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prf1

Gene
PRF1
Protein
Perforin-1
Organism
Homo sapiens
Length
555 amino acids
Function
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Similarity
Belongs to the complement C6/C7/C8/C9 family.
Mass
61.377 kDa
Sequence
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW

Gene
Prf1
Protein
Perforin-1
Organism
Mus musculus
Length
554 amino acids
Function
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Similarity
Belongs to the complement C6/C7/C8/C9 family.
Mass
62.081 kDa
Sequence
MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREAAANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHVEVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDPPGNRSGAVW

Gene
Prf1
Protein
Perforin-1
Organism
Rattus norvegicus
Length
554 amino acids
Function
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Similarity
Belongs to the complement C6/C7/C8/C9 family.
Mass
61.513 kDa
Sequence
MAAYLFLLGLFLLLPRPVPAPCYTATRSECKQNHKFVPGVWAAGEGVDVTTLRRSSSFPVNTGKFLRPDRTCTLCKNALMNDGIQRLPVAIAHWRPHGSHCQRNVATTKVSSTEGVAREAAANINNDWRAGLDVNPKPEANVHVSVAGSHSKIANFAAEKAHQDQYNFNTDTVECRMYSFRLAQKPPLHPDFRKALKNLPHNFNSSTEHAYRRLISSYGTHFITAVDLGGRVSVLTALRTCQLTLDGLTADEVGDCLSVEAQVSIGAQASVSSEYKACEEKKKQHKIATSFHQTYRERHVEVLGGPLDSSNDLLFGNQATPEHFSTWIASLPTRPDVVDYSLEPLHILLEDSDPKREALRQAISHYVMSRARWRDCNRPCRAGQHKSSRDSCQCVCQDSNVTNQDCCPRQRGLAKLMVRNFQAKGLWGDYITSTDAYLKVFFGGQEIRTGVVWNNNHPSWSDKMDFGNVLLSTGGPLRVQVWDADNGWDDDLLGTCDKSPKSGFHEVNCPLNHGSIKFIYQANCLPDLTGETCLEYAPQGLLGDPRGNRSGAVW

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
421 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.508 kDa
Sequence
MASTDSKQLYLFKKMLKELKSKKGKGTELISLYIPAGRRISDVAQHLREEMSQASNIKSKSTRKNVQSAIEAILQRLKLLKEPLEKGVVIFAGMVPRSGPGTEKMETYVIEPPEPIKTYIYRCDSEFYLEPLEEFLEDKDAYGVILVDRNEATIALVKGRNINILKKLTSGVPGKFKAGGQSARRLERLIDLAAHEFLQRVGQKANEQFLPLLQEKKLRGILVGGPGHTKNEFVEGDYLHHELKKIVLDTFDLCYTEEFGIRELLEKAAPLLKDVELMKEREAVQRFLKELIKEDGGLACYGEKEVLEALMMGAVDTLIVSEELEKYKVKIACNNCDYLEEKTVNKLELIKLEEELKNAQCPKCGGALSIVEEKDYIEYLSELCEQSGAKLVTVSSETEEGAMILNAFKGIAAILRYKIHQ

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
420 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.954 kDa
Sequence
MRVMTSRDAQLYELKKKIDELKKIRGRGTELISLYIPAGYDLSKVMQQLREEYSTAQNIKSKTTRKNVLGALERAMQHLKLYKQTPENGLALFVGNVSEMEGVTDIRLWAIIPPEPLNVRLYRCDQTFVTEPLEEMLRVKEAYGLITVEKNEATIGILRGKRIEVLDELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANRIFLPLLESGELKGIIVGGPGPTKEEFVEGDYLHHELKKKIIGIVDISYHGEYGLRELVAKAADILRDHEVIRERNLVNEFLKHIVKDTGLATYGEREVRKALELGAVDTLLISEGYDKVRVHVKCNNCGWEELKTMSEEEYEAYKKRIQTCPKCGSQNLTFEKWEVAEELIKIAEEAGSNVEIISLDTEEGQQFYRAFGGLGAILRFRIQGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Length
419 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.635 kDa
Sequence
MSENSSTDMYLFKKSLKELKGKRGKGTELISVYVPAGRRLSDISQHLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEKGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFIYRCDSEFYTESLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYSTESFMPILEEKKLRGLLIGGPGNTKNEFAEKDFLHHELKKKIIDTFDLCYTEEFGIRELLEKASDLLRDLDLMKEKNLIQKFFKELIKDDGGLSAYGESQVMRYLEMGAIDTLIVTEDIELTRVTIKCNNCNFKQEINVKTRDLYKFEDEVKTKICKQCSGSMYIEEEKDIIEYLSELCNIHNSDIVVVSTDTEEGSQISKAFKGMAAILRYKI

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
Length
419 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.202 kDa
Sequence
MSGNSSTDMYLFKKSLKELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLDKASDLLRDLDLMKEKNLIQKFFKELIKDDGGLSAYGEAQVMKYLEMGAIDTLIVTEDIGITRVTVKCNNCDYAQEVNVKTNEMFKFEEQLKTKACPTCGGAMYIDEEKDIIEHLSDLCHMHNTDIIVVSTDTEEGSQISRAFKGMAAILRYKL

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Length
419 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.219 kDa
Sequence
MSGNSSTDMYLFKKSLKELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLDKASDLLRDLDLMKEKNLIQRFFKELIKDDGGLSAYGEAQVMKYLEMGAIDTLIVTEDIGITRVTIKCNNCDYTQEVNVKTNEMFKFEEQLKTKACPTCGGAMYIDEEKDIIEHLSDLCNVHNTDIIVVSTDTEEGSQISRAFKGMAAILRYKL

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Length
419 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.201 kDa
Sequence
MSGNSSTDMYLFKKSLRELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLEKASDLLRDLDLMKEKNLIQRFFKELIKDDGGLSAYGEAQVMKYLGMGAIDTLIVTEDIGITRVTVKCNNCDYTQEVNVKTNEMFKFEDQLKTKACPTCGGAMYIDEEKDIIEYLSELCNVHNTDIIVVSTDTEEGSQISRAFKGMAAILRYKL

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcus maripaludis (strain S2 / LL)
Length
419 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.25 kDa
Sequence
MSGNSSTDLYLFKKSLKELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDNEVYGVILVDRNEATIGTVRGKTITILKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLDKASDLLRDIDLMKEKNLIQRFFKELIKDDGGLSAYGEAQVMKYLEMGAIDTLIVTEDIGITRVTVKCNNCDITQEVNVKTNEMFKFEEQLKTKACPTCGGAMYIDEEKDIIEYLSDLCNMHNTDLIVVSTDTEEGSQISRAFKGMAAILRYKL

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Length
418 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.641 kDa
Sequence
MSEQQEQEQSDKQKYEFRKVIEELKGYQGSGTQLVSIYIPEGKLISDVVAHVTQEHSEASNIKSKDTRTAVQDALTSIKDRLRYYDVRPPDNGLVVFSGAFDTGGGRTDMVTKVLESPPDPIESFRYHCDSEFLTEPLEHMLADKGLFGLIVLDRREANVGWLKGKRVEPVKSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMANDLFVADRHEIDGILVGGPSPTKDEFLDGDYLHHELQDMVLGKFDVAYTDESGLYDLVDAADDVLAEHEMLRDKELMEDFFKQLHNGDKATYGFDQTRQNLNMGAVEQLLISEDLRKDVVAYTCENGHDEYDLINSSAGTDDHECSRCGATVDADDGEREDAIDHLMELADQRGTETVFISTDFEKGEQLLTAFGGVAGLLRYSTGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Length
418 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.951 kDa
Sequence
MYFMADDEQIRRYEFKRALEELSKLHGRGTELISLYIPPEKQISDVVAYLRDEYSTSSNIKSKSTRKNVLAAIESIMSRLKYYRFPPPNGLVFFVGHIATRGDQTEMYTKIIEPPEPITTFMYKCDSEFHTEMLKAMLDEKEIYGLIVIDRKEATVGFLNGTRIEVVENVQSQVPSKHHQGGQSSRRFERLIEIAANEFFKKVGEIANNAFIPRIKEIRAIFLGGPGATKEYFFEKDYLRNEVKDKIKDLFDVGYTDESGLRELVEKASESIKDMKISREKDLMDRFLREVKKPDGGLAVYGEKAIRDALEQKMVDLLLISEGIRRVKYTYKCPTCGEEKTFSEEPSEWPVCDKDGTPLELIGEDDMIEDLYKLAKESGAQVEIISDQSDEGKLLKQAFGGLAAVLRFIRKDNVQNVM

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
417 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.788 kDa
Sequence
MSKMTRHDAQLYELKKKIEELKKIRGRGTELISLYIPAGYDLSKVMQQLREEYSTAQNIKSKTTRKNVLGALERAMQHLKLYKQTPENGLALFVGNVSEIEGNTDIRLWAIIPPEPLNVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIELLDELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANRAFLPLLEKGELKGIIIGGPGPTKEEFVEGEYLHHELKKKILGVVDISYHGEYGLRELVEKASDILRDHEVIREKKLVNEFLKHVVKDTGLATYGEREVRRALEIGAVDVLLISEGYNKVRVRVKCNHCGWEELKTMSEEEYEVYRKKITKCPKCGSQNLTIEKWDVAEELIKMAEEAGSDVEIISLDTEEGQQFYRAFGGLGAILRFKI

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
417 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
48.035 kDa
Sequence
MLFMEDDEQIRRYEFKRALEELSKLHGRGTELISLYIPPDKQISDVVAYLRDEYSTSSNIKSKSTRKNVLAAIESIMARLKYYKTPPPNGFVFFEGHIATRGDQTEMYTKIIEPPEPITTFMYKCDSEFHLEMLKTMLEEKEIYGLIVIDRKEATVGFLNGTRIEVVDNVQSQVPSKHHQGGQSSRRFERLIEIAANEFFKKVGEIANNAFMPKIKDIRAIFLGGPGATKEYFFEKDYLRNEVKEKIKDLFDVGYTDESGLRELVEKASESIKDMKISKEKDLMNRFLREVRKPDGGLAIYGEQAIRDALEQKMVDLLLISEGLRKVRYTYRCPTCQAELTLNQEPNEWPVCEKDGTPMELVAEDDFIEDLYRLAKESGAQVEIISDQSEEGKLLKQAFGGMAAVLRFIRKDNVQMM

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Length
416 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.717 kDa
Sequence
MSSDAQEASDDRRKYEFRKVIEELRDFEGSGTQLVTIYIPEDRQVSDVVAHVTQEHSEASNIKSKQTRTAVQDALTSIKDRLRYYDTFPPENGMVIFSGAIDAGGGQTDMVTRTLESPPQPVESFRYHCDSAFLTEPLEHMLEDSGLFGLIVLDRREANVGWLKGKRVEPVKSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVDKRHELDGILVGGPSPTKDEFLDGDYLHHELQDKVLGKFDVAYTDESGLKDLVDNASEALADQEIVEDKRHMDEFFENLHTGEEATYGFDQTRRNLIMGSVDRLLISEDLRSDVVVYECPNGHEEYEVVDSRHSTPSHECSECGEEADVDEREDVIEHLMSIAEQRGTDTKFISTDFEKGEQLLDAFGGIAGILRYSTGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
Length
416 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.638 kDa
Sequence
MSEQDEVPSEDRRKYEFRKVIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNIKSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGAVDSGGGRTDMVTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVPKRHEIDGILVGGPSPTKDEFLDGDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGGKLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNDHEEYETIDRRNTSPEHTCSDCGEEATEVDREDAIDHLMSIADQRGTETHFISTDFEKGEQLLTAFGGYAGILRYSTGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
416 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.638 kDa
Sequence
MSEQDEVPSEDRRKYEFRKVIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNIKSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGAVDSGGGRTDMVTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVPKRHEIDGILVGGPSPTKDEFLDGDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGGKLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNDHEEYETIDRRNTSPEHTCSDCGEEATEVDREDAIDHLMSIADQRGTETHFISTDFEKGEQLLTAFGGYAGILRYSTGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)
Length
416 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.638 kDa
Sequence
MSTDAEDVSNDRRKYEFRKVIEELREYEGSGTQLVTIYIPPDRQVSDVVAHITQEHSEASNIKSKQTRTNVQDALTSIKDRLRYYDTYPPDNGIVLFSGAVSTGGGQTTMVTRSLESPPEPVQSFRYHCDSDFLTDPLEDMLADKGLFGLIVLDRREANVGWLKGKRVEPVKSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMANDLFVPKRHEIDGVLVGGPSPTKDEFLDGDYLHHELGDVVVGKFDVSYTDESGLHDLVDSAQDVLADQEVMKDKAEMEEFFEKLHGGEEATYGFEPTRKNLMMGAVDRLLLSEDLRSDVVVYECPDGHEEYEVIDRRHDDPEHTCSDCGSASEKTEREDVIEYLMSIAEQRGTETKFISTDFEKGEQLHNAFGGIAGILRYATGI

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
415 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.338 kDa
Sequence
MSHKSAEMYELKKKVEELKSYRGRATELVSLYIPAGYDINKVMQQLREEYGTAQNIKSKSTRKNVLGALERAMQHLKLYKQTPENGLALFVGNVSEQEGVSDIKLWAIVPPEPLNVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIEVIDELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANKAFLPLLEKGELRGIIIGGPGPTKEEFVEGDYLHHELRKKVIGVVDISYHGEYGLRELVEKASDILKDHEAVKERQLIQEFFKHLVKDTGMITYGEKEVRKALELGAVDKLLISEGYDKVRVRAKCNNCGWEELKTMSEGEFHVYKKQLTHCPKCGSQNITFEKWDVAEELIKMAEESGADVEIISLDTEEGQQFYKAFGGLGAILRYKIQ

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Thermococcus onnurineus (strain NA1)
Length
415 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.281 kDa
Sequence
MSHKSAEMYELKKKVEELKSYRGRATELVSLYIPAGYDINKVMQQLREEYGTAQNIKSKSTRKNVLGALERAMQHLKLYRKTPENGLALFVGNVSEQEGVSDIKLWAIVPPEPLKVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIEVIDDLTSNVPGKTRAGGQSARRYERIREQETHEFMKRIAEHAAKAFLPLLEKGELKGIIIGGPGPTKEEFVDGDYLHHELRKKVIGVVDISYHGEYGLRELVEKASDILSEHEAVKERKLIQDFFRHLVKDTGLITYGEREVRKALELGAVDTLLISEGYDKVRVKAKCNACGWEELKTMSEQEFHVYKKKLTHCPKCGSQNISFEKWDVAEELIKLAEESGAEVEIISLDTEEGQQFYKAFGGLGAFLRYKIQ

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Length
415 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.314 kDa
Sequence
MSHKSAEMYELKKKVEELKKIRGRATELVSLYIPADYDLNKVMQQLREEYGTAQNIKSKTTRKNVLGALERAMQHLKLYRQTPETGLALFVGNVSEQEGVSDIRVFAIVPPEPLNVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGILRGKKIEVIEDLTSNVPGKTRAGGQSARRYERIREQEAHEFMKRIGEHASSVFLPLLEKDELKGIIIGGPGPTKEEFVEGEYLHHELRKRILGVVDISYHGEYGLRELVEKASDILREHEAVKERKLVQQFFKHLVKDTGLITYGEKEVRKALELGAVDILLLSEGYDRVRVKALCNNCGWEELKTMTEAEFELYKKNLKACPKCNSQNISVEKWDVAEELIKIAEEGGAEVEIISLDTEEGQQFYKAFGGIAAILRYKLQ

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
415 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.19 kDa
Sequence
MTEQSAHEKYEFKKKLEGLRDKKGRSTELISLYIPPDKQIFDVTNQLKDEHGQAANIKSKLTRTNVQGAIESLLSRLRYLDKVPENGIVYFTGAVDIGANKTSMESEVIVPPDPITVYKYHCDSSFYLEPLEDMLKDKNTYGLLVLDRREATIGLLVGKRIQPFRNLTSTVPGKQRKGGQSAHRFQQLRLIAIHDFYKRIGDAASEVFMAVDHKDLKGVLIGGPSPTKEEFHAGEFLHHELMKKILGLFDTAYTDESGLSELVNAAGEKLQDLELMGQKNAVRDFFKELIADSGKVAYGESQVRANLEINSVDVLLLSEDLRAERVTTKCSVCGYENKWTRRWKPGEPAPAAGNCPKCGSSLEVTDVTDIVDEFSELADKSNAKVVFVSTDFDEGSQLMNAFGGIAAILRYNTGV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
414 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
47.376 kDa
Sequence
MTRHDAQLYELKKKIEELKKIRGRGTELISLYIPAGYDLSKVMQQLREEYSTAQNIKSKTTRKNVLGALERAMQHLKLYKQTPENGLALFVGNVSEMEGNTDIRLWAIVPPEPLNVRLYRCDQTFVTEPLEEMLRVKDAYGLITVEKNEATIGLLRGKRIEVLDELTSNVPGKTRAGGQSARRYERIREQETHEFMKRIGEHANRVFLPLLEKGELKGIIVGGPGPTKEDFVEGDYLHHELKKKIIGVVDISYHGEYGLRELVEKASDILRDHEVIREKKLVNEFLKHVVKDTGLATYGEREVRRALEIGAVDTLLISEGYDKVRVRAKCNHCGWEELKTMSEEEFEVYKKKLTRCPKCGSQNLTIEKWDVAEELIKMAEEAGSDVEIISLDTEEGQQFYRAFGGLGAILRFKI

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
414 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.243 kDa
Sequence
MADQSSHQKYEFKKKLESLRGKKGRGTELISLYIPPDKQISDVVSQLRNEHSQASNIKSKLTKTNVQGAIDSIMSRLRYGTVPENGIVYFTGAVDVGANKTNMETTIVEPPQPIITYRYHCDSSFFLTPLEDMLKEAKTYGLLVLDRREATVGLLTGKQIEAFRNLTSTVPGKQRKGGQSAHRFQQLRLIAIHDFYKRIGDAASEVFLAVEQKDFEGVLIGGPSPTKEEFEAGNFFHHEIEKKVLDLFDVAYTDESGLSELVNAASERLEDLDLMVEKKLMQQFFRELVSDSGKATYGEDNVRENLIIGAVDILLISEDLRAVRETVKCTSCDYEQKTSREFKPGDSSSPTGNCPKCGSYLEITEKVDVVDQLSEICDQMGTRVEFISTDFEEGSQLLKAFGGVVAILRFNTGI

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)
Length
412 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.509 kDa
Sequence
MAEVSSKELYKFKKTLKELSEKKGRGTELVSVYIPHDKQISDVGKQMRDELGQSANIKSKQTRKNVQSAIEVIMQRIRLFKAAPENGLVLFVGMIPRGGPGTEKMETYVFEPPEPITTYWYQCNNEFFLEPLEYMIEERETYGLAVIDRKEATIATLRGKKVNILNHLTSGVPGKHKAGGQSQRRFDRVIDLAAHEFKKRIGEHMNEDFLALEELEGVIIGGPGFTKEEFVKGDYLNYEIKDKIIATVDTSYTGEFGIREVIDKSADILNDLDVMQEKKVVQKFLHELVKDKGLASYGEREVRTNLIMGAVDTLLLSEDLTAMRKVFKCPSCGNEEEITVKSQSEADKLEKPCSNCGEILKEESSQTLIEDFVEKAEEMNSEVELISTETEEGMQLLRAFGGVAAILRYHVG

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Length
411 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.549 kDa
Sequence
MSDVSSKEIYEVKKTLKELEDKKGRGTELVSVYIPPEKQISDVAKQMRDELGQSANIKSKQTRKNVQSAIEVIIQRLKLFPKPPEKGLVMFVGMIPKGGPGTEKMETYVFQPPEAVQTYTYHCDSQFFVEPLKQIIEYKEVYGVVVLDRKESTIATLRGKRIDIIKHLTSGVPGKHKAGGQSQRRFDRVIELAAHEFLKRIGRHVDEAFLPLKDELKGVLIGGPGHTKNDFVDGEYIHYEIHDKIINIVDTSYTGDFGIREVIDESADTLDEMDIMQEKKFMRKFLTGLISESGLSTYGEKEVRQNLQMGAVETLLISENLKSKRQTYTCPACNTVDVITTRQHQEPPEKRCPKCNEVMKITKTQETAEELIELAEEVKTHVEVISIETEEGTQLDKAFGGIAGILRYKVK

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Length
410 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.903 kDa
Sequence
MESEDYKRYEFKKALEELKDLHGRGTELISLYIPPDKQISDVVQYLREEYSTSSNIKSKSTRKNVLAAIESIMSRLKYYKQPPETGLVFFVGHIATRGDQTEMYTKIIEPPEPIQTFMYKCDSNFHLEQLESQLKEKDIYGLIVIDRKEATVGFLKGTRIEVVDYEQSLVPSKHHQGGQSSRRFERLIEIAANDFFKKIGEIANNAFMPLIKDINAVFIGGPGATKEYFLEKDYLRNEIKQKVKDLFDIGYTDESGLRELVEKASESIKDMKISREKDIINRFLREIKKPEGGLGVYGEDAIINALKSKNLDLLIISDTLKKRRYTYKCPVCNDTKTFTEKPRETPLCDKDNSEMELVDEDDLVEDLYKLADEAGTNVVFVSEDSDEGRLIKTAFGGLAGIMRYVPAIAP

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
409 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.485 kDa
Sequence
MAESSTVERYRFRKMIERLENLRGQGTELITIYIPPENRLSDVIAQMREEYSQASNIKSKRTRKNVQSAIEVVMQRLKMVGETPENGLVVLVGTVQDGTKEKMVAELIEPPEPVDRFIYRCDSKFYLEPLKEYLEEKDVYGILVMDRREATIGLVKGKRIEPVKRLTSDVPGKHKAGGQSQRRFDRLIEHAAHEFYQKVGEAAREAFEDVKDLKGIIVGGPGPTKEEFLDGDYLPKDLKEKVLTVVDVGNTDESGLREALNKAEEALKEAELVREKRLVRKFMEEAVNGELAAYGEEVDELLKMGAVEVLLVSEDLEGYKVILRCPECGYENIVTVKEKDEAKKYVEECPECGEAELNVEEIKDIVDYYVELAEQMGSNVEIISTETEEGAQFYNAFRGLGALLRFRPK

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
407 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.418 kDa
Sequence
MSEPSSKELFEFKRTLQELSDKRGRGTELVSVYIPPDRQISDVAKHMREELSQSANIKSKQTKKNVQSAIEVIMQRLKLFPKPPEKGLVMFVGMVPRGGPGTEKMETYVFEPPEPIKTYIYHCNSEFYLEPLREMLEEKETYGLAVLDRKEATIATLKGKRIDILKTLTSGVPGKHKAGGQSQRRFDRLIDLAAHEFLKRIGEHMNEAFLQIDDLKGIILGGPGHTKEEFLNGDYLHHELKKKVITTVDTSYTGEFGIREVIDKSMDVLSEIDVMREKKLVQRFLRELINEDGLASYGEREVRQHLQMGAVEVLLLSEDLKYQRGTYECASCGHRMEKTGRDLPDTETCPSCNDQMRLSDRRDMIDDLVEMAEEVGTEVEIISTETEEGMQLLRAFGGIGAILRYRP

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
407 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
46.671 kDa
Sequence
MSQKMMYEFKRKLEELEKYKGRGTELITLYIPPDKNIADVSNQLRSELSQASNIKSKQTRTNVLAGIEAILNRLKHFRKPPENGMVIISGVVNINGKEKHITEIIEPPEPVPLYKYHCDSKFYLDPLKEMLTEKKLYGLIVLDRREATVGLLKGKRIEVLDWDTSMVPGKHRQGGQSSVRFERLREIAIHEFYKKVGEMASEALLPYKDKLIGILIGGPSPTKEEFYEGEYLHHELQKKVLGLFDVGYTDESGLYELVEKAKDVLQEVDIIREKNLMQRFLKEVARDGLAAYGEEEVRRYIELGAVDTLLLSEDLRYERVKYRCPKCGKEVEVTVREGIEKPPFCEEDNVEMEEVERRDIVLELSELAESTGAKVEFLSTESEEGEMLYKAFGGIAAILRFKPDGGQ

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
388 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
43.509 kDa
Sequence
MSFNRPPNGVYYIRSAVELRAFVNLLKKFKGYATTLITLYINAERPIPDVVNLLRSEWSTAANIKDKTTRTHVQDTLERIINNLKGEAKAPENGMAVFAGFHMINQGNYEWVYYVVIPPQPINTFKYICDTAFHTELLEDQLHAGVVYGIVVIERGEAVIALLKGGQWEVVKSVEFFVPGKHHAGGQSANRFKRQTEHLAEAFYKMVAEEANKIFLQIPTLKGIIVAGPGPTKEDFLEEGGLDYRLKDKILAIVPACCANEYGVMEAIRNAQEQLKESEYVKAKEVMDKVMYYAVKKSEYLVYGRERALKALEMGIADIIVIAEELGEDAVLEVIMKAEEKGIKVEVVPRGVEESKTLMQAFGGYVALLSTPVWVLEQQLSIAEAAQR

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Length
373 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
41.95 kDa
Sequence
MSQGRLEERLTISKRELARLLKELKKWSAPATVLLSLYIPPGRPLSDVMTLLRQEYSITDNIKLKRTRQAVKRALSAAMDRLQMLTSTPPNGLVLFCGEDMSTGKFECFMFSPPEPIRVFYYRTDKRFITDFLEDMVEDNNAIGIIIVERDQATIGLLKGARLEVLKELEGFVPGKHKMGGQSQRRYERIIEQMVDEFFKKVGEEASNLLVPLAEKGVLKGVIVAGPGLAKQEFVEGNYLDYRLKKILAPELVDVAYQGLQGLKEAVMKAEKVVEAQMYRDAVNAMEEFKLHLAKGTGMIVYGEKDVEAALEMGAVKTLLIHESREDLEEWVEKAKSSGAQVIVVPESLAEAEWFLKTFGGLAGILRFRISTV

Gene
prf1
Protein
Peptide chain release factor subunit 1
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
369 amino acids
Function
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
Similarity
Belongs to the eukaryotic release factor 1 family.
Mass
42.31 kDa
Sequence
MSXDEYALNKQELKALIKELKKWKAPATVLLSLYIPPGRPIPDVVNLLRQEYSIAQNIKLKRTRDAVLSAIGAAIDRLNKIPKIDGNGLVLFCGENFDTEDFKCFMFSPPDKVPLFFYRTDKEFHLEFLEDMVEDTAVYGLIIVERDEATIGLLKGARIEILEEIEGFVPGKHMMGGQSQRRIDRIIDEMYHNFLKEVGEKVNAYFMPFVQNGKMKGVLLGGPGYAKEDFYKEDYVDYRIKNLILQPLIDVSDQGEVGLREMIMKAEDLLKNQQYIEVEKLLEELKYHLAKDDGLIIYGKEQIKKAMEIGAIEAIVIHEDSTDKELEKLAQDAENYGVKVFVVGDEVPEAEWVKKTFNGIVGKLRYRLY

Gene
PRF1
Protein
Prefoldin subunit 3
Organism
Elsinoe fawcettii
Length
197 amino acids
Function
Prefoldin subunit; part of the gene cluster that mediates the biosynthesis of elsinochromes, pigments consisting of at least four interconvertible tautomers (A, B, C and D) that have a core phenolic quinone to which various side chains are attached and which play an important role in fungal pathogenesis (PubMed:18957608). The non-reducing polyketide synthase PKS1 was proposed to iteratively catalyze decarboxylation between acetyl-CoA and malonyl-CoA subunits for polyketide chain elongation. The released polyketide undergoes cyclization to form an aromatic ring, and proceeds via serial modification steps to produce the heptaketide back- bone of elsinochrome. As elsinochrome has a symmetrical structure, two identical heptaketides are fused to form a core 1,2-dihydrobenzo-perylene ring structure, which can then be successively modified to produce the various derivatives of elsinochrome. Some of these reactions may be cooperatively carried out, at least in part, by the products of RDT1, OXR1 and PKS1. PRF1, embedded within the elsinochrome cluster possibly functions to stabilize some of the biosynthetic enzymes required for elsinochrome production. As prefoldin is a hexamer containing 2 a and 4 b subunits, additional prefoldin subunits, whose coding genes may not immediately link to the elsinochrome biosynthetic gene cluster, are required to fulfill the chaperone function. In addition, no methyltransferase-coding gene exists within the biosynthetic gene cluster, even though elsinochrome has four methyl groups at positions C3, C7, C8 and C12. Apparently, the identified gene cluster does not contain the entire entourage of genes responsible for elsinochrome biosynthesis. Once elsinochrome is synthesized, it must be exported outside the fungal cells, which is probably accomplished by the ECT1 transporter, to avoid toxicity (PubMed:21199563).
Similarity
Belongs to the prefoldin subunit alpha family.
Mass
22.121 kDa
Sequence
MASLALRGSSENPAPTKDTTTNPRGIPYAPFVDRVEDYVTSTTDVESTLKSFSEMISKYQFMESNTQRRSAGLKDKIPEIQKTLAMVRFLAGREEDDEPLETHFELNDTLYAKALVPTTKEVYLWLGANVMLAYPVDEAEELLVGKLGAAKTSLENCDEDLDFLREQITTLEVATARVYNWDVGQRRKEREGKGGKS