Protein
4'-phosphopantetheinyl transferase B, mitochondrial
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Acyl-carrier-protein synthase transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein (PubMed:21195204). The 4'-phosphopantetheine (4'-PPT) portion of CoA provides the essential prosthetic group for a number of carrier proteins and multi-domain enzymes, priming them for the acceptance of acyl building blocks in fatty acid synthesis and many aspects of secondary metabolism mediated by polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) (PubMed:21195204). PptB is specific for the mitochondrial acyl carrier protein acpA (PubMed:21195204).
Similarity
Belongs to the P-Pant transferase superfamily.
Sequence
MKLIPFPYPLNIGTDVVHLPRILRLINRPDYFHRFTRRILHEQEQRDFRTRFSLPPPSSGAEKTGLNPITPDMARWLAGRFAAKEAARKAAPAGASSLGWKDVIVRVGEADKGRPEIVYLDPMGCGETGGGRVGKLSISHDGDYVVATVLAAG