Protein
Prickle-like protein 1-A
Function
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Essential for gastrulation cell movements, cooperating with dvl2/dsh to activate jnk. Acts together with tes to control axial elongation.
Similarity
Belongs to the prickle / espinas / testin family.
Sequence
MPLEMDQKVNKLTFGCQRSSTSDDDSGCAMEEYTWVPPGLRLEQVQLYFACLPEEKIPYVNSVGEKYRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQMFSAQRKKEALGRGNIKMLSRAVMHATCEKCGEKINGGEVAIFVSRAGPGVCWHPSCFVCSTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMNHFCCYECETVLGGQRYIMKDGRPFCCGCFESHYAEYCESCGEHIGVDHAQMTYDGQHWHATETCFSCAQCKVSLLGCPFLPKKGRIYCCKACSLGEDVHASDSSDSAFQSARSRESRRSVRMGKSSRSADQCRQSLLLSPAVNYKFPGMFGNADDTLSRKMDDLSMSRQGAGFDNDTWKARDEQETAEDHEEWAEHDDYMTQLLLKFGEKGLFQQPPEDNRSNDHWMSENIKGKNDLQRNNRNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRKLQELDMDHGASGYMHEKMPWYKRSLECLSNNLKPQNENICDSMDSLALSNITGASVDAESKSRPSLFSYQNFQELNTRDFDKMSNMGTLNSSMLNRSTESLKSLNSEICQEKPPPEEKPMHTSALKRSKSQTRPQVKFSDDVIDNGDYSSIEIRRPPMSERSRRRVYNSEEQSQRPHHHHHHRRRKSRKSRSENALHLATDSKSSGKERKRSYTAEDYERLFHNKSAHEVQAYIQNADLFGQYSNAASNVGLPSQVVDKFLGLYGEDEDSWCSTCSSSSSDSEEEGYFLGQPIPKPRPQRYQYFSDDLCSPTNALSSSQFSQRTSKSKKKKGHKGKNCIIS