Protein
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function
Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).
Similarity
Belongs to the dihydropyrimidine dehydrogenase family.
Sequence
MLTKDLSVTFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGIVFKTIGFFIANEVSPRFDHLTKEDTGFIGFKNMEQIAEHPLEENLAAIRRLKQDYPDKVLIASIMGENEQQWQELARLVEEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSSLPMLAKMTPNIGDMCEVALAAKRGGADGIATINTVKSITNIDLNRKIGMPVVNGKSSISGYSGKAVKPIALRFIQQLRMHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFASLQEMIGLANGNIIPAEDLDRSYIVYPRINQEKCVGCGRCYISCYDGGHQAMEWDEHSRTPHCNTEKCVGCLLCGHVCPVACIDLGEVKFKKGEKEHALTL