praI

4-hydroxybenzoate 3-monooxygenase (NAD(P)H)

394 amino acids

Involved in the degradation of 4-hydroxybenzoate (4HB) via the protocatechuate (PCA) 2,3-cleavage pathway. Catalyzes the conversion of 4HB into 2-hydroxypenta-2,4-dienoate (HPD). It is highly specific for 4-hydroxybenzoate, and is able to utilize both NADH and NADPH as electron donors at approximately equal rates.

Belongs to the aromatic-ring hydroxylase family.

44.265 kDa

MRTQVGIIGAGPAGLLLSHLLYLQGIESIIIENRTREEIEGTIRAGVLEQGTVDLMNQMGVGARMMKEGHFHEGFELRFNGRGHRINVHELTGGKYVTVYAQHEVIKDLVAARLQTGGQIHFNVGDVSLHDVDTSSPKIRFRPNKDGELQEIECDFIAGCDGFRGPSRPAIPQSVRKEYQKVYPFSWLGILVEAPPSAHELIYANHERGFALVSTRSPQIQRLYLQVDAQDHIDNWSDDRIWSELHARLETRDGFKLLEGPIFQKGIVSMRSFVCDPMQHGRLFLAGDAAHIVPPTGAKGLNLAAADVQVLARGLEAYYKAGKMEILNRCTEICLRRIWKAERFSWFMTTMLHRDQGHTPFERGIQLAELDYVTSSRAASTSLAENYIGLPMEF