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priL

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
434 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
49.651 kDa
Sequence
MVSSLFINPFSEDAREIVRKYGSLDTIDDTRDELLEIGRRTRGQNLADNSLLPASIAELAVKRLEWYLRRQRKDFNHRDYAYLMNPEIEEYDVLAFYILAQAAGAGFMKASREARLVVESAGAMVEDRLNVFGGEREEIMAEVLYELGSEGLRWTELADLLGSGKLKLTDLILKEGRVIIDRDEFITSFQDSIRDRSPDRLYDILVGLEVRETMISRMIMQRTEEYIGMVREMSSTVEVHPLILETAERIRETVEEIMSFTGGPVKSARPGKLVQEAFPPCIRGTLDGVRSGNRNDAIVLLLTSFISYARLYPSVFRDRTPMKVSDLDPDLRITLGEILPVIYDAADRCEPPLFEDDPQEKLNITAKLGFGVHDMPELENEGESKWYTPMSCEKIKIHLPDLCRPDKLCSSISNPLTYYNRKRWKLRSSGEKEE

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
414 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
49.101 kDa
Sequence
MIIMLSEYLEEFKEYLERFKNIDINFSDVLKMSKKFIIWRLKQIFGDSSTIFTNISSEITIFDKIFQMIDYDIDGEVEKRLPKDESRFMIGVRREKEIEIKKEIITNLLDFLLIILLSHTPYFNAFVRKYAEIKKIKVIKKLPNKISVWEFIKIASRSRINDLHLERLDLENGFVDITKIKEIFAKEIIRVELMKLGENIKKRKLPDDSVVKELLNEISDYLKDKVKYEQISGIKALNYKGNIPLEWHPPCIRGILNDILSGGSPSHYARRSFVVYWFCAKFNPNLRPLDKNGNLVNVSATDIASEEEIERFIDELIEMLFKNVEDFDEKKTRYYIMHNIGYKVGHGRLTHCEYCKNWQDDGGKGLSYYCKPDELCKKKFIIHPLDYLCYNINKHLKKERFKKIKKEDKNGDNK

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
413 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
48.019 kDa
Sequence
MDEEHIALYPFASEVSAYVESLRVSLESLLNSPAFRRSRVRGMERVMQSIEGEIETTLIKDESWLLSETLSYPFAQILVACVDDQLFTKRYALKEAEAASKWLEKESTDFLLEFGEDFGIQAEAEELQFSMHFADYIRFSSSIREPVWKLTNRQLRSGMVVVTKKDFVRLLQEAIKERIEKSFPIPKIPSEVSSFCAPYVAEIKDKFEVHKKKFGTTDFGVVEPDLFPPCISHALANVQGGVNLAHSMRFAMTSFLLSVGMSVDEILNLFNVSPDFDAEVTLYQIEHIAGATGNVYKPPACDTMRTYGNCIGKDRLCEKINHPLAYYEKKIYLKNKEKEMEKEKEEKEEKEKQEEKKEEEEKEKQEEIKKKKKKEKQEEKGKKIKEGKKRERKQEKETKRREGKEKQEEKKRI

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
406 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
46.873 kDa
Sequence
MRSWFPHAPTVSVPEIEPEEALSYRDEIRTRVRSYAFGLDDWRAKVKTRRAYLRKVRDEDESEILRVYGALLTVAAAGPRPVRHLIAEGESAMAETALYALRHEDESAMSYPEERVLSDLYLWDVRVLERDLGLYAVHFSFPLIHRSPEGQKLKVLVWERASLEKVLKEVRSNRVLGVRVLDPSGWNDVWICPRCGATRRGGTGDLEQDHARRCSNCRGRMRKPDPNLLEMLKEPEGYLIMHFKTLARTFREDVRRLVVSDIESRDDVEDEELREFCLKLFPKVRKRLERVEKGAGGRFPPCIRELLRRAQEGENLPHEARFALAAFLVNVGWDVDRVVEVFSNLPDFDEERTQYQVRHIAGEVGGGTRYLPPNCDKMKAWGLCPGKDCGVKNPLAYYRRPRADDG

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
400 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
46.524 kDa
Sequence
MLDPFGKRAESLIREEFGDLLALLERVPSAISVEEPISLVSWMLESENPPQELVEVDNLEELRDLFKFYALLGAASISPYGLEAEVVKRATLRLYSERIKASKNLSETMLPVVPVGENEIPHNDLNILERRMDRNLSPEEKEKLKIKYKIPIKDLLNLWGSSLKEVYIRNGYAYLRWETALKMWEKAFEKRFERAVNILYEYRDELPEFYHRLREKLEEIAEEYFKERGEMFKGTASPLRFDLFPPCVKEALKGVPAGMRNYAITVLLTSFLSYARICPNPPKKDVRIKDCINDLKIIEEEILPVIIEAGNRCKPPLFEDQPHEIKNIWYHLGFGLTDSPTMEDSGNSTWYFPPNCDKIRANAPQLCKPDKYCRGIKNPLSYYLKRLYLEGKKKEGETSE

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
396 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
46.209 kDa
Sequence
MLDPFSEKAKELLKEFGSMNEFLQAIPSLVDIEEVMNRLKFAKESEISEDILNIEDIRDLASFYAQIGALAYSPYGLELELVKKANLRIYTERIRRRRKIRSDEIGIEVKIAVEFPENDIKTLEKVYGGLPEYIVSLREFLDLVPDEKLSSYYVYDGNVYLRKDDLLKVWSKAFERNVEKAVNIIYEIRDELPEFYRRLAGEIRSFAEKEFSDKFREVQAGELKHHLFPPCVKNALRGVPQGMRNYAITVLLTSFLSYARICPNPPRRNVKIRDCIKDMRVITEEILPIIIEAGNRCSPPLFEDQPNEIKNIWYHLGFGYTANPTLEDSGNSTWYFPPNCDKIKANAPQLCTPDKHCRYIRNPLTYYLRRLYLEEKRRAKHADEGSDKGGKERILQ

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
394 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
45.949 kDa
Sequence
MLDPFSEKAKELLKGFGSINDFMDAIPKIVSVDDVIERIRVVKNEKLIDKFLDQDNVMDLAQFYALLGALSYSPYGIELELVKKANLIIYSERLKRKKEIKPEEISIDVSTAIEFPTEDVRKIERVYGKIPEYTMKISDFLDLVPDEKLANYYIYEGRVYLKREDLIRIWSKAFERNVERGVNMLYEIRDELPEFYRKVLGEIQAFAEEEFGRKFGEIQGGKLRPEFFPPCIKNALKGVPQGIRNYAITVLLTSFLSYARICPNPPRRNVRVKDCIKDIRVITEEILPIIIEAANRCSPPLFEDQPNEIKNIWYHLGFGYTANPSLEDSGNSTWYFPPNCEKIRANAPQLCTPDKHCKYIRNPLTYYLRRLYLEGRRNAPKRGNKRGKKELLHQ

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
393 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Displays gap-filling and strand-displacement activities.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
45.486 kDa
Sequence
MLDPFSEKAKELLKEFGSINDFLNSIPRIVDVEEVIERVKIASDRKLLEGFVDIEDIKDLAQFYALLGALSYSPYGLELELVKKANILLYSERIRREKEIRPEEISLRINKAIEFPIDDLKKIERVFGKLPEYTIHLAEFLDLIPGERLSEYYIYNGNVYLRKEDLIKVWMKAFERNIEKSVNMLYEIRDELPGFFREVLGGIKEVAEQEFGKSGEVKAGTLRPDLFPPCVKNALKGVPQGLRNYAITVLLTSFLSYARICPNPPRRNVRVKDCIDDIRIITDEILPLIIEAANRCSPPLFEDQPNEIKNIWYHLGFGYTANPKLEDSGNSTWYFPPNCDKIRANAPQLCTPDKHCKYVRNPLTYYLRRLYLEGRKNASKGGNERGEKRVLQQ

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
371 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
42.277 kDa
Sequence
MQAEKLAYYPFISEASAHVGDLGISLESLLNSRAYRTARARGIERVKEALEGEIKKPPVSEEAQVLSELLSYPFARMLVACVDDQLFTRRYALAEAKAAYTFLRNETPDFLLEFGEDFGISAEIRDSHFSMHFTDYIRFSNSLKEPSWKLTNRQFRAGKIKITKEEFARLLEEAVRERIEQSFPIPEIPPEVSAFCAPYVAEIKEQFEVQKKKFGATDFGAVEPELFPPCISHALANVQGGVNLAHSMRFAMTSFLLNVGMSVEEILNLFNVSPDFDAEKTLYQIEHIAGATGNEYKPPACDTMRTYGNCIGKDGLCAKISHPLGYYERRIFLKNKEREKEEGKEKGNEEKKEKREEHEKKNEKGNEIKEK

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
370 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
41.698 kDa
Sequence
MQAEKLAYYPFTSEASAYVGNLGISLESLLNSRAYRAARARGIERVKEALEGEIKKSPVSGEAQVLSELLSYPFARMLVACVDDQLFTRRYALAEAKAAYTFLRNENPDFLLEFGDDFGISADSQDSYFSMHFTDYIRFSNSLKDPSWKLTNRQLRAGKIKITKEEFSRLLEEAVRERIEQSFPVPEIPPEVSSFCSPYAAEIKDKFEVQKKKFGSTDFGAVKPELFPPCIAYALANVQGGVNLAHSMRFAMTSFLLNVGMSVDEILNLFNISPDFNAEKTLYQIEHIAGATGNTYKPPACDTMRTYGNCVGKDRLCEKISHPLGYYEKKVFIKNKEGEEAQGKEQGKEKDDGKEKENGKESEVKKKKEK

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
370 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
42.844 kDa
Sequence
MKYLPLYPILARYPFLRIASRVFSFNIEDELRKFLDTVEAAKRIVDKAIDGRVEYDRFTDESEFFCLGCEENCYDCQKRGTLEGCDLCMGCFENCSLYYPREAVERFYTNAKLSLLTYIASRMIVSAMEDWVRMRYAVNEASYYSRLLREDVEESGKEPIVRLVAIDLGAKLKGWKMHVSTFVRVSARIKDDKWRLVNRKLRNGWVETTKAEVLRGLEELLRMKLFEKVPVSEAVSEAVRELSRKAKRESEKFAMDLGEVDLNCLPPCMREILSELQRGMNIPHTARFAITSFLLNIGMTVDEIIALFKSAPDFDDEKTRYQVEHIAGERGKGAEYTSPSCDTMRTYSNCVADCRVSHPLIYYKKCKSKS

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Length
366 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
41.463 kDa
Sequence
MDAVGFAKYPFTQEALSYVRDRNYSMEDILQKPAYGQVRLRAKKRVLNSIKGDVQADDLLPDPERELLSYPVARMLVAMTEDQYLMKRFALWESKRAYTLLLDESDTGLMDVGRDFGITARAKDREFIIHFTDYLRYAAGLRNLEWKLINRKVVAGMVYVSRETFTRLLEEAVREKIQAGFGAKVPAEMKPVLEPYLAEIRESLDKLKSEKGLSGDGEVTQDSFPPCMKNLLADLQKGINLPHTARFALTSFLANIGLDKDAIMDLYRMAPDFREDLTHYQVQHITGGSGTEYTCPGCKTMMTYGNCIGKNKLCEYVTHPLSYYRKSQRRRAKEMAAAQAFKGSKDKAVDTVAENVHVETGNSPGN

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
364 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
41.42 kDa
Sequence
MDNRHLALYPFVTEASEYVGSLGFSPDKLLSSRALESARIRGRERVIQALEGEIEKPSPSSSEEGKILTELLSYPFSRILVSCIDDPFLTRKYALAEAKAAYHLLKTQQPEFLQDLATDFRINAEIYENPETHDIFFDLHFTDYIKLASPLKDLNWKLVNRKMKKGYVKISKEELARLLQEAIRLRIQNSLPVTVPKEICEACIPHTDTISEELEKKKTEFGVGEFQRVESDLFPPCITQAIANVRAGVNLAHSMRFAMTSFLINIGMSVDEVVAMFNISPDFDEEKTRYQIEHIAGTSSGTTYKPPSCNTMRTYGNCSAPDELCKGVKHPLGYYSRRVWVKNRMQNDNEKGHEEKKEGETPPQ

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Length
360 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
39.739 kDa
Sequence
MNARHARYPFLGDARDAVEEAGVDLARVVTEDDAVVERARERVVSALTDGTIGEPAATVSTRVEVLSYPVARVLVSIVDESVLVRKYATAEADAAYDRFTADESTDTDLKSVSDTTRVSRDTLLSEFDLRAHVHATPDAHTVDVPTYLLLASSLRDDDWRLVNRALDDGRVPVTDAELDTLIREAIRERVADGLPLSVPDQIADALDEPVAAIQDALADLDLTREIDTVVPELFPPCMKHLLDQVQRGDHLPHHARFAITSFLSNVGLSTDEIVDIYEVNPGFGEEMTRYQTDHIQGDSSPTEYTAPSCATMKAYGNCVNPDDLCDAINHPLSYYEVKLDDGDDDDLADWRDREDDDSPD

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
360 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
39.739 kDa
Sequence
MNARHARYPFLGDARDAVEEAGVDLARVVTEDDAVVERARERVVSALTDGTIGEPAATVSTRVEVLSYPVARVLVSIVDESVLVRKYATAEADAAYDRFTADESTDTDLKSVSDTTRVSRDTLLSEFDLRAHVHATPDAHTVDVPTYLLLASSLRDDDWRLVNRALDDGRVPVTDAELDTLIREAIRERVADGLPLSVPDQIADALDEPVAAIQDALADLDLTREIDTVVPELFPPCMKHLLDQVQRGDHLPHHARFAITSFLSNVGLSTDEIVDIYEVNPGFGEEMTRYQTDHIQGDSSPTEYTAPSCATMKAYGNCVNPDDLCDAINHPLSYYEVKLDDGDDDDLADWRDREDDDSPD

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Length
358 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
39.976 kDa
Sequence
MEPLHARYPFLARSREAVEAAAVDLGEIVATDETVTARALERVESAITDGTVGEPHRRTRVELLSYPVARVLVSLVDVHICTRKYAQAEAEAAYDRFTEEFATTTELKSTQRETLDRTELLGEFDLASAVSDAGDGYRVEVGAYLDLAADQRGDSWRLVNRPLTDGEVRVTAEELNVLLKQAIRHRVTDGLPFTVPDAIADELTAEVEQLEEVLSELELTREIDTVVPELFPPCMKSLLDQVQKGEHLEHHSRFAIATFLVGIGMTTDEIVDLFQVNPGFGEEATRYQVDHIRGDTSPTEYSTPACSTMQSYGDCVNMDDLCEAISHPMGYYEQKLDDTDEEELVDWREDEGEEEADA

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
340 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
39.049 kDa
Sequence
MILPDRKQILDRELIRRIADTTISGSGHSDGLSEYASIRKAAFAFVESAVLGDQAYSPIENAELAFIVWILAALDENIITARTIIKARDTVEKQLRLVEHYEDLEEFGSRLGIEISVFGEQIGKDHLYRIGVADFATYASRVTGSKYRLSNQIVREGYVYVDEDVMAKVLREAFVSFMFDTLDQIRKEDAIETIKSVLDDLEKIRESYRKAHNVRMIAGKGDASMFPPCMKEIIKNLESGVNVSHMGRLALASFLHKAGYSEDEIVPYFRNAPDFDENITRYQIKHISGEISGTEYTPPKCETMRSNHLCYMDDDPLCHREWMKHPLTYYEVKRRNRKIR

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Length
327 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
37.915 kDa
Sequence
MRFPPLLFFQDSEAVKRIANSVRGTKDDDAEIKDHSMRFIRNAISGDQQKEILNVDMLRYIAWVLVALNENIVTARTVIRERDAVEDALKNQQPEDIENFADDLKINMKYNRDLERFEIGVFDFVKYASRVTGSQYRLSNQSVIKGIVYCQKDVAIKILRESFVSNMFKVIDSIDQTTASPVLSDQTDSINELREFYKKSVYAKLTIGRGNTKAFPPCMKEIIRNLHEGINVPHMGRLAIASFLHKVGYTEDEIVEYFRNAPDFDESITRYQIKHLSGEISGVEYSPPKCETMRSNHLCFMDDDKLCHQDWMKHPLTYYEVKSRRLG

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
307 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template-independent 3'-terminal nucleotidyl transferase activity.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
35.734 kDa
Sequence
MALDVKKYPFIKSLDDELKKYGGGITLTDLLLNSTTLIDQAKDRIQKTKSGDELPHYVSYNEPVLVFYTTLLSLAILNDVKLIRRYAYAEAKQFRSLLHTENEENLLEISKLLDLKINRCDPIKFYLEKKRRIIQKEFCVHFIDYLKYTKDLKEDWKLSGQILHKGYVYLDKNQLIGLIAESIKSKIVEMIRPLNLKEIPEKLKSLIERRGIIPPCIENILAKEKLNEEEIRTLITFYIDIGKGLSGIVSIMKKYNVSNVEDLYRKYRGDKGTRYIVYSCAKMKQLGLCVSSCNVKNPLQLYFLSNE

Gene
priL
Protein
DNA primase large subunit PriL
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
306 amino acids
Function
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Similarity
Belongs to the eukaryotic-type primase large subunit family.
Mass
35.753 kDa
Sequence
MLILDFRKYPFLKPLEDELKKYAGGISLNDLLVSGSYYLDQAKERIDKILKDKELESYDKIKDSVLVFYTTLYLVAALDNDMLKKKFLDKESQIIEKNLLNESEETLVEIANYLGLNINYNNIEIKYKKNKKTLSLSLKYSLNFIDFLKYTRELRKIDNKFSLASHILKDGKVYLTKEEIVRILVFQIRDKLMKMVNVSDVVIPEQIRKLADELKGRKTPPCILELKRKKELNNTELGVLIAYYIDIGDEKSVIDLTKDENIVKKFKGDKKTKYILYSCKKMKELGLCVASCNTLNPLQFYYGKLE