prdF

3-hydroxyproline 2-epimerase

335 amino acids

Catalyzes the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp) in vitro. Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t3LHyp) to cis-4-hydroxy-D-proline (c4DHyp), albeit with 3.6-fold lower efficiency. Displays no proline racemase activity.

Belongs to the proline racemase family.

36.485 kDa

MKISRSLSTVEVHTGGEAFRIVTSGLPRLPGDTIVRRRAWLKEHADEIRRALMFEPRGHADMYGGYLTEPVSPNADFGVIFVHNEGYSDHCGHGVIALSTAAVELGWVQRTVPETRVGIDAPCGFIEAFVQWDGEHAGPVRFVNVPSFIWQRDVAVDTPSFGTVTGDIAYGGAFYFYVDGAPFDLPVRESAVERLIRFGAEVKAAANAKYPVEHPEIPEINHIYGTIIANAPRDPRSTQANCCVFADREVDRSPTGSGTGGRVAQLYQRGLLAAGDTLVNESIVGTVFKGRVLRETTVGGMPAVIPEVEGSAHICGFANWIVDERDPLTYGFLVR

prdF

Trans-3-hydroxy-L-proline dehydratase

334 amino acids

Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline. Can also catalyze the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) in vitro. Displays no proline racemase activity.

Belongs to the proline racemase family.

36.841 kDa

MKVSKVYTTIDAHVAGEPLRIITGGVPEIKGDTQLERRAYCMEHLDHLREVLMYEPRGHHGMYGCIITPPASAHADFGVLFMHNEGWSTMCGHGIIAVITVGIETGMFEVTGEKQNFIIDSPAGEVIAYAKYNGSEVESVSFENVPSFVYKKDVPIIIDDYEFQVDIAFGGAFYAVVDSKEFGLKVDFKDLSAIQMWGGKIKHYIESKMEVKHPLEEGLKGIYGVIFSDEPKGEDATLRNVTIFADGQVDRSPCGTGTSARIATLFEKDALQKGEIFVHECITDGKFEGEVLSVTAVDTYEAVVPKVTGHAFITGFHQFVVDPRDDLKRGFLLG