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prmt1

Gene
PRMT1
Protein
Probable protein arginine N-methyltransferase 1
Organism
Oryza sativa subsp. indica
Length
387 amino acids
Function
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate histones).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
43.014 kDa
Sequence
MDQRKGSGSDANGGLAEATASRLRFEDPDEVMEENPAAAAATVGAEEEGGEGGGGEEVIGSDKTSADYYFDSYSHFGIHEEMLKDVVRTKSYQNVITQNSFLFKDKIVLDVGAGTGILSLFCAKAGAKHVYAIECSQMADMAKEIVKTNGYSNVITVIKGKVEEIELPVPKVDVIISEWMGYFLLFENMLNTVLYARDKWLADGGVVLPDKASLHLTAIEDAEYKEDKIEFWNNVYGFDMRCIKKQAMMEPLVDTVDANQIVTNCQLLKTMDISKMTPGDASFTVPFKLVAERNDYIHALVAYFNVSFTKCHKMMGFSTGPRSKATHWKQTVLYLEDVLTICEGETITGSMTVTPNKKNPRDIDIKLCYALSGHRCQVSRTQHYKMR

Gene
PRMT1
Protein
Probable protein arginine N-methyltransferase 1
Organism
Oryza sativa subsp. japonica
Length
387 amino acids
Function
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate histones).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
43.014 kDa
Sequence
MDQRKGSGSDANGGLAEATASRLRFEDPDEVMEENPAAAAATVGAEEEGGEGGGGEEVIGSDKTSADYYFDSYSHFGIHEEMLKDVVRTKSYQNVITQNSFLFKDKIVLDVGAGTGILSLFCAKAGAKHVYAIECSQMADMAKEIVKTNGYSNVITVIKGKVEEIELPVPKVDVIISEWMGYFLLFENMLNTVLYARDKWLADGGVVLPDKASLHLTAIEDAEYKEDKIEFWNNVYGFDMRCIKKQAMMEPLVDTVDANQIVTNCQLLKTMDISKMTPGDASFTVPFKLVAERNDYIHALVAYFNVSFTKCHKMMGFSTGPRSKATHWKQTVLYLEDVLTICEGETITGSMTVTPNKKNPRDIDIKLCYALSGHRCQVSRTQHYKMR

Gene
PRMT1
Protein
Protein arginine N-methyltransferase 1
Organism
Homo sapiens
Length
371 amino acids
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
42.462 kDa
Sequence
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR

Gene
Prmt1
Protein
Protein arginine N-methyltransferase 1
Organism
Mus musculus
Length
371 amino acids
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:15327772, PubMed:19858291). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:19858291).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
42.436 kDa
Sequence
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR

Gene
Prmt1
Protein
Protein arginine N-methyltransferase 1
Organism
Rattus norvegicus
Length
353 amino acids
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:12737817, PubMed:15837430, PubMed:18492485). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (By similarity). May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway (By similarity). Methylates RBM15, promoting ubiquitination and degradation of RBM15 (By similarity). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (By similarity).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
40.522 kDa
Sequence
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR

Gene
prmt1
Protein
Protein arginine N-methyltransferase 1
Organism
Xenopus tropicalis
Length
351 amino acids
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Methylates ilf3 to regulate its DNA-binding activity. Required for neural induction, playing a key role in the control of epidermal versus neural cell fate choice (By similarity). Methylates cirbp to regulate its subcellular location. Acts transiently during metamorphosis as a transcription coactivator, enhancing thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR binding to the T3 response element (TRE), and histone modification through recruitment of other coactivators.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
40.454 kDa
Sequence
MAEASTCNMEVSCTQPESSVKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGAKKVIGIECSSISDYAIKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIYARDKWLTPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVDDLTFTSPFCLQVKRNDYIHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTISMKPNAKNNRDLDFTVDIDFKGQLCELSCSTDYRMR

Gene
PRMT1
Protein
Protein arginine N-methyltransferase 1
Organism
Chlamydomonas reinhardtii
Length
345 amino acids
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Mediates asymmetric dimethylation of components of the axoneme during flagellum resorption, such as CCDC40/FAP172, CCDC65/FAP250, RSP1, RSP2, RPS5, RSP6, and tektin (PubMed:24152136).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
38.836 kDa
Sequence
MATAMDTGAGASAPAVPQGDRTSADYYFDSYSHFGIHEEMLKDSVRTRTYMNAILNNAYLFKDKIVLDIGCGTGILSLFSAKAGAKHVYGIECSTIAEQATQIVKDNKFDDRVTIIKGKVEEVTLPVDKVDIIISEWMGYFLFYESMLDTVIYARDKWLVPGGIIMPDKATLSLCAIEDGEYKHDKIEFWDNVYGFNMSCIKQLAIAEPLVDIVEPDQIASTIQTVVSVDISTMKKEDATFTVPYELTMTRNDYVHALVGFFDVSFTRGHKPLSFTTSPRARATHWKQTVFYLEDTLMASKDETISGKLECKPNAKNPRDLDISIAYEFEGERGQVKNTQQYRMR

Gene
prmt1
Protein
Protein arginine N-methyltransferase 1
Organism
Dictyostelium discoideum
Length
341 amino acids
Function
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues present in proteins such as ribonucleoproteins and histones.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Mass
39.121 kDa
Sequence
MTETNKNVDALEKINQMSSADYYFDSYSHFGIHEEMLKDEVRTLAYRRAIINNRKLFEGKVVLDVGCGTGILCMFAAQAGAKMVIGVDNSEMLPIAQKIITANNFDKTITLIKGKMEEVVLPVDKVDIIISEWMGYFMLYEGMLDTVLYARDKYLVPGGVILPDKASLYITAIEDQDYKEEKINYWNNVYGFDMSCIREIALKEPLVDVVQPNMIVTNDCCILTVDIMTITKDELKFRSDFKLKALRDDLIHAFVVYFDIEFSKGDKPVCFSTGPKAKYTHWKQSIMYFEDHIKIQQGEIITGTMDCAPFDKNQRDLKIKLDFNFAGELMKSSSSLEYHMR