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pop-1

Gene
pop-1
Protein
Protein pop-1
Organism
Caenorhabditis briggsae
Length
439 amino acids
Function
Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.
Similarity
Belongs to the TCF/LEF family.
Mass
48.851 kDa
Sequence
MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKDAVMEAELDGAGRVPLIGGLKAEIKAEPSPSFPMPSMLPCGPYSPFSGLPIMFPMVVPQYLSPNPNINMMNMMTMRAAMAGAPLSPAFPAMFSPNPLFPFPGVVAKQHLENTMPMHMRAGPLSSLNHMKMPPYMPHQMMPQHNERRGHGGGKVKKEDHIKKPLNAFMWYMKENRPKLLEEVGNDQKQSAELNKELGKRWHDLPKEEQQKYFEMAKKDRESHKEKYPQWSARENYAVNKKKPKRKRDKSVVSGSENNDQKKCRARFGVTNTSMWCKPCQRKKKCIYATDRSGSELNDGHDGRGTSGGCSSSSESSSPNNNQPMPMNAPQTVAAMHAMLMGMQIGQSAHLASSHSTGSSGTSPPVANPSDSESDVDEDEDIDPTITQQTQEYIMQESVCTL

Gene
pop-1
Protein
Protein pop-1
Organism
Caenorhabditis elegans
Length
438 amino acids
Function
Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos (PubMed:11742996, PubMed:11807036, PubMed:19427847). Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape (PubMed:11807036). Represses expression of target genes via its interaction with hda-1 histone deacetylase (PubMed:11742996). Required for specification of the M lineage-derived coelomocyte and sex myoblast fate (PubMed:19427847). Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors (PubMed:19427847).
Similarity
Belongs to the TCF/LEF family.
Mass
48.627 kDa
Sequence
MMADEELGDEVKVFRRDEDADDDPMISGETSEQQLADDKKEAVMEAELDGAGRNPSIDVLKSAFPKVEPMSPSFPGLMSHFSPGYSAAALPMFMPLFMNPYAAALRSPSLMFPMGAMSPTFPMFPPSPVYGAAIAAAAAKQHFENMAPLNMRAGHPMNQMGMPPYMHPSSMAPQNVDRRAQGGGKAKKDDHVKKPLNAFMWFMKENRKALLEEIGNNEKQSAELNKELGKRWHDLSKEEQAKYFEMAKKDKETHKERYPEWSARENYAVNKKKTKKRRDKSIPSENNDQKKCRARFGVNNTEMWCKFCKRKKKCEYATDRSGGSDITDSQDGRGTSGAYSSSSESPSPKANAGIALTTQQQQAAMMHTMLMQMRLGSTTGASTHVPSPLASSSAGRSPLDANASDSESDVEEEEDEQIDPTVMQQTHDMLMQESMCTI