prlC

Oligopeptidase A

681 amino acids

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) (By similarity).

Belongs to the peptidase M3 family.

78.017 kDa

MSMSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWVGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYATRASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKGYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGAWMDDCIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQIDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN

prlC

Oligopeptidase A

680 amino acids

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4).

Belongs to the peptidase M3 family.

77.167 kDa

MTNPLLTPFELPPFSKILPEHVVPAVTKALNDCRENVERVVAQGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQAEAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYSTRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKSLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGGAWMDDCVGQMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIFNRETGQSFLDNILSRGGSEEPMDLFKRFRGREPQLDAMLEHYGIKG

prlC

Oligopeptidase A

680 amino acids

May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4).

Belongs to the peptidase M3 family.

76.944 kDa

MTNPLLTSFSLPPFSAIKPEHVVPAVTKALADCRAAVEGVVAHGAPYSWENLCQPLAEADDVLGRIFSPISHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYNAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKLITDEAELAGMPESALAAAKAQAEAKEQEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYSTRASDQGPNAGKWDNSPVMEEILALRHELAQLLGFENYAHESLATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAKAEFGVEELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERTDVDVWHPEVRFFELYDENNELRGSFYLDLYAREHKRGGAWMDDCVGQMRKADGTLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALFILRQLEFGLFDFRLHAEFNPQQGAKILETLFEIKKQVAVVPSPTWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAYSRFEEEGIFNRETGQSFLDNILTRGGSEEPMELFKRFRGREPQLDAMLEHYGIKG

prlC

Trans-enoyl reductase prlC

360 amino acids

Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of pyrrolocin, a bright yellow trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:25226362, PubMed:25351193). The PKS module of prlS together with the enoylreductase prlC catalyze the formation of the polyketide unit which is then conjugated to L-serine by the condensation domain of the prlS NRPS module (PubMed:25226362). Diels-Alderase gNR600 is involved in endo-selective Diels-Alder cycloaddition to form the decalin ring (By similarity). Subsequent methylation is carried leads to pyrrolocin A (PubMed:25226362). The methyltransferase involved in that last step has not been identified yet and is probably located outside of the prl cluster (PubMed:25226362).

Belongs to the zinc-containing alcohol dehydrogenase family.

38.112 kDa

MGSLEKARRTQTAVVGNNQGGVQLSHDAPIPEAKGDIVVVRAEAVSVNPVDAKMRGQYVTSGAIGGCDFAGVVVEVGLDAAKYDIKVGDRVCAAIMGMNPLEPAHGAFSEYVGAHAFALVKIPPTVSFESAAALCTCFMTCGLALFRSLQLPGHPLSPSSKPLPVLVYGGATATGTAAIQLLRLAGFTPVVTCSPHSYDLIKSYGAEAAFDYHDPDCAAQIRAQTKNGLRFALDCITNTQSMQICYAALGRAGGRYTALDPYPEAVAATRKIIKADWVIGPVMLGLDIGWPAPHGRKADPDLFEFGQRWKATVQQLLNQGLIREHPLFVQSGGLSRVIDSMEAILAKKVSGKKMVCKLSQ