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ppp1r11

Gene
Ppp1r11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Mus musculus
Length
131 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (By similarity).
Mass
14.544 kDa
Sequence
MAETGAGISETVTETTVTETTVTETTEPENQSLIMKLRKRKPEKKVEWSSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEDEEEGCSHKHCVRGHRKGRRPTTPAPTPTTPPQPPDPSQPPPGPMQH

Gene
Ppp1r11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Rattus norvegicus
Length
127 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Mass
13.936 kDa
Sequence
MAEAGAGGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWSSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEDEEEGCGHTHCVRGHRKGRRPTTPGPTPTTPPQPPDPSQPPPGPMQH

Gene
PPP1R11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Homo sapiens
Length
126 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).
Mass
13.953 kDa
Sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPPPGPMQH

Gene
PPP1R11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Macaca mulatta
Length
126 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Mass
13.953 kDa
Sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPPPGPMQH

Gene
PPP1R11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Pan troglodytes
Length
126 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Mass
13.953 kDa
Sequence
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPPPGPMQH

Gene
ppp1r11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Danio rerio
Length
122 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Inhibitor of protein phosphatase 1.
Mass
13.106 kDa
Sequence
MAEVPGTSSETITETVQTGTPPPPQQEGRSLTIKLRKRKTEKKVEWSSDTVDNEHLGRRSSKCCCIYEKPRQFGESSSESEGDDEEGCGSAHCILGHGRRGHGQREGGGTTVPPSSGGTNPH

Gene
ppp1r11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Xenopus laevis
Length
119 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Inhibitor of protein phosphatase 1.
Mass
13.032 kDa
Sequence
MAETSGPTAAGGSTSSTVTTESETQPEHRSLTLKLRKRKPDKKVEWTCDTVDNENLGRRSSKCCCIYEKPRPFGESSSESEDDDDCCESAHCIRGHKKATSGSKETPSSHHDKTGSMQH

Gene
ppp1r11
Protein
E3 ubiquitin-protein ligase PPP1R11
Organism
Xenopus tropicalis
Length
119 amino acids
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Inhibitor of protein phosphatase 1.
Mass
12.988 kDa
Sequence
MAESSGPTAGGGATSSTVTTESDTQPEHRSLTLKLRKRKPDKKVEWTCDTVDNENLGRRSSKCCCIYEKPRPFGESSSESEDEDDCCESAHCIRGHKKATSGSKETPSSHHDKTGSMQH