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proC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Homo sapiens
Length
461 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
Similarity
Belongs to the peptidase S1 family.
Mass
52.071 kDa
Sequence
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
Protein
Vitamin K-dependent protein C: PROC

Gene
Proc
Protein
Vitamin K-dependent protein C
Organism
Rattus norvegicus
Length
461 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
51.912 kDa
Sequence
MWQFRIFLLFASTWGISGVSAHPDPVFSSSEGAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL
Protein
Vitamin K-dependent protein C: Proc

Gene
Proc
Protein
Vitamin K-dependent protein C
Organism
Mus musculus
Length
460 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
51.818 kDa
Sequence
MWQFRVFLLLMSTWGISSIPAHPDPVFSSSEHAHQVLRVRRANSFLEEMRPGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSAPPLDHQCDSPCCGHGTCIDGIGSFSCSCDKGWEGKFCQQELRFQDCRVNNGGCLHYCLEESNGRRCACAPGYELADDHMRCKSTVNFPCGKLGRWIEKKRKILKRDTDLEDELEPDPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCVEGTKKLTVRLGEYDLRRRDHWELDLDIKEILVHPNYTRSSSDNDIALLRLAQPATLSKTIVPICLPNNGLAQELTQAGQETVVTGWGYQSDRIKDGRRNRTFILTFIRIPLVARNECVEVMKNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHTNNYGIYTKVGSYLKWIHSYIGEKGVSLKSQKL
Protein
Vitamin K-dependent protein C: Proc

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Sus scrofa
Length
459 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
51.867 kDa
Sequence
MWQLASLLLLLIIWAVSSTPVPPDSVFSSSQRAHQMLRSKRANSFLEELRPSSLERECKEETCDFEEAREIFQNTENTMAFWSKYHDGDQCAVSPPEHLCDSPCCGRGTCIDGLGGFRCDCAQGWEGRFCLHEVRFSNCSTENGGCAHYCLEEEGGRRCACAPGYRLGDDHLQCEPKVRSPCGRLGNRMEKKRKNLKRDTDQVDKKEDQIDPRLVNGKQSPWGESPWQVILLDSKKKLACGAVLIHVSWVLTAAHCLDDYKKLTVRLGEYDLRRREKWEVDLDIKEFLVHPNYTRSTSDNDIALLRLAEPATFSQTIVPICLPDSGLSERELTRVGQETVVTGWGYRSEAKTNRSFILNFIKVPVAPHNECVQAMHNKISENMLCAGILGDSRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRLHNYGVYTKVSRYLDWIHGHIRMEEAFHKNQVP
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Oryctolagus cuniculus
Length
458 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
51.088 kDa
Fragment
single
Sequence
IPDDVGYRNQKTASKEGVCVVSKCQDGPNTLPRAKRANSFLEELRPSSLERECVEEVCDLEEAKEIFQSVDDTLAFWYKYVDGDQCAALPSEHPCSSQCCGHGTCADSIGGFSCQCHGGWEGSFCQYEVRFSNCSVDNGGCAHYCLEEEAGRSCSCAPGYELADDHLQCEPAVRFPCGRLGWKRIEKKRGNVKRDLEQVDEMDEVDPRLIDGKLTRRGDSPWQVILLDSKKKLACGAVLIHVSWVLTAAHCMEEPKKLFVRLGEYDLRRKERWELDLNIQEVLIHPNYSRSTTDNDIALLRLAQPATLSQTIVPICLPDNGLAERELMQAGQETVVTGWGYHSSREKEAKRNRTFILNFITVPVAPQNECEQVMSNIISENMLCAGILGDRRDACDGDSGGPMVASFRGTWFLVGLVSWGEGCGDLNNYGVYTKVSRYLDWIHSHIEEKEAAPESPAP
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Bos taurus
Length
456 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
51.409 kDa
Fragment
single
Sequence
XTSLLLFVTIWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGNVERECSEEVCEFEEAREIFQNTEDTMAFWSFYSDGDQCEDRPSGSPCDLPCCGRGKCIDGLGGFRCDCAEGWEGRFCLHEVRFSNCSAENGGCAHYCMEEEGRRHCSCAPGYRLEDDHQLCVSKVTFPCGRLGKRMEKKRKTLKRDTNQVDQKDQLDPRIVDGQEAGWGESPWQAVLLDSKKKLVCGAVLIHVSWVLTVAHCLDSRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNYTKSTSDNDIALLRLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKRNRTFVLSFIKVPVVPYNACVHAMENKISENMLCAGILGDPRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAQEAPLESQVP
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Canis lupus familiaris
Length
456 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
50.814 kDa
Sequence
MWQLASLSLLLTICGTCSTAAPPGSVFSSSESAHQVLRIRKRANSFLEEIRAGSLERECMEEICDFEEAKEIFQNVDDTLAYWSKYVDGDQCAALPPEHACDSPCCGHGSCIDGIGAFHCDCGRGWEGRFCQHEVSYINCSLDNGGCSHYCLEEEGGRHCSCAPGYRLGDDHLQCQPAVKFPCGRPGKQMEKKRKHLKRDTNQTDQIDPRLVNGKVTRRGESPWQVVLLDSKKKLACGAVLIHTSWVLTAAHCMEDSKKLIVRLGEYDLRRWEKGEMDVDIKEVLIHPNYSKSTTDNDIALLHLAQPAIFSQTIVPICLPDSGLAERELTQVGQETVVTGWGYRSETKRNRTFVLNFINIPVAPHNECIQAMYNMISENMLCAGILGDSRDACEGDSGGPMVTSFRGTWFLVGLVSWGEGCGRLHNYGIYTKVSRYLDWIHSHIRGEEASLENQVP
Protein
Vitamin K-dependent protein C: PROC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
295 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.172 kDa
Sequence
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
295 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.172 kDa
Sequence
MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Mycobacterium leprae (strain TN)
Length
294 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.237 kDa
Sequence
MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRARYLADTYSVLVTSVTDAVENAMFVVVAVKPTDVESVMGDLVQAAAVANDSAEQVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVGAGVTVLAKGRFVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPAYFFLLVEALVDAGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAEVAPLGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAKIRSEQLRITSE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Pasteurella multocida (strain Pm70)
Length
275 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.556 kDa
Sequence
MQAKSICFIGGGNMAQAIIFGLLKQGYPANQITVSDPNAAKRQCLAEKGVNTVEASQTDTQDAVETSEVLLLAVKPQMIAAVCQGLSAVDFSQKLVISIAAGVSVTKLQSRLPTAKQIVRVMPNTPALVAEGMSGLFAQNSLKPEYKQFTQDLLNAVGKTCWVTQEADMHTITAGSGSSPAYFFLFMEAMQQALCQMNMDEDTARLLVQQSALGAAKMVIENPDLPIATLRENVTSKGGTTAAALQVLNQQQLQHIVQQAMQACVERSQQMEKLF
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
PROC
Protein
Pyrroline-5-carboxylate reductase
Organism
Pisum sativum
Length
273 amino acids
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.238 kDa
Sequence
MEILPILSDSYTLGFIGAGKMAESIAKGASRSGVLPSSRIVTAHSNPSRRAAFESIGITVLSSNDDVVRASNVVVFSVKPQLVKDVVLKLKPLLTKDKLLVSVAAGIKLKDLQEWAGHERFIRVMPNTPAAVGQAASVMSLGGAATEEDANLISQLFGSIGKIWKADDKFFDAITGLSGSGPAYIYLAIEALADGGVAAGLPRDLALSLASQTVLGAASMATLSGKHPGQLKDDVTSPGGTTIAGVHELEKGGFRGTLMNAVVAAAKRSRELS
Protein
Pyrroline-5-carboxylate reductase: PROC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
273 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.094 kDa
Sequence
MSTPRIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Vibrio alginolyticus
Length
272 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.026 kDa
Sequence
MEHKKIAFIGAGNMVRAIVSGLVANGYPAQNITATAPSEARRLPLEQDFGIRTTSDNIQAATEADVVVLSVKPQMMADVCKPLQAIDFTNKLVISIAAGINCSRLDDMLATKLNLVRVMPNTPSQLGLGMSGLFAPIHVTEHDKAFAAELMEAVGKVCWVEQESGINNVIAAAGSAPAYFFLFMEAMQAEAIAQGFDKESARLLVQQAALGAASMVVSNPETELSTLRENVTSKGGTTAEALRTFNEHQLSDIVAKAMQAAVARAEEMEKLF
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.124 kDa
Sequence
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSAIKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVNDETQMHAVTAASGSSPAYFFLMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAALAVFDAQHFNQTIEQAMQACLSRSQEMETLF
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain COL)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.84 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.826 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNVEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain N315)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.826 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNVEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain MRSA252)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.84 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNIEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain MSSA476)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.826 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNVEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus aureus (strain MW2)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.826 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSSNLDANDIYLTNKSNEQALKAFAEKLGVNYSYDDATLLKDADYVFLGTKPHDFDALATRIKPHITKDNCFISIMAGIPIDYIKQQLECQNPVARIMPNTNAQVGHSVTGISFSNNFDPKSKDEINDLVKAFGSVIEVSEDHLHQVTAITGSGPAFLYHVFEQYVKAGTKLGLEKEQVEESIRNLIIGTSKMIERSDLSMAQLRKNITSKGGTTQAGLDTLSQYDLVSIFEDCLNAAVDRSIELSNVEDQ
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.111 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSNNLNANDIYLTNKSNEQALKSFAEKLGVNYSYDDEALLKDADYVFLGTKPHDFENLANRIREHITNDNRFISIMAGLSIDYIRQQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFDPKSKNEVDELINAFGSVIEVSEEHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERNQVEESIRNLIIGTSKMIERSDLSMSQLRKNITSKGGTTQAGLDALSQYDIVSMFEDCLGAAVNRSMELSHKEDE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.111 kDa
Sequence
MKLVFYGAGNMAQAIFTGIINSNNLNANDIYLTNKSNEQALKSFAEKLGVNYSYDDEALLKDADYVFLGTKPHDFENLANRIREHITNDNRFISIMAGLSIDYIRQQLNTNNPLARIMPNTNAQVGHSVTGISFSNNFDPKSKNEVDELINAFGSVIEVSEEHLHQVTAITGSGPAFLYHVFEQYVKAGTELGLERNQVEESIRNLIIGTSKMIERSDLSMSQLRKNITSKGGTTQAGLDALSQYDIVSMFEDCLGAAVNRSMELSHKEDE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
30.168 kDa
Sequence
MKLVFYGAGNMAQAIFKGIINSKKLKSHDIYLTNKSNEEALKNFAEELGVEYSYDDEKLLQDADYVFLGSKPYDFEKVAQRIQPYINENNRFISIMAGLPINYIQEQLQVENPIARIMPNTNAQVGHSVTGISFSGNFGPKSKEEVNDLVNAFGSVIEVDEDHLHQVTAITGSGPAFLYHVFEQYVKAGTDLGLEKDQVEESIKNLIIGTSKMIERSDLSMEQLRKNITSKGGTTQAGLNALAQHDIEAIFKDCLNAAVHRSVELSKNEDN
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
271 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
29.87 kDa
Sequence
MKLVFYGAGNMAHAIFTGIVNSKVIDSNDIYLTNRSNEVALKEYAEKLGVNYSYDDEALLKAADYVFLGTKPYDFESLAERIKPFITDKNKFISIMAGLPISYIREKLEADNPIARIMPNTNAHVGHSVTGISFSSNFGPNSKDEVDELINAFGSAIEVPEDNLHQVTAITGSGPAFLYHVFEQYVTAGTRLGLEKAQVEESIRNLIIGTSKMIERSELSMEQLRKNITSKGGTTQAGLNALSQHDLESVFEDCLRAAVDRSVELSSQDED
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
270 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.242 kDa
Sequence
MTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAAIRELEESGIRGAFYRAAQACADRSEELGKR
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Corynebacterium melassecola
Length
270 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.223 kDa
Sequence
MTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAAIRELEESGIRGAFYRAAQACADRSEELGKH
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
270 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
27.943 kDa
Sequence
MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKK
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Escherichia coli (strain K12)
Length
269 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Does not catalyze the reverse reaction.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.145 kDa
Sequence
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQFGINAAESAQEVAQIADIIFAAVKPGIMIKVLSEITSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAVRVLEEKGFRAAVIEAMTKCMEKSEKLSKS
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Shigella flexneri
Length
269 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.145 kDa
Sequence
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQFGINAAESAQEVAQIADIIFAAVKPGIMIKVLSEITSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPALVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKMVLETGEHPGALKDMVCSPGGTTIEAVRVLEEKGFRAAVIEAMTKCMEKSEKLSKS
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
267 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
27.883 kDa
Sequence
MSIQLGIIGGGVMAEAILARLIAEKTYAPEEIIVGEPHGARRDYLQKTYQVRVSPDNQEAANVSEVLLLAVKPQVLDRVLASLAGGANRPLVISILAGVSLQRIQKGFPDHAIIRAMPNTPATVGAGMTAIAANKMVEPDQLAKAKAIFSAVGNVVEVPENLMDAVTGVSGSGPAYVALMIEALADGGVLAGLPRAIAQKLALQTVLGTAELIKETEEHPAQIKDKVTSPGGTTIAGVAVLEKMGFRSAIIEAVRAAYRRSQELGKK
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Aquifex aeolicus (strain VF5)
Length
265 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.814 kDa
Sequence
MHAIILTMRVGIVGFGNMGQAFALCFSKKLGKENIIVTDKVQEKRNLATEMGIAFASDVKFLADNSDVVLVAVKPKDSQEVLQKLKDYKGIILSIMAGVSIEKMEKILGKDKKIVRVMPNVNVAVGSGVMAITDNGNLSEEERSKVEELLLSCGTLYRIEERLFDAFTALAGSGPAFVFSFIDALALAGVHQGFSYEQALRIALDTVMGSAKLLKEFQVNPNELIAKVTSPGGTTIEGIKYLEEKGFKGTVMECINRTSQKAKKL
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Treponema pallidum (strain Nichols)
Length
263 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
27.645 kDa
Sequence
MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRDRQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGVLALEEQGLRRAVIHAVRAALSSS
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Length
261 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
27.819 kDa
Sequence
MRLAFVGLGKMGRSILKGALERGFLRPEEVGVLGRTPERSRELAEPFGVRPLTRADLGMAERVLIAVQPRDFPALAPEIAHHRLGYISIMAGISTSVLARRLDNRRVVRAMPNLAVVIGESSTALTALKEAREAEDLAFARALFATVGDVYEIPEHLFDAFTGMSASAPAYLAVVAEALADAGVKMGMPRALALRLAADALAATGELLKGRHPAQVKDEVASPGGTTIHGLHALEARAVRAAFYEAVEAATRRGHELGESE
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Length
257 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.203 kDa
Sequence
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKDAIDIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVNFEALSNAINSLHYLKCMPNIASKFALSSTAVCEKSVAPSISEKALNIIESFGNCVRVGNEEQVDSSVATNGSALAFLSLVASSLKDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGVRGAFIKACHESVKKMRL
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
257 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
28.162 kDa
Sequence
MEILQFIGYGNMAQAILEGAHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKDAIDIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVGFKALSDAIDSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGHEELVDASVATNGSALAFLSLVANSLKDAGIREGLNARGSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGVRGAFIEACHKSVKKMRL
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
proC
Protein
Pyrroline-5-carboxylate reductase
Organism
Methanobrevibacter smithii
Length
251 amino acids
Function
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Similarity
Belongs to the pyrroline-5-carboxylate reductase family.
Mass
27.859 kDa
Sequence
MNLGIIGYGNIGELLSQNIISHDFCNLNKLYIANRTLSKINHLKDIDPRISITDDNIEVAKTCEKIIISVKTPDLAIVLDPLKPHITKNQQIIHTCAGTDLEFKDCGLSCVIPTISSTYDEDNPKKGVSIIMHDENVSGENREFVEKLFSKFSQIKVVDSPMDLEIATIAASCMPAFIALGVDLFAGELEEKCNLSKEETFKILAETLNSTAYILKEDIYSPDELINKVATKNGITQKGLDVLDKRPARYL
Protein
Pyrroline-5-carboxylate reductase: proC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Macaca mulatta
Length
161 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
17.77 kDa
Fragment
single
Sequence
EKWELDLDIEEVFIHPNYTKSTTDNDIALLRLAQPATLSQTIVPICLPDSGLAERELTQAGQETLVTGWGYHSSREKEAKRNRTFILNFIKIPVVPRNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGV
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Capra hircus
Length
157 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
17.251 kDa
Fragment
single
Sequence
ESWEVDLDIKEVIVRPNYTKSTSDNDIALLHLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKKNRTSILNFIKIPVVSYNACVHAMENKVSENMLCAGILGNPRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRLNNYGI
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Felis catus
Length
157 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
17.142 kDa
Fragment
single
Sequence
EKWELDLDIKEVLMHPNYSRSTSDNDIALLRLAQPAILSQTIVPICLPDSGLAERELTQAGQETVVTGWGHRSEAKRNRTFVLNFIKVPVVPQNECINAMHNMISENMLCAGILGDSQDACEGDSGGPMVASFRGTSFLVGLVTWGEGCGRLHNYGV
Protein
Vitamin K-dependent protein C: PROC

Gene
PROC
Protein
Vitamin K-dependent protein C
Organism
Equus caballus
Length
157 amino acids
Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Similarity
Belongs to the peptidase S1 family.
Mass
17.2 kDa
Fragment
single
Sequence
ENGEVDLDIQEVIMHPNYSKSSSDNDIALLRLARPATFSQTIVPICLPDSGLSERELTQAGQETVVTGWGYRSETKRNRTFVLNFIKVPVVPHSECVRTMHNLVSENMLCAGILGDTRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRLHNYGV
Protein
Vitamin K-dependent protein C: PROC

Gene
proC
Protein
Profilin-3
Organism
Dictyostelium discoideum
Length
126 amino acids
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
Similarity
Belongs to the profilin family.
Mass
13.315 kDa
Sequence
MTWQAYIDTNLIGSGFISAQILSSADGSSWANSNGFSVSATEAQHILSCFKDSNKASAMGITINNVKNFVLKADDKSIYAKKDAGGVVLVKTNQTILVAVYNSNLQPGAAANACEALGDYLREQGF
Protein
Profilin-3: proC