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polk-1

Gene
polk-1
Protein
DNA polymerase kappa
Organism
Caenorhabditis elegans
Length
596 amino acids
Function
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
Similarity
Belongs to the DNA polymerase type-Y family.
Mass
67.942 kDa
Sequence
MLTFNDNKAGMNGLDKEKITKVIEENTSASYSSFSKKQQSRIEEKVLEIKNRLQTATREERQKSEILMENLEMKLESSRDLSRDCVCIDMDAYFAAVEMRDNPALRTVPMAVGSSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEKKTFKRHRFGGDCPCWLPRFDENENTLEDLKIEESICPKCEKSRKIYYDHVEFGTGREEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKNAIMEFLKDLPIRKVGGIGRVCEAQLKAMDIQTVGDMNLKKNLYPLCFTPLSQESFLRTALGLPGRPSESDPRRKSISVERTFSPTSDFNILLEEHQEICRMLEEDVRKSGIVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKEKGKEIRLLGVRLSQLIFEEDEKKRSKTITEFWNEKKLQIQNLQGSENVDDDDVIMMDTRPCPICGTDVENRLDVMNCHVDECILKVQNDDGPELICVSVENKSTQKPERPSTKKRKLQEKRPKAKKMVTIDSFWKKSG