Protein
Lysosomal thioesterase PPT2-B
Function
Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, may be unable to remove palmitate from peptides or proteins (By similarity).
Similarity
Belongs to the palmitoyl-protein thioesterase family.
Sequence
MRGYLLLLPLLLCLVDNSVSYKPVILVHGLLSSSKSFDKLIQFIKKAHPGTDIYPVDMFNHLKSLNPMWKQVYEIRKYISPIIKNAGLKGVHLICYSQGGLICRGLLETMPEHNVDTFIALSSPLMGQYGMTLYVQKALPLVNISALQEVCYRKFFKEISICGYWRDPHRYEKYLEYSAFLPKLNNELLDSNSTERKRNFLRLRKLVLIGGPDDEVIAPWQSSHFGFYNEKEEVVNMKDQMVYQKDTFGLQSLDGRGAITIYSVPGVLHASWPNNQTVFKNYIEKWLT