRLDRAIEIGHIFQLGRKYADAFQLDVLGKEGKPVRVTMGSYGIGVSRAVAALAEQTADEQGLCWPKEIAPADVHVVAAGKALQTELALDVAEKLGAAGVRVLVDDRAGVSPGVKFTDAELIGVPQILVAGRRSAEGVLELKDRKTGEREELTVEEAIARLSA