Protein
3-hydroxyproline 2-epimerase
Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Function
Catalyzes the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t3LHyp) to cis-4-hydroxy-D-proline (c4DHyp), albeit with 3.6-fold lower efficiency. Displays no proline racemase activity.
Similarity
Belongs to the proline racemase family.
Sequence
MKISRSLSTVEVHTGGEAFRIVTSGLPRLPGDTIVRRRAWLKEHADEIRRALMFEPRGHADMYGGYLTEPVSPNADFGVIFVHNEGYSDHCGHGVIALSTAAVELGWVQRTVPETRVGIDAPCGFIEAFVQWDGEHAGPVRFVNVPSFIWQRDVAVDTPSFGTVTGDIAYGGAFYFYVDGAPFDLPVRESAVERLIRFGAEVKAAANAKYPVEHPEIPEINHIYGTIIANAPRDPRSTQANCCVFADREVDRSPTGSGTGGRVAQLYQRGLLAAGDTLVNESIVGTVFKGRVLRETTVGGMPAVIPEVEGSAHICGFANWIVDERDPLTYGFLVR