pol

Genome polyprotein

3390 amino acids

RNA-directed RNA polymerase NS5: Replicates the viral (+) and (-) RNA genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.

In the N-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0-1 NS5-type methyltransferase family.

377.956 kDa

MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSKGLLNGQGPMKLVMAFIAFLRFLAIPPTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINKRKKTSLCLMMIMPAALAFHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGERRRDKRSVALAPHVGMGLDTRTQTWMSAEGAWRQVEKVETWALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVTPSMTMRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEAVLPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLEPIEGKVVQYENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTTEAILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWTSGATTETPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQNSGGTSIFAGHLKCRLKMDKLELKGMSYAMCTNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDNALKINWYKKGSSIGKMFEATARGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWVMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQADMGCVINWKGKELKCGSGIFVTNEVHTWTEQYKFQADSPKRLATAIAGAWENGVCGIRSTTRMENLLWKQIANELNYILWENNIKLTVVVGDIIGVLEQGKRTLTPQPMELKYSWKTWGKAKIVTAETQNSSFIIDGPNTPECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAAVKDERAVHADMGYWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWSNGVLESDMIIPKSLAGPISQHNHRPGYHTQTAGPWHLGKLELDFNYCEGTTVVITENCGTRGPSLRTTTVSGKLIHEWCCRSCTLPPLRYMGEDGCWYGMEIRPISEKEENMVKSLVSAGSGKVDNFTMGVLCLAILFEEVMRGKFGKKHMIAGVFFTFVLLLSGQITWRDMAHTLIMIGSNASDRMGMGVTYLALIATFKIQPFLALGFFLRKLTSRENLLLGVGLAMATTLQLPEDIEQMANGIALGLMALKLITQFETYQLWTALISLTCSNTMFTLTVAWRTATLILAGVSLLPVCQSSSMRKTDWLPMAVAAMGVPPLPLFIFSLKDTLKRRSWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGLLIACYVITGTSADLTVEKAADITWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTVLLKTALLIVSGVFPYSIPATLLVWHTWQKQTQRSGVLWDVPSPPETQKAELEEGVYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTYNGKRLEPNWASVKKDLISYGGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTMPGTFQTTTGEIGAIALDFKPGTSGSPIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHTGREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFPQSNAPIQDEERDIPERSWNSGNEWITDFAGKTVWFVPSIKAGNDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPRRCLKPVILTDGPERVILAGPMPVTAASAAQRRGRVGRNPQKENDQYIFTGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGQRNNQILEENMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRKSIALDLVTEIGRVPSHLAHRTRNALDNLVMLHTSEHGGRAYRHAVEELPETMETLLLLGLMILLTGGAMLFLISGKGIGKTSIGLICVIASSGMLWMAEIPLQWIASAIVLEFFMMVLLIPEPEKQRTPQDNQLAYVVIGILTLAAIIAANEMGLLETTKRDLGMSKEPGVVSPTSYLDVDLHPASAWTLYAVATTVITPMLRHTIENSTANVSLAAIANQAVVLMGLDKGWPISKMDLGVPLLALGCYSQVNPLTLTAAVLLLITHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDPVIYDSKFEKQLGQVMLLVLCAVQLLLMRTSWALCEALTLATGPITTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSIMKSVGTGKRGTGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVASVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPETPNMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRSMPGTRRVMGITAEWLWRTLGRNKKPRLCTREEFTKKVRTNAAMGAVFTEENQWDSAKAAVEDEDFWKLVDRERELHKLGKCGSCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKADLENPHLPEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEDNPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW

pol

Genome polyprotein

3390 amino acids

RNA-directed RNA polymerase NS5: Replicates the viral (+) and (-) RNA genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.

In the N-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0-1 NS5-type methyltransferase family.

377.923 kDa

MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSKGLLNGQGPMKLVMAFIAFLRFLAIPPTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINQRKKTSLCLMMILPAALAFHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGEHRRDKRSVALAPHVGMGLDTRTQTWMSAEGAWRQVEKVETWALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVTPSMTMRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEAVLPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLEPIEGKVVQYENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTTEAILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWASGATTETPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQNSGGTSIFAGHLKCRLKMDKLELKGMSYAMCTNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDNALKINWYKKGSSIGKMFEATERGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWVMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQADMGCVINWKGKELKCGSGIFVTNEVHTWTEQYKFQADSPKRLATAIAGAWENGVCGIRSTTRMENLLWKQIANELNYILWENNIKLTVVVGDTLGVLEQGKRTLTPQPMELKYSWKTWGKAKIVTAETQNSSFIIDGPNTPECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAAVKDERAVHADMGYWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWTNGVLESDMIIPKSLAGPISQHNYRPGYHTQTAGPWHLGKLELDFNYCEGTTVVITESCGTRGPSLRTTTVSGKLIHEWCCRSCTLPPLRYMGEDGCWYGMEIRPISEKEENMVKSLVSAGSGKVDNFTMGVLCLAILFEEVLRGKFGKKHMIAGVFFTFVLLLSGQITWRDMAHTLIMIGSNASDRMGMGVTYLALIATFKIQPFLALGFFLRKLTSRENLLLGVGLAMATTLQLPEDIEQMANGVALGLMALKLITQFETYQLWTALVSLTCSNTIFTLTVAWRTATLILAGVSLLPVCQSSSMRKTDWLPMTVAAMGVPPLPLFIFSLKDTLKRRSWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGLLIACYVITGTSADLTVEKAPDVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTVLLKTALLIVSGIFPYSIPATLLVWHTWQKQTQRSGVLWDVPSPPETQKAELEEGVYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTHNGKRLEPNWASVKKDLISYGGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTTPGTFQTTTGEIGAIALDFKPGTSGSPIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHTGREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFPQSNAPIQDEERDIPERSWNSGNEWITDFAGKTVWFVPSIKAGNDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPRRCLKPVILTDGPERVILAGPMPVTAASAAQRRGRVGRNPQKENDQYIFTGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGQRNNQILEENMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRKSIALDLVTEIGRVPSHLAHRTRNALDNLVMLHTSEDGGRAYRHAVEELPETMETLLLLGLMILLTGGAMLFLISGKGIGKTSIGLICVIASSGMLWMAEVPLQWIASAIVLEFFMMVLLIPEPEKQRTPQDNQLAYVVIGILTLAATIAANEMGLLETTKRDLGMSKEPGVVSPTSYLDVDLHPASAWTLYAVATTVITPMLRHTIENSTANVSLAAIANQAVVLMGLDKGWPISKMDLGVPLLALGCYSQVNPLTLTAAVLLLITHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDSVIFDSKFEKQLGQVMLLVLCAVQLLLMRTSWALCEALTLATGPITTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSIMKSVGTGKRGTGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVSRGSAKLQWFVERNMVVPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPETPNMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPMPGTRKAMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNAAMGAVFTEENQWDSAKAAVEDEEFWKLVDRERELHKLGKCGSCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDIISRKDQRGSGQLGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW

pol

Gag-Pro-Pol polyprotein

1880 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

207.175 kDa

MGQASSHSENDLFISHLKESLKVRRIRVRKKDLVSFFSFIFKTCPWFPQEGSIDSRVWGRVGDCLNDYYRVFGPETIPITTFNYYNLIRDVLTNQSDSPDIQRLCKEGHKILISHSRPPSRQAPVTITTSEKASSRPPSRAPSTCPSVAIDIGSHDTGQSSLYPNLATLTDPPIQSPHSRAHTPPQHLPLLANSKTLHNSGSQDDQLNPADQADLEEAAAQYNNPDWPQLTNTPALPPFRPPSYVSTAVPPVAVAAPVLHAPTSGVPGSPTAPNLPGVALAKPSGPIDETVSLLDGVKTLVTKLSDLALLPPAGVMAFPVTRSQGQVSSNTTGRASPHPDTHTIPEEEEADSGESDSEDDEEESSEPTEPTYTHSYKRLNLKTIEKIKTAVANYGPTAPFTVALVESLSERWLTPSDWFFLSRAALSGGDNILWKSEYEDISKQFAERTRVRPPPKDGPLKIPGASPYQNNDKQAQFPPGLLTQIQSAGLKAWKRLPQKGAATTSLAKIRQGPDESYSDFVSRLQETADRLFGSGESESSFVKHLAYENANPACQSAIRPFRQKELSTMSPLLWYCSAHAVGLAIGAALQNLAPAQLLEPRPAFAIIVTNPAIFQETAPKKIQPPTQLPTQPNAPQASLIKNLGPTTKCPRCKKGFHWASECRSRLDINGQPIIKQGNLEQGPAPGPHYRDELRGFTVHPPIPPANPCPPSNQPRRYVTDLWRATAGSAGLDLCTTTDTILTTQNSPLTLPVGIYGPLPPQTFGLILAEPALPSKGIQVLPGILDNDFEGEIHIILSTTKDLVTIPKGTRLAQIVILPLQQINSNFHKPYRGASAPGSSDVYWVQQISQQRPTLKLKLNGKLFSGILDTGADATVISYTHWPRNWPLTTVATHLRGIGQATNPQQSAQMLKWEDSEGNNGHITPYVLPNLPVNLWGRDILSQMKLVMCSPNDTVMTQMLSQGYLPGQGLGKNNQGITQPITITPKKDKTGLGFHQNLPRSRAIDIPVPHADKISWKITDPVWVDQWPLTYEKTLAAIALVQEQLAAGHIEPTNSPWNTPIFIIKKKSGSWRLLQDLRAVNKVMVPMGALQPGLPSPVAIPLNYHKIVIDLKDCFFTIPLHPEDRPYFAFSVPQINFQSPMPRYQWKVLPQGMANSPTLCQKFVAAAIAPVRSQWPEAYILHYMDDILLACDSAEAAKACYAHIISCLTSYGLKIAPDKVQVSEPFSYLGFELHHQQVFTPRVCLKTDHLKTLNDFQKLLGDIQWLRPYLKLPTSALVPLNNILKGDPNPLSVRALTPEAKQSLALINKAIQNQSVQQISYNLPLVLLLLPTPHTPTAVFWQPNGTDPTKNGSPLLWLHLPASPSKVLLTYPSLLAMLIIKGRYTGRQLFGRDPHSIIIPYTQDQLTWLLQTSDEWAIALSSFTGDIDNHYPSDPVIQFAKLHQFIFPKITKCAPIPQATLVFTDGSSNGIAAYVIDNQPISIKSPYLSAQLVELYAILQVFTVLAHQPFNLYTDSAYIAQSVPLLETVPFIKSSTNATPLFSKLQQLILNRQHPFFIGHLRAHLNLPGPLAEGNALADAATQIFPIISDPIHEATQAHTLHHLNAHTLRLLYKITREQARDIVKACKQCVVATPVPHLGVNPRGLVPNAIWQMDVTHFTPFGKQRFVHVTVDTFSGFILATPQTGEASKNVISHVIHCLATIGKPHTIKTDNGPGYTGKNFQDFCQKLQIKHVTGIPYNPQGQGVVERAHQTLKNALNRLARSPLGFSMQQPRNLLSHALFQLNFLQLDSQGRSAADRLWHPQTSQQHATVMWRDPLTSVWKGPDPVLIWGRGSACIYDQKEDGPRWLPERLIRHINNQTAPLCDRPSNPNTAPGPKGSP

pol

DNA polymerase

1829 amino acids

Belongs to the DNA polymerase type-B family.

211.879 kDa

MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKDDSAIDEIKAIKGERHGKIVRVVDAVKVKKKFLGRDVEVWKLIFEHPQDVPALRGKIREHPAVIDIYEYDIPFAKRYLIDKGLIPMEGDEELKLMAFDIETFYHEGDEFGKGEIIMISYADEEEARVITWKNIDLPYVDVVSNEREMIKRFVQIVREKDPDVLITYNGDNFDLPYLIKRAEKLGVTLLLGRDKEHPEPKIHRMGDSFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAIWETEESMKKLAQYSMEDARATYELGKEFFPMEAELAKLIGQSVWDVSRSSTGNLVEWYLLRVAYERNELAPNKPDEEEYRRRLRTTYLGGYVKEPERGLWENIAYLDFRCHPADTKVIVKGKGIVNISDVKEGDYILGIDGWQRVKKVWKYHYEGKLININGLKCTPNHKVPVVTENDRQTRIRDSLAKSFLSGKVKGKIITTKLFEKIAEFEKNKPSEEEILKGELSGIILAEGTLLRKDIEYFDSSRGKKRISHQYRVEITIGENEKELLERILYIFDKLFGIRPSVKKKGDTNALKITTAKKAVYLQIEELLKNIESLYAPAVLRGFFERDATVNKIRSTIVVTQGTNNKWKIDIVAKLLDSLGIPYSRYEYKYIENGKELTKHILEITGRDGLILFQTLVGFISSEKNEALEKAIEVREMNRLKNNSFYNLSTFEVSSEYYKGEVYDLTLEGNPYYFANGILTHNSLYPSIIVTHNVSPDTLEREGCKNYDVAPIVGYKFCKDFPGFIPSILGELITMRQEIKKKMKATIDPIEKKMLDYRQRAVKLLANSILPNEWLPIIENGEVKFVKIGEFIDRYMEEQKDKVRTVDNTEVLEVDNIFAFSLNKESKKSEIKKVKALIRHKYKGEAYEVELNSGRKIHITRGHSLFTIRNGKIKEIWGEEVKVGDLIIVPKKVKLNEKEAVINIPELISKLPDEDTADVVMTTPVKGRKNFFKGMLRTLKWIFGEESKRIRTFNRYLFHLEELGFVKLLPRGYEVTDWEGLKRYRQLYEKLVKNLRYNGNKREYLVRFNDIKDSVSCFPRKELEEWKIGTXKGFRXKCILKVDEDFGKFLGYYVSEGYAGAQKNKTGGMSYSVKLYNENPNVLKDMKNIAEKFFGKVRVGKNCVDIPKKMAYLLAKSLCGVTAENKRIPSIIFDSSEPVRWAFLRAYFVGDGDIHPSKRLRLSTKSELLANQLVFLLNSLGVSSIKIGFDSGVYRVYINEDLPFLQTSRQKNTYYPNLIPKEVLEEIFGRKFQKNITFEKFKELADSGKLDKRKVKLLDFLLNGDIVLDRVKNVEKREYEGYVYDLSVEDNENFLVGFGLLYAHNSYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIKEIEEKFGFKVLYADSVTGDTEIIVKRNGRIEFVPIEKLFERVDYRIGEKEYCILEDVEALTLDNRGKLIWKKVPYVMRHRAKKKVYRIWITNSWYIDVTEDHSLIVAEDGLKEARPMEIEGKSLIATKDDLSGVEYIKPHAIEEISYNGYVYDIEVEGTHRFFANGILVHNTDGFYATIPGEKPETIKKKAKEFLKYINSKLPGLLELEYEGFYLRGFFVAKKRYAVIDEEGRITTRGLEVVRRDWSEIAKETQAKVLEAILKEDSVEKAVEIVKDVVEEIAKYQVPLEKLVIHEQITKDLSEYKAIGPHVAIAKRLAAKGIKVRPGTIISYIVLRGSGKISDRVILLSEYDPKKHKYDPDYYIENQVLPAVLRILEAFGYRKEDLKYQSSKQVGLDAWLKK

pol

Gag-Pro-Pol polyprotein

1772 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

198.23 kDa

MGQELSQHERYVEQLKQALKTRGVKVKYADLLKFFDFVKDTCPWFPQEGTIDIKRWRRVGDCFQDYYNTFGPEKVPVTAFSYWNLIKELIDKKEVNPQVMAAVAQTEEILKTSSHTELTTKPSQNPDLDLISLDSDDEGAKGSSLKDKNLSCTKKPKRFPVLLTAQTSADPEDPNPSEVDWDGLEDEAAKYHNPDWPPFLTRPPPYNKATPSAPTVMAVVNPKEELKEKIAQLEEQIKLEELHQALISKLQKLKTGNETVTSPETAGGFSRTPHWPGQHIPKGKCCASREKEEQTPKDIFPVTETVDGQGQAWRHHNGFDFTVIKELKTAASQYGATAPYTLAIVESVADNWLTPTDWNTLVRAVLSGGDHLLWKSEFFENCRETAKRNQQAGNGWDFDMLTGSGNYSSTDAQMQYDPGLFAQIQAAATKAWRKLPVKGDPGASLTGVKQGPDEPFADFVHRLITTAGRIFGSAEAGVDYVKQLAYENANPACQAAIRPYRKKTDLTGYIRLCSDIGPSYQQGLAMAAAFSGQTVKDFLNNKNKEKGGCCFKCGRKGHFAKNCHEHIHNNSETKAPGLCPRCKRGKHWANECKSKTDSQGNPLPPHQGNRTEGPAPGPETSLWGGQLCSSQQKQPISKLTRATPGSAGLDLSSTSHTVLTPEMGPQALSTGIYGPLPPNTFGLILGRSSITIKGLQVYPGVIDNDYTGEIKIMAKAVNNIVTVPQGNRIAQLILLPLIETDNKVQQPYRGQGSFGSSDIYWVQPITCQKPSLTLWLDDKMFTGLIDTGADVTIIKLEDWPPNWPITDTLTNLRGIGQSNNPKQSSKYLTWRDKENNSGLIKPFVIPNLPVNLWGRDLLSQMKIMMCSPSDIVTAQMLAQGYSPGKGLGKNENGILHPIPNQGQFDKKGFGNFLTAAIDMLAPQQCAEPITWKSDEPVWVDQWPLTSEKLAAAQQLVQEQLEAGHITESNSPWNTPIFVIKKKSGKWRLLQDLRAVNATMVLMGALQPGLPSPVAIPQGYLKIIIDLKDCFFSIPLHPSDQKRFAFSLPSTNFKEPMQRFQWKVLPQRMANSPTLCQKYVATAIHKVRHAWKQMYIIHYMDDILIAGKDGQQVLQCFDQLKQELTIAGLHIAPEKIQLQDPYTYLGFELNGPKITNQKAVIRKDKLQTLNDFQKLLGDINWLRPYLKLTTADLKPLFDTLKGDSNPNSHRSLSKEALALLDKVETAIAEQFVTHINYSLPLMFLIFNTALTPTGLFWQNNPIMWVHLPASPKKVLLPYYDAIADLIILGRDHSKKYFGIEPSVIIQPYSKSQIDWLMQNTEMWPIACASYVGILDNHYPPNKLIQFCKLHAFIFPQIISKTPLNNALLVFTDGSSTGMAAYTLADTTIKFQTNLNSAQLVELQALIAVLSAFPNQPLNIYTDSAYLAHSIPLLETVAQIKHISETAKLFLQCQQLIYNRSIPFYIGHVRAHSGLPGPIAHGNQKADLATKTVASNINTNLESAQNAHTLHHLNAQTLKLMFNIPREQARQIVRQCPICATYLPVPHLGVNPRGLLPNMIWQMDVTHYSEFGNLKYIHVSIDTFSGFLLATLQTGETTKHVITHLLHCFSIIGLPKQIKTDNGPGYTSKNFQEFCSTLQIKHVTGIPYNPQGQGIVERAHLSLKTTIEKIKKGEWYPTKGTPRNILNHALFILNFLNLDDQNHSAADRFWHSNPRKQFAMVKWKDPLDNTWPWPDPVIIWGRGSVCVYSQTHDAARWLPERLVKQIPNNNQSRE

pol

Gag-Pro-Pol polyprotein

1768 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

197.91 kDa

MGQELSQHELYVEQLKKALKTRGVKVKGNDLLKFFDFVKDTCPWFPQEGTIDIKRWRRVGDCFQDYYNTFGPEKIPVTAFSYWNLIKDLIDKKEADPQVMAAVTQTEKILKVSSQTDLRDNSHNKDMDLISLESDDEEAKAPSEKMTMSNKSPKKYPAMLASQNNNTDKDPDLSEVDWDGLEDEAAKYHNPDWPPFLSRPPPYNRTAATAPAVMAVVNPKEELKEKISQLEEQIKLEELHQSLIIRLQKLKTGNERVTSSGNIESHSRTPKWPGQCLPKGKYLINKNTEEYPPKDIFPVTETMDGQGQAWRHHNGFDFTVIKELKTAVSQYGATAPYTLAIVESIADNWLTPTDWNTLVRAVLSGGDHLIWKSEFFENCRDTAKRNQQAGNGWDFDMLTGSGNYANTDAQMQYDPGLFAQIQAAATNAWRKLPVKGDPGASLTGVKQGPDEPFADFVHRLITTAGRIFGNAEAGVDYVKQLAYENANPACQAAIRPYRKKTDLTGYIRLCSDIGPSYQQGLAMAAAFSGQTVKDLLNNKNKDRGGCFKCGKKGHFAKDCRDHSNKNPESKVPGLCPRCKRGKHWANECKSKTDSQGNPLPPHQGNRDEGPAPGPEASLWGSQLCSSQQQQSISKLNRASPGSAGLDLCSTTHTVLTPEMGPQTLATGVYGPLPPNTFGLILGRGSTTVKGLQIYPGVIDNDYTGEFKIMARAISSIITIPQGERIAQLVLLPLLRTAHKIQHPYRGDKNFGSSDIFWVQPITHQKPSLVLWLDGKAFTGLIDTGADVTIIKQEDWPSHWPTTETLTNLRGIGQSNNPRQSSKYLTWKDKENNSGLIKPFVIPNLPVNLWGRDLLSQMKIMMCSPNDIVTAQMLAQGYSPGKGLGKREDGILQPIPNSGQLDRKGFGNFLATAVDILAPQRYADPITWKSDEPVWVDQWPLTQEKLAAAQQLVQEQLQAGHIIESNSPWNTPIFVIKKKSGKWRLLQDLRAVNATMVLMGALQPGLPSPVAIPQGYFKIVIDLKDCFFTIPLQPVDQKRFAFSLPSTNFKQPMKRYQWKVLPQGMANSPTLCQKYVAAAIEPVRKSWAQMYIIHYMDDILIAGKLGEQVLQCFAQLKQALTTTGLQIAPEKVQLQDPYTYLGFQINGPKITNQKAVIRRDKLQTLNDFQKLLGDINWLRPYLHLTTGDLKPLFDILKGDSNPNSPRSLSEAALASLQKVETAIAEQFVTQIDYTQPLTFLIFNTTLTPTGLFWQNNPVMWVHLPASPKKVLLPYYDAIADLIILGRDNSKKYFGLEPSTIIQPYSKSQIHWLMQNTETWPIACASYAGNIDNHYPPNKLIQFCKLHAVVFPRIISKTPLDNALLVFTDGSSTGIAAYTFEKTTVRFKTSHTSAQLVELQALIAVLSAFPHRALNVYTDSAYLAHSIPLLETVSHIKHISDTAKFFLQCQQLIYNRSIPFYLGHIRAHSGLPGPLSQGNHITDLATKVVATTLTTNLTEAQTAHALHHLNAQSLRLMFKITREQARQIVKQCPTCVTYLPIPHFGVNPKGLVPNMLWQMDVTHYSEFGKLKYVHVSIDTFSGFLVATLQTGEATKHVIAHLLHCFSIIGQPIHIKTDNGPGYTSSNFRAFCSKLHIKHTFGIPYNPQGQGIVERAHLSLKNTLEKIKKGEWYPTQGSPRNILNHALFILNFLNLDAQNKSAADRFWHTSSKKEYAMVKWKDPLDNTWHGPDPVLIWGRGSVCVYSQTHDAARWLPERLVRQVSNVTQSRE

pol

Gag-Pol polyprotein

1739 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

195.114 kDa

MGQTVTTPLSLTLDHWKDVERTAHNQSVEIRKRRWVTLCSAEWPTFNVGWPRDGTFNPDIITQVKIKVFSSGPHGHPDQVPYIVTWEALAADPPPWVKPFVHPKPPPLLLPPSAPSLPPEPPFPTPPQSSLYPALTSPLNTKPRPQVLPDSGGPLIDLLTEDPPPYRDPGPSSSDGNGGSGEVAPTEGAPDSSPMVSRLRGRREPPVADSTTSQAFPLRQGGNGQFQYWPFSSSDLYNWKNNNPSFSEDPAKLTALIESVLLTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGEDGRPTQLPNDINDAFPLERPDWDYNTQRGRNHLVHYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDPGQETNVAMSFIWQSAPDIGRKLERLEDLKSKTLGDLVREAEKIFNKRETPEEREERIRRETEEKEERRRAEDEQREKERDRRRHREMSKLLATVISGQRQDRQGGERRRPQLDHDQCAYCKEKGHWARDCPKKPRGPRGPRPQASLLTLDDQGGQGQEPPPEPRITLKVGGQPVTFLVDTGAQHSVLTQNPGPLSDKSAWVQGATGGKRYRWTTDRRVHLATGKVTHSFLHVPDCPYPLLGRHLLTKLKAQIHFEGSGAQVVGPMGQPLQVLTLNIEDEYRLHETSKGPDVPLGSTWLSDFPQAWAETGGMGLAFRQAPLIISLKATSTPVSIKQYPMSQEARLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQSLFAFEWKDPEMGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSELDCQQGTRALLQTLGDLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETVMGQPTPKTPRQLREFLGTAGLCRLWIPGFAEMAAPLYPLTKTGTLFKWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDVGKLTMGQPLVILAPHAVEALVKQPPDRWLSNARMTHYQALLLDTDRVQFGPIVALNPATLLPLPEEGLQHDCLDILAEAHGTRPDLTDQPLPDADHTWYTDGSSFLQEGQRRAGAAVTTETEVIWAKALPAGTSAQRAELIALTQALKMAAGKKLNVYTDSRYAFATAHIHGEIYRRRGLLTSEGKEIKNKDEILALLKALFLPKRLSIIHCPGHQKGNHAEARGNRMADQAAREVATRETPETSTLLIENSAPYTREHFHYTVTDIKDLTKLGATYDDAKKCWVYQGKPVMPDQFTFELLDFLHQLTHLSFSKTKALLERSYSPSYMLNRDRTLKDITETCKACAQVNASKSAVKQGTRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKKETAKVVTKKLLEEIFPRFGMPQVLGTDNGPAFVSKVSQTVADLLGVDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLATGSRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFPDPDMAKVTHNPSLQAHLQALYLVQHEVWRPLAAAYQEQLDRPVVPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADTRIEPPAESTWRVQRSQNPLKIRLTRGTS

pol

Gag-Pol polyprotein

1738 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

195.173 kDa

MGQAVTTPLSLTLDHWKDVERTAHNLSVEVRKRRWVTFCSAEWPTFNVGWPRDGTFNPDIITQVKIKVFSPGPHGHPDQVPYIVTWEAIAVDPPPWVRPFVHPKPPLSLPPSAPSLPPEPPLSTPPQSSLYPALTSPLNTKPRPQVLPDSGGPLIDLLTEDPPPYRDPGPPSPDGNGDSGEVAPTEGAPDPSPMVSRLRGRKEPPVADSTTSQAFPLRLGGNGQYQYWPFSSSDLYNWKNNNPSFSEDPAKLTALIESVLLTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGEDGRPTQLPNDINDAFPLERPDWDYNTQRGRNHLVHYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDPGQETNVAMSFIWQSAPDIGRKLERLEDLKSKTLGDLVREAEKIFNKRETPEEREERIRRETEEKEERRRAEDVQREKERDRRRHREMSKLLATVVSGQRQDRQGGERRRPQLDHDQCAYCKEKGHWARDCPKKPRGPRGPRPQASLLTLDDQGGQGQEPPPEPRITLRVGGQPVTFLVDTGAQHSVLTQNPGPLSDKSAWVQGATGGKRYRWTTDRRVHLATGKVTHSFLHVPDCPYPLLGRDLLTKLKAQIHFEGSGAQVVGPMGQPLQVLTLNIEDEYRLHETSKGPDVPLGSTWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQSLFAFEWRDPEMGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSELDCQQGTRALLQTLGDLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETVMGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTGTLFEWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAVEALVKQPPDRWLSNARMTHYQALLLDTDRVQFGPIVALNPATLLPLPEEGLQHDCLDILAEAHGTRPDLTDQPLPDADHTWYTDGSSFLQEGQRKAGAAVTTETEVVWAKALPAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHIHGEIYRRRGLLTSEGKEIKNKDEILALLKALFLPKRLSIIHCPGHQKGNRAEARGNRMADQAAREVATRETPETSTLLIENSAPYTHEHFHYTVTDIKDLTKLGATYDDAKKCWVYQGKPVMPDQFTFELLDFLHQLTHLSFSKTKALLERNYCPYYMLNRDRTLKDITETCQACAQVNASKSAVKQGTRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFIDTFSGWVEAFPTKKETAKVVTKKLLEEIFPRFGMPQVLGTDNGPAFVSKVSQTVADLLGVDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLATGSRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFPDPDMAKVTHNPSLQAHLQALYLVQHEVWRPLAAAYQEQLDRPVVPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADTRIEPPSESTWRVQRSQNPLKIRLTRGTS

pol

Gag-Pol polyprotein

1738 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

195.265 kDa

MGQTATTPLSLTLDHWKDVERTAHNQSVEVRKRRWVTFCSAEWPTFNVGWPRDGTFNPDIITQVKIKVFSPGPHGHPDQVPYIVTWEALAVDPPPWVKPFVHPKPPLLLPPSAPSLPPEPPLSTPPQSSLYPALTSPLNTKPRPQVLPDSGGPLIDLLTEDPPPYRDPGPPSPDGKGDSGEVAPTEGAPDSSPMVSRLRGRREPPVADSTTSQAFPLRLGGNGQFQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLLTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGEDGRPTQLPNDINDAFPLERPDWDYNTQRGRNHLVHYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDPGQETNVSMSFIWQSAPDIGRKLERLEDLKNKTLGDLVREAEKIFNKRETPEEREERVRRETEEKEERRRAEDERREKERDRRRHREMSKLLATVVSGQRQDRQGGERRRPQLDHDQCAYCKEKGHWARDCPKKPRGPRGPRPQASLLTLDDQGGQGQEPPPEPRITLKVGGQPVTFLVDTGAQHSVLTQNPGPLSDKSAWVQGATGGKRYRWTTDRRVHLATGKVTHSFLHVPDCPYPLLGRDLLTKLKAQIHFEGSGAQVVGPMGQPLQVLTLNIEDEYRLHETSKGPDVPLGSTWLSDFPQAWAETGGMGLAVRQAPLIIPLRAASTPVSIKQYPMSREARLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQSLFAFEWRDPEMGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSELDCQQGTRALLQTLGDLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETVMGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTGTLFKWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAVEALVKQPPDRWLSNARMTHYQALLLDTDRVQFGPIVTLNPATLLPLPEEGLQHDCLDILAEAHGTRPDLTDQPLPDADHTWYTDGSSFLQEGQRKAGAAVTTETEVIWAKALPAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHIHGEIYRRRGLLTSEGKEIKNKEEILALLKALFLPKRLSIIHCPGHQKGNRAEARGNRMADQAAREVATRETPETSTLLIENSAPYTREHFHYTVTDIKDLTKLGATYDNAQKCWVYQGKPVMPDQFTFELLDFLHQLTHLSFSKTKALLERSYSPYYMLNRDRTLKDITETCKACAQVNASKSAVKQGTRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKKETAKVVTKKLLEEIFPRFGMPQVLGTDNGPAFVSKVSQTVADLLGVDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLATGSRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFPDPDMAKVTHNPSLQAHLQALYLVQHEVWRPLAAAYQEQLDRPVVPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAADTKIEPPSESTWRVQRSQNPLKIRLTRGTS

pol

Gag-Pol polyprotein

1734 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

194.217 kDa

MGQTVTTPLSLTLEHWGDVQRIASNQSVEVKKRRRVTFCPAEWPTFDVGWPQDGTFNLDIILQVKSKVFSPGPHGHPDQVPYIVTWEAIAYEPPSWVKPFVSPKLSLSPTAPILPSGPSTQPPPRSALYPALTPSIKPRPSKPQVLSDNGGPLIDLLTEDPPPYGEQGPSSPDGDGDREEATYTSEIPAPSPMVSRLRGKRDPPAADSTTSRAFPLRLGGNGQLQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLTTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGNDGRPTQLPNEVNSAFPLERPDWDYTTPEGRNHLVLYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDHGQETSVSMSFIWQSAPDIGRKLERLEDLKSKTLRDLVREAEKIFNKRETPEEREERFRRETEENEERRRAEDEQREKERDRRRQREMSKLLATVVTGQRQDRQGGERKRPQLDKDQCAYCKEKGHWAKDCPKKPRGPRGPRPQTSLLTLDDQGGQGQEPPPEPRITLKVGGQPVTFLVDTGAQHSVLTQNPGPLSDRSAWVQGATGGKRYRWTTDRKVHLATGKVTHSFLHVPDCPYPLLGRDLLTKLKAQIHFKGSGAQIVGPMGQPLQVLTLNIEDEYRLHEISTEPDVSPGSTWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEAKLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQGLREVNKRVEDIHPTVPNPYNLLSGLPTSHRWYTVLDLKDAFFCLRLHPTSQPLFASEWRDPGMGISGQLTWTRLPQGFKNSPTLFDEALHRGLADFRIQHPDLILLQYVDDLLLAATSELDCQQGTRALLKTLGNLGYRASAKKAQICQKQVKYLGYLLREGQRWLTEARKETVMGQPTPKTPRQLREFLGTAGFCRLWIPRFAEMAAPLYPLTKTGTLFNWGPDQQKAYHEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAVEALVKQPPDRWLSNARMTHYQAMLLDTDRVQFGPVVALNPATLLPLPEEGAPHDCLEILAETHGTEPDLTDQPIPDADHTWYTDGSSFLQEGQRKAGAAVTTETEVIWARALPAGTSAQRAELIALTQALKMAEGKRLNVYTDSRYAFATAHIHGEIYKRRGLLTSEGREIKNKSEILALLKALFLPKRLSIIHCLGHQKGDSAEARGNRLADQAAREAAIKTPPDTSTLLIEDSTPYTPAYFHYTETDLKKLRELGATYNQSKGYWVFQGKPVMPDQFVFELLDSLHRLTHLGYQKMKALLDRGESPYYMLNRDKTLQYVADSCTVCAQVNASKAKIGAGVRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKHETAKIVTKKLLEEIFPRFGMPQVLGTDNGPAFVSQVSQSVAKLLGIDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLATGTRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFHDPEMSKFTNSPSLQAHLQALQAVQREVWKPLAAAYQDQLDQPVIPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGISAWIHAAHVKAATTPPIRPSWRVQRSQNPLKIRLTRGAP

pol

Gag-Pol polyprotein

1734 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

194.081 kDa

MGQTVTTPLSLTLEHWEDVQRIASNQSVDVKKRRWVTFCSAEWPTFGVGWPQDGTFNLDIILQVKSKVFSPGPHGHPDQVPYIVTWEAIAYEPPPWVKPFVSPKLSPSPTAPILPSGPSTQPPPRSALYPALTPSIKPRPSKPQVLSDNGGPLIDLLSEDPPPYGGQGLSSSDGDGDREEATSTSEIPAPSPIVSRLRGKRDPPAADSTTSRAFPLRLGGNGQLQYWPFSSSDLYNWKNNNPSFSEDPGKLTALIESVLTTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGNDGRPTQLPNEVDAAFPLERPDWDYTTQRGRNHLVLYRQLLLAGLQNAGRSPTNLAKVKGITQGPNESPSAFLERLKEAYRRYTPYDPEDPGQETNVSMSFIWQSAPDIGRKLERLEDLKSKTLGDLVREAERIFNKRETPEEREERVRRETEEKEERRRAEEEQKEKERDRRRHREMSKLLATVVSGQRQDRQGGERRRPQLDKDQCAYCKEKGHWAKDCPKKPRGPRGPRPQTSLLTLDDQGGQGQEPPPEPRITLTVGGQPVTFLVDTGAQHSVLTQNPGPLSDRSAWVQGATGGKRYRWTTDRKVHLATGKVTHSFLHVPDCPYPLLGRDLLTKLKAQIHFEGSGAQVVGPKGQPLQVLTLNLEDEYRLYETSAEPEVSPGSTWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEAKLGIKPHIQRLLDQGILVPCQSPWNTPLLPVKKPGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHRWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDPGMGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDILLAATSELDCQQGTRALLLTLGNLGYRASAKKAQLCQKQVKYLGYLLKEGQRWLTEARKETVMGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTGTLFNWGPDQQKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRRPVAYLSKKLDPVAAGWPPCLRMVAAIAVLRKDAGKLTMGQPLVILAPHAVEALVKQPPDRWLSNARMTHYQAMLLDTDRVQFGPVVALNPATLLPLPEEGAPHDCLEILAETHGTRPDLTDQPIPDADHTWYTDGSSFLQEGQRKAGAAVTTETEVIWARALPAGTSAQRAELIALTQALKMAEGKRLNVYTDSRYAFATAHIHGEIYRRRGLLTSEGREIKNKSEILALLKALFLPKRLSIIHCLGHQKGDSAEARGNRLADQAAREAAIKTPPDTSTLLIEDSTPYTPAYFHYTETDLKKLRELGATYNQSKGYWVFQGKPVMPDQFVFELLDSLHRLTHLGYQKMKALLDRGESPYYMLNRDKTLQYVADSCTVCAQVNASKAKIGAGVRVRGHRPGSHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKRETARVVSKKLLEEIFPRFGMPQVLGSDNGPAFTSQVSQSVADLLGIDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLAAGTRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFHDPDMSELTNSPSLQAHLQALQTVQREIWKPLAEAYRDQLDQPVIPHPFRIGDSVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGISAWIHAAHVKAATTPPIKPSWRVQRSQNPLKIRLTRGAP

pol

Gag-Pol polyprotein

1727 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

192.98 kDa

MGQTLTTPLSLTLTHFSDVRARAHNLSVGVRKGRWQTFCSSEWPTLHVGWPRDGTFDLSVILQVKTKVMDPGPHGHPDQVAYIITWEDLVRNPPPWVKPFLHTPSTSKSTLLALEVPKNRTLDPPKPVLPDESQQDLLFQDPLPHPPHNPLLEPPPYNSPSPPVLSPVSPTTPSAPTPSSLVSSSTPPSSPAPPELTPRTPPQTPRLRLRRAEGQDGPSTWQSSLFPLRTVNRTIQYWPFSASDLYNWKTHNPSFSQDPQALTSLIESILLTHQPTWDDCQQLLQVLLTTEERQRVLLEARKNVPGPGGLPTQLPNEIDEGFPLTRPDWDYETAPGRESLRIYRQALLAGLKGAGKRPTNLAKVRTITQGKDESPAAFMERLLEGFRMYTPFDPEAPEHKATVAMSFIDQAALDIKGKLQRLDGIQTHGLQELVREAEKVYNKRETPEEREARLIKEQEEREDRRDRKRDKHLTKILAAVVTEKRAGKSGETRRRPKVDKDQCAYCKERGHWIKDCPKRPRDQKKPAPVLTLGEDSEQGCQGSGAPPEPRLTLSVGGHPTTFLVDTGAQHSVLTKANGPLSSRTSWVQGATGRKMHKWTNRRTVNLGQGMVTHSFLVVPECPYPLLGRDLLTKLGAQIHFSEAGAQVLDRDGQPIQILTVSLQDEHRLFDIPVTTSLPDVWLQDFPQAWAETGGLGRAKCQAPIIIDLKPTAVPVSIKQYPMSLEAHMGIRQHIIKFLELGVLRPCRSPWNTPLLPVKKPGTQDYRPVQDLREINKRTVDIHPTVPNPYNLLSTLKPDYSWYTVLDLKDAFFCLPLAPQSQELFAFEWKDPERGISGQLTWTRLPQGFKNSPTLFDEALHRDLTDFRTQHPEVTLLQYVDDLLLAAPTKKACTQGTRHLLQELGEKGYRASAKKAQICQTKVTYLGYILSEGKRWLTPGRIETVARIPPPRNPREVREFLGTAGFCRLWIPGFAELAAPLYALTKESTPFTWQTEHQLAFEALKKALLSAPALGLPDTSKPFTLFLDERQGIAKGVLTQKLGPWKRPVAYLSKKLDPVAAGWPPCLRIMAATAMLVKDSAKLTLGQPLTVITPHTLEAIVRQPPDRWITNARLTHYQALLLDTDRVQFGPPVTLNPATLLPVPENQPSPHDCRQVLAETHGTREDLKDQELPDADHTWYTDGSSYLDSGTRRAGAAVVDGHNTIWAQSLPPGTSAQKAELIALTKALELSKGKKANIYTDSRYAFATAHTHGSIYERRGLLTSEGKEIKNKAEIIALLKALFLPQEVAIIHCPGHQKGQDPVAVGNRQADRVARQAAMAEVLTLATEPDNTSHITIEHTYTSEDQEEARAIGATENKDTRNWEKEGKIVLPQKEALAMIQQMHAWTHLGNRKLKLLIEKTDFLIPRASTLIEQVTSACKVCQQVNAGATRVPAGKRTRGNRPGVYWEIDFTEVKPHYAGYKYLLVFVDTFSGWVEAFPTRQETAHIVAKKILEEIFPRFGLPKVIGSDNGPAFVSQVSQGLARILGINWKLHCAYRPQSSGQVERMNRTIKETLTKLTLETGLKDWRRLLSLALLRARNTPNRFGLTPYEILYGGPPPLSTLLNSFSPSNSKTDLQARLKGLQAVQAQIWAPLAELYRPGHSQTSHPFQVGDSVYVRRHRSQGLEPRWKGPYIVLLTTPTAIKVDGIATWIHASHAKAAPGTPGPTSSGTWRLRRSEDPLKIRLSRT

pol

Gag-Pro-Pol polyprotein

1726 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

193.421 kDa

MGHTHSRQLFVHMLSVMLKHRGITVSKTKLINFLSFIEEVCPWFPREGTVNLETWKKVGEQIRTHYTLHGPEKVPVETLSFWTLIRDCLDFDNDELKRLGNLLKQEEDPLHTPDSVPSYDPPPPPPPSLKMHPSDNDDSLSSTDEAELDEEAAKYHQEDWGFLAQEKGALTSKDELVECFKNLTIALQNAGIQLPSNNNTFPSAPPFPPAYTPTVMAGLDPPPGFPPPSKHMSPLQKALRQAQRLGEVVSDFSLAFPVFENNNQRYYESLPFKQLKELKIACSQYGPTAPFTIAMIESLGTQALPPNDWKQTARACLSGGDYLLWKSEFFEQCARIADVNRQQGIQTSYEMLIGEGPYQATDTQLNFLPGAYAQISNAARQAWKKLPSSSTKTEDLSKVRQGPDEPYQDFVARLLDTIGKIMSDEKAGMVLAKQLAFENANSACQAALRPYRKKGDLSDFIRICADIGPSYMQGIAMAAALQGKSIKEVLFQQQARNKKGLQKSGNSGCFVCGQPGHRAAVCPQKHQTSVNTPNLCPRCKKGKHWARDCRSKTDVQGNPLPPVSGNLGEGPAPGPETMLWGNTAGSKRTIADLCRATRGSAGLDLCATSYTVLTPEMGVQTLATGVFGPLPPGTVGLLLGRSSASLKGILIHPGVIDSDYTGEIKILASAPNKIIVINAGQRIAQLLLVPLVIQGKTINRDRQDKGFGSSDAYWVQNVTEARPELELRINANFFRGVLDTGADISVISDKYWPTTWPKQMAISTLQGIGQTTNPEQSSSLLTWKDKDGHTGQFKPYILPYLPVNLWGRDILSKMGVYLYSPSPTVTDLMLDQGLLPNQGLGKQHQGIILPLDLKPNQDRKGLGCFPLGTSDSPVTHADPIDWKSEEPVWVDQWPLTQEKLSAAQQLVQEQLRLGHIEPSTSAWNSPIFVIKKKSGKWRLLQDLRKVNETMMHMGALQPGLPTPSAIPDKSYIIVIDLKDCFYTIPLAPQDCKRFAFSLPSVNFKEPMQRYQWRVLPQGMTNSPTLCQKFVATAIAPVRQRFPQLYLVHYMDDILLAHTDEHLLYQAFSILKQHLSLNGLVIADEKIQTHFPYNYLGFSLYPRVYNTQLVKLQTDHLKTLNDFQKLLGDINWIRPYLKLPTYTLQPLFDILKGDSDPASPRTLSLEGRTALQSIEEAIRQQQITYCDYQRSWGLYILPTPRAPTGVLYQDKPLRWIYLSATPTKHLLPYYELVAKIIAKGRHEAIQYFGMEPPFICVPYALEQQDWLFQFSDNWSIAFANYPGQITHHYPSDKLLQFASSHAFIFPKIVRRQPIPEATLIFTDGSSNGTAALIINHQTYYAQTSFSSAQVVELFAVHQALLTVPTSFNLFTDSSYVVGALQMIETVPIIGTTSPEVLNLFTLIQQVLHCRQHPCFFGHIRAHSTLPGALVQGNHTADVLTKQVFFQSAIDAARKSHDLHHQNSHSLRLQFKISREAARQIVKSCSTCPQFFVLPQYGVNPRGLRPNHLWQTDVTHIPQFGRLKYVHVSIDTFSNFLMASLHTGESTRHCIQHLLFCFSTSGIPQTLKTDNGPGYTSRSFQRFCLSFQIHHKTGIPYNPQGQGIVERAHQRIKHQLLKQKKGNELYSPSPHNALNHALYVLNFLTLDTEGNSAAQRFWGERSSCKKPLVRWKDPLTNLWYGPDPVLIWGRGHVCVFPQDAEAPRWIPERLVRAAEELPDASDATHDPE

pol

Gag-Pol polyprotein

1712 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

192.423 kDa

MGQTITTPLSLTLDHWSEVRARAHNQGVEVRKKKWITLCEAEWVMMNVGWPREGTFSLDNISQVEKKIFAPGPYGHPDQVPYITTWRSLATDPPSWVRPFLPPPKPPTPLPQPLSPQPSAPLTSSLYPVLPKSDPPKPPVLPPDPSSPLIDLLTEEPPPYPGGHGPPPSGPRTPTASPIASRLRERRENPAEESQALPLREGPNNRPQYWPFSASDLYNWKSHNPPFSQDPVALTNLIESILVTHQPTWDDCQQLLQALLTGEERQRVLLEARKQVPGEDGRPTQLPNVIDETFPLTRPNWDFATPAGREHLRLYRQLLLAGLRGAARRPTNLAQVKQVVQGKEETPAAFLERLKEAYRMYTPYDPEDPGQAASVILSFIYQSSPDIRNKLQRLEGLQGFTLSDLLKEAEKIYNKRETPEEREERLWQRQEERDKKRHKEMTKVLATVVAQNRDKDREESKLGDQRKIPLGKDQCAYCKEKGHWVRDCPKRPRKKPANSTLLNLGDQESQGQDPPPEPRITLKIGGQPVTFLVDTGAQHSVLTRPDGPLSDRTALVQGATGSKNYRWTTDRRVQLATGKVTHSFLYVPECPYPLLGRDLLTKLKAQIHFTGEGANVVGPKGLPLQVLTLQLEEEYRLFEPESTQKQEMDIWLKNFPQAWAETGGMGTAHCQAPVLIQLKATATPISIRQYPMPHEAYQGIKPHIRRMLDQGILKPCQSPWNTPLLPVKKPGTEDYRPVQDLREVNKRVEDIHPTVPNPYNLLSTLPPSHPWYTVLDLKDAFFCLRLHSESQLLFAFEWRDPEIGLSGQLTWTRLPQGFKNSPTLFDEALHSDLADFRVRYPALVLLQYVDDLLLAAATRTECLEGTKALLETLGNKGYRASAKKAQICLQEVTYLGYSLKDGQRWLTKARKEAILSIPVPKNSRQVREFLGTAGYCRLWIPGFAELAAPLYPLTRPGTLFQWGTEQQLAFEDIKKALLSSPALGLPDITKPFELFIDENSGFAKGVLVQKLGPWKRPVAYLSKKLDTVASGWPPCLRMVAAIAILVKDAGKLTLGQPLTILTSHPVEALVRQPPNKWLSNARMTHYQAMLLDAERVHFGPTVSLNPATLLPLPSGGNHHDCLQILAETHGTRPDLTDQPLPDADLTWYTDGSSFIRNGEREAGAAVTTESEVIWAAPLPPGTSAQRAELIALTQALKMAEGKKLTVYTDSRYAFATTHVHGEIYRRRGLLTSEGKEIKNKNEILALLEALFLPKRLSIIHCPGHQKGDSPQAKGNRLADDTAKKAATETHSSLTVLPTELIEGPKRPPWEYDDSDLDLVQKLEAHYEPKRGTWEYRGKTIMPEKYAKELISHLHKLTHLSARKMKTLLEREETGFYLPNRDLHLRQVTESCRACAQINAGKIKFGPDVRARGRRPGTHWEVDFTEIKPGMYGYKYLLVFIDTFSGWAEAYPAKHETAKVVAKKLLEEIFPRYGIPQVLGSDNGPAFISQVSQSVATLLGINWKLHCAYRPQSSGQVERMNRSIKETLTKLTLETGSKDWVLLLPLVLYRVRNTPGPHGLTPFEILYGAPPPMAHFFDTDISSFATSPTMQAHLRALQLVQEEIQRPLAAAYREKLETPVVPHPFKPGDSVWVRRHQTKNLEPRWKGPHIVLLTTPTALKVDGVAAWIHASHVKAAGPTTNQDLSDSPSSDDPSRWKVQRTQNPLKIRLSRGT

pol

DNA polymerase

1702 amino acids

Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the homing site in gene that lack the intein.

Belongs to the DNA polymerase type-B family.

197.294 kDa

MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKDDSAIEEIKAIKGERHGKTVRVLDAVKVRKKFLGREVEVWKLIFEHPQDVPAMRGKIREHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKLLAFDIETFYHEGDEFGKGEIIMISYADEEEARVITWKNIDLPYVDVVSNEREMIKRFVQVVKEKDPDVIITYNGDNFDLPYLIKRAEKLGVRLVLGRDKEHPEPKIQRMGDSFAVEIKGRIHFDLFPVVRRTINLPTYTLEAVYEAVLGKTKSKLGAEEIAAIWETEESMKKLAQYSMEDARATYELGKEFFPMEAELAKLIGQSVWDVSRSSTGNLVEWYLLRVAYARNELAPNKPDEEEYKRRLRTTYLGGYVKEPEKGLWENIIYLDFRSLYPSIIVTHNVSPDTLEKEGCKNYDVAPIVGYRFCKDFPGFIPSILGDLIAMRQDIKKKMKSTIDPIEKKMLDYRQRAIKLLANSILPNEWLPIIENGEIKFVKIGEFINSYMEKQKENVKTVENTEVLEVNNLFAFSFNKKIKESEVKKVKALIRHKYKGKAYEIQLSSGRKINITAGHSLFTVRNGEIKEVSGDGIKEGDLIVAPKKIKLNEKGVSINIPELISDLSEEETADIVMTISAKGRKNFFKGMLRTLRWMFGEENRRIRTFNRYLFHLEKLGLIKLLPRGYEVTDWERLKKYKQLYEKLAGSVKYNGNKREYLVMFNEIKDFISYFPQKELEEWKIGTLNGFRTNCILKVDEDFGKLLGYYVSEGYAGAQKNKTGGISYSVKLYNEDPNVLESMKNVAEKFFGKVRVDRNCVSISKKMAYLVMKCLCGALAENKRIPSVILTSPEPVRWSFLEAYFTGDGDIHPSKRFRLSTKSELLANQLVFLLNSLGISSVKIGFDSGVYRVYINEDLQFPQTSREKNTYYSNLIPKEILRDVFGKEFQKNMTFKKFKELVDSGKLNREKAKLLEFFINGDIVLDRVKSVKEKDYEGYVYDLSVEDNENFLVGFGLLYAHNSYYGYMGYPKARWYSKECAESVTAWGRHYIEMTIREIEEKFGFKVLYADSVSGESEIIIRQNGKIRFVKIKDLFSKVDYSIGEKEYCILEGVEALTLDDDGKLVWKPVPYVMRHRANKRMFRIWLTNSWYIDVTEDHSLIGYLNTSKTKTAKKIGERLKEVKPFELGKAVKSLICPNAPLKDENTKTSEIAVKFWELVGLIVGDGNWGGDSRWAEYYLGLSTGKDAEEIKQKLLEPLKTYGVISNYYPKNEKGDFNILAKSLVKFMKRHFKDEKGRRKIPEFMYELPVTYIEAFLRGLFSADGTVTIRKGVPEIRLTNIDADFLREVRKLLWIVGISNSIFAETTPNRYNGVSTGTYSKHLRIKNKWRFAERIGFLIERKQKRLLEHLKSARVKRNTIDFGFDLVHVKKVEEIPYEGYVYDIEVEETHRFFANNILVHNTDGFYATIPGEKPELIKKKAKEFLNYINSKLPGLLELEYEGFYLRGFFVTKKRYAVIDEEGRITTRGLEVVRRDWSEIAKETQAKVLEAILKEGSVEKAVEVVRDVVEKIAKYRVPLEKLVIHEQITRDLKDYKAIGPHVAIAKRLAARGIKVKPGTIISYIVLKGSGKISDRVILLTEYDPRKHKYDPDYYIENQVLPAVLRILEAFGYRKEDLRYQSSKQTGLDAWLKR

pol

DNA polymerase

1699 amino acids

PI-TspGE8I and PI-TspGE8II are endonucleases.

Belongs to the DNA polymerase type-B family.

197.325 kDa

MILDTDYITEDGKPVIRVFKKENGEFKIEYDRNFEPYFYALLKDDSAIEEVKKITAKRHGTVVKVKRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIREHPAVIDIYEYDIPFAKRYLIDKGLIPMEGDEKLKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKKVDLPYVDVVSTEKEMIKRFLRVVKEKDPDVLITYNGDNFDFAYLKRRSEKLGVKFILGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGKPKEKVYAEEIATAWETGEGLERVARYSMEDAKVTFELGKEFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDERELARRRQSYAGGYVKEPERGLWNNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKIKRKMRATIDPVEKKLLDYRQRAIKILANSILPDEWLPLLVNGRLKLVRIGDFVDNTMKKGQPLENDGTEVLEVSGIEAISFNRKTKIAEIKPVKALIRHRYRGKVYDIKLSSGRNIKVTEGHSLFAFRDGELVEVTGGEIKPGDFIAVPRRVNLPERHERINLIEILLGLPPEETSDIVLTIPVKGRKNFFKGMLRTLRWIFEEEQRPRTARRYLEHLQKLGYVKLMKRAYEIVNKEALRNYRKLYEVLAERVKYNGNKREYLVHFNDLRNEIKFMPDEELEEWKVGTLNGFRMEPFIEVGEDFAKLLGYYVSEGYARKQRNQKNGWSYSVKIYNNDQRVLDDMEKLASKFFGRVRRGKNYVEISRKMAYVLFESLCGTLAENKRVPEVIFTSPESVRWAFFEGYFIGDGDLHPSKRVRLSTKSEELVNGLVVLLNSLGISAIKIRFDSGVYRVLVNEELPFLGNRKRKNAYYSHVIPKEILEETFGKQFQKNMSPAKLNEKVEKGELDAGKARRIAWLLEGDIVLDRVEKVTVEDYEGYVYDLSVEENENFLAGFGMLYAHNSYYGYYGYAKARWYCRECAESVTAWGRSYIETTIREIEEKFGFKVLYADSVAGNTEVIIRRNGKVEFVPIEKLFQRVDYRIGEKEYCALEGVEALTLDNRGRLVWRKVPYIMRHKTNKKIYRVWFTNSWYLDVTEDHSLIGYLNTSKVKSEKPLKERLVEVKPRELGEKVKSLITLNRAIARSIKANPIAVRLWELIGLLVGDGNWGGHSKWAKYYVGLSCGLDKAEIEEKVLRPLKEAGIISNYYGKSKKGDVSILSKWLAGFMVKYFKDENGNKRIPSFMFNLPREYIEAFLRGLFSADGTVSLRRGIPEIRLTSVNRELSNEVRKLLWLVGVSNSMFTETTPNKYLGNESGTRSIHVRIKNKHRFAKRIGFLLDRKATKLSDNLREHTNKKMAYRYDFDLVYPKKIEEINYDRYVYDIEVEGTHRFFANGILVHNTDGFFATIPGADAETVKKKAMEFLKYINAKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQVGLGAWLKVKGKK

pol

Gag-Pol polyprotein

1687 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

188.011 kDa

MGQNNSTPLSLTLDHWKDVRTRAHNLSVKIRKGKWQTFCSSEWPTFGVGWPPEGTFNLSVIFAVKRIVFQETGGHPDQVPYIVVWQDLAQSPPPWVPPSAKIAVVSSPENTRGPSAGRPSAPPRPPIYPATDDLLLLSEPPPYPAALPPPLAPPAVGPAPGQAPDSSDPEGPAAGTRSRRARSPADDSGPDSTVILPLRAIGPPAEPNGLVPLQYWPFSSADLYNWKSNHPSFSENPAGLTGLLESLMFSHQPTWDDCQQLLQILFTTEERERILLEARKNVLGDNGAPTQLENLINEAFPLNRPQWDYNTAAGRERLLVYRRTLVAGLKGAARRPTNLAKVREVLQGPAEPPSVFLERLMEAYRRYTPFDPSEEGQQAAVAMAFIGQSAPDIKKKLQRLEGLQDYSLQDLVREAEKVYHKRETEEERQEREKKEAEERERRRDRRQEKNLTRILAAVVSERGSRDRQTGNLSNRARKTPRDGRPPLDKDQCAYCKEKGHWARECPQKKNVREAKVLALDDQGSRGSDPLPEPRVTLTVEGTPIEFLVDTGAEHSVLTQPMGKVGSRRTVVEGATGSKVYPWTTKRLLKIGHKQVTHSFLVIPECPAPLLGRDLLTKLKAQIQFSAEGPQVTWEDRPTMCLVLNLEEEYRLHEKPVPSSIDPSWLQLFPTVWAERAGMGLANQVPPVVVELRSGASPVAVRQYPMSKEAREGIRPHIQRFLDLGVLVPCQSPWNTPLLPVKKPGTNDYRPVQDLREINKRVQDIHPTVPNPYNLLSSLPPSHTWYSVLDLKDAFFCLKLHPNSQPLFAFEWRDPEKGNTGQLTWTRLPQGFKNSPTLFDEALHRDLAPFRALNPQVVLLQYVDDLLVAAPTYRDCKEGTQKLLQELSKLGYRVSAKKAQLCQKEVTYLGYLLKEGKRWLTPARKATVMKIPPPTTPRQVREFLGTAGFCRLWIPGFASLAAPLYPLTKESIPFIWTEEHQKAFDRIKEALLSAPALALPDLTKPFTLYVDERAGVARGVLTQTLGPWRRPVAYLSKKLDPVASGWPTCLKAVAAVALLLKDADKLTLGQNVTVIASHSLESIVRQPPDRWMTNARMTHYQSLLLNERVSFAPPAVLNPATLLPVESEATPVHRCSEILAEETGTRRDLKDQPLPGVPAWYTDGSSFIAEGKRRAGAAIVDGKRTVWASSLPEGTSAQKAELVALTQALRLAEGKDINIYTDSRYAFATAHIHGAIYKQRGLLTSAGKDIKNKEEILALLEAIHLPKRVAIIHCPGHQKGNDPVATGNRRADEAAKQAALSTRVLAETTKPQELIXPAQVKTRPGELTPDRGKEFIQRLHQLTHLGPEKLLQLVNRTSLLIPNLQSAVREVTSQCQACAMTNAVTTYRETGKRQRGDRPGVYWEVDFTEVKPGRYGNRYLLVFIDTFSGWVEAFPTKTETALTVCKKILEEILPRFGIPKVLGSDNGPAFVAQVSQGLATQLGINWKLHCAYRPQSSGQVERMNRTIKETLTKLALETGXKDWVALLPLALLRARNTPGRFGLTPYEILYGGPPPILESGGTLGPDDNFLPVLFTHLKALEVVRTQIWDQIKEVYKPGTVAIPHPFQVGDQVLVRRHRPGSLEPRWKGPYLVLLTTPTAVKVDGIAAWVHASHLKPAPPSAPDESWELEKADHPLKLRIRRRRNESAK

pol

Gag-Pol polyprotein

1686 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising the viral genome, matrix protein and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from each 3' end of the viral DNA, leaving recessed CA OH's at the 3' ends. In the second step that requires cell division, the PIC enters cell nucleus. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. The last step is viral DNA integration into host chromosome.

Belongs to the retroviral Pol polyprotein family.

188.09 kDa

MGQDNSTPISLTLNHWRDVRTRAHNLSVEIKKGKWQTFCSSEWPTFGVGWPPEGTFNLSVIFAVKKIVFQENGGHPDQVPYIVVWQDLAQNPPPWVPASAKVAVVSDTRRPVAGRPSAPPRPPIYPATDDLLLLSEPTPPPYPAALPPPLAPQAIGPPSGQMPDSSDPEGPAAGTRSRRARSPADNSGPDSTVILPLRAIGPPAEPNGLVPLQYWPFSSADLYNWKSNHPSFSENPAGLTGLLESLMFSHQPTWDDCQQLLQILFTTEERERILLEARKNVLGDNGAPTQLENLINEAFPLNRPHWDYNTAAGRERLLVYRRTLVAGLKGAARRPTNLAKVREVLQGPAEPPSVFLERLMEAYRRYTPFDPSSEGQQAAVAMAFIGQSAPDIKKKLQRLEGLQDYSLQDLVKEAEKVYHKRETEEERQEREKKEAEEKERRRDRPKKKNLTKILAAVVSREGSTGRQTGNLSNQAKKTPRDGRPPLDKDQCAYCKEKGHWARECPRKKHVREAKVLALDNXGSQGSDPLPEPRVTLTVEGTPIEFLVDTGAEHSVLTQPMGKVGSRRTVVEGATGSKVYPWTTKRLLKIGHKQVTHSFLVIPECPAPLLGRDLLTKLKAQIQFSAEGPQVTWGERPTMCLVLNLEEEYRLHEKPVPSSIDPSWLQLFPTVWAERAGMGLANQVPPVVVELRSGASPVAVRQYPMSKEAREGIRPHIQKFLDLGVLVPCRSPWNTPLLPVKKPGTNDYRPVQDLREINKRVQDIHPTVPNPYNLLSSLPPSYTWYSVLDLKDAFFCLRLHPNSQPLFAFEWKDPEKGNTGQLTWTRLPQGFKNSPTLFDEALHRDLAPFRALNPQVVLLQYVDDLLVAAPTYEDCKKGTQKLLQELSKLGYRVSAKKAQLCQREVTYLGYLLKEGKRWLTPARKATVMKIPVPTTPRQVREFLGTAGFCRLWIPGFASLAAPLYPLTKESIPFIWTEEHQQAFDHIKKALLSAPALALPDLTKPFTLYIDERAGVARGVLTQTLGPWRRPVAYLSKKLDPVASGWPTCLKAVAAVALLLKDADKLTLGQNVTVIASHSLESIVRQPPDRWMTNARMTHYQSLLLNERVSFAPPAVLNPATLLPVESEATPVHRCSEILAEETGTRRDLEDQPLPGVPTWYTDGSSFITEGKRRAGAPIVDGKRTVWASSLPEGTSAQKAELVALTQALRLAEGKNINIYTDSRYAFATAHIHGAIYKQRGLLTSAGKDIKNKEEILALLEAIHLPRRVAIIHCPGHQRGSNPVATGNRRADEAAKQAALSTRVLAGTTKPQEPIEPAQEKTRPRELTPDRGKEFIKRLHQLTHLGPEKLLQLVNRTSLLIPNLQSAVREVTSQCQACAMTNAVTTYRETGKRQRGDRPGVYWEVDFTEIKPGRYGNKYLLVFIDTFSGWVEAFPTKTETALIVCKKILEEILPRFGIPKVLGSDNGPAFVAQVSQGLATQLGINWKLHCAYRPQSSGQVERMNRTIKETLTKLALETGGKDWVTLLPLALLRARNTPGRFGLTPYEILYGGPPPILESGETLGPDDRFLPVLFTHLKALEIVRTQIWDQIKEVYKPGTVTIPHPFQVGDQVLVRRHRPSSLEPRWKGPYLVLLTTPTAVKVDGIAAWVHASHLKPAPPSAPDESWELEKTDHPLKLRIRRRRDESAK

pol

DNA polymerase

1671 amino acids

Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the homing site in gene that lack the intein. PI-PkoI recognizes 5'-GATTTAGATCCCTGTACC-3' and PI-PkoII recognizes 5'-CAGCTACTACGGTTAC-3'.

Belongs to the DNA polymerase type-B family.

193.405 kDa

MILDTDYITEDGKPVIRIFKKENGEFKIEYDRTFEPYFYALLKDDSAIEEVKKITAERHGTVVTVKRVEKVQKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHPAVIDIYEYDIPFAKRYLIDKGLVPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKNVDLPYVDVVSTEREMIKRFLRVVKEKDPDVLITYNGDNFDFAYLKKRCEKLGINFALGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGQPKEKVYAEEITTAWETGENLERVARYSMEDAKVTYELGKEFLPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEKELARRRQSYEGGYVKEPERGLWENIVYLDFRCHPADTKVVVKGKGIINISEVQEGDYVLGIDGWQRVRKVWEYDYKGELVNINGLKCTPNHKLPVVTKNERQTRIRDSLAKSFLTKKVKGKIITTPLFYEIGRATSENIPEEEVLKGELAGILLAEGTLLRKDVEYFDSSRKKRRISHQYRVEITIGKDEEEFRDRITYIFERLFGITPSISEKKGTNAVTLKVAKKNVYLKVKEIMDNIESLHAPSVLRGFFEGDGSVNRVRRSIVATQGTKNEWKIKLVSKLLSQLGIPHQTYTYQYQENGKDRSRYILEITGKDGLILFQTLIGFISERKNALLNKAISQREMNNLENNGFYRLSEFNVSTEYYEGKVYDLTLEGTPYYFANGILTHNSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQKIKKKMKATIDPIERKLLDYRQRAIKILANSILPEEWLPVLEEGEVHFVRIGELIDRMMEENAGKVKREGETEVLEVSGLEVPSFNRRTKKAELKRVKALIRHDYSGKVYTIRLKSGRRIKITSGHSLFSVRNGELVEVTGDELKPGDLVAVPRRLELPERNHVLNLVELLLGTPEEETLDIVMTIPVKGKKNFFKGMLRTLRWIFGEEKRPRTARRYLRHLEDLGYVRLKKIGYEVLDWDSLKNYRRLYEALVENVRYNGNKREYLVEFNSIRDAVGIMPLKELKEWKIGTLNGFRMSPLIEVDESLAKLLGYYVSEGYARKQRNPKNGWSYSVKLYNEDPEVLDDMERLASRFFGKVRRGRNYVEIPKKIGYLLFENMCGVLAENKRIPEFVFTSPKGVRLAFLEGYFIGDGDVHPNKRLRLSTKSELLANQLVLLLNSVGVSAVKLGHDSGVYRVYINEELPFVKLDKKKNAYYSHVIPKEVLSEVFGKVFQKNVSPQTFRKMVEDGRLDPEKAQRLSWLIEGDVVLDRVESVDVEDYDGYVYDLSVEDNENFLVGFGLVYAHNSYYGYYGYARARWYCKECAESVTAWGREYITMTIKEIEEKYGFKVIYSDTDGFFATIPGADAETVKKKAMEFLKYINAKLPGALELEYEGFYKRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEIAKETQARVLEALLKDGDVEKAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLKDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPTKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLSAWLKPKGT

pol

DNA polymerase

1668 amino acids

PI-ThyI and PI-ThyII are endonucleases. PI-ThyI cleaves the inteinless sequence of the Thy DNA pol gene. It requires a 21-bp minimal recognition sequence.

Belongs to the DNA polymerase type-B family.

193.321 kDa

single

FEPYIYALLKDDSAIEEVKKITAGRHGRVVKVKRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDEIRRHSAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMMSFDIETLYHEGEEFGTGPILMISYADEGEARVITWKKIDLPYVEVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRCEKIGIKFTLRRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGTPKEKVYPEEITTAWETGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYERNEIAPNKPDERELARRRGGYAGGYVKEPERGLWDNIVYLDFMSLYPSIIITHNVSPDTFNREGCKEYDTAPQVGHKFCKDVQGFIPSLLGALLDERQKIKKRMKASIDPLEKKLLDYRQKAIKILANSLLPEEWIPLVENGKVRLHRIGEFVDKLMETDSELVKRNGDTEVLEVRGIRALSFDRKSKKARVMPVKAVIRHRYSGDVYEIVLGSGRRITVTEGHSLFAYGDGELREVTGGEIKAGDLLAVPRRVNLPEKKERLNLVELLRRLPEEETGDIILTIPVKGRKNFFKGMLRTLRWISGEEKRPRTARRYLEHLEGLGYVRLKKIGYEVTDREGLERYRKLYERLVEAVRYNGNKREYLVEFNAVRDVIALMPEEELRDWLVGTRNGFRMRPFVEIEEDFAKLLGYYVSEGNARKWRNQKNGWSYTVKLYNENQRVLDDMESLAERFFGRVKRGKNYIEIPRKMAYIIFENLCGTLAENKRVPEAIFTSPESVRWAFIEGYFIGDGDVHPSKRVRLSTKSELLVNGLVLLLNSLGVSAIKIRHDSGVYRVYVNEELPFTDYRKKKNAYYSHVIPKEILEETFGKVFQRSVSYEKFRELVKSEKLDGEKAKRIEWLLNGDVVLDKVLEVKKRPYEGYVYDLSVEEDENFLAGFGLLYAHNSYYGYYGYARARWYCKECAESVTAWGRDYIETTIHEIEERFGFKVLYADSVTGETEIIIKRNGKVEFVAIEELFQRVDYRIGEKEYCVLEGVEALTLDNRGRLVWKSVPYVMRHRTNKRIYRVWFTNSWYLDVTEDHSLIGYMNTSKVKPGKPLKERLVEVKPGELGESVKSLITPNRAIAHGIRVNPIAVKLWELIGLLVGDGNWGGQSNWAKYNVGLSLGLDKEEIEEKILKPLKNTGIISNYYDKSKKGDVSILSKWLARFMVRYFKDESGSKRIPEFMFNLPREYIEAFLRGLFSADGTVSLRKGVPEVRLTSVNPELSSSVRKLLWLVGVSNSMFVETNPNRYLGKESGTHSVHVRIKDKHRFAERIGFLLDRKATKLSENLGGHTSKKRAYKYDFDLVYPKKVEEIAYDGYVYDIEVEGTHRFFANGILVHNTDGFFATIPGADAETVKKKAKEFLKYINAKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILRHGDVEEAVRIVKDVTEKLSKYEVPPEKLVIHEQITRELKDYKATGPHVAIAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPTKHRYDAEYYIENQVLPAVERILKAFGYKKEELRYQKTRQVGLGAWLKLKGKK

pol

DNA polymerase

1634 amino acids

Belongs to the DNA polymerase type-B family.

191.71 kDa

MGMSMGKIKIDALIDNTYKTIEDKAVIYLYLINSILKDRDFKPYFYVELHKEKVENEDIEKIKEFLLKNDLLKFVENIEVVKKIILRKEKEVIKIIATHPQKVPKLRKIKECEIVKEIYEHDIPFAKRYLIDNEIIPMTYWDFENKKPVSIEIPKLKSVAFDMEVYNRDTEPNPERDPILMASFWDENGGKVITYKEFNHPNIEVVKNEKELIKKIIETLKEYDVIYTYNGDNFDFPYLKARAKIYGIDINLGKDGEELKIKRGGMEYRSYIPGRVHIDLYPISRRLLKLTKYTLEDVVYNLFGIEKLKIPHTKIVDYWANNDKTLIEYSLQDAKYTYKIGKYFFPLEVMFSRIVNQTPFEITRMSSGQMVEYLLMKRAFKENMIVPNKPDEEEYRRRVLTTYEGGYVKEPEKGMFEDIISMDFRCHPKGTKVVVKGKGIVNIEDVKEGNYVLGIDGWQKVKKVWKYEYEGELINVNGLKCTPNHKIPLRYKIKHKKINKNDYLVRDIYAKSLLTKFKGEGKLILCKDFETIGNYEKYINDMDEDFILKSELIGILLAEGHLLRRDIEYFDSSRGKKRISHQYRVEITVNEDEKDFIEKIKYIFKKLFNYELYVRRKKGTKAITLGCAKKDIYLKIEEILKNKEKYLPNAILRGFFEGDGYVNTVRRAVVVNQGTNNYDKIKFIASLLDRLGIKYSFYTYSYEERGKKLKRYVIEIFSKGDLIKFSILISFISRRKNNLLNEIIRQKTLYKIGDYGFYDLDDVCVSLESYKGEVYDLTLEGRPYYFANGILTHNSLYPSIIISYNISPDTLDCECCKDVSEKILGHWFCKKKEGLIPKTLRNLIERRINIKRRMKKMAEIGEINEEYNLLDYEQKSLKILANSILPDEYLTIIEEDGIKVVKIGEYIDDLMRKHKDKIKFSGISEILETKNLKTFSFDKITKKCEIKKVKALIRHPYFGKAYKIKLRSGRTIKVTRGHSLFKYENGKIVEVKGDDVRFGDLIVVPKKLTCVDKEVVINIPKRLINADEEEIKDLVITKHKDKAFFVKLKKTLEDIENNKLKVIFDDCILYLKELGLIDYNIIKKINKVDIKILDEEKFKAYKKYFDTVIEHGNFKKGRCNIQYIKIKDYIANIPDKEFEDCEIGAYSGKINALLKLDEKLAKFLGFFVTRGRLKKQKLKGETVYEISVYKSLPEYQKEIAETFKEVFGAGSMVKDKVTMDNKIVYLVLKYIFKCGDKDKKHIPEELFLASESVIKSFLDGFLKAKKNSHKGTSTFMAKDEKYLNQLMILFNLVGIPTRFTPVKNKGYKLTLNPKYGTVKDLMLDEVKEIEAFEYSGYVYDLSVEDNENFLVNNIYAHNSVYGYLAFPRARFYSRECAEIVTYLGRKYILETVKEAEKFGFKVLYIDTDGFYAIWKEKISKEELIKKAMEFVEYINSKLPGTMELEFEGYFKRGIFVTKKRYALIDENGRVTVKGLEFVRRDWSNIAKITQRRVLEALLVEGSIEKAKKIIQDVIKDLREKKIKKEDLIIYTQLTKDPKEYKTTAPHVEIAKKLMREGKRIKVGDIIGYIIVKGTKSISERAKLPEEVDIDDIDVNYYIDNQILPPVLRIMEAVGVSKNELKKEGAQLTLDKFFK

pol

DNA polymerase

1634 amino acids

Belongs to the DNA polymerase type-B family.

191.71 kDa

MGMSMGKIKIDALIDNTYKTIEDKAVIYLYLINSILKDRDFKPYFYVELHKEKVENEDIEKIKEFLLKNDLLKFVENIEVVKKIILRKEKEVIKIIATHPQKVPKLRKIKECEIVKEIYEHDIPFAKRYLIDNEIIPMTYWDFENKKPVSIEIPKLKSVAFDMEVYNRDTEPNPERDPILMASFWDENGGKVITYKEFNHPNIEVVKNEKELIKKIIETLKEYDVIYTYNGDNFDFPYLKARAKIYGIDINLGKDGEELKIKRGGMEYRSYIPGRVHIDLYPISRRLLKLTKYTLEDVVYNLFGIEKLKIPHTKIVDYWANNDKTLIEYSLQDAKYTYKIGKYFFPLEVMFSRIVNQTPFEITRMSSGQMVEYLLMKRAFKENMIVPNKPDEEEYRRRVLTTYEGGYVKEPEKGMFEDIISMDFRCHPKGTKVVVKGKGIVNIEDVKEGNYVLGIDGWQKVKKVWKYEYEGELINVNGLKCTPNHKIPLRYKIKHKKINKNDYLVRDIYAKSLLTKFKGEGKLILCKDFETIGNYEKYINDMDEDFILKSELIGILLAEGHLLRRDIEYFDSSRGKKRISHQYRVEITVNEDEKDFIEKIKYIFKKLFNYELYVRRKKGTKAITLGCAKKDIYLKIEEILKNKEKYLPNAILRGFFEGDGYVNTVRRAVVVNQGTNNYDKIKFIASLLDRLGIKYSFYTYSYEERGKKLKRYVIEIFSKGDLIKFSILISFISRRKNNLLNEIIRQKTLYKIGDYGFYDLDDVCVSLESYKGEVYDLTLEGRPYYFANGILTHNSLYPSIIISYNISPDTLDCECCKDVSEKILGHWFCKKKEGLIPKTLRNLIERRINIKRRMKKMAEIGEINEEYNLLDYEQKSLKILANSILPDEYLTIIEEDGIKVVKIGEYIDDLMRKHKDKIKFSGISEILETKNLKTFSFDKITKKCEIKKVKALIRHPYFGKAYKIKLRSGRTIKVTRGHSLFKYENGKIVEVKGDDVRFGDLIVVPKKLTCVDKEVVINIPKRLINADEEEIKDLVITKHKDKAFFVKLKKTLEDIENNKLKVIFDDCILYLKELGLIDYNIIKKINKVDIKILDEEKFKAYKKYFDTVIEHGNFKKGRCNIQYIKIKDYIANIPDKEFEDCEIGAYSGKINALLKLDEKLAKFLGFFVTRGRLKKQKLKGETVYEISVYKSLPEYQKEIAETFKEVFGAGSMVKDKVTMDNKIVYLVLKYIFKCGDKDKKHIPEELFLASESVIKSFLDGFLKAKKNSHKGTSTFMAKDEKYLNQLMILFNLVGIPTRFTPVKNKGYKLTLNPKYGTVKDLMLDEVKEIEAFEYSGYVYDLSVEDNENFLVNNIYAHNSVYGYLAFPRARFYSRECAEIVTYLGRKYILETVKEAEKFGFKVLYIDTDGFYAIWKEKISKEELIKKAMEFVEYINSKLPGTMELEFEGYFKRGIFVTKKRYALIDENGRVTVKGLEFVRRDWSNIAKITQRRVLEALLVEGSIEKAKKIIQDVIKDLREKKIKKEDLIIYTQLTKDPKEYKTTAPHVEIAKKLMREGKRIKVGDIIGYIIVKGTKSISERAKLPEEVDIDDIDVNYYIDNQILPPVLRIMEAVGVSKNELKKEGAQLTLDKFFK

pol

DNA polymerase

1523 amino acids

PI-TfuII is a highly active homing endonuclease using Mg(2+) as cofactor. Its minimal recognition and cleavage site is 21 bp long either on linear or circular DNA substrates. Its endonuclease activity is strongly inhibited by the 3' digestion product, which remains bound to the enzyme after the cleavage reaction.

Belongs to the DNA polymerase type-B family.

175.918 kDa

MILDTDYITEDGRPVIRVFKKENGEFKIEYDRDFEPYIYALLKDDSAIEDVKKITASRHGTTVRVVRAGKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIREHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKKIDLPYVDVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRHTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWETGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLVGQSFWDVSRSSTGNLVEWYLLRKAYERNELAPNKPSGRELERRRGGYAGGYVKEPERGLWENIAYLDFRCHPADTKVIVKGKGVVNISEVREGDYVLGIDGWQKVQRVWEYDYEGELVNINGLKCTPNHKLPVVRRTERQTAIRDSLAKSFLTKKVKGKLITTPLFEKIGKIEREDVPEEEILKGELAGIILAEGTLLRKDVEYFDSSRGKKRVSHQYRVEITVGAQEEDFQRRIVYIFERLFGVTPSVYRKKNTNAITFKVAKKEVYLRVREIMDGIENLHAPSVLRGFFEGDGSVNKVRKTVVVNQGTNNEWKIEVVSKLLNKLGIPHRRYTYDYTEREKTMTTHILEIAGRDGLILFQTIVGFISTEKNMALEEAIRNREVNRLENNAFYTLADFTAKTEYYKGKVYDLTLEGTPYYFANGILTHNSLYPSIIISHNVSPDTLNREGCGEYDEAPQVGHRFCKDFPGFIPSLLGDLLDERQKVKKHMKATVDPIEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIETTMREIEEKFGFKVLYADSVTGDTEVTIRRNGRIEFVPIEKLFERVDHRVGEKEYCVLGGVEALTLDNRGRLVWKKVPYVMRHKTDKRIYRVWFTNSWYLDVTEDHSLIGYLNTSKVKPGKPLKERLVEVKPEELGGKVKSLITPNRPIARTIKANPIAVKLWELIGLLVGDGNWGGQSNWAKYYVGLSCGLDKAEIERKVLNPLREASVISNYYDKSKKGDVSILSKWLAGFMVKYFKDENGNKAIPSFMFNLPREYIEAFLRGLFSADGTVSLRRGIPEIRLTSVNRELSDAVRKLLWLVGVSNSLFTETKPNRYLEKESGTHSIHVRIKNKHRFADRIGFLIDRKSTKLSENLGGHTNKKRAYKYDFDLVYPRKIEEITYDGYVYDIEVEGTHRFFANGILVHNTDGFFATIPGADAETVKKKAREFLNYINPKLPGLLELEYEGFYRRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEVAKETQARVLEAILRHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRELKDYKATGPHVAIAKRLAARGIKVRPGTVISYIVLKGSGRIGDRTIPFDEFDPTKHRYDAEYYIENQVLPAVERILKAFGYKKEDLRYQKTRQVGLGAWLKMGKK

pol

Gag-Pol polyprotein

1506 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

171.94 kDa

MAKQGSKEKKGYPELKEVIKATCKIRVGPGKETLTEGNCLWALKTIDFIFEDLKTEPWTITKMYTVWDRLKGLTPEETSKREFASLQATLACIMCSQMGMKPETVQAAKGIISMKEGLHENKEAKGEKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVVFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLAMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQICLQWVITALRSVRHMSHRPGNPMLVKQKNTESYEDFIARLLEAIDAEPVTDPIKTYLKVTLSYTNASTDCQKQMDRTLGTRVQQATVEEKMQACRDVGSEGFKMQLLAQALRPQGKAGHKGVNQKCYNCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKQQGKQQEGATCGAVRAPYVVTEAPPKIEIKVGTRWKKLLVDTGADKTIVTSHDMSGIPKGRIILQGIGGIIEGEKWEQVHLQYKDKMIKGTIVVLATSPVEVLGRDNMRELGIGLIMANLEEKKIPSTRVRLKEGCKGPHIAQWPLTQEKLEGLKEIVDRLEKEGKVGRAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLAEAQLGLPHPGGLQRKKHVTILDIGDAYFTIPLYEPYRQYTCFTMLSPNNLGPCVRYYWKVLPQGWKLSPAVYQFTMQKILRGWIEEHPMIQFGIYMDDIYIGSDLGLEEHRGIVNELASYIAQYGFMLPEDKRQEGYPAKWLGFELHPEKWKFQKHTLPEITEGPITLNKLQKLVGDLVWRQSLIGKSIPNILKLMEGDRALQSERYIESIHVREWEACRQKLKEMEGNYYDEEKDIYGQLDWGNKAIEYIVFQEKGKPLWVNVVHSIKNLSQAQQIIKAAQKLTQEVIIRTGKIPWILLPGREEDWILELQMGNINWMPSFWSCYKGSVRWKKRNVIAELVPGPTYYTDGGKKNGRGSLGYIASTGEKFRIHEEGTNQQLELRAIEEACKQGPEKMNIVTDSRYAYEFMLRNWDEEVIRNPIQARIMELVHNKEKIGVHWVPGHKGIPQNEEIDRYISEIFLAKEGRGILQKRAEDAGYDLICPQEISIPAGQVKRIAIDLKINLKKDQWAMIGTKSSFANKGVFVQGGIIDSGYQGTIQVVIYNSNNKEVVIPQGRKFAQLILMPLIHEELEPWGETRKTERGEQGFGSTGMYWIENIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKMPSTLRGSNKRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRVQTMKWYAMFAPKSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQALVERTHQTLKNTLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDIFIFNKEQQRIQQQSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGAIVVKDRGTDRYLVIANKDVKFIPPPKEIQKE

pol

Gag-Pol polyprotein

1506 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

171.964 kDa

MAKQGSKEKKGYPELKEVIKATCKIRVGPGKETLTEGNCLWALKTIDFIFEDLKTEPWTITKMYTVWDRLKGLTPEETSKREFASLQATLACIMCSQMGMKPETVQAAKGIISMKEGLQENKEAKGEKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVVFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLAMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQICRQWVITALRSVRHMSHRPGNPMLVKQKNTESYEDFIARLLEAIDAEPVTDPIKTYLKVTLSYTNASTDCQKQMDRTLGTRVQQATVEEKMQACRDVGSEGFKMQLLAQALRPQGKAGHKGVNQKCYNCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKQQGKQQEGATCGAVRAPYVVTEAPPKIEIKVGTRWKKLLVDTGADKTIVTSHDMSGIPKGRIILQGIGGIIEGEKWEQVHLQYKDKIIRGTIVVLATSPVEVLGRDNMSELGIGLIMANLEEKKIPITEVRLKEGCKGPHIAQWPLTQEKLEGLKEIVDRLEKEGKVGRAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLAEAQLGLPHPGGLQRKKHVTILDIGDAYFTIPLYEPYRQYTCFTMLSPNNLGPCVRYYWKVLPQGWKLSPSVYQFTMQKILRGWIEEHPMIQFGIYMDDIYIGSDLGLEEHRGIVNELASYIAQYGFMLPEDKRQEGYPAKWLGFELHPEKWKFQKHTLPEITEGPITLNKLQKLVGDLVWRQSLIGKSIPNILKLMEGDRALQSERYIESIHVREWEACRQKLKEMEGNYYDEEKDIYGQLDWGNKAIEYIVFQEKGKPLWVNVVHSIKNLSQAQQIIKAAQKLTQEVIIRTGKIPWILLPGREEDWILELQMGNINWMPSFWSCYKGSVRWKKRNVIAEVVSGPTYYTDGGKKNGRGSLGYIASTGEKFRIYEEGTNQQLELRAIEEACKQGPEKMNIVTDSRYAYEFMLRNWDEEVIRNPIQARIMELMHNKEKIGVHWVPGHKGIPQNEEIDRYISEIFLAKEGRGILQKRAEDAGYDLICPQEISIPAGQVKRIAIDLKINLKKDQWAMIGTKSSFANKGVFVQGGIIDSGYQGTIQVVIYNSNNKEVVIPQGRKFAQLILMPLIHEELEPWGETRKTERGEQGFGSTGMYWIENIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKMPSTLRGSNKRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRVQTMKWYAMFAPKSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQALVERTHQTLKNTLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDIFIFNKEQQRIQQQSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGAIVVKDRGTDRYLVIANKDVKFIPPPKEIQKE

pol

Gag-Pol polyprotein

1506 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

171.974 kDa

MAKQGSKEKKGYPELKEVIKATCKIRVGPGKETLTEGNCLWALKTIDFIFEDLKTEPWTITKMYTVWDRLKGLTPEETSKREFASLQATLACIMCSQMGMKPETVQAAKGIISMKEGLQENKEAKGEKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVVFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLVMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQICLQWVITALRSVRHMSHRPGNPMLVKQKNTESYEDFIARLLEAIDAEPVMDPIKTYLKVTLSYTNASTDCQKQMDRTLGTRVQQATVEEKMQACRDVGSEGFKMQLLAQALRPQGKAGHKGVNQKCYNCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKQQGKQQEGATCGAVRAPYVVTEAPPKIEIKVGTRWKKLLVDTGADKTIVTSHDMSGIPKGRIILQGIGGIIEGEKWEQVHLQYKDKMIKGTIVVLATSPVEVLGRDNMRELGIGLIMANLEEKKIPSTRVRLKEGCKGPHIAQWPLTQEKLEGLKEIVDRLEKEGKVGRAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLAEAQLGLPHPGGLQRKKHVTILDIGDAYFTIPLYEPYRQYTCFTMLSPNNLGPCVRYYWKVLPQGWKLSPAVYQFTMQKILRGWIEEHPMIQFGIYMDDIYIGSDLGLEEHRGIVNELASYIAQYGFMLPEDKRQEGYPAKWLGFELHPEKWKFQKHTLPEITEGPITLNKLQKLVGDLVWRQSLIGKSIPNILKLMEGDRALQSERYIESIHVREWEACRQKLKEMEGNYYDEEKDIYGQLDWGNKAIEYIVFQEKGKPLWVNVVHSIKNLSQAQQIIKAAQKLTQEVIIRTGKIPWILLPGREEDWILELQMGNINWMPSFWSCYKGSVRWKKRNVIAEVVPGPTYYTDGGKKNGRGSLGYIASTGEKFRIHEEGTNQQLELRAIEEACKQGPEKMNIVTDSRYAYEFMLRNWDEEVIRNPIQARIMELVHNKEKIGVHWVPGHKGIPQNEEIDRYISEIFLAKEGRGILQKRAEDAGYDLICPQEISIPAGQVKRIAIDLKINLKKDQWAMIGTKSSFANKGVFVQGGIIDSGYQGTIQVVIYNSNNKEVVIPQGRKFAQLILMPLIHEELKPWGETRKTERGEQGFGSTGMYWIENIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKMPSTLRGSNKRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRVQTMKWYAMFAPKSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQALVERTHQTLKNTLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDIFIFNKEQQRIQQQSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGAIVVKDRGTDRYLVIANKDVKFIPPPKEIQKE

pol

Gag-Pol polyprotein

1506 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

171.957 kDa

MAKQGSKEKKGYPELKEVIKATCKIRVGPGKETLTEGNCLWALKTIDFIFEDLKTEPWTITKMYTVWDRLKGLTPEETSKREFASLQATLACIMCSQMGMKPETVQAAKGIISMKEGLHENKEAKGEKVEQLYPNLEKHREVYPIVNLQAGGRSWKAVESVVFQQLQTVAMQHGLVSEDFERQLAYYATTWTSKDILEVLAMMPGNRAQKELIQGKLNEEAERWVRQNPPGPNVLTVDQIMGVGQTNQQASQANMDQARQICLQWVITALRSVRHMSHRPGNPMLVKQKNTESYEDFIARLLEAIDAEPVTDPIKTYLKVTLSYTNASTDCQKQMDRTLGTRVQQATVEEKMQACRDVGSEGFKMQLLAQALRPQGKAGQKGVNQKCYNCGKPGHLARQCRQGIICHHCGKRGHMQKDCRQKKQQGKQQEGATCGAVRAPYVVTEAPPKIEIKVGTRWKKLLVDTGADKTIVTSHDMSGIPKGRIILQGIGGIIEGEKWEQVHLQYKDKIIRGTIVVLATSPVEVLGRDNMRELGIGLIMANLEEKKIPSTRVRLKEGCKGPHIAQWPLTQEKLEGLKEIVDRLEKEGKVGRAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLAEAQLGLPHPGGLQRKKHVTILDIGDAYFTIPLYEPYRQYTCFTMLSPNNLGPCVRYYWKVLPQGWKLSPAVYQFTMQKILRGWIEEHPMIQFGIYMDDIYIGSDLGLEEHRGIVNELASYIAQYGFMLPEDKRQEGYPAKWLGFELHPEKWKFQKHTLPEITEGPITLNKLQKLVGDLVWRQSLIGKSIPNILKLMEGDRALQSERYIESIHVREWEACRQKLKEMEGNYYDEEKDIYGQLDWGNKAIEYIVFQEKGKPLWVNVVHSIKNLSQAQQIIKAAQKLTQEVIIRTGKIPWILLPGREEDWILELQMGNINWMPSFWSCYKGSVRWKKRNVIAEVVPGPTYYTDGGKKNGRGSLGYITSTGEKFRIHEEGTNQQLELRAIEEACKQGPEKMNIVTDSRYAYEFMLRNWDEEVIRNPIQARIMELVHNKEKIGVHWVPGHKGIPQNEEIDRYISEIFLAKEGRGILQKRAEDAGYDLICPQEISIPAGQVKRIAIDLKINLKKDQWAMIGTKSSFANKGVFVQGGIIDSGYQGTIQVVIYNSNNKEVVIPQGRKFAQLILMPLIHEELEPWGETRKTERGEQGFGSTGMYWIENIPLAEEEHNKWHQDAVSLHLEFGIPRTAAEDIVQQCDVCQENKMPSTLRGSNKRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRVQTMKWYAMFAPKSLQSDNGPAFVAESTQLLMKYLGIEHTTGIPWNPQSQALVERTHQTLKNTLEKLIPMFNAFESALAGTLITLNIKRKGGLGTSPMDIFIFNKEQQRIQQQSKSKQEKIRFCYYRTRKRGHPGEWQGPTQVLWGGDGAIVVKDRGTDRYLVIANKDVKFIPPPKEIQKE

pol

Gag-Pro-Pol polyprotein

1416 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

156.937 kDa

MGNSPSYNPPAGISPSDWLNLLQSAQRLNPRPSPSDFTDLKNYIHWFHKTQKKPWTFTSGGPASCPPGKFGRVPLVLATLNEVLSNDEGAPGASAPEEQPPPYDPPAVLPIISEGNRNRHRAWALRELQDIKKEIENKAPGSQVWIQTLRLAILQADPTPADLEQLCQYIASPVDQTAHMTSLTAAIAAEAANTLQGFNPQNGTLTQQSAQPNAGDLRSQYQNLWLQAWKNLPTRPSVQPWSTIVQGPAESYVEFVNRLQISLADNLPDGVPKEPIIDSLSYANANKECQQILQGRGLVAAPVGQKLQACAHWAPKTKQPAILVHTPGPKMPGPRQPAPKRPPPGPCYRCLKEGHWARDCPTKTTGPPPGPCPICKDPSHWKRDCPTLKSKKLIEGGPSAPQIITPITDSLSEAELECLLSIPLARSRPSVAVYLSGPWLQPSQNQALMLVDTGAENTVLPQNWLVRDYPRTPAAVLGAGGISRNRYNWLQGPLTLALKPEGPFITIPKILVDTFDKWQILGRDVLSRLQASISIPEEVHPPVVGVLDAPPSHIGLEHLPPPPEVPQFPLNLERLQALQDLVHRSLEAGYISPWDGPGNNPVFPVRKPNGAWRFVHDLRVTNALTKPIPALSPGPPDLTAIPTHLPHIICLDLKDAFFQIPVEDRFRSYFAFTLPTPGGLQPHRRFAWRVLPQGFINSPALFERALQEPLRQVSAAFSQSLLVSYMDDILYVSPTEEQRLQCYQTMAAHLRDLGFQVASEKTRQTPSPVPFLGQMVHERMVTYQSLPTLQISSPISLHQLQTVLGDLQWVSRGTPTTRRPLQLLYSSLKGIDDPRAIIHLSPEQQQGIAELRQALSHNARSRYNEQEPLLAYVHLTRAGSTLVLFQKGAQFPLAYFQTPLTDNQASPWGLLLLLGCQYLQAQALSSYAKTILKYYHNLPKTSLDNWIQSSEDPRVQELLQLWPQISSQGIQPPGPWKTLVTRAEVFLTPQFSPEPIPAALCLFSDGAARRGAYCLWKDHLLDFQAVPAPESAQKGELAGLLAGLAAAPPEPLNIWVDSKYLYSLLRTLVLGAWLQPDPVPSYALLYKSLLRHPAIFVGHVRSHSSASHPIASLNNYVDQLLPLETPEQWHKLTHCNSRALSRWPNPRISAWDPRSPATLCETCQRLNPTGGGKMRTIQRGWAPNHIWQADITHYKYKQFTYALHVFVDTYSGATHASAKRGLTTQTTIEGLLEAIVHLGRPKKLNTDQGANYTSKTFVRFCQQFGISLSHHVPYNPTSSGLVERTNGLLKLLLSKYHLDEPHLPMTQALSRALWTHNQINLLPILKTRWELHHSPPLAVISEGGETPKGSDKLFLYKLPGQNNRRWLGPLPALVEASGGALLATNPPVWVPWRLLKAFKCLKNDGPEDAPNRSSDG

pol

Gag-Pro-Pol polyprotein

1416 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

156.397 kDa

MGNSPSYNPPAGISPSDWLNLLQSAQRLNPRPSPSDFTDLKNYIHWFHKTQKKPWTFTSGGPTSCPPGRFGRVPLVLATLNEVLSNEGGAPGASAPEEQPPPYDPPAILPIISEGNRNRHRAWALRELQDIKKEIENKAPGSQVWIQTLRLAILQADPTPADLEQLCQYIASPVDQTAHMTSLTAAIAAAEAANTLQGFNPKTGTLTQQSAQPNAGDLRSQYQNLWLQAGKNLPTRPSAPWSTIVQGPAESSVEFVNRLQISLADNLPDGVPKEPIIDSLSYANANRECQQILQGRGPVAAVGQKLQACAQWAPKNKQPALLVHTPGPKMPGPRQPAPKRPPPGPCYRCLKEGHWARDCPTKATGPPPGPCPICKDPSHWKRDCPTLKSKNKLIEGGLSAPQTITPITDSLSEAELECLLSIPLARSRPSVAVYLSGPWLQPSQNQALMLVDTGAENTVLPQNWLVRDYPRIPAAVLGAGGVSRNRYNWLQGPLTLALKPEGPFITIPKILVDTSDKWQILGRDVPSRLQASISIPEEVRPPVVGVLDTPPSHIGLEHLPPPPEVPQFPLNLERLQALQDLVHRSLEAGYISPWDGPGNNPVFPVRKPNGAWRFVHDLRATNALTKPIPALSPGPPDLTAIPTHPPHIICLDLKDAFFQIPVEDRFRFYLSFTLPSPGGLQPHRRFAWRVLPQGFINSPALFERALQEPLRQVSAAFSQSLLVSYMDDILYASPTEEQRSQCYQALAARLRDLGFQVASEKTSQTPSPVPFLGQMVHEQIVTYQSLPTLQISSPISLHQLQAVLGDLQWVSRGTPTTRRPLQLLYSSLKRHHDPRAIIQLSPEQLQGIAELRQALSHNARSRYNEQEPLLAYVHLTRAGSTLVLFQKGAQFPLAYFQTPLTDNQASPWGLLLLLGCQYLQTQALSSYAKPILKYYHNLPKTSLDNWIQSSEDPRVQELLQLWPQISSQGIQPPGPWKTLITRAEVFLTPQFSPDPIPAALCLFSDGATGRGAYCLWKDHLLDFQAVPAPESAQKGELAGLLAGLAAAPPEPVNIWVDSKYLYSLLRTLVLGAWLQPDPVPSYALLYKSLLRHPAIVVGHVRSHSSASHPIASLNNYVDQLLPLETPEQWHKLTHCNSRALSRWPNPRISAWDPRSPATLCETCQKLNPTGGGKMRTIQRGWAPNHIWQADITHYKYKQFTYALHVFVDTYSGATHASAKRGLTTQTTIEGLLEAIVHLGRPKKLNTDQGANYTSKTFVRFCQQFGVSLSHHVPYNPTSSGLDERTNGLLKLLLSKYHLDEPHLPMTQALSRALWTHNQINLLPILKTRWELHHSPPLAVISEGGETPKGSDKLFLYLLPGQNNRRWLGPLPALVEASGGALLATDPPVWVPWRLLKAFKCLKNDGPEDAHNRSSDG

pol

DNA polymerase

1312 amino acids

Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the homing site in gene that lack the intein.

Belongs to the DNA polymerase type-B family.

152.854 kDa

MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVRKITAERHGKIVRIIDAEKVRKKFLGRPIEVWRLYFEHPQDVPAIRDKIREHSAVIDIFEYDIPFAKRYLIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEEAKVITWKKIDLPYVEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPKMQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRKAYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVSPDTLNREGCREYDVAPEVGHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKMLDYRQRAIKILANSILPEEWVPLIKNGKVKIFRIGDFVDGLMKANQGKVKKTGDTEVLEVAGIHAFSFDRKSKKARVMAVKAVIRHRYSGNVYRIVLNSGRKITITEGHSLFVYRNGDLVEATGEDVKIGDLLAVPRSVNLPEKRERLNIVELLLNLSPEETEDIILTIPVKGRKNFFKGMLRTLRWIFGEEKRVRTASRYLRHLENLGYIRLRKIGYDIIDKEGLEKYRTLYEKLVDVVRYNGNKREYLVEFNAVRDVISLMPEEELKEWRIGTRNGFRMGTFVDIDEDFAKLLGYYVSEGSARKWKNQTGGWSYTVRLYNENDEVLDDMEHLAKKFFGKVKRGKNYVEIPKKMAYIIFESLCGTLAENKRVPEVIFTSSKGVRWAFLEGYFIGDGDVHPSKRVRLSTKSELLVNGLVLLLNSLGVSAIKLGYDSGVYRVYVNEELKFTEYRKKKNVYHSHIVPKDILKETFGKVFQKNISYKKFRELVENGKLDREKAKRIEWLLNGDIVLDRVVEIKREYYDGYVYDLSVDEDENFLAGFGFLYAHNSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYIDTDGLYATIPGAKPEEIKKKALEFVDYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDEEGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEEFDLRKHKYDAEYYIENQVLPAVLRILEAFGYRKEDLRWQKTKQTGLTAWLNIKKK

Pol

LINE-1 retrotransposable element ORF2 protein

1281 amino acids

Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome.

149.581 kDa

MPTLTTKIKGSNNYFSLISLNINGLNSPIKRHRLTDWLHKQDPTFCCLQETHLREKDRHYLRVKGWKTIFQANGLKKQAGVAILISDKIDFQPKVIKKDKEGHFILIKGKILQEELSILNIYAPNARAATFIRDTLVKLKAYIAPHTIIVGDFNTPLSSKDRSWKQKLNRDTVKLTEVMKQMDLTDIYRTFYPKTKGYTFFSAPHGTFSKIDHIIGHKTGLNRYKNIEIVPCILSDHHGLRLIFNNNINNGKPTFTWKLNNTLLNDTLVKEGIKKEIKDFLEFNENEATTYPNLWDTMKAFLRGKLIALSASKKKRETAHTSSLTTHLKALEKKEANSPKRSRRQEIIKLRGEINQVETRRTIQRINQTRSWFFEKINKIDKPLARLTKGHRDKILINKIRNEKGDITTDPEEIQNTIRSFYKRLYSTKLENLDEMDKFLDRYQVPKLNQDQVDHLNSPISPKEIEAVINSLPTKKSPGPDGFSAEFYQTFKEDLIPILHKLFHKIEVEGTLPNSFYEATITLIPKPQKDPTKIENFRPISLMNIDAKILNKILANRIQEHIKAIIHPDQVGFIPGMQGWFNIRKSINVIHYINKLKDKNHMIISLDAEKAFDKIQHPFMIKVLERSGIQGPYLNMIKAIYSKPVANIKVNGEKLEAIPLKSGTRQGCPLSPYLFNIVLEVLARAIRQQKEIKGIQIGKEEVKISLLADDMIVYISDPKNSTRELLNLINSFGEVVGYKINSNKSMAFLYTKNKQAEKEIRETTPFSIVTNNIKYLGVTLTKEVKDLYDKNFKSLKKEIKEDLRRWKDLPCSWIGRINIVKMAILPKAIYRFNAIPIKIPTQFFNELEGAICKFVWNNKKPRIAKSLLKDKRTSGGITMPDLKLYYRAIVIKTAWYWYRDRQVDQWNRIEDPEMNPHTYGHLIFDKGAKTIQWKKDSIFNNWCWHNWLLSCRRMRIDPYLSPCTKVKSKWIKELHIKPETLKLIEEKVGKSLEDMGTGEKFLNRTAMACAVRSRIDKWDLMKLQSFCKAKDTVNKTKRPPTDWERIFTYPKSDRGLISNIYKELKKVDFRKSNNPIKKWGSELNKEFSPEEYRMAEKHLKKCSTSLIIREMQIKTTLRFHLTPVRMAKIKNSGDSRCWRGCGERGTLLHCWWECRLVQPLWKSVWRFLRKLDIVLPEDPAIPLLGIYPEDAPTGKKDTCSTMFIAALFIIARSWKEPRCPSTEEWIQKMWYIYTMEYYSAIKKNEFMKFLAKWMDLEGIILSEVTHSQRNSHNMYSLISGY

POL

Retrovirus-related Pol polyprotein from transposon 412

1237 amino acids

143.042 kDa

QQSEQLQQKQCQCTSNPRTGQLATAFRYSVEEDRRVYTINYNLNIFSTFIHAKTGVKLVFLLDTGADISILKENSDKFSNIQITNKINIQGIGQQKIQSRGQTFIEIQTGKYVIPHDFHLVDKNFPIPCDGIIGIDFIKKYNCQIDLNQEEDWFIIRPNNLKFPIYIPIAYSSGINTTLLPARSQVVRRLIVSSKDDNILIPNQEIQTGIYVANTIATSSNTFVRILNTTDSDQLVNMDTLKYEPLSNYNVVQANSEHRNKTVLSQLKKNFPELFKSQLENICSEYIDIFALESEPITVNNLYKQQLRLKDDEPVYTKNYRSPHSQVEEIQAQVQKLIKDKIVEPSVSQYNSPLLLVPKKSSPNSDKKKWRLVIDYRQINKKLLADKFPLPRIDDILDQLGRAKYFSCLDLMSGFHQIELDEGSRDITSFSTSNGSYRFTRLPFGLKIAPNSFQRMMTIAFSGIEPSQAFLYMDDLIVIGCSEKHMLKNLTEVFGKCREYNLKLHPEKCSFFMHEVTFLGHKCTDKGILPDDKKYDVIQNYPVPHDADSARRFVAFCNYYRRFIKNFADYSRHITRLCKKNVPFEWTDECQKAFIHLKSQLINPTLLQYPDFSKEFCITTDASKQACGAVLTQNHNGHQLPVAYASRAFTKGESNKSTTEQELAAIHWAIIHFRPYIYGKHFTVKTDHRPLTYLFSMVNPSSKLTRIRLELEEYNFTVEYLKGKDNHVADALSRITIKELKDITGNILKVTTRFQSRQKSCAGKEQLDLQKQTKEIASEPNVYEVITNDEVRKVVTLQLNDSICLFKHGKKIIARYDVGDLYTNGILDLDQFLQRLELQAGIYDISQIKMAPWKKIFEHVSIDKFKNMGNKILKNLKVALLNPVTQINNEKEKEAILSTLHDDPIQGGHTGITKTLAKVKRHYYWKNMSKYIKEYVRKCQKCQKAKTTKHTKTPMTITETPEHAFDRVVVDTIGPLPKSENGNEYAVTLICDLTKYLVAIPIANKSAKTVAKAIFESFILKYGPMKTFITDMGTEYKNSIITDLCKYLKIKNITSTAHHHQTVGVVERSHRTLNEYIRSYISTDKTDWDVWLQYFVYCFNTTQSMVHNYCPYELVFGRTSNLPKHFNKLHSIEPIYNIDDYAKESKYRLEVAYARARKLLEAHKEKNKENYDLKVKDIELEVGDKVLLRNEVGHKLDFKYTGPYKIESIGDNNNITLLTNKNKKQIVHKDRLKKFHS

pol

DNA polymerase

1235 amino acids

Belongs to the DNA polymerase type-B family.

143.087 kDa

MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLRDDSAIDEIKKITAQRHGKVVRIVETEKIQRKFLGRPIEVWKLYLEHPQDVPAIRDKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEKLTFLAVDIETLYHEGEEFGKGPVIMISYADEEGAKVITWKKIDLPYVEVVSSEREMIKRLIRVIKEKDPDVIITYNGDNFDFPYLLKRAEKLGIKLLLGRDNSEPKMQKMGDSLAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWETGEGLERVAKYSMEDAKVTYELGREFFPMEAQLARLVGQPVWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDEKEYERRLRESYEGGYVKEPEKGLWEGIVSLDFRSLYPSIIITHNVSPDTLNREGCEEYDVAPKVGHRFCKDFPGFIPSLLGQLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSILPDEWLPIVENEKVRFVKIGDFIDREIEENAERVKRDGETEILEVKDLKALSFNRETKKSELKKVKALIRHRYSGKVYSIKLKSGRRIKITSGHSLFSVKNGKLVKVRGDELKPGDLVVVPGRLKLPESKQVLNLVELLLKLPEEETSNIVMMIPVKGRKNFFKGMLKTLYWIFGEGERPRTAGRYLKHLERLGYVKLKRRGCEVLDWESLKRYRKLYETLIKNLKYNGNSRAYMVEFNSLRDVVSLMPIEELKEWIIGEPRGPKIGTFIDVDDSFAKLLGYYISSGDVEKDRVKFHSKDQNVLEDIAKLAEKLFGKVRRGRGYIEVSGKISHAIFRVLAEGKRIPEFIFTSPMDIKVAFLKGLNGNAEELTFSTKSELLVNQLILLLNSIGVSDIKIEHEKGVYRVYINKKESSNGDIVLDSVESIEVEKYEGYVYDLSVEDNENFLVGFGLLYAHNSYYGYYGYAKARWYCKECAESVTAWGRQYIDLVRRELEARGFKVLYIDTDGLYATIPGVKDWEEVKRRALEFVDYINSKLPGVLELEYEGFYARGFFVTKKKYALIDEEGKIVTRGLEIVRRDWSEIAKETQARVLEAILKHGNVEEAVKIVKDVTEKLTNYEVPPEKLVIYEQITRPINEYKAIGPHVAVAKRLMARGIKVKPGMVIGYIVLRGDGPISKRAISIEEFDPRKHKYDAEYYIENQVLPAVERILKAFGYKREDLRWQKTKQVGLGAWIKVKKS

POL

DNA polymerase

1198 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

135.67 kDa

MALVQAHRARRLHAEAPDSGDQPPRRRVRQQPPRAAPAPARARRRRAPAPSPGGSRAPPTSGGPPASPLLDASSKDTPAAHRPPRGTVVAPRGCGLLQVIDAATNQPLEIRYHLDLARALTRLCEVNLQELPPDLSPRELQTMDSSHLRDVVIKLRPPRADIWTLGSRGVVVRSTITPLEQPDGQGQAAEVEDHQPNPPGEGLKFPLCFLVRGRQVNLVQDVQPVHRCQYCARFYKSQHECSARRRDFYFHHINSHSSNWWREIQFFPIGSHPRTERLFVTYDVETYTWMGAFGKQLVPFMLVMKFGGDEPLVTAARDLAVDLGWDRWEQDPLTFYCITPEKMAIGRQFRTFRDHLQMLMARDLWSSFVASNPHLADWALSEHGLSSPEELTYEELKKLPSIKGTPRFLELYIVGHNINGFDEIVLAAQVINNRSEVPGPFRITRNFMPRAGKILFNDVTFALPNPRSKKRTDFLLWEQGGCDDTDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCAYQAVNQFYMLGSYRSEADGFPIQEYWKDREEFVLNRELWKKKGQDKYDIIKETLDYCALDVQVTAELVNKLRDSYASFVRDAVGLTDASFNVFQRPTISSNSHAIFRQIVFRAEQPARSNLGPDLLAPSHELYDYVRASIRGGRCYPTYLGILREPLYVYDICGMYASALTHPMPWGPPLNPYERALAARAWQQALDLQGCKIDYFDARLLPGVFTVDADPPDETQLDPLPPFCSRKGGRLCWTNERLRGEVATSVDLVTLHNRGWRVHLVPDERTTVFPEWRCVAREYVQLNIAAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDAATLKGITAGQVNIKSSSFLETDNLSAEVMPAFEREYSPQQLALADSDAEESEDERAPTPFYSPPSGTPGHVAYTYKPITFLDAEEGDMCLHTLERVDPLVDNDRYPSHLASFVLAWTRAFVSEWSEFLYEEDRGTPLEDRPLKSVYGDTDSLFVTERGHRLMETRGKKRIKKHGGNLVFDPERPELTWLVECETVCGACGADAYSPESVFLAPKLYALKSLHCPSCGASSKGKLRAKGHAAEGLDYDTMVKCYLADAQGEDRQRFSTSRTSLKRTLASAQPGAHPFTVTQTTLTRTLRPWKDMTLARLDEHRLLPYSESRPNPRNEEICWIEMP

POL

DNA polymerase

1193 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

135.21 kDa

MALVQTHGSRGLHPEASDPGRQPSRRRSRQSSPGAVPEPARARRRRAPATTASGSRAAPTARRASSPPLLTMEAKPLPPAKKKRGTVVTPQGHGTLQAIDVATNGAVEIKYHLDLPRALEKLLQVNRAPPLPTDLTPQRLRTLDSSGLRALVLALRPVRAEVWTCLPRGLVSMTTIEAEEGQADHHDVVQHQMQAPRLHFPLKFLVKGTQVQLVQHVHPVQRCEHCGRLYKHKHECSARRRHFYFHHINSHSSNWWQEIQFFPIGSHPRTERLFLTYDVETYTWMGSFGKQLVPFMLVMKLSGDDRLVELALDLALQLKWDRWHGDPRTFYCVTPEKMAVGQQFRQYRDRLQTALAVDLWTSFLRANPHLADWALEQHGLSDPDELTYEELKKLPHVKGRPRFVELYIVGHNINGFDEIVLAAQVINNRAEVPQPFRITRNFMPRAGKILFNDVTFALPNPAYKKRTDFQLWEQGGCDDIDFKHQFLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCAYKAVNQFYMLGSYRADQDGFPLEEYWKDREEFLLNRELWKQKGQLKYDIIQETLDYCALDVLVTAELVAKLQDSYAHFIRDSVGLPHAHFNIFQRPTISSNSHAIFRQIVYRAEKPSRANLGAGLLAPSHELYDYVRATIRGGRCYPTYIGILDEPLYVYDICGMYASALTHPMPWGTPLSPYERALAVREWQASLDDLGTCISYFDPDLLPGIFTIDADPPDELMLDPLPPFCSRKGGRLCWTNEPLRGEVATSVDLITLHNRGWQVRIVPDELTTVFPEWKCVAREYVQLNIAAKERADKEKNQTMRSIAKLLSNALYGSFATKLDNKKIVFSDQMDEGLLKGISAGTVNIKSSSFLETDNLSAEVMPAFEREYLPQHVALLDSDPEDSEDEQRPAPFYTPPAGTPGHVAYTYKPITFLDVDEGDMCLHTLEKVDPLVDNDRYPSHVASFVLAWTRAFVSEWSGFLYDEDRGVPLEDRPIKSVYGDTDSLFVTQRGHELMETRGKKRIKKNGGKLVFDPNQPDLTWLVECETVCAHCGADAYAPESVFLAPKLYALKSLLCPACGQTSKGNVRAKGHAAEALNYELMVNCYLADAQGADRERFSTSRMSLKRTLASAQPGAHPFTVTETTLTRTLRPWKDRTLAALDAHRLAPYSRSRPNPRNEEVCWIEMP

POL

DNA polymerase

1188 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

135.289 kDa

MALVPSPRAGGFLPAETHSGPQPPRRRVRQSTAGAAPTATRAPRRRAATASPGEPPSTTASGRPPAANNVSLTPNSRLRGTIVAPRGQGLLYAIDTATNSPMEIKFHRRLASALTRLLQVNLRSVPADLNEAFLDSLDSSQIRTLALKLKVPRVEVWTCGSRGVVVPSIIHPQQERAGAEEGDEGERQDTEDFLNFPLRFLVRGRQVHLIQEMQSVQRCEYCARFYKYQHECTVRRRDFYFHHINAHSSGWWQKINFFPIGSHPRVERLFVTYDVETYTWMGAFGKQLVPFMLVMHLSGEEALVKEACRLACELQWDTWGNDERTFYVVTPEKLAVGKKFREYRNRLQAHFALQLWRGFLAANPQLAEWACLEMGLFSPDYLTYEELQKAPKLQGRPRFLELYIVGHNINGFDEIVLAAQVINNRSDVPGPFKITRNFMPRAGKILFNDITFALPNPSSKKRTDYRLWEQGACDDSDFKYQFLKVMVRDTFALTHTSLRKAAQAYTLPVEKGCCPYKAVNEFYMLGSYRADERGFPAEDYWKDREEYLLNRELWEKKQCPHYDLVRETLDYCALDVLVTAALVQKLRESYAQFIRDAVGLPEASFNVFQRPTISSNSHAIFRQILYRTVKPQRSDLGGSLLAPSHEMYDYVRASIRGGRCYPTYIGVLREPLYVYDICGMYASALTHPMPWGFPLNPYERALAVRDWEHALLQVGTPIDYFNRTLLPGIFTIDADPPPENLLDVLPPLCSRKGGRLCWTNEPLRGEVVTSVDLITLHNRGWHVRLLPDERATVFPEWRCVAKEYVHLNITAKERADREKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDSATIKSIAAGQINIKSTSFVETDTLSAEVMPTFQRAYSPEQLAVVHSDAEESDEEPGHAPFYTPTHKPNDHVTYTYKPITFMDAEEDDLCLHTLEKVDPLVENNRYPSQIASFVLAWTRAFVSEWSEILYAEDRGTPLEQRTLKSVYGDTDSLFVTEAGYRLMETRGKKRIKKHGGNLVFDPKHPELAWLVECETVCAQCGADAYSPESVFLAPKLYALKCLRCPSCQQISKGKLRAKGHAAETLNYDLMLKCYLADFQGEDARFHTSRMSLKRTLASAQPGARPFTVTETNLTRTLRPWKDITLAPLDAHRLVPYSQSRPNPRNQEVCWIEMP

pol

Pro-Pol polyprotein

1156 amino acids

Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising at least the viral genome, matrix protein, and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from the 3' end of the viral DNA right (U5) end, leaving the left (U3) intact. In the second step, the PIC enters cell nucleus. This process is mediated through the integrase and allows the virus to infect both dividing (nuclear membrane disassembled) and G1/S-arrested cells (active translocation), but with no viral gene expression in the latter. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. It is however not clear how integration then proceeds to resolve the asymmetrical cleavage of viral DNA (By similarity).

131.499 kDa

MDLLKPLTVERKGVKIKGYWDSQADITCVPKDLLQGEEPVRQQNVTTIHGTQEGDVYYVNLKIDGRRINTEVIGTTLDYAIITPGDVPWILKKPLELTIKLDLEEQQGTLLNNSILSKKGKEELKQLFEKYSALWQSWENQVGHRRIRPHKIATGTVKPTPQKQYHINPKAKPDIQIVINDLLKQGVLIQKESTMNTPVYPVPKPNGRWRMVLDYRAVNKVTPLIAVQNQHSYGILGSLFKGRYKTTIDLSNGFWAHPIVPEDYWITAFTWQGKQYCWTVLPQGFLNSPGLFTGDVVDLLQGIPNVEVYVDDVYISHDSEKEHLEYLDILFNRLKEAGYIISLKKSNIANSIVDFLGFQITNEGRGLTDTFKEKLENITAPTTLKQLQSILGLLNFARNFIPDFTELIAPLYALIPKSTKNYVPWQIEHSTTLETLITKLNGAEYLQGRKGDKTLIMKVNASYTTGYIRYYNEGEKKPISYVSIVFSKTELKFTELEKLLTTVHKGLLKALDLSMGQNIHVYSPIVSMQNIQKTPQTAKKALASRWLSWLSYLEDPRIRFFYDPQMPALKDLPAVDTGKDNKKHPSNFQHIFYTDGSAITSPTKEGHLNAGMGIVYFINKDGNLQKQQEWSISLGNHTAQFAEIAAFEFALKKCLPLGGNILVVTDSNYVAKAYNEELDVWASNGFVNNRKKPLKHISKWKSVADLKRLRPDVVVTHEPGHQKLDSSPHAYGNNLADQLATQASFKVHMTKNPKLDIEQIKAIQACQNNERLPVGYPKQYTYELQNNKCMVLRKDGWREIPPSRERYKLIKEAHNISHAGREAVLLKIQENYWWPKMKKDISSFLSTCNVCKMVNPLNLKPISPQAIVHPTKPFDKFYMDYIGPLPPSEGYVHVLVVVDAATGFTWLYPTKAQTSKATIKVLNHLTGLAIPKVLHSDQGSAFTSEEFAQWAKERNIQLEFSTPYHPQSSGKVERKNSEIKKLLTKLLVGRPLKWYNLISSVQLALNNTHVVSTKYTPHQLMFGIDCNLPFANKDTLDWTREEELALLQEIRESLQHPVQPPTCSGWSPYVGQLVQERVYRPSQLRPKWRKPTKVLEILNPRTVIIVDHLGQRKSVSIDNLKPTAHQHNGTRTCDDPEGMDGMECSQTTTETSVDSS

pol

Gag-Pol polyprotein

1152 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

Belongs to the retroviral Pol polyprotein family.

128.06 kDa

single

MSKESVAIIGATGNIRNYPKSEGRLVDLGRGLVTHSFLVIPECPDPLLGRDLLQKLRATISFTGEGPPEIRTEGKLLVTAPLEEEYRLFLEAPIQNVTLLEQWKREIPKVWAEINPPGLASTQAPIHVQLLSTALPVRVRQYPITLEAKRSLRETIRKFRAAGILRPVHSPWNTPLLPVRKSGTSEYRMVQDLREVNKRVETIHPTVPNPYTLLSLLPPDRIWYSVLDLKDAFFCIPLAPESQLIFAFEWADAEEGESGQLTWTRLPQGFKNSPTLFDEALNRDLQGFRLDHPSVSLLQYVDDLLIAADTQAACLSATRDLLMTLAELGYRVSGKKAQLCQEEVTYLGFKIHKGSRSLSNSRTQAILQIPVPKTKRQVREFLGTIGYCRLWIPGFAELAQPLYAATRGGNDPLVWGEKEEEAFQSLKLALTQPPALALPSLDKPFQLFVEETSGAAKGVLTQALGPWKRPVAYLSKRLDPVAAGWPRCLRAIAAAALLTREASKLTFGQDIEITSSHNLESLLRSPPDKWLTNARITQYQVLLLDPPRVRFKQTAALNPATLLPETDDTLPIHHCLDTLDSLTSTRPDLTDQPLAQAEATLFTDGSSYIRDGKRYAGAAVVTLDSVIWAEPLPIGTSAQKAELIALTKALEWSKDKSVNIYTDSRYAFATLHVHGMIYRERGLLTAGGKAIKNAPEILALLTAVWLPKRVAVMHCKGHQKDDAPTSTGNRRADEVAREVAIRPLSTQATISDAPDMPDTETPQYSNVEEALGHRLRGTKDPAGWWHLPDGRLLLPRAVGRKVLEQTHRATHLGESKLTELVRKHYLICGIYRAARDITTRCVACAQVNPGAAPVEKGLNSRIRGAAPGEHWEVDFTEMITAKGGYKYLLVLVDTFSGWVEAYPAKRETSQVVIKHLIHDIIPRFGLPVQIGSDNGPAFVAKVTQQLCEALNVSWKLHCAYRPQSSGQVERMNRTLKETIAKLRIETGGDWVSLLPQALLRARCTPGREGLSPFEILYGLKPPVVPRVGCDKLASITNQTLLKSLQALQATRSLARATLRDQLPQKEAQQDRTPLFQPGDLVFVKKHDFQQLGPRWDGPYTVVLSTPTAVKVAGKTPWIHYSRLKKAPDNQEEWTVSPTSDPLRVKLTRRAKP

POL

DNA polymerase

1150 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

130.46 kDa

MSLVQGHGTSGLFTEPPNPINQQESSGPSLPAQDAAQAFASSPRAGATSTIVNPPKRKYKGAVVVQRATLSISAVLDNGQCVEIKYHSNLASALTNLCNTNLYDLPACLNRPITAHNLPALIEEAAAPYSLICYYQRGTVRRVEFQAEVPLLSFPLKFLVKQGKVFLIKDISQMQKCEFCGSFFKVTHTCALRRRDFYFHHVAAHSADWWEKISFTPIGAPPNTERLFIVYDVETYTWHGKFGKQLVPFMLVFQLLGDDHLVNVAKTLATEQNWEIWNGKEQDTLYYCITPEKRAIGVKFKKFRDTLQQHIAASLWSHVICQNPQLQEKATTLGLESPEELTPDQLKKFKLKGNPRFIEVYAVGHNITGFDEILLAAQVVSTRAEIPPVFEICRNFMPRAGRLLFNDITYSLPNPSYVPAKSYEHWEQGQVLASDLKSQYIKFMVRDTFSLTHTSLKNAAKAYSLTVSKGCCPYQAVNEFYMLGSYQQDADGFPDLKYWKDQEEYSFNKDLWIKEKKGAYDIIQQTLDYCALDVQVTAQLVNKLIESYQIFIKNSVNLPETSFNVFQRPTISSNSHAIFKQILYKAEKPNTHHLSTILMAPSNEMYEYVRLSIRGGRCYPTYIGVLQEPVFVYDICGMYASALTHPFPAGSPLNPYERALAIKAYEQKMLNHKTISYFDKDLLPGIFTIDADPPAEEFLDVLPPFCSRKGGRLCWTNEPLRGEIATSIDVITLHNRGWKVTLIPDTRTTVFPEWKCLAREYVQLNISAKEEADKSKNQTMRSIAKLLSNALYGSFATKLDNKKTVFSDQIESNIAKEIASGAYVVKSSSYIETDNLCAEIMPEFVVAYPPVNSDVRQLAPPSCSEEDPTKDPLAEAPFMHNFSMTSYHYKPIMFIDAEDDDFCLHTLEKSTPLIANNRYPSQIASFVLAWTRAFVSEWSQFLYENDAGTPLENRVLKSVYGDTDSLFTTMEGYKLMEEKGKKRLKKNGGKLVFDPSNPELTWLVECETQCEKCGSDAYSSESVYLAPKLYALKDTTCPKCHHVGKGKLRAKGHATSTLSYDVLKACYYADMQQGSDVFKTSRMSLRRTLTSVQAHVQPFTVTETTLTRKLRPWKDKTLHALDMHRLIPYSRKHPNPRNTETTWMELQWMT

pol

Pro-Pol polyprotein

1149 amino acids

Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising at least the viral genome, matrix protein, and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from the 3' end of the viral DNA right (U5) end, leaving the left (U3) intact. In the second step, the PIC enters cell nucleus. This process is mediated through the integrase and allows the virus to infect both dividing (nuclear membrane disassembled) and G1/S-arrested cells (active translocation), but with no viral gene expression in the latter. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. It is however not clear how integration then proceeds to resolve the asymmetrical cleavage of viral DNA.

130.32 kDa

MDPLQLLQPLEAEIKGTKLKAHWDSGATITCVPEAFLEDERPIQTMLIKTIHGEKQQDVYYLTFKVQGRKVEAEVLASPYDYILLNPSDVPWLMKKPLQLTVLVPLHEYQERLLQQTALPKEQKELLQKLFLKYDALWQHWENQVGHRRIKPHNIATGTLAPRPQKQYPINPKAKPSIQIVIDDLLKQGVLIQQNSTMNTPVYPVPKPDGKWRMVLDYREVNKTIPLIAAQNQHSAGILSSIYRGKYKTTLDLTNGFWAHPITPESYWLTAFTWQGKQYCWTRLPQGFLNSPALFTADVVDLLKEIPNVQAYVDDIYISHDDPQEHLEQLEKIFSILLNAGYVVSLKKSEIAQREVEFLGFNITKEGRGLTDTFKQKLLNITPPKDLKQLQSILGLLNFARNFIPNYSELVKPLYTIVANANGKFISWTEDNSNQLQHIISVLNQADNLEERNPETRLIIKVNSSPSAGYIRYYNEGSKRPIMYVNYIFSKAEAKFTQTEKLLTTMHKGLIKAMDLAMGQEILVYSPIVSMTKIQRTPLPERKALPVRWITWMTYLEDPRIQFHYDKSLPELQQIPNVTEDVIAKTKHPSEFAMVFYTDGSAIKHPDVNKSHSAGMGIAQVQFIPEYKIVHQWSIPLGDHTAQLAEIAAVEFACKKALKISGPVLIVTDSFYVAESANKELPYWKSNGFLNNKKKPLRHVSKWKSIAECLQLKPDIIIMHEKGHQQPMTTLHTEGNNLADKLATQGSYVVHCNTTPSLDAELDQLLQGHYPPGYPKQYKYTLEENKLIVERPNGIRIVPPKADREKIISTAHNIAHTGRDATFLKVSSKYWWPNLRKDVVKSIRQCKQCLVTNATNLTSPPILRPVKPLKPFDKFYIDYIGPLPPSNGYLHVLVVVDSMTGFVWLYPTKAPSTSATVKALNMLTSIAIPKVLHSDQGAAFTSSTFADWAKEKGIQLEFSTPYHPQSSGKVERKNSDIKRLLTKLLIGRPAKWYDLLPVVQLALNNSYSPSSKYTPHQLLFGVDSNTPFANSDTLDLSREEELSLLQEIRSSLHQPTSPPASSRSWSPSVGQLVQERVARPASLRPRWHKPTAILEVVNPRTVIILDHLGNRRTVSVDNLKLTAYQDNGTSNDSGTMALMEEDESSTSST

POL

DNA polymerase

1149 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

130.939 kDa

MSLVQSHGTSGLFTEPPNSINQQESSGPSLPAQDATQASASSARAGATPAINSTKRKYRGAVVAQRATLSISAILDNGQCVQIKYHSNLASALTNLCNTNLYDLPACLNKPITVHNLPTLIEEAAASYSLIYYYQRGTVRKVEFRAEIPLLSFPLKFLVKHGKVFLIKDISPMQRCEFCGSFFKVTHTCTLRRRDFYFHHVASHSGDWWEKISFSPIGAPANTERLFIVYDVETYTWHGKFGKQLVPFMLVFQLLGDEHLVNAAKNLATTQNWDTWNSNEQTALYYCITPEKRAIGVKFKTFRDTLQQHFANNLWSHVLCQNPKLMEEAAALGLENPEDITANQLKKFKLQGTPRFIEVYVVGHNITGFDEILLAAQVVSTRAEIPPVFDISRNFMPRAGRLLFNDITYSLPNPSYVPSKDYRHWEQGQVLASDLKTQYIKFMVRDTFSLTHTSLKNAAKAYSLTVSKGCCPYQAVNEFYMLGSYQQDADGFPDLKYWKDQEEYCFNKDLWKKEKKGAYDIIQQTLDYCALDVQVTAQLVNKLIESYQIFIKNSVNLPETYFNVFQRPTISSNSHAIFKQILYRAEKPNAPHLNTIIMAPSNEMYEYVRLSIRGGRCYPTYIGVLQEPVFVYDICGMYASALTHPFPAGSPLNPYERAVAIKAYEHKMQEHKTISYFDEDLLPGIFTIDADPPAEEFLDVLPPFCSRKGGRLCWTNEPLRGEVTTSIDVITLHNRGWKVTLIPDTRTTVFPEWKCLAREYVQLNINAKEKADKSKNQTMRSIAKLLSNALYGSFATKLDNKKTVFSDQIESNIAKEIASGAYVVKSSSYIETDNLCAEIMPEFVVAYPPVNFDVHRLAPPSYSEEYPTENPHAEGPFMQNFNMTSYRYKPIMFIDAEDDDFCLHTLEKSTPLITNNRYASQIASFVLAWTRAFVSEWSQFLYENDAGIPLEKRILKSVYGDTDSLFTTMEGYRLMEEKGKRRLKKNGGNLVFDPNNPELTWLVECETKCEKCGADAYSSESVYLAPKLYALKDTTCPECQYVGKGKLRAKGHATSTLSYDVLKACYYADLQQGSDIFKTSRMSLRRTLTSVQTHVQPFTVTETTLTRKLRPWKDKTLHALDMNRLIPYSRKYPNPRNNETTWMELQWMT

pol

Pro-Pol polyprotein

1146 amino acids

Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising at least the viral genome, matrix protein, and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from the 3' end of the viral DNA right (U5) end, leaving the left (U3) intact. In the second step, the PIC enters cell nucleus. This process is mediated through the integrase and allows the virus to infect both dividing (nuclear membrane disassembled) and G1/S-arrested cells (active translocation), but with no viral gene expression in the latter. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. It is however not clear how integration then proceeds to resolve the asymmetrical cleavage of viral DNA (By similarity).

129.934 kDa

MNPLQLLQPLPAEVKGTKLLAHWDSGATITCIPESFLEDEQPIKQTLIKTIHGEKQQNVYYLTFKVKGRKVEAEVIASPYEYILLSPTDVPWLTQQPLQLTILVPLQEYQDRILNKTALPEEQKQQLKALFTKYDNLWQHWENQVGHRKIRPHNIATGDYPPRPQKQYPINPKAKPSIQIVIDDLLKQGVLTPQNSTMNTPVYPVPKPDGRWRMVLDYREVNKTIPLTAAQNQHSAGILATIVRQKYKTTLDLANGFWAHPITPDSYWLTAFTWQGKQYCWTRLPQGFLNSPALFTADAVDLLKEVPNVQVYVDDIYLSHDNPHEHIQQLEKVFQILLQAGYVVSLKKSEIGQRTVEFLGFNITKEGRGLTDTFKTKLLNVTPPKDLKQLQSILGLLNFARNFIPNFAELVQTLYNLIASSKGKYIEWTEDNTKQLNKVIEALNTASNLEERLPDQRLVIKVNTSPSAGYVRYYNESGKKPIMYLNYVFSKAELKFSMLEKLLTTMHKALIKAMDLAMGQEILVYSPIVSMTKIQKTPLPERKALPIRWITWMTYLEDPRIQFHYDKTLPELKHIPDVYTSSIPPLKHPSQYEGVFCTDGSAIKSPDPTKSNNAGMGIVHAIYNPEYKILNQWSIPLGHHTAQMAEIAAVEFACKKALKVPGPVLVITDSFYVAESANKELPYWKSNGFVNNKKEPLKHISKWKSIAECLSIKPDITIQHEKGHQPINTSIHTEGNALADKLATQGSYVVNCNTKKPNLDAELDQLLQGNNVKGYPKQYTYYLEDGKVKVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCKQCLITNASNKTSGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVIVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRASLYQPSTPPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLEVLNPRTVVILDHLGNNRTVSIDNLKPTSHQNGTTNDTATMDHLEQNEQSS

pol

Pol polyprotein

1146 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

129.51 kDa

TAWTFLKAMQKCSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVPRSERNKKGIQCQGEGSSRGSQPGQFVGVTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQGTGIIGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGAKLVLAQLSKEIKFRKIELKEGTMGPKIPQWPLTKEKLEGAKEIVQRLLSEGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWNCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILLEEGFETPDDKLQEVPPYSWLGYQLCPENWKVQKMQLDMVKNPTLNDVQKLMGNITWMSSGVPGLTVKHIAATTKGCLELNQKVIWTEEAQKELEENNEKIKNAQGLQYYNPEEEMLCEVEITKNYEATYVIKQSQGILWAGKKIMKANKGWSTVKNLMLLLQHVATESITRVGKCPTFKVPFTKEQVMWEMQKGWYYSWLPEIVYTHQVVHDDWRMKLVEEPTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDTRDKQVNIVTDSYYCWKNITEGLGLEGPQSPWWPIIQNIREKEIVYFAWVPGHKGICGNQLADEAAKIKEEIMLAYQGTQIKEKRDEDAGFDLCVPYDIMIPVSDTKIIPTDVKIQVPPNSFGWVTGKSSMAKQGLLINGGIIDEGYTGEIQVICTNIGKSNIKLIEGQKFAQLIILQHHSNSRQPWDENKISQRGDKGFGSTGVFWVENIQEAQDEHENWHTSPKILARNYKIPLTVAKQITQECPHCTKQGSGPAGCVMRSPNHWQADCTHLDNKIILTFVESNSGYIHATLLSKENALCTSLAILEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDNTQTLEAALQLALITCNKGRESMGGQTPWEVFITNQAQVIHEKLLLQQAQSSKKFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIKPN

pol

Pol polyprotein

1146 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

129.509 kDa

TAWTFLKAMQKCSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVPRSERNKKGIQCQGEGSSRGSQPGQFVGVTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQGTGIIGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGAKLVLAQLSKEIKFRKIELKEGTMGPKIPQWPLTKEKLEGAKEIVQRLLSEGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWNCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILLEKGFETPDDKLQEVPPYSWLGYQLCPENWKVQKMQLDMVKNPTLNDVQKLMGNITWMSSGVPGLTVKHIAATTKGCLELNQKVIWTEEAQKELEENNEKIKNAQGLQYYNPEEEMLCEVEITKNYEATYVIKQSQGILWAGKKIMKANKGWSTVKNLMLLLQHVATESITRVGKCPTFKVPFTKEQVMWEMQKGWYYSWLPEIVYTHQVVHDDWRMKLVEEPTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDTRDKQVNIVTDSYYCWKNITEGLGLEGPQSPWWPIIQNIREKEIVYFAWVPGHKGICGNQLADEAAKIKEEIMLAYQGTQIKEKRDEDAGFDLCVPYDIMIPVSDTKIIPTDVKIQVPPNSFGWVTGKSSMAKQGLLINGGIIDEGYTGEIQVICTNIGKSNIKLIEGQKFAQLIILQHHSNSRQPWDENKISQRGDKGFGSTGVFWVENIQEAQDEHENWHTSPKILARNYKIPLTVAKQITQECPHCTKQGSGPAGCVMRSPNHWQADCTHLDNKIILTFVESNSGYIHATLLSKENALCTSLAILEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDNTQTLEAALQLALITCNKGRESMGGQTPWEVFITNQAQVIHEKLLLQQAQSSKKFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIKPN

pol

Pol polyprotein

1145 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

129.52 kDa

TAWTFLKAMQKCSKKREARGSREAPETNFPDTTEESAQQICCTRDSSDSKSVPRSERNKKGIQCQGEGSSRGSQPGQFVGVTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQGTGIIGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGAKLVLAQLSKEIKFRKIELKEGTMGPKIPQWPLTKEKLEGAKETVQRLLSEGKISEASDNNPYNSPIFVIKKRSGKWRLLQDLRELNKTVQVGTEISRGLPHPGGLIKCKHMTVLDIGDAYFTIPLDPEFRPYTAFTIPSINHQEPDKRYVWKCLPQGFVLSPYIYQKTLQEILQPFRERYPEVQLYQYMDDLFVGSNGSKKQHKELIIELRAILQKGFETPDDKLQEVPPYSWLGYQLCPENWKVQKMQLDMVKNPTLNDVQKLMGNITWMSSGVPGLTVKHIAATTKGCLELNQKVIWTEEAQKELEENNEKIKNAQGLQYYNPEEEMLCEVEITKNYEATYVIKQSQGILWAGKKIMKANKGWSTVKNLMLLLQHVATESITRVGKCPTFKVPFTKEQVMWEMQKGWYYSWLPEIVYTHQVVHDDWRMKLVEEPTSGITIYTDGGKQNGEGIAAYVTSNGRTKQKRLGPVTHQVAERMAIQMALEDTRDKQVNIVTDSYYCWKNITEGLGLEGPQNPWWPIIQNIREKEIVYFAWVPGHKGIYGNQLADEAAKIKEEIMLAYQGTQIKEKRDEDAGFDLCVPYDIMIPVSDTKIIPTDVKIQVPPNSFGWVTGKSSMAKQGLLINGGIIDEGYTGEIQVICTNIGKSNIKLIEGQKFAQLIILQHHSNSRQPWDENKISQRGDKGFGSTGVFWVENIQEAQDEHENWHTSPKILARNYKIPLTVAKQITQECPHCTKQGSGPAGCVMRSPNHWQADCTHLDNKIILHFVESNSGYIHATLLSKENALCTSLAILEWARLFSPKSLHTDNGTNFVAEPVVNLLKFLKIAHTTGIPYHPESQGIVERANRTLKEKIQSHRDNTQTLEAALQLALITCNKGRESMGGQTPWEVFITNQAQVIHEKLLLQQAQSSKKFCFYKIPGEHDWKGPTRVLWKGDGAVVVNDEGKGIIAVPLTRTKLLIKPN

pol

Pro-Pol polyprotein

1143 amino acids

Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising at least the viral genome, matrix protein, and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from the 3' end of the viral DNA right (U5) end, leaving the left (U3) intact. In the second step, the PIC enters cell nucleus. This process is mediated through the integrase and allows the virus to infect both dividing (nuclear membrane disassembled) and G1/S-arrested cells (active translocation), but with no viral gene expression in the latter. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. It is however not clear how integration then proceeds to resolve the asymmetrical cleavage of viral DNA (By similarity).

129.615 kDa

MDPLQLLQPLEAEIKGTKLKAHWDSGATITCVPQAFLEEEVPIKNIWIKTIHGEKEQPVYYLTFKIQGRKVEAEVISSPYDYILVSPSDIPWLMKKPLQLTTLVPLQEYEERLLKQTMLTGSYKEKLQSLFLKYDALWQHWENQVGHRRIKPHHIATGTVNPRPQKQYPINPKAKASIQTVINDLLKQGVLIQQNSIMNTPVYPVPKPDGKWRMVLDYREVNKTIPLIAAQNQHSAGILSSIFRGKYKTTLDLSNGFWAHSITPESYWLTAFTWLGQQYCWTRLPQGFLNSPALFTADVVDLLKEVPNVQVYVDDIYISHDDPREHLEQLEKVFSLLLNAGYVVSLKKSEIAQHEVEFLGFNITKEGRGLTETFKQKLLNITPPRDLKQLQSILGLLNFARNFIPNFSELVKPLYNIIATANGKYITWTTDNSQQLQNIISMLNSAENLEERNPEVRLIMKVNTSPSAGYIRFYNEFAKRPIMYLNYVYTKAEVKFTNTEKLLTTIHKGLIKALDLGMGQEILVYSPIVSMTKIQKTPLPERKALPIRWITWMSYLEDPRIQFHYDKTLPELQQVPTVTDDIIAKIKHPSEFSMVFYTDGSAIKHPNVNKSHNAGMGIAQVQFKPEFTVINTWSIPLGDHTAQLAEVAAVEFACKKALKIDGPVLIVTDSFYVAESVNKELPYWQSNGFFNNKKKPLKHVSKWKSIADCIQLKPDIIIIHEKGHQPTASTFHTEGNNLADKLATQGSYVVNINTTPSLDAELDQLLQGQYPKGFPKHYQYQLENGQVMVTRPNGKRIIPPKSDRPQIILQAHNIAHTGRDSTFLKVSSKYWWPNLRKDVVKVIRQCKQCLVTNAATLAAPPILRPERPVKPFDKFFIDYIGPLPPSNGYLHVLVVVDSMTGFVWLYPTKAPSTSATVKALNMLTSIAVPKVIHSDQGAAFTSATFADWAKNKGIQLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPAKWYDLLPVVQLALNNSYSPSSKYTPHQLLFGIDSNTPFANSDTLDLSREEELSLLQEIRSSLYLPSTPPASIRAWSPSVGQLVQERVARPASLRPRWHKPTPVLEVINPRAVVILDHLGNRRTVSVDNLKLTAYQKDGTPNESAAVVAMEKDE

pol

Pro-Pol polyprotein

1143 amino acids

Integrase catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions. This enzyme activity takes place after virion entry into a cell and reverse transcription of the RNA genome in dsDNA. The first step in the integration process is 3' processing. This step requires a complex comprising at least the viral genome, matrix protein, and integrase. This complex is called the pre-integration complex (PIC). The integrase protein removes 2 nucleotides from the 3' end of the viral DNA right (U5) end, leaving the left (U3) intact. In the second step, the PIC enters cell nucleus. This process is mediated through the integrase and allows the virus to infect both dividing (nuclear membrane disassembled) and G1/S-arrested cells (active translocation), but with no viral gene expression in the latter. In the third step, termed strand transfer, the integrase protein joins the previously processed 3' ends to the 5' ends of strands of target cellular DNA at the site of integration. It is however not clear how integration then proceeds to resolve the asymmetrical cleavage of viral DNA (By similarity).

129.742 kDa

MNPLQLLQPLPAEIKGTKLLAHWDSGATITCIPESFLEDEQPIKKTLIKTIHGEKQQNVYYVTFKVKGRKVEAEVIASPYEYILLSPTDVPWLTQQPLQLTILVPLQEYQEKILSKTALPEDQKQQLKTLFVKYDNLWQHWENQVGHRKIRPHNIATGDYPPRPQKQYPINPKAKPSIQIVIDDLLKQGVLTPQNSTMNTPVYPVPKPDGRWRMVLDYREVNKTIPLTAAQNQHSAGILATIVRQKYKTTLDLANGFWAHPITPESYWLTAFTWQGKQYCWTRLPQGFLNSPALFTADVVDLLKEIPNVQVYVDDIYLSHDDPKEHVQQLEKVFQILLQAGYVVSLKKSEIGQKTVEFLGFNITKEGRGLTDTFKTKLLNITPPKDLKQLQSILGLLNFARNFIPNFAELVQPLYNLIASAKGKYIEWSEENTKQLNMVIEALNTASNLEERLPEQRLVIKVNTSPSAGYVRYYNETGKKPIMYLNYVFSKAELKFSMLEKLLTTMHKALIKAMDLAMGQEILVYSPIVSMTKIQKTPLPERKALPIRWITWMTYLEDPRIQFHYDKTLPELKHIPDVYTSSQSPVKHPSQYEGVFYTDGSAIKSPDPTKSNNAGMGIVHATYKPEYQVLNQWSIPLGNHTAQMAEIAAVEFACKKALKIPGPVLVITDSFYVAESANKELPYWKSNGFVNNKKKPLKHISKWKSIAECLSMKPDITIQHEKGISLQIPVFILKGNALADKLATQGSYVVNCNTKKPNLDAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKASGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSGSKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQNGTTNDTATMDHLEKNE

pol

Pol polyprotein

1124 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

127.494 kDa

KEFGKLEGGASCSPSESNAASSNAICTSNGGETIGFVNYNKVGTTTTLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGRQNMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPVVKVKMKDPNKGPQIKQWPLTNEKIEALTEIVERLEKEGKVKRADSNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTEKGAEVQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSKKEHKEKVEELRKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTLNELQKLAGKINWASQAIPDLSIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEEQVQLGYYDPSKELYAKLSLVGPHQISYQVYQKDPEKILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIGKEPRYEIPTSREAWESNLINSPYLKAPPPEVEYIHAALNIKRALSMIKDAPIPGAETWYIDGGRKLGKAAKAAYWTDTGKWRVMDLEGSNQKAEIQALLLALKAGSEEMNIITDSQYVINIILQQPDMMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGDGILDKRSEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGYWGLIIGKSSIGSKGLDVLGGVIDEGYRGEIGVIMINVSRKSITLMERQKIAQLIILPCKHEVLEQGKVVMDSERGDNGYGSTGVFSSWVDRIEEAEINHEKFHSDPQYLRTEFNLPKMVAEEIRRKCPVCRIIGEQVGGQLKIGPGIWQMDCTHFDGKIILVGIHVESGYIWAQIISQETADCTVKAVLQLLSAHNVTELQTDNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENVNHTLKVWIQKFLPETTSLDNALSLAVHSLNFKRRGRIGGMAPYELLAQQESLRIQDYFSAIPQKLQAQWIYYKDQKDKKWKGPMRVEYWGQGSVLLKDEEKGYFLIPRRHIRRVPEPCALPEGDE

pol

Pol polyprotein

1124 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

127.605 kDa

KKFGKLEGGASCSPSESSAANSNAICTSNGGKIIGFINYNKVGTTTSLEKRPEILIFVNGYPIKFLLDTGADITILNRRDFQVKNSIENGRQNMIGVGGGKRGTNYINVHLEIRDENYKTQCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPIVKVKMKDPNKGPQIKQWPLSNEKIEALTEIVERLEREGKVKRADPNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTEKGAEVQLGLPHPAGLQMKKQITVLDIGDAYFTNPLDPDYAPYTAFTLPRKNNAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSKKEHKEKVEELRKLLLWWGFETPEDKLQEEPPYKWMGYELHPLTWTIQQKQLEIPEKPTLNELQKLAGKINWASQTIPELSIKSLTNMTRGNQNLNSTREWTEEARLEVQKAKRAIEEQVQLGYYDPSKELYAKLSLVGPHQISYQVYQKCPEKILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIGKEPRYEIPTSREAWESNLINSPYLKAPPPEVDYIHAALNIKRALSMIKDPPISGAETWYIDGGRKLGKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAGPEEMNIITDSQYMINILSQQPDKMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGDGILDKRTEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGHWGLIMGKSSIGSKGLDVLGGVIDEGYRGEIGVIMINLSKKSITLLEQQKIAQLIILPHKHEALEQGKVVMDSERGEKGYGSTGVFSSWVDRIEEAETNHEKFHSDPQYLRTEFNLPKMVAEEIRRKCPVCRIRGEQVGGQLKIGPGIWQMDCTHFDGKIILVAIHVESGYIWAQIISQETADCTVKAVLQLLSAHIVTELQTDNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENVNQTLKVWVHKFLPETTSLDNALALAVHCLNFKQRGRIGGMAPYELLAQQESLRIQDYFSAIPQKLQAQWIYYKDQKDKKWKGPMRVEYWGQGSVLLKDEEKGYFLIPRRHVKRVPEPCALPEGDE

pol

Pol polyprotein

1124 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

128.101 kDa

ENLGKREGGASCSPSKPSAANSTICTSNGGETIRFINYNTIGTTTTLERRPEIQIFVNGHPIKFLLDTGADITILNRKDFQIGNSIENGKQNMIGVGGGKRGTNYINVHLEIRDENYRMQCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISEKIPIVKVRMKDPTQGPQVKQWPLSNEKIEALTDIVERLESEGKVKRADPNNPWNTPVFAIKKKSGKWRMLIDFRVLNKLTDKGAEVQLGLPHPAGLQMKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRYVWCSLPQGWVLSPLIYQSTLNNILQPFIKQNSELDIYQYMDDIYIGSNLNKKEHKQKVEELRKLLLWWGFETPEDKLQEEPPYKWMGYELHPLTWSIQQKQLEIPERPTLNELQKLAGKINWASQTIPDLSIKELTNMMRGDQKLDSIREWTVEAKREVQKAKEAIETQAQLNYYDPNRGLYAKLSLVGPHQICYQVYQKNPEHILWYGKINRQKKKAENTCDIALRACYKIREESIIRIGKEPVYEIPASREAWESNLIRSPYLKAPPPEVEFIHAALSIKRALSMIQDAPIIGAETWYIDGSRKQGKAARAAYWTNTGKWQIMEIEGSNQKAEVQALLLALKAGSEEMNIITDSQYILNILNQQPDLMEGLWQEVLEQMEKKIAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGEGILEKRSEDAGYDLLAAAQETHFLPGEVRIVPTKTRIMLPKGHWGLIMGKSSIGSKGVDVLGGVIDEGYRGELGVIMINLTKKSITILEKQKIAQLIILPCRHEGLQQGEIQMNSERGEKGFGSAGVFSSWVDRIEEAELNHEKFHSDPQYLRTEFNLPRIVAEEIKRKCPLCRIRGEQVGGQLKIRPGIWQMDCTHFNGKIIIVAVHVESGFLWAQIIPQETADCTVKALLQLICAHNVTELQTDNGPNFKNQKMEGLLNYMGIKHKLGIPGNPQSQALVENANNTLKVWIQKFLPETTSLDNALALALHCLNFKQRGRLGRMAPYELYIQQESLRIQDYFSAIPQKLMMQWLYYKDQKDKKWKGPMRVEYWGQGSVLLKDEEKGIFLVPRRHIRRVPEPCTLPEGDE

POL

DNA polymerase

1122 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

128.635 kDa

MQEATEPPPPKRKNKGTVVAPKGHGTLQAIDISTNGPVEIKYHLNLPHALEKIMQVNLLTLPTNLTPQRLRTLDSSGLRALVLELRPCRAEVWTCLPRGLVSMTTIETEDGHADADNIVEREVQAPSLNFPLKFLVKGSQVQLIHEVHPVNRCEYCGRLYKHKHECSARRREFYFHHINSHSSNWWQEIQFFPIGSHPRTERLFLTYDVETYTWMGSFGKQLIPFMLVMKLSGDQRLVNIAYDIAMKLKWDRWRQDPQTFYCITPEKMAVGQHFRQYRDQLQTALAVDLWSSFLKANPHMHEWALEHYALTDPTDLTFEELKKLPHVRGTPRFLELYIVGHNINGFDEIVLAAQVINNRAEVPQPFKITRNFMPRAGEILFNDVTFALPNPAYKKRADFQLWEQGACDDIDFKYQFLKVMVRDTFALTHTSLRNAAQAYSLPVEKGCCPYKAVNQFYMLGSYRAEKDGFPLEEYWKDHEEYLLNRELWEKKSQPRYDIIQETLNYCALDVLVTAELVAKLQESYAHFIRDSVGLPHVHFNIFQRPTISSNSHAIFRQIVYRAEKPNRTNLGPGLLAPSHELYDYVRASIRGGRCYPTYIGILEEPLYVYDICGMYASALTHPMPWGTPLNPYERALAVREWQMTLDDPATISYFDKDLLPGIFTIDADPPDEFMLDPLPPFCSRKGGRLCWTNEPLRGEVATTVDLITLHNRGWRVRIVPDELTTIFPEWKCVAREYVQLNIAAKERADKEKNQTMRSIAKLLSNALYGSFATKLDNKKIVFSDQMDESLIKGISAGTVNIKSSSFLETDNLSAEVMPAFEREYLPQQLALLDSDPEDSEDEQRSAPFYTPPAGTPGHVAYTYKPITFLDVEEGDMCLHTVEKVDPLVDNDRYPSHVASFVLAWTRAFVSEWAGFLYEEDRGTPLEDRPIKSVYGDTDSLFVTQRGHELMETKGKKRIKKHGGKLVFDPDEPDLTWLVECETVCVSCGADAYSPESIFLAPKLYALKCIYCPACHKTSKGKLRAKGHAAEALNYELMVNCYLADMQGADRQRFSTSRMSLKRTLASAQPGAHPFTVTETTLTRTLRPWKDRTLAALDAHRLIPYSRSRPNPRNEEVCWIEMP

POL

DNA polymerase

1121 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

129.396 kDa

MLIAKNVTGEWVWITSRTPVQQCPTCGRHWVRRHSCNERRSAFYYHAVQGSGSDLWQHVHFSCPAQHPHIRQLYITYDIETYTVFEKKGKRMHPFMLCFMLSGDPQLVSRAERLARQDDRLKALDEGFYWLDSHPGEVARRFRNFRSRLQIEFAQNLVDRYAAANRDYCDQLVKDGKYGSVHKIPYELFEKPTSPLSLPDNFYSVDIVVLGHNICKFDELLLATELVERRDLFPEACKCDRSFMPRVGRLLFNDIIFRMPNPNYVKKDASRVERWSRGIVSHQDARSVFVRFMVRDTLQLTSGAKLSKAAAAYALDLCKGHCPYEAINEFISTGRFHADADGFPVERYWEDPSVIAEQKNLWQKEHPGQQYDIVQACLEYCMQDVRVTQKLAHTLHDSYDAYFQRELGMEGHFNIFVRPTIPSNTHAFWKQLTFSNYVREQRATCPPSVPEPPKKKGRTKKKKQPSPDYVAEVYAPHRPMFKYIRQALRGGRCYPNVLGPYLKPVYVFDICGMYASALTHPMPHGMPLDPKFTAQHVEELNRLLTNESHLSYFDARIKPSILKIEAYPPPPEMLDPLPPICSRRGGRLVWTNEALYDEVVTVIDILTLHNRGWRVQVLHDEMNIVFPEWKTLCADYVTKNILAKEKADREKNEVIRSISKMLSNALYGAFATNMDTTRIIFEQDLSEADKKNIYEGTEIVKHVTLLNDDSFNGTEVTLENAPNPFSEESLRQQFRYADDPEQEEPEAEEDGEEEGDDSDRESARKPKNALTEDDPLVAVDLEVEATLATGPYIPEGELSSAHYARANETRFKPMRLLEATPEALTVLHLESLDKQVANKRYATQIACFVLGWSRAFFSEWCDILYGPDRGVHILRREEPRSLYGDTDSLFVTETGYHRMKSRGAHRIKTESTRLTFDPENPGLYWACDCDIKCKACGSDTYSSETIFLAPKLYGLKNSICVNEQCRTVGPGKIRSKGHRQSELIYDTLLRCWRRHEDVQFGAQSNIPELHTRRTIFKTTLLNKVSRYDPFTIHNEQLTRVLRPWKDLTLYEHGDYLYPYDNEHPNPRTTGDVRPVPIVGHEDPLAPLRWEPYAFLSEEECGQVHDLLFADDSSQEAESLGV

pol

Pol polyprotein

1109 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

127.678 kDa

TRNHMSQLWKERTYAKRMQRKERHKGKTAGKREEGDTCGAVRSSYGITSAPPMVQVRIGSQQRNLLFDTGADRTIVRWHEGSGNPAGRIKLQGIGGIVEGEKWNNVELEYKGETRKGTIVVLPQSPVEVLGRDNMARFGIKIIMANLEEKRIPITKVKLKEGCTGPHVPQWPLTEEKLKGLTEIIDKLVEEGKLGKAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLTEAQLGLPHPGGLQKKKHVTILDIGDAYFTIPLYEPYREYTCFTLLSPNNLGPCKRYYWKVLPQGWKLSPSVYQFTMQEILEDWIQQHPEIQFGIYMDDIYIGSDLEIKKHREIVKDLANYIAQYGFTLPEEKRQKGYPAKWLGFELHPQTWKFQKHTLPELTKGTITLNKLQKLVGELVWRQSIIGKSIPNILKLMEGDRELQSERKIEEVHVKEWEACRKKLEEMEGNYYNKDKDVYGQLAWGDKAIEYIVYQEKGKPLWVNVVHNIKNLSIPQQVIKAAQKLTQEVIIRTGKIPWILLPGKEEDWRLELQLGNITWMPKFWSCYRGHTRWRKRNIIEEVVEGPTYYTDGGKKNKVGSLGFIVSTGEKFRKHEEGTNQQLELRAIEEALKQGPQTMNLVTDSRYAFEFLLRNWDEEVIKNPIQARIMEIAHKKDRIGVHWVPGHKGIPQNEEIDKYISEIFLAKEGEGILPKREEDAGYDLICPEEVTIEPGQVKCIPIELRLNLKKSQWAMIATKSSMAAKGVFTQGGIIDSGYQGQIQVIMYNSNKIAVVIPQGRKFAQLILMDKKHGKLEPWGESRKTERGEKGFGSTGMYWIENIPLAEEDHTKWHQDARSLHLEFEIPRTAAEDIVNQCEICKEARTPAVIRGGNKRGVNHWQVDYTHYENIILLVWVETNSGLIYAEKVKGESGQEFRIKVMHWYALFGPESLQSDNGPAFAAEPTQLLMQYLGVKHTTGIPWNPQSQAIVERAHQLLKSTLKKFQPQFVAVESAIAAALVAINIKRKGGLGTSPMDIFIYNKEQKRINNKYNKNSQKIQFCYYRIRKRGHQESGKDQPRYCGKGKEPIVVKDIESEKYLVIPYKDAKFIPPPTKEKE

pol

Pol polyprotein

1086 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

124.515 kDa

SNITAGKQQEGATCGAVRAPYVVTEAPPKIDIKVGTNWKKVLVDTGADRTIVRYHDNSGIPTGRIKLQGIGGIIEGEKWDKVVIQYKEKRIEGTIVVLPSSPVEVLGRDNMAKLDIGIIMANLEEKKIPITQVKLKEGCKGPHIAQWPLTQEKLEGLKEIVDKLEKEGKVGRAPPHWTCNTPIFCIKKKSGKWRMLIDFRELNKQTEDLAEAQLGLPHPGGLQKKKHVTILDIGDAYFTIPLYEPYRPYTCFTMLSPNNLGPCTRYYWKVLPQGWKLSPSVYQFTMQEILRDWIAKHPMIQFGIYMDDIYIGSDLDIMKHREIVEELASYIAQYGFMLPEEKRQEGYPAKWLGFELHPEKWRFQKHTLPEIKEGTITLNKLQKLVGDLVWRQSLIGKSIPNILKLMEGDRALQSERRIELRHVKEWEECRRKLAEMEGNYYDEEKDVYGQIDWGDKAIEYIVFQERGKPLWVNVVHNIKNLSQSQQIIKAAQKLTQEVIIRIGKIPWILLPGKEEDWILELQIGNITWMPSFWSCYRGSIRWKKRNVITEVVEGPTYYTDGGKKNGKGSLGFIASTGVKFRKHEEGTNQQLELRAIEEACKQGPEKMNIVTDSRYAYEFMRRNWDEEVIKNPIQARIMKLVHDKEQIGVHWVPGHKGIPQNEEIDKYISEIFLAREGSGILPKRAEDAGYDLICPQEVCIPAGQVRKIPINLRINLKEDQWAMVGTKSSFASKGVFVQGGIIDSGYQGIIQVVVYNSNDKEVIIPQGRKFAQLILMPLIHEDLEAWGETRRTERGNQGFGSTGAYWIENIPLAEEDHSKWHQDAGSLHLDFGIPRTAAEDIVQQCEVCQENKMPSTIRGSNRRGIDHWQVDYTHYEDKIILVWVETNSGLIYAERVKGETGQEFRIMTIRWYGLFAPKSLQSDNGPAFVAEPTQLLMKYLGITHTTGIPWNPQSQALVERTHQTLKNTIEKFVSMFASFDSAIAAALITLNIKRKGGLGTSPMDIFIFNKEQQRIQQQSTRNQSKFRFCYYRVRKRGHPGEWLGPTQVLWEGEGAIVIKDKNLEKYLVIAKKDVKFIPQPKEIQTE

POL

DNA polymerase

1085 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

123.88 kDa

MEASTTTVKARSTHYICGHAGDSFVKIIYYKDKVKAVVSYLNMNDYLNTYALKCVIPEKITKDFFSSCPDDLLYSTLASIQRGYSPKKKEELGGKWEPLLLLYHRGEEYIIRAVVPQRRCEDCGKQFVSSHQCNVRRREFYHHAVLPDTKTWWKPIKFSPIGALSNAKRLFIIYDIETYTFHSGYGKQLVPYLLVMQFKGDSRLRCEAEKIALECGFQPYRQCFMMLNKARDVIGHKFKDMRVQLQKRAASDIWSRYREKHDILSEEGVSYAQLEAMAKDNLLKTDAEPEFTEIIVVGHNITGFDEIVLASHVLEGLPKDEELQMFKITRNFMPRAGKLLFNDVIMALPNAAFQKPKQSTFQRWKTGDLRPEDLKWEGVRFMVRDTVLLTHSSLRNAAQAYQLEVSKGHCPYDALNQYFMVGTYLCDENMYPAREYWSSDEEYLENKPPDGEKYDLVQKAVDYCVNDVKVTVALVKKLCSGYQQFCDEVLKLDCTFNVFQRPTISSTTHAMFKQMFYKSEPSAVGKFLPNLEAPSEVMYEHIRKSVRGGRCYPSFLGVFTEPHLCYDICGMYASALSHPMPYGPTLSPFDSAVAIAEFQRKLDGQSELSYFDPDIFPMIVVADAFPPSLHCLDVLPPLCSKRSGKLCWTNEPLLGEVLTTVDLIMLKNRGWRVKLIQNAECYAVWREWRPLCREYVSINIAAKEKADREKNQTQRSISKLLSNALYGSFATRLDNKQVVFMDDMSSTTQSELRSGKASIVSMTSVCSRSLPQKDTSFWERYFNLPQVEDSISAELNDEPETEPFIGGERSHVIYKPITFLSAECDNLLLATVQSNSDWVKNDRYATQVASFVLAWSRAFMSEWATILYGEDIGVPYEQRKLKSVYGDTDSLFLTGEGHRLMITKGRHKLKSSGNSLVYRDDGNLAWLVECETSCPSCKSDSFSSESCFLAPKLYALKDTTCPSCGLVSGGKLRAKGHAKSCITYDVLKSCFLDHYLLERPTEQYQSERTPIKRTLANGSANSAPFTVVEKQLARVIRPWNDPTMARGTDLSQGFLLFPYDQKRPNPRPQEPLLENPFWDDSSQTA

POL

DNA polymerase

1085 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

123.88 kDa

MEASTTTVKARSTHYICGHAGDSFVKIIYYKDKVKAVVSYLNMNDYLNTYALKCVIPEKITKDFFSSCPDDLLYSTLASIQRGYSPKKKEELGGKWEPLLLLYHRGEEYIIRAVVPQRRCEDCGKQFVSSHQCNVRRREFYHHAVLPDTKTWWKPIKFSPIGALSNAKRLFIIYDIETYTFHSGYGKQLVPYLLVMQFKGDSRLRCEAEKIALECGFQPYRQCFMMLNKARDVIGHKFKDMRVQLQKRAASDIWSRYREKHDILSEEGVSYAQLEAMAKDNLLKTDAEPEFTEIIVVGHNITGFDEIVLASHVLEGLPKDEELQMFKITRNFMPRAGKLLFNDVIMALPNAAFQKPKQSTFQRWKTGDLRPEDLKWEGVRFMVRDTVLLTHSSLRNAAQAYQLEVSKGHCPYDALNQYFMVGTYLCDENMYPAREYWSSDEEYLENKPPDGEKYDLVQKAVDYCVNDVKVTVALVKKLCSGYQQFCDEVLKLDCTFNVFQRPTISSTTHAMFKQMFYKSEPSAVGKFLPNLEAPSEVMYEHIRKSVRGGRCYPSFLGVFTEPHLCYDICGMYASALSHPMPYGPTLSPFDSAVAIAEFQRKLDGQSELSYFDPDIFPMIVVADAFPPSLHCLDVLPPLCSKRSGKLCWTNEPLLGEVLTTVDLIMLKNRGWRVKLIQNAECYAVWREWRPLCREYVSINIAAKEKADREKNQTQRSISKLLSNALYGSFATRLDNKQVVFMDDMSSTTQSELRSGKASIVSMTSVCSRSLPQKDTSFWERYFNLPQVEDSISAELNDEPETEPFIGGERSHVIYKPITFLSAECDNLLLATVQSNSDWVKNDRYATQVASFVLAWSRAFMSEWATILYGEDIGVPYEQRKLKSVYGDTDSLFLTGEGHRLMITKGRHKLKSSGNSLVYRDDGNLAWLVECETSCPSCKSDSFSSESCFLAPKLYALKDTTCPSCGLVSGGKLRAKGHAKSCITYDVLKSCFLDHYLLERPTEQYQSERTPIKRTLANGSANSAPFTVVEKQLARVIRPWNDPTMARGTDLSQGFLLFPYDQKRPNPRPQEPLLENPFWDDSSQTA

POL

DNA polymerase

1061 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

121.728 kDa

MLFSLTDTMDSSRLYALISRFRPSRAEIWTCRSRGTVTLSVLAFEDPNGSGNAAEEEEDERQLPSGIDFPICFLVRGRQVHLIQQIQPVQRCEHCARFYKHQHECSVRRRDFYFHHINSHSSNWWQEIHFFPIGSHPRTERLFITYDVETYTWMGAFGKQLVPFMLVMKLSGDDNLVKHALQLALELGWDQWEKDSTTFYCLTPEKMKVGQQFRTYRNRLQTSLATDLWMTFLQKNPHLSQWAQEENGLVALEDLSYEDLKRAPAIKGEPRFVELYIVGHNINGFDEIVLAAQVINNRLDVPGPFKISRNFIPRAGKILFNDITFALPNPHYKKRTNFLLWEHGGCDDQDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCPYKAVNQFYMLGSYRADANGFPLEEYWKDKEEYLLNQELWKKKGEKNYNLIGETLNYCALDVLVTASLVEKLRSSYAQFVTDAVGLDAAHFNVFQRPTISSNSHAIFRQILYRAEKPQRTHLGPNILAPSHELYDYVRASIRGGRCYPTYIGVLKEPIYVYDICGMYASALTHPMPWGPPLNPYERALAVRQWQVALENYTCKIDYFDKNLCPGIFTIDADPPDENQLDVLPPFCSRKGGRLAWTNESLRGEVVTSVDLVTLHNRGWRLRLLSDERTTIFPTWKCLAREYVQLNIAAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMEESLMKEIAAGRLNIKSSSFIETDTLSTEVMPAFERVYSPNQLALVNSEAEESDEDQGPAPFYSPPPENCEHVTYTYKPITFMDAEEGDMCLHTLESSNPLINNDRYPSHVASFVLAWTRAFVSEWSEFLYEEDRGIPLKDRPLKSVYGDTDSLFVTEKGRRLMESQGKKRIKKYGGKLVFDPSCPELTWSVECETVCSYCGADAYSPESVFLAPKLYALKCLQCPHCGSTSKGKIRAKGHATEALSYDLMLKCYLAEAQGEDTRFSTSRLSLKRTLASAQPGAHPFTVTETTLTRTLRPWKDKTLVHLDAHRLVPYSNSQPNPRNEEVCWIEMA

pol

Retrovirus-related Pol polyprotein from transposon 297

1059 amino acids

123.311 kDa

TKRKFSVNSSGKYEYIKIVYKGRSYKCLLDTGSTINMINENIFCLPIQNSRCEVLTSNGPITLNDLIMLPRNSIFKKTEPFYVHRFSNNYDMLIGRKLLKNAQSVINYKNDTVTLFDQTYKLITSESERNQNLYIQRTPESIASSDQESIKKLDFSQFRLDHLNQEETFKLKGLLNKFRNLEYKEGEKLTFTNTIKHVLNTTHNSPIYSKQYPLAQTHEIEVENQVQEMLNQGLIRESNSPYNSPTWVVPKKPDASGANKYRVVIDYRKLNEITIPDRYPIPNMDEILGKLGKCQYFTTIDLAKGFHQIEMDEESISKTAFSTKSGHYEYLRMPFGLRNAPATFQRCMNNILRPLLNKHCLVYLDDIIIFSTSLTEHLNSIQLVFTKLADANLKLQLDKCEFLKKEANFLGHIVTPDGIKPNPIKVKAIVSYPIPTKDKEIRAFLGLTGYYRKFIPNYADIAKPMTSCLKKRTKIDTQKLEYIEAFEKLKALIIRDPILQLPDFEKKFVLTTDASNLALGAVLSQNGHPISFISRTLNDHELNYSAIEKELLAIVWATKTFRHYLLGRQFLIASDHQPLRWLHNLKEPGAKLERWRVRLSEYQFKIDYIKGKENSVADALSRIKIEENHHSEATQHSAEEDNSNLIHLTEKPINYFKKQIIFIKSDKNKVEHSKIFGNSITTIQYDVMTLEKAKQILLDHFIHRNITIYIESDVDFEIVQRAHIEIVNTTYTKVIRSLFLLKNVGSYAEFKEIILQSHEKLLHPGIQKMTKLFKENHFFPNSQLLIQNIINECNICNLAKTEHRNTKMPLKITPNPEHCREKFVVDIYSSEGKHYISCIDIYSKFATLEQIKTKDWIECRNALMRIFNQLGKPKLLKADRDGAFSSLALKRWLEEEEVELQLNTAKNGVADVERLHKTINEKIRIINSSDDEEVKLSKIETILYTYNQKIKHDTTGQRPAQIFLYAGHPILDTQKIKEKKIEKINEDRREFNIDTNYRKGPLQKGKLENPFKPTKNVEQTDPDHYKITNRNRVTHYYKTQFKKQKKNNKLSISQAPGTR

pol

Retrovirus-related Pol polyprotein from transposon 17.6

1058 amino acids

122.698 kDa

TGRKFSATSLGKPQYITIKYKENNLKCLIDTGSTVNMTSKNIFDLPIQNTSTFIHTSNGPLIVNKSIIIPSKILFPTTNEFLLHPFSENYDLLLGRKLLAEAKATISYRDQEVTLYNNKYKLIEGIATHEQSHFQNVNMIPDTMLRQPNKISPILESDLYRLEHLNNEEKQRLCALLQKYHDIQYHEGDKLTFTNQTKHTINTKHNLPLYSKYSYPQAYEQEVESQIQDMLNQGIIRTSNSPYNSPIWVVPKKQDASGKQKFRIVIDYRKLNEITVGDRHPIPNMDEILGKLGRCNYFTTIDLAKGFHQIEMDPESVSKTAFSTKHGHYEYLRMPFGLKNAPATFQRCMNDILRPLLNKHCLVYLDDIIVFSTSLDEHLQSLGLVFEKLAKANLKLQLDKCEFLKQETTFLGHVLTPDGIKPNPEKIEAIQKYPIPTKPKEIKAFLGLTGYYRKFIPNFADIAKPMTKCLKKNMKIDTTNPEYDSAFKKLKYLISEDPILKVPDFTKKFTLTTDASDVALGAVLSQDGHPLSYISRTLNEHEINYSTIEKELLAIVWATKTFRHYLLGRHFEISSDHQPLSWLYRMKDPNSKLTRWRVKLSEFDFDIKYIKGKENCVADALSRIKLEETYLSEQTQHSAEEDNSDLIFITERPLNTFNRQVIFSKGPPDIKVTKYFKKHITQIFYDIMTREKAEQYLIDHFCGKKSALYIESDADFEVIQAAHKLAINTKYTKILRSTILLKNITTYAEFKELILTAHEKLLHPGIQKTTKLFGETYYFPNSQLLIQNIINECSICNLAKTEHRNTDMPTKTTPKPEHCREKFMIDIYSSEGKHYVSCIDIYSKFATLEEIKTKDWIECKNALMRIFNQLGKPKLLKADRDGAFSSLALKRWLESEEVELQLNTTKTGVADIERLHKTINEKIRIIKTSDDEETKLSKMETVLNIYNHKTKHDTTGQTPAHIFLYAGQPILDTQQNKENKINKINNDRVEYEVDTRYRKGPLQKGKLENPFKPTKNVEQTDSDHYKITNRNRITHYYKTQFKKRKKNNQLSISQAPGT

pol

Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM

1057 amino acids

120.041 kDa

FERKNFSDGLVPQRKFIHIGTTSTNNEPRIPLHNLMTTRPSVDIFPEDQYEPNAAATLSRVPCTVCGRSFNSKRGLGVHMRSRHPDELDEERRRVDIKARWSDEEKWMMARKEVELTANGCKHINKQLAVYFANRSVEAIKKLRQRGDYKEKIEQIRGQSALAPEVANLTIRRRPSRSEQDHQVTTSETTPITPFEQSNREILRTLRGYSPVECHSKWRAQELQTIIDRAHLEGKETTLQCLSLYLLGIFPAQGVRHTLTRPPRRPRNRRESRRQQYAVVQRNWDKHKGRCIKSLLNGTDESVMPSQEIMVPYWREVMTQPSPSSCSGEVIQMDHSLERVWSAITEQDLRASRVSLSSSPGPDGITPKSAREVPSGIMLRIMNLILWCGNLPHSIRLARTVFIPKTVTAKRPQDFRPISVPSVLVRQLNAILATRLNSSINWDPRQRGFLPTDGCADNATIVDLVLRHSHKHFRSCYIANLDVSKAFDSLSHASIYDTLRAYGAPKGFVDYVQNTYEGGGTSLNGDGWSSEEFVPARGVKQGDPLSPILFNLVMDRLLRTLPSEIGAKVGNAITNAAAFADDLVLFAETRMGLQVLLDKTLDFLSIVGLKLNADKCFTVGIKGQPKQKCTVLEAQSFYVGSSEIPSLKRTDEWKYLGINFTATGRVRCNPAEDIGPKLQRLTKAPLKPQQRLFALRTVLIPQLYHKLALGSVAIGVLRKTDKLIRYYVRRWLNLPLDVPIAFVHAPPKSGGLGIPSLRWVAPMLRLRRLSNIKWPHLTQNEVASSFLEAEKQRARDRLLAEQNELLSRPAIEKYWANKLYLSVDGSGLREGGHYGPQHGWVSQPTRLLTGKEYMDGIRLRINALPTKSRTTRGRHELERQCRAGCDAPETTNHIMQKCYRSHGRRVARHNCVVNRIKRGLEERGCVVIVEPSLQCESGLNKPDLVALRQNHIDVIDTQIVTDGHSMDDAHQRKINRYDRPDIRTELRRRFEAAGDIEFHSATLNWRGIWSGQSVKRLIAKGLLSKYDSHIISVQVMRGSLGCFKQFMYLSGFSRDWT

POL

DNA polymerase

1056 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

120.401 kDa

MDSSHLRDVVIKLRPPRADIWTLGSRGVVVRSTVTPLEQPDGQGQAAEVEDHQPNPPGEGLKFPLCFLVRGRQVNLVQDVQPVHRCQYCARFYKSQHECSARRRDFYFHHINSHSSNWWREIQFFPIGSHPRTERLFVTYDVETYTWMGAFGKQLVPFMLVMKFGGDEPLVTAARDLAANLGWDRWEQDPLTFYCITPEKMAIGRQFRTFRDHLQMLMARDLWSSFVASNPHLADWALSEHGLSSPEELTYEELKKLPSIKGIPRFLELYIVGHNINGFDEIVLAAQVINNRSEVPGPFRITRNFMPRAGKILFNDVTFALPNPRSKKRTDFLLWEQGGCDDTDFKYQYLKVMVRDTFALTHTSLRKAAQAYALPVEKGCCAYQAVNQFYMLGSYRSEADGFPIQEYWKDREEFVLNRELWKKKGQDKYDIIKETLDYCALDVQVTAELVNKLRDSYASFVRDAVGLTDASFNVFQRPTISSNSHAIFRQIVFRAEQPARSNLGPDLLAPSHELYDYVRASIRGGRCYPTYLGILREPLYVYDICGMYASALTHPMPWGPPLNPYERALAARAWQQALDLQGCKIDYFDARLLPGVFTVDADPPDETQLDPLPPFCSRKGGRLCWTNERLRGEVATSVDLVTLHNRGWRVHLVPDERTTVFPEWRCVAREYVQLNIAAKERADRDKNQTLRSIAKLLSNALYGSFATKLDNKKIVFSDQMDAATLKGITAGQVNIKSSSFLETDNLSAEVMPAFQREYSPQQLALADSDAEESEDERAPTPFYSPPSGTPGHVAYTYKPITFLDAEEGDMCLHTLERVDPLVDNDRYPSHLASFVLAWTRAFVSEWSEFLYEEDRGTPLEDRPLKSVYGDTDSLFVTERGHRLMETRGKKRIKKHGGNLVFDPERPELTWLVECETVCGACGADAYSPESVFLAPKLYALKSLHCPSCGASSKGKLRAKGHAAEGLDYDTMVKCYLADAQGEDRQRFSTSRTSLKRTLASAQPGAHPFTVTQTTLTRTLRPWKDMTLARLDEHRLLPYSESRPNPRNEEICWIEMP

pol

Pol polyprotein

1046 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

117.101 kDa

single

LQDFPQAWAETGGLGRAKCQVPIIIDLKPTAMPVSIRQYPMSKEAHMGIQPHITRFLELGVLRPCRSPWNTPLLPVKKPGTRDYRPVQDLREVNKRTMDIHPTVPNPYNLLSTLSPDRTWYTVLDLKDAFFCLPLAPQSQELFAFEWRDPERGISGQLTWTRLPQGFKNSPTLFDEALHRDLTDFRTQHPEVTLLQYVDDLLLAAPTKEACIRGTKHLLRELGDKGYRASAKKAQICQTKVTYLGYILSEGKRWLTPGRIETVAHIPPPQNPREVREFLGTAGFCRLWIPGFAELAAPLYALTKESAPFTWQEKHQSAFEALKEALLSAPALGLPDTSKPFTLFIDEKQGIAKGVLTQKLGPWKRPVAYLSKKLDPVAAGWPPCLRIMAATAMLVKDSAKLTLGQPLTVITPHALEAIVRQTPDRWITNARLTHYQALLLDTDRIQFGPPVTLNPATLLPAPEDQQSAHDCRQVLAETHGTREDLKDQELPDADHSWYTDGSSYIDSGTRRAGAAVVDGHHIIWAQSLPPGTSAQKAELIALTKALELSEGKKANIYTDSRYAFATAHTHGSIYERRGLLTSEGKEIKNKAEIIALLKALFLPRKVAIIHCPGHQKGQDPIATGNRQADQVARQVAVAETLTLTTKLEETNLTTNKYAYTPEDQEEAKAIGAILNQDTKDWEKEGKIVLPRKEALAMIQQMHAWTHLSNQKLKLLIEKTDFLIPKAGTLIEQVTSACKVCQQVNAGATRVPEGKRTRGNRPGVYWEIDFTEVKPHYAGYKYLLVFVDTFSGWVEAYPTRQETAHMVAKKILEEIFPRFGLPKVIGSDNGPAFVSQVSQGLARTLGINWKLHCAYRPQSSGQVERMNRTIKETLTKLTLETGLKDWRRLLSLALLRARNTPNRFGLTPYEILYGGPPPLSTLLNSFSPSDPKTDLQARLKGLQAVQAQIWTPLAELYRPGHPQTSYPFQVGDSVYVRWHRSQGLEPRWKGPYIVLLTTPTAIKVDGIAAWIHASHAKAAPKTPGPETPKTWKLHRSENPLKIRLSRV

pol

Retrovirus-related Pol polyprotein from transposon gypsy

1035 amino acids

117.818 kDa

RLVEFFRGRSRLPFIERRLAGRTLKMLIDTDAAKNYIRPVKELKNVMPVASPFSVSSIHGSTEIKHKCLMKVFKHISPFFLLDSLNAFDAIIGLDLLTQAGVKLNLAEDSLEYQGIAEKLHYFSCPSVNFTDVNDIVVPDSVKKEFKDTIIRRKKAFSTTNEALPFNTAVTATIRTVDNEPVYSRAYPTLMGVSDFVNNEVKQLLKDGIIRPSRSPYNSPTWVVDKKGTDAFGNPNKRLVIDFRKLNEKTIPDRYPMPSIPMILANLGKAKFFTTLDLKSGYHQIYLAEHDREKTSFSVNGGKYEFCRLPFGLRNASSIFQRALDDVLREQIGKICYVYVDDVIIFSENESDHVRHIDTVLKCLIDANMRVSQEKTRFFKESVEYLGFIVSKDGTKSDPEKVKAIQEYPEPDCVYKVRSFLGLASYYRVFIKDFAAIARPITDILKGENGSVSKHMSKKIPVEFNETQRNAFQRLRNILASEDVILKYPDFKKPFDLTTDASASGIGAVLSQEGRPITMISRTLKQPEQNYATNERELLAIVWALGKLQNFLYGSREINIFTDHQPLTFAVADRNTNAKIKRWKSYIDQHNAKVFYKPGKENFVADALSRQNLNALQNEPQSDAATIHSELSLTYTVETTDKPLNCFRNQIILEAARFPLKRNLVLFRSKSRHLISFTDKSWLLKTLKEVVNPDVVNAIHCDLPTLASFQHDLIAHFPATQFRHCKNVVLDITDKNEQIEIVTAEHNRAHRAAQENIKQVLRDYYFPKMGSLAKEVVANCRVCTQAKYDRHPKKQELGETPIPSYTGEMVHIDIFSTDRKLFLTCIDKFSKYAIVQPVVSRTIVDITAPLLQIINLFPNIKTVYCDNEPAFNSETVTSMLKNSFGIDIVNAPPLHSSSNGQVERFHSTLAEIARCLKLDKKTNDTVELILRATIEYNKTVHSVTRERPIEVVHPGAHERCLEIKARLVKAQQDSIGRNNPSRQNRVFEVGERVFVKNNKRLGNKLTPLCTEQKVQADLGTSVLIKGRVVHKDNLK

POL

DNA polymerase

1023 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

117.729 kDa

MCVYKTYKGKLKITSIPARADRPRLPFPLNFLIHKRKLYLIDTIAEVQRCADCGSYFKQTHTCSTRRRDFYFHHINTQSSDWWEEIKFFPLGAHPDTRRLFVVYDVETYTWHGSFGKQLMPFMLVFTLFGDAQLCEQAVNIAKKQKWSSWPKQANTFYYLNPQRNKVGSLFKQYRDALQEAASTLLWRQFLADNPCLENLCLKLGYVHASDIPFEELCTLELKGQPTFLEVYVVGHNINGFDEIVLAAQVINNKQGIPAAFKVSRNFMPRCGKILFNDLTFALPNPTHAARKDFKDWEEGTPTSADYKFQFVKFMVRDTFALTHTSLRNAAAAYALPVEKGCCPYKAVNEFYMLGTYRTDADSFPQRDYWSSDEEYLLNKSLWLQENSGAYDIVQRTLDYCAMDVLVTAELVKKLQASYLDFVHTSVGLPHCNFNVLQRPTISSNSHAIFRQVVYRSQRPNRSSLGNFLLAPSNEMYDYVRESIRGGRCYPTYIGVLTEAIYVYDICGMYASALTHPFPAGKPLNPFDRALAIKNWQDRLTQLHRPIDYFDRTLLPAIFTIDADPPPEAFLDVIPPFCSRKGGRLCWTNETLRGEVVTCLDAITLHNRGWRVQILNDPRTTVFPQWECLARDYVQLNIAAKERADKEKNQTLRSIAKLLSNALYGSFATKLDNRVTVFSDQMEDKYVRGISDGTYDIKSTAFVETDNLSSSVMAELKITYSPVKQQTDATRKHRQCTPTSNSSSDEDAPFYTLGDPQNHHVTYTYKPITFLEADDSALCLHTLQKKSSLIFNNRYPSHIASFVLAWTRAFVSEWADILYLEDRGTPLEDRILKFVYGDTDSMFLTQRGKELMDTRGKHRLKGNNRPLVFDPTNPQLTWLVECETQCPRCHGDAHSQESVFLAPKLYALKNIYCPSCRAESSGKLRAKGHATSQLSYDLLVTCYYSTEQLGDEKFGTSRLSLRRSLVSRQTHQQPFTVTETTLARTLRPWKDRTLRAIDRHRLAPYSNSHPNPRNKELCWMEMY

POL

DNA polymerase

1017 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

117.003 kDa

MLEALKPAEGATFTYIKGRLIKQQAAVENPILPFPIFFLIKQNKVFLIKSFQSSQKCEFCGDFFANSHTCSVRRRDFYFHHINFKSSEWWSQISFQPIGSCDDTKRFFLTYDVETYTWHGKHGKQLVPFMLVFHLSGELELVSLSANIAEQQRWLAWDTPHTYYYVSPIKGEIGKAFKDLRYEIQKQVTRLLWDNFVGENPELAEIQERHHVNHIDDITAEMHKIKTKGSPQFIEIYVIGHNICGFDEIVLAAQVIHNRTDVLPAFKINRNFMPRNGKILFNDISFCLPNPKYEKRKDFADWECGKLTAADHKYQFVKFMVRDTFALTHTSLRNAAGAYELPVEKGSCPYEAVNEFYRIGSYQQDEDGFPSLRYWKSSEEYQLNKALWREKNVGAYDIIQQTLHYCVQDVLVTSALVNKLQESYKNFIASQVNLPDASFNIFQRPTISSNSHAIFKQILYREVRPNKANLDNVLLAPSHEMYDYVRQSIRGGRCYPTYIGIMEQPIYVYDICGMYASALTHPFPSGQPLNPYERALAATEWIRKLENLEQKIDYFDECLLPGIFTIDADPPDELFLDELPPFCSRKGGRLCWANEPLRGEVATSIDLITLHNRGWAVRILPDERTTIFPEWKCVAKEYVQLNIGAKEKADKEKNQTMRSIAKLLSNALYGSFATKLDNKKIVFSDQLEASASKTIARGNFSIKSSSFIETDNFSAEIMPEFVVTYPPAPSAELDESDENEEHTLFIPKDSHVTYKYKPITFLETEDDDICLHTLENNSPLIENNRYASHIASFVLAWTRVFVSEWAEFLYAEDRGKPLHQRTIKSVYGDTDSLFVTEEGHRLMEQRGKHRIKKNGGKLVFDPKNPSITWLVECETQCEKCKSDAFSSESVFLAPKLYALKNTVCTCCGHVGKGKLRAKGHATTELCYDTLAKCYLSDAQQGSQRFHTSRLSLKRTLATNQSNAAPFTVTETTLTRTVRPWKDKTLVDIDGHRLMPYSKSNPNPRNNDVCWMTLPWNM

POL

DNA polymerase

1014 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

115.823 kDa

MSSVNLMEWSALKTQLQAGRDAGKARVSIGPADTARITRMTYADNHLIVFMNARLAKENHRLYQFYAEVRCDLYSYKSCYGTHASATCHRNCTSYKTFVMPGLRDVHTDKLHVVKFKRSDEKRDKNCLDGYLADVNRVHMQTSLLEGQYVRFKNAHACRDYRLSHTAKDVHEFESMLERVQVSALSHEILPVVACYDIETHSDGQRFSAPDADFIISIAVVVRRDAADTRICLFYSPDDPVDLSSSSSSPPAAPDTAAVHFRAERDMIAAFFQLLPLLNADVVLDFNGDKFDLPFLTGRANKLCGPAEAARATKIARYDLSPVNVVTQQSYDKFSNKLHSHYLTYYIHIDLYQFLSTDSEHNDLENFQLNTVAEHYLKKSKVDLPIHDMLQMYGEKRLSRIVEYNVQDCVLPVELFLKLEIADYMYTQCMLLYLCTDDLLRNISHKITVAYFHLALTNTVAAADPTPDPYFFNKYDLSVTSGRKRAFNEPAPSANAIDLSQLKRTPVDAARIPPSAVKLCSTRQSCTYKGGKVLSPKPGFNRWVATLDFNALYPTIMMWEGVCMSNVFIASDGNVYLDKNVNAVNPKLLKTLSEMRVRYKGLRDQCEYNSFYYKLYDKIQNALKRIANSIYGYYGIFFKPLANYITKMGRGKLKEVVGKVEAMSDDPRILREFGLSKINFSVIYGDTDSCFIRVLFDEAELAPDRRQTAIRSIVQDHVCKTLNDSWCGYKMSLENIMLSLILLKKKKYCYLNNEQRTKYKGWLIKRDMPLFMRKAFRATVDSLLRGHSTACALGLLAEQMLRYYREFGAPRENLVDYCFSMSYNETSTTAKRRKEEDPARKPVITIAKHCRELLANPGVDFLPGNGDRIQYVLVDVKEKITQKAFPLKLFDPDSPTLQISWLKHMNILCTFMNELIQVFGNRPEFEHYFGAIVDEYTSAQMYDVRYPVLVPTRRAKAGKSAKKNDSDSDSDSDDDDDPATTPVNYHSLFSMHLKKPKRQAVGEFEPCPQCVARA

POL

DNA polymerase

1014 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

115.823 kDa

MSSVNLMEWSALKTQLQAGRDAGKARVSIGPADTARITRMTYADNHLIVFMNARLAKENHRLYQFYAEVRCDLYSYKSCYGTHASATCHRNCTSYKTFVMPGLRDVHTDKLHVVKFKRSDEKRDKNCLDGYLADVNRVHMQTSLLEGQYVRFKNAHACRDYRLSHTAKDVHEFESMLERVQVSALSHEILPVVACYDIETHSDGQRFSAPDADFIISIAVVVRRDAADTRICLFYSPDDPVDLSSSSSSPPAAPDTAAVHFRAERDMIAAFFQLLPLLNADVVLDFNGDKFDLPFLTGRANKLCGPAEAARATKIARYDLSPVNVVTQQSYDKFSNKLHSHYLTYYIHIDLYQFLSTDSEHNDLENFQLNTVAEHYLKKSKVDLPIHDMLQMYGEKRLSRIVEYNVQDCVLPVELFLKLEIADYMYTQCMLLYLCTDDLLRNISHKITVAYFHLALTNTVAAADPTPDPYFFNKYDLSVTSGRKRAFNEPAPSANAIDLSQLKRTPVDAARIPPSAVKLCSTRQSCTYKGGKVLSPKPGFNRWVATLDFNALYPTIMMWEGVCMSNVFIASDGNVYLDKNVNAVNPKLLKTLSEMRVRYKGLRDQCEYNSFYYKLYDKIQNALKRIANSIYGYYGIFFKPLANYITKMGRGKLKEVVGKVEAMSDDPRILREFGLSKINFSVIYGDTDSCFIRVLFDEAELAPDRRQTAIRSIVQDHVCKTLNDSWCGYKMSLENIMLSLILLKKKKYCYLNNEQRTKYKGWLIKRDMPLFMRKAFRATVDSLLRGHSTACALGLLAEQMLRYYREFGAPRENLVDYCFSMSYNETSTTAKRRKEEDPARKPVITIAKHCRELLANPGVDFLPGNGDRIQYVLVDVKEKITQKAFPLKLFDPDSPTLQISWLKHMNILCTFMNELIQVFGNRPEFEHYFGAIVDEYTSAQMYDVRYPVLVPTRRAKAGKSAKKNDSDSDSDSDDDDDPATTPVNYHSLFSMHLKKPKRQAVGEFEPCPQCVARA

POL

DNA polymerase

1008 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

113.955 kDa

MELKCLNWFENRGNDSRFLFLKARRADNAVVYLRFVQHFYYVVRADAVADIAQPLAWTRALGPMSVVSIDEIVARSAKIPERQRSEIELCLVASERKLAPPEVFMSDFLNVSWFFVAHDIDPDGCYRVDPALLRDLGSNCFHCDDPGACFAEKIPRFNVTRSGLFLDIECHFEKKFPSVFKNAVSHISFCVVDKDGAERRFTLTNSDMLSDADLEEAARREIPVCLDPADVKFDAEVTLCPEVTLLRVAKRLLEMPLDFVVTFNGHNFDLRYLDSRLSLLTGEHIRFRLPDGTETVNFCVYERTKSSHKGVGGVSSTTFHINNNNGTIYFDLYAFIQRTEKLDSYKLDAISKNAFHCTAVVEDARPDAVRFRGDRSTDADGNAAVFARVLSTGNYVTVDERVCRVLHKRVDEDGFTVDLADPAARAPGDRVTLAFGKDDVSLADMYANYSLDVCLDMARYCLHDACLCLYLWSHYGVETKIAAAASTYLLPQSVVFEYRASTCIKGPLMKLLLENRTVMVRADTKSKFFYEGGRVMAPKQKMHNKHVLIFDYNSLYPNVCIYANLSPETLVGVVVSDNRLDAEVAAVDVRRMFPAPRYIAVPCEPRSPELVAEVAIFDREAKGIIPMLLRSFLDARAKYKKLMKAAETAVDREIYNSMQYTYKITANSVYGLMGFRNSALFSYASAKSCTAIGRTMIAYLERTLDGASVCGTRLSLAAAPDNPLLRDEAFAGRAAELEIDAAVAGERTERVGFRSVYGDTDSVFLEVGASDIAFSRRVGRCLERVINEHVLFANFKVEFEAVYCNLIMQSKKKYTTIKFAVSDGGGSERVSKGTSETRRDVAPFHKLMIRKYKDMLCRALAEEGSGNVGVEILRSLEDELTFEFEARSMPLDWFLLSRTHHKNFKSPDNPNVALVTRYNAANAEAIEIGERYFFAYVCEEGPWRRRIANVKSYERVVDKTFRLDKNERIMYEVYFKRLCTEIVNLLDNKAMCTLFFERLFGSKPVFTG

POL

DNA polymerase

1008 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

113.955 kDa

MELKCLNWFENRGNDSRFLFLKARRADNAVVYLRFVQHFYYVVRADAVADIAQPLAWTRALGPMSVVSIDEIVARSAKIPERQRSEIELCLVASERKLAPPEVFMSDFLNVSWFFVAHDIDPDGCYRVDPALLRDLGSNCFHCDDPGACFAEKIPRFNVTRSGLFLDIECHFEKKFPSVFKNAVSHISFCVVDKDGAERRFTLTNSDMLSDADLEEAARREIPVCLDPADVKFDAEVTLCPEVTLLRVAKRLLEMPLDFVVTFNGHNFDLRYLDSRLSLLTGEHIRFRLPDGTETVNFCVYERTKSSHKGVGGVSSTTFHINNNNGTIYFDLYAFIQRTEKLDSYKLDAISKNAFHCTAVVEDARPDAVRFRGDRSTDADGNAAVFARVLSTGNYVTVDERVCRVLHKRVDEDGFTVDLADPAARAPGDRVTLAFGKDDVSLADMYANYSLDVCLDMARYCLHDACLCLYLWSHYGVETKIAAAASTYLLPQSVVFEYRASTCIKGPLMKLLLENRTVMVRADTKSKFFYEGGRVMAPKQKMHNKHVLIFDYNSLYPNVCIYANLSPETLVGVVVSDNRLDAEVAAVDVRRMFPAPRYIAVPCEPRSPELVAEVAIFDREAKGIIPMLLRSFLDARAKYKKLMKAAETAVDREIYNSMQYTYKITANSVYGLMGFRNSALFSYASAKSCTAIGRTMIAYLERTLDGASVCGTRLSLAAAPDNPLLRDEAFAGRAAELEIDAAVAGERTERVGFRSVYGDTDSVFLEVGASDIAFSRRVGRCLERVINEHVLFANFKVEFEAVYCNLIMQSKKKYTTIKFAVSDGGGSERVSKGTSETRRDVAPFHKLMIRKYKDMLCRALAEEGSGNVGVEILRSLEDELTFEFEARSMPLDWFLLSRTHHKNFKSPDNPNVALVTRYNAANAEAIEIGERYFFAYVCEEGPWRRRIANVKSYERVVDKTFRLDKNERIMYEVYFKRLCTEIVNLLDNKAMCTLFFERLFGSKPVFTG

POL

DNA polymerase

1006 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

116.877 kDa

MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLSCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA

POL

DNA polymerase

1006 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

116.903 kDa

MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA

POL

DNA polymerase

1006 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site.

Belongs to the DNA polymerase type-B family.

116.929 kDa

MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVYLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA

POL

DNA polymerase

1005 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

116.644 kDa

MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLAPPPFNARPMGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRNIQNATMDEFLNISWFYISNGISPDGCYSLDDQYLTKINNGCYHCGDPRNCFAKEIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLQIAKQLLELTFDYIVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAVFAKVLTTGNYVTVDDIICKVIHKDIWENGFKVVLSCPTLTNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFGYKASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSSNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIIANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINSRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKIYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHLNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSRPTFYEA

pol

Retrovirus-related Pol polyprotein from transposon opus

1003 amino acids

114.635 kDa

MITHRLVGKFFKPLGNDSDITFFVLPNLHSFDGIIGDDTLKDLKAIVDRKNNCLIITPGIKIPLLARASINVNPLLAAEHPDGTQEILNSLLGEFPRIFEPPLSGMSVETAVKAEIRTNTQDPIYAKSYPYPVNMRGEVERQIDELLQDGIIRPSNSPYNSPIWIVPKKPKPNGEKQYRMVVDFKRLNTVTIPDTYPIPDINATLASLGNAKYFTTLDLTSGFHQIHMKESDIPKTAFSTLNGKYEFLRLPFGLKNAPAIFQRMIDDILREHIGKVCYVYIDDIIVFSEDYDTHWKNLRLVLASLSKANLQVNLEKSHFLDTQVEFLGYIVTADGIKADPKKVRAISEMPPPTSVKELKRFLGMTSYYRKFIQDYAKVAKPLTNLTRGLYANIKSSQSSKVPITLDETALQSFNDLKSILCSSEILAFPCFTKPFHLTTDASNWAIGAVLSQDDQGRDRPIAYISRSLNKTEENYATIEKEMLAIIWSLDNLRAYLYGAGTIKVYTDHQPLTFALGNRNFNAKLKRWKARIEEYNCELIYKPGKSNVVADALSRIPPQLNQLSTDLDANPEDDMQSLATAHSALHDSSRLIPHVESPINVFKNQLIFDTTRSKYLCEHPFPGYTRHLIPLKDGSLADLTNSLQSCLRPVIINGVKIPEAHLQRFQSICLANFLLYKIRITQRLVADVSGAEEICEIIEKEHRRAHRGPTEIRLQLLEKYYFPRMSSTIRLQTSSCQCCKLYKYERHPNKPNLQPTPIPNYPCEILHIDIFALEKRLYLSCIDKFSKFAKLFHLQSKASVHLRETLVEALHYFTAPKVLVSDNERGLLCPTVLNYLRSLDIDLYYAPTQKSEVNGQVERFHSTFLEIYRCLKDELPTFKPVELVHIAVDRYNTSVHSVTNRKPADVFFDRSSRVNYQGLTDFRRQTLEDIKGLIEYKQIRGNMARNKNRDEPKSYGPGDEVFVANKQIKTKEKARFRCEKVQEDNKITVKTRSGKIFHKSDLRN

POL

DNA polymerase

990 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.275 kDa

MKIVTYNQLQEAFRDYSPRDFAISRDNVFRVMRIYYNENVGQLVAFCNTQLAGRLAQFYFTIKMDLYSYKQCYNSHIFATCRNRCSSYNTFVAPGVKNVYMDKINVIKFKRNGSSFGEKAAALDKFLHNANRVHMQTPVIEGTYMRFRRAQRCRNNCVTDDARPFELERFADDFQVVNPATLTTKIEPVMACFDIETHSDGHNSSKPECDVIMCIGLAVLKDNRYDKICFVYHKELVEISGNDEYTHVVVFNNESHMIASFFDFFKYANPDVILDYNGDVFDLPYIRGRLKGDKPLLGRYDLPALQPNTKLFITKIGNRTDTYYFNYYIHIDLYKYFGADANKRDVENFELNTLSQYYLNDNKVDLNWQTMVAMYNNKQLGTMIDYNLKDCLLPIRLFNKLKLNDFMYSQCLMYRLCTDDFICNISHLISSTFFHLALTNTRTDPVTGLVVHDPYFFNKDDLGRMSSKDAGFCAGMSRLQRKRIPLKDLPANSIRLGAINEIVNYEGGKVLQPRAGVYEFAFSLDFNSLYLTIMIDICACLTNLILCEDGNVYLNQDKQAINVQLLLQLLKQRSELKKCRDSQTDSEFLYDLYDQMQNLSKRTANSIYGYYGIFCKLLANYITRVGREKLTAAIGMIEGLSNDAELLSKFNLSTLTFRVLYGDTDSTFVLPTFKRDEIPEESCMVTLTRICAAVETRVNGLFANGYKMAFENLMSVLILLKKKKYCYINSANKIVFKGWLVKKDMPVFMRVAFRTAIEQVLRHQDLQKCLDSLLINMLMYFDAFGTTKPLTDYSFSMTYNDGAGKVTENESRPTKRRVVTVARHCREILLNKGTDFVPGNGDRIPYVLLDIQGSVTQKAYPLRLFDPRTMRISWLKHMTILNTFMNELLEIFGDEHTSALNKCYDAILTKYMQHQAYDKKRVTLIKINAAYKRKAPSDDAARKRARAGPSALRKQKAASNDEDSSDEDDEDCSQAIGSNNTFKFSLYKYK

POL

DNA polymerase

990 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.275 kDa

MKIVTYNQLQEAFRDYSPRDFAISRDNVFRVMRIYYNENVGQLVAFCNTQLAGRLAQFYFTIKMDLYSYKQCYNSHIFATCRNRCSSYNTFVAPGVKNVYMDKINVIKFKRNGSSFGEKAAALDKFLHNANRVHMQTPVIEGTYMRFRRAQRCRNNCVTDDARPFELERFADDFQVVNPATLTTKIEPVMACFDIETHSDGHNSSKPECDVIMCIGLAVLKDNRYDKICFVYHKELVEISGNDEYTHVVVFNNESHMIASFFDFFKYANPDVILDYNGDVFDLPYIRGRLKGDKPLLGRYDLPALQPNTKLFITKIGNRTDTYYFNYYIHIDLYKYFGADANKRDVENFELNTLSQYYLNDNKVDLNWQTMVAMYNNKQLGTMIDYNLKDCLLPIRLFNKLKLNDFMYSQCLMYRLCTDDFICNISHLISSTFFHLALTNTRTDPVTGLVVHDPYFFNKDDLGRMSSKDAGFCAGMSRLQRKRIPLKDLPANSIRLGAINEIVNYEGGKVLQPRAGVYEFAFSLDFNSLYLTIMIDICACLTNLILCEDGNVYLNQDKQAINVQLLLQLLKQRSELKKCRDSQTDSEFLYDLYDQMQNLSKRTANSIYGYYGIFCKLLANYITRVGREKLTAAIGMIEGLSNDAELLSKFNLSTLTFRVLYGDTDSTFVLPTFKRDEIPEESCMVTLTRICAAVETRVNGLFANGYKMAFENLMSVLILLKKKKYCYINSANKIVFKGWLVKKDMPVFMRVAFRTAIEQVLRHQDLQKCLDSLLINMLMYFDAFGTTKPLTDYSFSMTYNDGAGKVTENESRPTKRRVVTVARHCREILLNKGTDFVPGNGDRIPYVLLDIQGSVTQKAYPLRLFDPRTMRISWLKHMTILNTFMNELLEIFGDEHTSALNKCYDAILTKYMQHQAYDKKRVTLIKINAAYKRKAPSDDAARKRARAGPSALRKQKAASNDEDSSDEDDEDCSQAIGSNNTFKFSLYKYK

POL

DNA polymerase

988 amino acids

Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).

Belongs to the DNA polymerase type-B family.

116.661 kDa

MDIRCVNWFENKGETKYIYLKAINRESNVIFIRFNYYYHYVYDASKELEYKPNECIDLGPFKIINIDEKLSTDIRYVEPRNYYTSELVLVKDLKRNREKQYLQEYLDITWFYLLNNITPDGCYKIDIEHLTPIKKDCYHCDDVSKVFIQEIPIFEVKFTYLLFDIECQFDKKFPSVFVNPISHISCWIIDKVTEYKFTLINTDILPDKEPSILHHKDFSPKDRITYCTEIVMLLIMKKILEHRFDFVITFNGNNFDIRYISGRLEILEKSFIYFSLPDATETVKLKIFERFVTGGTFTNKTYHINNNNGVMFFDLYAFIQKTERLDSYKLDSISKNIFNCNVAIKEIDDTILTLEATVKDNSKDKLSIFSRVLETGNYITIGDNNVSKIVYKDINQDSFIIKVISNRDYEIGSVHNISFGKDDVDLKDMYKNYNLEIALDMERYCIHDACLCKYIWDYYRVPSKINAASSTYLLPQSLALEYRASTLIKGPLLKLLLEERVIYTRKITKVRYPYIGGKVFLPSQKTFENNVMIFDYNSLYPNVCIYGNLSPEKLVCILLNSNKLESEINMRTIKSKYPYPEYVCVSCESRLSDYYSEIIVYDRREKGIIPKLLEMFIGKRKEYKNLLKTASTTIESTLYDSLQYIYKIIANSVYGLMGFSNSTLYSYSSAKTCTTIGRNMITYLDSIMNGAVWENDKLILADFPRNIFSGETMFNKELEVPNMNESFKFRSVYGDTDSIFSEISTKDIEKTAKIAKHLEHIINTKILHANFKIEFEAIYTQLILQSKKKYTTIKYLANYKPGDKPIRVNKGTSETRRDVALFHKHMIQRYKDMLMKLLMESKGQQEITRLILQSLETDMISEFTHNREFEKYLLSRKHHNNYKSATHSNFELVKRYNLENTEKIEIGERYYYIYICDISLPWQKKLCNILSYEVIADSKFYLPKDKRIFYEIYFKRIASEVVNLLTDKTQCMLFFSRLFGTKPVFSSD

POL

DNA polymerase

986 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.419 kDa

MKIYSYNELKTRFAEYAKPGEFSITSADTFRIIRLHYDEKQGCLFAFCNTNIEKRVLQFYFKVKLNLYSYKQCYDKHIFPSCRNKCISYTTFVAPGVEGNCLNKINVIKYERNKAAPSDNAACLDKFLHNVNRVHMQTPFVEGAYMRFKKTQRCQNNYVGGSTTRMFNLQHFYEDFELVDEMTLTSGIMPVLSCYDIETHSDGHNMSKASVDCIMSIGFVVYKNDEYARFCFMYHKLPTEIPETHDDDTHVVMFQNEVDMITAFFDMIKITNPDVILDFNGDVFDLPYILGRLNKTKMLLKRYDLPAAAPTTKLFINKLGNKVDTYYFNYYIHIDLYKFFSSDSNQHKVENFQLNTISSYYLGENKIDLPWTEMVKMYNTRRLDVIAKYNVQDCMLPIKLFVKLKMADSVYSQCILHRLCTDDVICNISHLISVACFYAAITNTRINESTGKEEPDPYFFNKNDLSIISGQFNADKATAGISNLKRKLTPLKNIPKDAINLGPANQTVKYKGGKVLQPRASIYKNAFSLDFNSLYLTIMIAICACLSNLVLCEDGNVYLNHNSRAIVVKLLLKLLSERCKFKKNRDNQSESAFLYDLYDQKQNSVKRTANSIYGYYGIFYKVLANYITRVGRNQLRRAISLIEGLSNDPEILKKFNLNSIGFKVVYGDTDSTFVLPTFNYNEIFDETDTLKQICTHVETRVNSSFTDGYKMAFENLMKVLIILKKKKYCYLNSENKIVYKGWLVKKDMPVFMRIAFRTAVEQILRHLDINKCLQSLQASFYEYYDEFAKSKPMTDYSFSMTYNDNPGKKRKSADDNNEGPSPKRRVITVARHCREILVNKGTDFVPGNGDRIPYLLIDIEGKVTEKAYPLRLFDPVKMRISWIKHMGILCTFMNELLEIFGDEQKDNLAKCFTAIMQKYMQNQLYDRKEPVLVKINQKKCSVKRKRDDDDDNNDDDDDDGCDSSDSENDTQCANNTYKFCLYKIKK

POL

DNA polymerase

986 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.419 kDa

MKIYSYNELKTRFAEYAKPGEFSITSADTFRIIRLHYDEKQGCLFAFCNTNIEKRVLQFYFKVKLNLYSYKQCYDKHIFPSCRNKCISYTTFVAPGVEGNCLNKINVIKYERNKAAPSDNAACLDKFLHNVNRVHMQTPFVEGAYMRFKKTQRCQNNYVGGSTTRMFNLQHFYEDFELVDEMTLTSGIMPVLSCYDIETHSDGHNMSKASVDCIMSIGFVVYKNDEYARFCFMYHKLPTEIPETHDDDTHVVMFQNEVDMITAFFDMIKITNPDVILDFNGDVFDLPYILGRLNKTKMLLKRYDLPAAAPTTKLFINKLGNKVDTYYFNYYIHIDLYKFFSSDSNQHKVENFQLNTISSYYLGENKIDLPWTEMVKMYNTRRLDVIAKYNVQDCMLPIKLFVKLKMADSVYSQCILHRLCTDDVICNISHLISVACFYAAITNTRINESTGKEEPDPYFFNKNDLSIISGQFNADKATAGISNLKRKLTPLKNIPKDAINLGPANQTVKYKGGKVLQPRASIYKNAFSLDFNSLYLTIMIAICACLSNLVLCEDGNVYLNHNSRAIVVKLLLKLLSERCKFKKNRDNQSESAFLYDLYDQKQNSVKRTANSIYGYYGIFYKVLANYITRVGRNQLRRAISLIEGLSNDPEILKKFNLNSIGFKVVYGDTDSTFVLPTFNYNEIFDETDTLKQICTHVETRVNSSFTDGYKMAFENLMKVLIILKKKKYCYLNSENKIVYKGWLVKKDMPVFMRIAFRTAVEQILRHLDINKCLQSLQASFYEYYDEFAKSKPMTDYSFSMTYNDNPGKKRKSADDNNEGPSPKRRVITVARHCREILVNKGTDFVPGNGDRIPYLLIDIEGKVTEKAYPLRLFDPVKMRISWIKHMGILCTFMNELLEIFGDEQKDNLAKCFTAIMQKYMQNQLYDRKEPVLVKINQKKCSVKRKRDDDDDNNDDDDDDGCDSSDSENDTQCANNTYKFCLYKIKK

POL

DNA polymerase

985 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

112.581 kDa

MKILTYNQLQEAFRDYAPRDFAVSRDDAFRVMRIYYNEGGGNLVAFCNAQLGGRLAQFYFVMKMDLYSYKPCHNSHIFATCRNRCSSYNTFVAPGVKNVYMDKINVIKFKRNGSSFGEKTMALDKFLHNANRVHMQTPVIEGTYLRFRRAQRCRNNCVADDARPFALERFSDDFEVLDPSTLTTNIAPVMACYDIETHSDGHNSSKPECDVIMCIGLAVFKNDRFEKVCFVYHSEAVEIPQASDDTYVVVFNNENHMITAFFEFLKTVNPDVILDYNGDVFDLPYIRGRLKGDKPLLRRYDLPAMQPNTKLFITKIGNRTDTYYFNYYIHIDLYKYFGVDANKRDVENFQLNTLSQYYLGDAKVDLNWQTMVEMYNNKQLGTIIKYNVQDCLLPIRLFNKLKLTDFMYSQCIMYRLCTDDFICNISHLISSTFFHLALTNTRADPATGLTVSDPYFFNKDDLGLMSSKGSAGLTTGMSRLRRRRIPLKDVPATAIRLGAIDENVKYEGGKVLQPRAGVYEFAFSLDFNSLYLTIMIDICACLTNLILCEDGNVYLNQDKQAINVQLLLQLLKQRSELKKCRDSQTESEFLYDLYDQMQNLSKRTANSIYGYYGIFCKLLANHITRVGREKLTAAIGTVEGLSNDPDLLREFGLSTLTFKVLYGDTDSTFVLPVFRREEIPEEGRMATLGRICAAVEARVNGLFTNGYKMAFENLMSVLILLKKKKYCYINNNNKIVFKGWLVKKDMPVFMRVAFRAAIEQVLRHQDLSKCLDSLKANMLMYLDAFGITKPLTDYSFSMTYNDGAGKTAADDDEAAPPKRRVITVARHCREILVNKATDFVPGNGDRIPYVLLDMQGNVTQKAYPLRLFDAQTMRISWLKHMTILNTFMNELLEIFGDEHKDALAECYSAILEKYMQHQAYDKKRAALVKIATKRKAPSASDASGKRARKGAAPSDDESGSSEDEDAPCEPKCANNTFKFCLYKAQ

POL

DNA polymerase

985 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

112.581 kDa

MKILTYNQLQEAFRDYAPRDFAVSRDDAFRVMRIYYNEGGGNLVAFCNAQLGGRLAQFYFVMKMDLYSYKPCHNSHIFATCRNRCSSYNTFVAPGVKNVYMDKINVIKFKRNGSSFGEKTMALDKFLHNANRVHMQTPVIEGTYLRFRRAQRCRNNCVADDARPFALERFSDDFEVLDPSTLTTNIAPVMACYDIETHSDGHNSSKPECDVIMCIGLAVFKNDRFEKVCFVYHSEAVEIPQASDDTYVVVFNNENHMITAFFEFLKTVNPDVILDYNGDVFDLPYIRGRLKGDKPLLRRYDLPAMQPNTKLFITKIGNRTDTYYFNYYIHIDLYKYFGVDANKRDVENFQLNTLSQYYLGDAKVDLNWQTMVEMYNNKQLGTIIKYNVQDCLLPIRLFNKLKLTDFMYSQCIMYRLCTDDFICNISHLISSTFFHLALTNTRADPATGLTVSDPYFFNKDDLGLMSSKGSAGLTTGMSRLRRRRIPLKDVPATAIRLGAIDENVKYEGGKVLQPRAGVYEFAFSLDFNSLYLTIMIDICACLTNLILCEDGNVYLNQDKQAINVQLLLQLLKQRSELKKCRDSQTESEFLYDLYDQMQNLSKRTANSIYGYYGIFCKLLANHITRVGREKLTAAIGTVEGLSNDPDLLREFGLSTLTFKVLYGDTDSTFVLPVFRREEIPEEGRMATLGRICAAVEARVNGLFTNGYKMAFENLMSVLILLKKKKYCYINNNNKIVFKGWLVKKDMPVFMRVAFRAAIEQVLRHQDLSKCLDSLKANMLMYLDAFGITKPLTDYSFSMTYNDGAGKTAADDDEAAPPKRRVITVARHCREILVNKATDFVPGNGDRIPYVLLDMQGNVTQKAYPLRLFDAQTMRISWLKHMTILNTFMNELLEIFGDEHKDALAECYSAILEKYMQHQAYDKKRAALVKIATKRKAPSASDASGKRARKGAAPSDDESGSSEDEDAPCEPKCANNTFKFCLYKAQ

POL

DNA polymerase

984 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.308 kDa

MKIYPYNELKTRFAEYAKPGEFNITSADTFRIIRLHYDEKQGCLFAFCNTNIKERVLQFYFKVKLNLYSYKQCYDKHIFPSCRNKCISYTTFVAPGVEGNYLNKINVIKYERNKAAPSDNAACLDKFLHNVNRVHMQTPFVEGAYMRFKKTQRCQNNYVGGSTTRMFNLQHFNEDFELVDEMTLTSGIMPVLSCYDIETHSDGHNMSKASVDCIMSIGFVVYKNDEYAKFCFMYHKLPTQIPETYDDDTYVVMFQNEIDMITAFFDMIKITNPDVILDFNGDVFDLPYILGRLNKTKMLLKRYDLPAAAPTTKLFINKLGNKVDTYYFNYYIHIDLYKFFSSDSNQHKVENFQLNTISSYYLGENKIDLPWTEMVKMYNTRRLDVIAKYNVQDCMLPIKLFVKLKMADSVYSQCILHRLCTDDVICNISHLISVACFYAAITNTRINESTGKEEPDPYFFNKNDLSIISGQFKADKAAAGISNLKRKLIPLKNIPKDAINLGPANQTVKYKGGKVLKPRAGIYKNAFSLDFNSLYLTIMIAICACLSNLILCEDGNVYLNHNSRAIVVKLLLKLLSERCKFKKNRDNQSESAFLYDLYDQKQNSVKRTANSIYGYYGIFYKVLANYITRVGRNQLRLAISLIEGLSNDPEILEKFNLGSITFKVVYGDTDSTFVLPTFNYNEISNETDTLKQICTHVETRVNNSFTDGYKMAFENLMKVLILLKKKKYCYLNSENKIVYKGWLVKKDMPVFMRIAFRTAVEQILRHLDMDKCLQSLQTSFYEYYDEFAKSKSLTDYSFSMTYNDNPGKKRKSTDDNEGPSPKRRVITVARHCREILVNKGTDFVPGNGDRIPYLLIDIEGKVTEKAYPLRLFDPVKMRISWIKHMGILCTFMNELLEIFGDEQKDKIAKCFTAIMQKYMQNQLYDRKEPVLVKINQKKCSVKRKRDDDDDNDDDDDDDCDSSDSENDTQCANNTYKFCLYKMKK

POL

DNA polymerase

984 amino acids

Replicates the viral genome, host DNA polymerases cannot substitute for the viral enzyme in this process.

Belongs to the DNA polymerase type-B family.

114.308 kDa

MKIYPYNELKTRFAEYAKPGEFNITSADTFRIIRLHYDEKQGCLFAFCNTNIKERVLQFYFKVKLNLYSYKQCYDKHIFPSCRNKCISYTTFVAPGVEGNYLNKINVIKYERNKAAPSDNAACLDKFLHNVNRVHMQTPFVEGAYMRFKKTQRCQNNYVGGSTTRMFNLQHFNEDFELVDEMTLTSGIMPVLSCYDIETHSDGHNMSKASVDCIMSIGFVVYKNDEYAKFCFMYHKLPTQIPETYDDDTYVVMFQNEIDMITAFFDMIKITNPDVILDFNGDVFDLPYILGRLNKTKMLLKRYDLPAAAPTTKLFINKLGNKVDTYYFNYYIHIDLYKFFSSDSNQHKVENFQLNTISSYYLGENKIDLPWTEMVKMYNTRRLDVIAKYNVQDCMLPIKLFVKLKMADSVYSQCILHRLCTDDVICNISHLISVACFYAAITNTRINESTGKEEPDPYFFNKNDLSIISGQFKADKAAAGISNLKRKLIPLKNIPKDAINLGPANQTVKYKGGKVLKPRAGIYKNAFSLDFNSLYLTIMIAICACLSNLILCEDGNVYLNHNSRAIVVKLLLKLLSERCKFKKNRDNQSESAFLYDLYDQKQNSVKRTANSIYGYYGIFYKVLANYITRVGRNQLRLAISLIEGLSNDPEILEKFNLGSITFKVVYGDTDSTFVLPTFNYNEISNETDTLKQICTHVETRVNNSFTDGYKMAFENLMKVLILLKKKKYCYLNSENKIVYKGWLVKKDMPVFMRIAFRTAVEQILRHLDMDKCLQSLQTSFYEYYDEFAKSKSLTDYSFSMTYNDNPGKKRKSTDDNEGPSPKRRVITVARHCREILVNKGTDFVPGNGDRIPYLLIDIEGKVTEKAYPLRLFDPVKMRISWIKHMGILCTFMNELLEIFGDEQKDKIAKCFTAIMQKYMQNQLYDRKEPVLVKINQKKCSVKRKRDDDDDNDDDDDDDCDSSDSENDTQCANNTYKFCLYKMKK

POL

DNA polymerase

964 amino acids

Catalyzes DNA synthesis.

Belongs to the DNA polymerase type-B family.

114.819 kDa

MKLKKLYIFYFDIYEYFLCDLQLSETNEILKYIKNNIDKYTNSFNSSYIILKDFNIITNEVELQSYYNFTEDSKIKLNNTDLILFMTPYKIERIYSKYNRNFNQYRWFYILNNIEPAGSYKINMSNLQNINIYDKNKTAYYCKNPKLLFLTPIEIDKFIPVSRVSIDIECQHFGEFPTPNKFPISHICIDWFMESNINPVKKIITLINYEIIKNYKGEQKDRFIYTEIDELLTKDKVYITIYCTEKYMLHFILYTLRKDFDYILTYNGHSFDFTYIQGRRKFYNLNELCLVNAHKSNELKIYSYNKDTTYEIDSNNGIIFLDLYNYIKKIYNYNSYKLGEIAKERFNILSKIIDNGDEYIIMPLDTADNKNKVSIFYDVIRTANYCFINNIPYKIKDKTKIINDKEKLYDPISIENSLYQQFKIYKNNTPISDETTKVMLSKDDVDIGNKNAYVNFTKDKSDDIAYYCTHDTVLCNCIFKYDMIHDKVIAFSNEYLLPQYMSFKYKSTTNISGLLLKTLFCNRSMIVSGNLEFEKFEGGYVLEPKQKYIDSITAVFDFNSEYPSNIIEANLSPEKVEKVIKLQDDEYAVDIVENYLKEKYPYPDYCYMLIKKDKTYKFIVMDRRKPGIITQMIDKGMKSKNEYKNLKNINKNNPVLYNYYTSALYSKKITINSLYGLLGSERFDFNSPYCAEYCTALGQKCIKYIKNLVDKSRYIDNNLYLNEQNNPFSNEPVITRYSGNLDVNFTFYIIYGDTDSLFINIKFDNKFDNKEDLVNKSHECFQFLSNIINDEKNIILSKNFNFEYEKMYIWMLLLAKKKYIGEVVSSMNPLQLISDSKGTALIRRDCTEIHKTILKNTIDILKEYLTNNCTIQDVNNKINNYLMFTFKNIIENIQNLDINEFKKSVKYTGIYKDPNFYIELCVKKYNSKNPNDKIVKGQRFDFIYAHEIDIWDIETKKWNTKYTS

pol

RNA-directed DNA polymerase from mobile element jockey

916 amino acids

103.431 kDa

MTQPTLKIGLWNARGLTRGSEELRIFLSDHDIDVMLTTETHMRVGQRIYLPGYLMYHAHHPSGNSRGGSAVIIKSRLCHSPLTPISTNDRQIARVHLQTSVGTVTVAAVYLPPAERWIVDDFKSMFAALGNKFIAGGDYNAKHAWWGNPRSCPRGKMLQEVIAHGQYQVLATGEPTFYSYNPLLTPSALDFFITCGYGMGRLDVQTLQELSSDHLPILAVLHATPLKKPQRVRLLAHNADINIFKTHLEQLSEVNMQILEAVDIDNATSLFMSKLSEAAQLAAPRNRHEVEAFRPLQLPSSILALLRLKRRVRKEYARTGDPRMQQIHSRLANCLHKALARRKQAQIDTFLDNLGADASTNYSLWRITKRFKAQPTPKSAIKNPSGGWCRTSLEKTEVFANNLEQRFTPYNYAPESLCRQVEEYLESPFQMSLPLSAVTLEEVKNLIAKLPLKKAPGEDLLDNRTIRLLPDQALQFLALIFNSVLDVGYFPKAWKSASIIMIHKTGKTPTDVDSYRPTSLLPSLGKIMERLILNRLLTCKDVTKAIPKFQFGFRLQHGTPEQLHRVVNFALEAMENKEYAVGAFLDIQQAFDRVWHPGLLYKAKRLFPPQLYLVVKSFLEERTFHVSVDGYKSSIKPIAAGVPQGSVLGPTLYSVFASDMPTHTPVTEVDEEDVLIATYADDTAVLTKSKSILAATSGLQEYLDAFQQWAENWNVRINAEKCANVTFANRTGSCPGVSLNGRLIRHHQAYKYLGITLDRKLTFSRHITNIQQAFRTKVARMSWLIAPRNKLSLGCKVNIYKSILAPCLFYGLQVYGIAAKSHLNKIRILQAKTLRRISGAPWYMRTRDIERDLKVPKLGDKLQNIAQKYMERLNVHPNSLARKLGTAAVVNADPRTRVKRRLKRHHPHDLPNLVLT

pol

Pol polyprotein

895 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

98.588 kDa

TVALHLAIPLKWKPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLHDLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSVNNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHDGLEAAGEEVISTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDVQKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALERWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKLRASAVRTFGKEVDILLLPACFREDLPLPEGILLALKGFAGKIRSSDTPSIFDIARPLHVSLKVRVTDHPVPGPTVFTDASSSTHKGVVVWREGPRWEIKEIADSGASVQQLEARAVAMALLLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEVPGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAAQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDITQKDEVTKKDEASPLFAGISDWAPWKGEQEGLQEEVASNKQERPGEDTLAANES

pol

Intracisternal A-particle Pol-related polyprotein

867 amino acids

97.779 kDa

single

WKPRQTGSGFSLAAIGAARPIPWKTGDPVWVPQWHLSSEKLEAVIQLVEEQLKLGHIDPSTSPWNTPIFVIKKKSGKWRLLHDLRPINEQMNLFGPVQRGLPVLSALPRGWNLIIIDIKDCFFSIPLCPRDRPRFAFTIPSINSDEPDNRYQWKVLPQGMSNSPTMCQLYVQEALLPVREQFPSLILLLYMDDILLCHKELTMLQKAYPFLLKTLSQWGLQIATEKVQISDTGQFLGSVVSPDKIVPQKVEIRRDHLHTLNNFQKLLGDINWLRPFLKIPSAELRPLFWYLEGDPHISSPRTLTLAANQALQKVEKALQNAQLQAIEDSQPFSLCVFKTAQLPTAVLWQNGPLLWIHPNVSPAKIIDWYPDAIAQLALKGLKAAITHFGRSPYLLIVPYTAAQVQTLAATSNDWAVLVTSFSGKIDNHYPKHPILQFAQNQSVVFPQITVRNPLKNGIVVYTDGSKTGIGAYVANGKVVSKQYNENSPRMVECLVVLEVLKTFLEPLNIVSDSCYVVNAVNLLEGGWSDKPSSRVANIFQQIQLVLLSRSPVYITHVRAHSGLPTSAPWLSGNDLADKATSGGCSLSSPVEAAQEIFITTFHVTAEHYRSRNSLTRKEARDIVTQCQSCCEFLPVPHVGINPRGIRPLQVWQMDVTHVSSFGKLQYLHVSIDTCSGIMFASPLTGEKASHVIQHCLEAWSAWGKPRLLKTDNGPAYTSQKFQQFCRQMDVTHLTGLPYNPQGQGIVERAHRTLKTYLIKQKRELEEILPQHQESLSMALFTLNFLNIDVHGHTAAERQCSEPDRPNEMVKWKNVLHNKWYGPDPILIRSRGAVCVFHRMKTTHFGYQKDSPEKSRLTKGIPDVPRLW

pol

Intracisternal A-particle Pol-related polyprotein

863 amino acids

Belongs to the retroviral Pol polyprotein family.

97.037 kDa

single

LGAVEASRPIPWKTEEPLWVSQWPLSSEKLEAVTRLVQEQERLGHLEPSTSPWNTPIFVIKKKSGKWRLLHDLRAINNQMHLFGPVQRGLPLLSALPQDWKLIIIDIKDCFFSIPLYPRDRPRFAFTIPSLNHMEPDKRFQWKVLPQGMANSPTICQLYVQEALEPIRKQFTSLIVIHYMDDILICHKELDVLQKAFPMLVAELKQWGLEIASEKVQIADTGLFLGSKITPKNIVPQKIEIRKDHLQTLNDFQKLLGDINWLRPFLKIPSADLKPLFDLLEGEPHISSPRKFTPAAHRALQMVEEALQEAQITTNSPAKIIDWYPDAVAQPRSRIKAAVTHFGRDPDSLIVPYTAAQVQTLAATSSDWAVLVTSFSGQIDNHFPKHPILQFALNQAIVFPQVTAKDPLPDGTVVYTDGSKTGLGAYVVKDRVISKQYNETSPQVVECLIVLEVLEAFPGPLNIVSDSSYVVNAVNLLEIAGIIRSSSRVANIFQKIQAALLNRRFPVFITHVRAHSGLPGPMSLGNDLADKATKLVATALSTHAQAAKEFHKRFHVTAETLRRRFALSRKEAREIVTQCQNCCEFLPTPHMGINPRGIRPLQMWQMDVTHIPSFGRLQYVHVSVDTCSGVMFATPLTGEKASYVIQHCLEAWSAWGKPRIKTDNGPAYTSQKFRQFCRQMDVTHLTGLPYNPQGQGIVERAHRTLKSYLIKQKGSIEDVLPSVPRVAVSMALFTLNFLNCDAQGHTAADRHSLEPDRPKEMVKWKDVLTDLWKGPDPILIRSRGAVCVFPQEEENPLWIPERLTRRAPSQLQNKKDGGQVGDEDSPTRDDGSYDGRVTVGHHVYLPPTDASDAECPGVPIFHK

POL

Protein phosphatase 2C 32

856 amino acids

Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems.

Belongs to the PP2C family.

95.571 kDa

MGNGTSRVVGCFVPSNDKNGVDLEFLEPLDEGLGHSFCYVRPSIFESPDITPSNSERFTIDSSTIDSETLTGSFRNDIVDDPSFLNRHNSKGLAETTFKAISGASVSANVSTARTGNQMALCSSDVLEPAASFESTSSFASIPLQPLPRGGSGPLNGFMSGPLERGFASGPLDRNNGFMSGPIEKGVMSGPLDVSDRSNFSAPLSFRRKKPRFQRFMRSVSGPMKSTLARTFSRRSGGLSWMHRFFLHPETRVSWAVGKDGKLHGEDPESCLESNRNLQWAHGKAGEDRVHVVLSEEQGWLFIGIYDGFSGPDAPDFVMSHLYKAIDKELEGLLWDYEEPSEDNQLQPDQEPPTEENMCDPESISEQHSKSVVAESEEVMIDDISSLGNTDTQIADGPPGDSAGPGKKSMRLYELLQLEQWEGEEIGLKRYGGNVALNNMTNQVENPSTSGGGAGNDPCTTDRSALDGIPNSGQRHGTKKSQISSKIRRMYQKQKSLRKKLFPWSYDWHREEGICVEEKIVESSGPIRRRWSGTVDHDAVLRAMARALESTEEAYMDMVEKSLDINPELALMGSCVLVMLMKDQDVYVMNVGDSRAILAQERLHDRHSNPGFGNDEGIGHKSRSRESLVRIELDRISEESPIHNQATPISVSNKNRDVTSYRLKMRAVQLSSDHSTSVEEEIWRIRSEHPEDDQSILKDRVKGQLKVTRAFGAGFLKKPNFNEALLEMFQVEYIGTDPYITCEPCTVHHRLTSSDRFMVLSSDGLYEYFSNEEVVAHVTWFIENVPEGDPAQYLIAELLSRAATKNGMEFHDLLDIPQGDRRKYHDDVSVMVVSLEGRIWRSSGQYYPERKQKFNR

pol

DNA polymerase

824 amino acids

Belongs to the DNA polymerase type-B family.

96.755 kDa

MDLDYNSKDLCIDMYYKNCGLKKPEINLQKECEFKPYFYVDTSEPKEIYDYLDGLNQEIDLKKLEPEFENNTSLKVQDLITNIEIIEKIVYSDYILNGKDISEVSDFKNKKERKICKVYVKYPNHVKIIREYFKEFGKSYEFDIPFLRRYMIDQDIVPSAKYSEDNKIDNSIPELNCIAFDMELYCKKEPNAKKDPIIMVNLFSKDYQKVITYKKFENSEYNGCVDYVKDEKELIQKTIEILKQYDVIYTYNGDNFDFPYLKKRANIYEIELDFDNASNSQQPQIIKISKGGINRKSKIPGIIHIDLYPIARKLLNLTKYKLENVVQELFKINKEAVDYGDIPKMWETEDTTLLRYAYEDALYTYKMGNYFLPLEIMFSRIVNQPLYDTSRMNSSQMVEFLLLKRSFEQNMISPNRPSSSSYRERAKFSYEGGYVREPLKGIQEDIVSLDFMSLYPSILISHNISPETVIYEEKERENMELGIIPKTLNELLSRRKHIKMLLKDKIQKNEFDEEYSRLEHEQKSIKVLANSHYGYLAFPMARWYSDKCAEMVTGLGRKYIQETIEKAEEFGFKVIYADTDGFYAKWDYDKLQKGKKEENDKSDKLSNLPKLSKEELIILTKKFLKGINEELPEGMELEFEGHFKRGLFVTKKKYALIEDDGHIVVKGLEVVRRDWSNIAKDTQQAVIRALLEDGDVNLAKKIIKNTIDNLKKGNIDKNDLLIHTQLTKNIEEYKSTAPHIEVAKKIKQRGDSVRVGDVISYIIVKGSRSISERAELLEYAGDYDINYYIDNQVLPPVIRIMESLGISEDELKNSGKQFKLDQFM

pol

DNA polymerase

824 amino acids

Belongs to the DNA polymerase type-B family.

96.755 kDa

MDLDYNSKDLCIDMYYKNCGLKKPEINLQKECEFKPYFYVDTSEPKEIYDYLDGLNQEIDLKKLEPEFENNTSLKVQDLITNIEIIEKIVYSDYILNGKDISEVSDFKNKKERKICKVYVKYPNHVKIIREYFKEFGKSYEFDIPFLRRYMIDQDIVPSAKYSEDNKIDNSIPELNCIAFDMELYCKKEPNAKKDPIIMVNLFSKDYQKVITYKKFENSEYNGCVDYVKDEKELIQKTIEILKQYDVIYTYNGDNFDFPYLKKRANIYEIELDFDNASNSQQPQIIKISKGGINRKSKIPGIIHIDLYPIARKLLNLTKYKLENVVQELFKINKEAVDYGDIPKMWETEDTTLLRYAYEDALYTYKMGNYFLPLEIMFSRIVNQPLYDTSRMNSSQMVEFLLLKRSFEQNMISPNRPSSSSYRERAKFSYEGGYVREPLKGIQEDIVSLDFMSLYPSILISHNISPETVIYEEKERENMELGIIPKTLNELLSRRKHIKMLLKDKIQKNEFDEEYSRLEHEQKSIKVLANSHYGYLAFPMARWYSDKCAEMVTGLGRKYIQETIEKAEEFGFKVIYADTDGFYAKWDYDKLQKGKKEENDKSDKLSNLPKLSKEELIILTKKFLKGINEELPEGMELEFEGHFKRGLFVTKKKYALIEDDGHIVVKGLEVVRRDWSNIAKDTQQAVIRALLEDGDVNLAKKIIKNTIDNLKKGNIDKNDLLIHTQLTKNIEEYKSTAPHIEVAKKIKQRGDSVRVGDVISYIIVKGSRSISERAELLEYAGDYDINYYIDNQVLPPVIRIMESLGISEDELKNSGKQFKLDQFM

pol

DNA polymerase

781 amino acids

Belongs to the DNA polymerase type-B family.

89.851 kDa

MERVEGWLIDADYETIGGKAVVRLWCKDDQGIFVAYDYNFDPYFYVIGVDEDILKNAATSTRREVIKLKSFEKAQLKTLGREVEGYIVYAHHPQHVPKLRDYLSQFGDVREADIPFAYRYLIDKDLACMDGIAIEGEKQGGVIRSYKIEKVERIPRMEFPELKMLVFDCEMLSSFGMPEPEKDPIIVISVKTNDDDEIILTGDERKIISDFVKLIKSYDPDIIVGYNQDAFDWPYLRKRAERWNIPLDVGRDGSNVVFRGGRPKITGRLNVDLYDIAMRISDIKIKKLENVAEFLGTKIEIADIEAKDIYRYWSRGEKEKVLNYARQDAINTYLIAKELLPMHYELSKMIRLPVDDVTRMGRGKQVDWLLLSEAKKIGEIAPNPPEHAESYEGAFVLEPERGLHENVACLDFASMYPSIMIAFNISPDTYGCRDDCYEAPEVGHKFRKSPDGFFKRILRMLIEKRRELKVELKNLSPESSEYKLLDIKQQTLKVLTNSFYGYMGWNLARWYCHPCAEATTAWGRHFIRTSAKIAESMGFKVLYGDTDSIFVTKAGMTKEDVDRLIDKLHEELPIQIEVDEYYSAIFFVEKKRYAGLTEDGRLVVKGLEVRRGDWCELAKKVQREVIEVILKEKNPEKALSLVKDVILRIKEGKVSLEEVVIYKGLTKKPSKYESMQAHVKAALKAREMGIIYPVSSKIGYVIVKGSGNIGDRAYPIDLIEDFDGENLRIKTKSGIEIKKLDKDYYIDNQIIPSVLRILERFGYTEASLKGSSQMSLDSFFS

pol

DNA polymerase

781 amino acids

Belongs to the DNA polymerase type-B family.

89.851 kDa

MERVEGWLIDADYETIGGKAVVRLWCKDDQGIFVAYDYNFDPYFYVIGVDEDILKNAATSTRREVIKLKSFEKAQLKTLGREVEGYIVYAHHPQHVPKLRDYLSQFGDVREADIPFAYRYLIDKDLACMDGIAIEGEKQGGVIRSYKIEKVERIPRMEFPELKMLVFDCEMLSSFGMPEPEKDPIIVISVKTNDDDEIILTGDERKIISDFVKLIKSYDPDIIVGYNQDAFDWPYLRKRAERWNIPLDVGRDGSNVVFRGGRPKITGRLNVDLYDIAMRISDIKIKKLENVAEFLGTKIEIADIEAKDIYRYWSRGEKEKVLNYARQDAINTYLIAKELLPMHYELSKMIRLPVDDVTRMGRGKQVDWLLLSEAKKIGEIAPNPPEHAESYEGAFVLEPERGLHENVACLDFASMYPSIMIAFNISPDTYGCRDDCYEAPEVGHKFRKSPDGFFKRILRMLIEKRRELKVELKNLSPESSEYKLLDIKQQTLKVLTNSFYGYMGWNLARWYCHPCAEATTAWGRHFIRTSAKIAESMGFKVLYGDTDSIFVTKAGMTKEDVDRLIDKLHEELPIQIEVDEYYSAIFFVEKKRYAGLTEDGRLVVKGLEVRRGDWCELAKKVQREVIEVILKEKNPEKALSLVKDVILRIKEGKVSLEEVVIYKGLTKKPSKYESMQAHVKAALKAREMGIIYPVSSKIGYVIVKGSGNIGDRAYPIDLIEDFDGENLRIKTKSGIEIKKLDKDYYIDNQIIPSVLRILERFGYTEASLKGSSQMSLDSFFS

pol

DNA polymerase

775 amino acids

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

90.113 kDa

MILDVDYITEEGKPVIRLFKKENGKFKIEHDRTFRPYIYALLRDDSKIEEVKKITGERHGKIVRIVDVEKVEKKFLGKPITVWKLYLEHPQDVPTIREKVREHPAVVDIFEYDIPFAKRYLIDKGLIPMEGEEELKILAFDIETLYHEGEEFGKGPIIMISYADENEAKVITWKNIDLPYVEVVSSEREMIKRFLRIIREKDPDIIVTYNGDSFDFPYLAKRAEKLGIKLTIGRDGSEPKMQRIGDMTAVEVKGRIHFDLYHVITRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWESGENLERVAKYSMEDAKATYELGKEFLPMEIQLSRLVGQPLWDVSRSSTGNLVEWFLLRKAYERNEVAPNKPSEEEYQRRLRESYTGGFVKEPEKGLWENIVYLDFRALYPSIIITHNVSPDTLNLEGCKNYDIAPQVGHKFCKDIPGFIPSLLGHLLEERQKIKTKMKETQDPIEKILLDYRQKAIKLLANSFYGYYGYAKARWYCKECAESVTAWGRKYIELVWKELEEKFGFKVLYIDTDGLYATIPGGESEEIKKKALEFVKYINSKLPGLLELEYEGFYKRGFFVTKKRYAVIDEEGKVITRGLEIVRRDWSEIAKETQARVLETILKHGDVEEAVRIVKEVIQKLANYEIPPEKLAIYEQITRPLHEYKAIGPHVAVAKKLAAKGVKIKPGMVIGYIVLRGDGPISNRAILAEEYDPKKHKYDAEYYIENQVLPAVLRILEGFGYRKEDLRYQKTRQVGLTSWLNIKKS

pol

DNA polymerase

775 amino acids

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

90.113 kDa

MILDVDYITEEGKPVIRLFKKENGKFKIEHDRTFRPYIYALLRDDSKIEEVKKITGERHGKIVRIVDVEKVEKKFLGKPITVWKLYLEHPQDVPTIREKVREHPAVVDIFEYDIPFAKRYLIDKGLIPMEGEEELKILAFDIETLYHEGEEFGKGPIIMISYADENEAKVITWKNIDLPYVEVVSSEREMIKRFLRIIREKDPDIIVTYNGDSFDFPYLAKRAEKLGIKLTIGRDGSEPKMQRIGDMTAVEVKGRIHFDLYHVITRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWESGENLERVAKYSMEDAKATYELGKEFLPMEIQLSRLVGQPLWDVSRSSTGNLVEWFLLRKAYERNEVAPNKPSEEEYQRRLRESYTGGFVKEPEKGLWENIVYLDFRALYPSIIITHNVSPDTLNLEGCKNYDIAPQVGHKFCKDIPGFIPSLLGHLLEERQKIKTKMKETQDPIEKILLDYRQKAIKLLANSFYGYYGYAKARWYCKECAESVTAWGRKYIELVWKELEEKFGFKVLYIDTDGLYATIPGGESEEIKKKALEFVKYINSKLPGLLELEYEGFYKRGFFVTKKRYAVIDEEGKVITRGLEIVRRDWSEIAKETQARVLETILKHGDVEEAVRIVKEVIQKLANYEIPPEKLAIYEQITRPLHEYKAIGPHVAVAKKLAAKGVKIKPGMVIGYIVLRGDGPISNRAILAEEYDPKKHKYDAEYYIENQVLPAVLRILEGFGYRKEDLRYQKTRQVGLTSWLNIKKS

pol

DNA polymerase

775 amino acids

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

90.418 kDa

MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVKKITAERHGKIVRIVDVEKVKKKFLGRPIEVWKLYFEHPQDVPAIRDKIREHPAVVDIFEYDIPFAKRYLIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEGAKVITWKKVDLPYVEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPKMQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWETGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRKAYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVSPDTLNREGCREYDVAPEVKHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKMLDYRQRAIKILANSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYIDTDGLYATIPGAKPEEIKRKALEFVEYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDEEGKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEKLVIYEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEEFDPRKHKYDAEYYIENQVLPAVLRILEAFGYRKGDLRWQKTKQTGLTAWLNVKKK

pol

DNA polymerase

775 amino acids

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

90.113 kDa

MILDVDYITEEGKPVIRLFKKENGKFKIEHDRTFRPYIYALLRDDSKIEEVKKITGERHGKIVRIVDVEKVEKKFLGKPITVWKLYLEHPQDVPTIREKVREHPAVVDIFEYDIPFAKRYLIDKGLIPMEGEEELKILAFDIETLYHEGEEFGKGPIIMISYADENEAKVITWKNIDLPYVEVVSSEREMIKRFLRIIREKDPDIIVTYNGDSFDFPYLAKRAEKLGIKLTIGRDGSEPKMQRIGDMTAVEVKGRIHFDLYHVITRTINLPTYTLEAVYEAIFGKPKEKVYADEIAKAWESGENLERVAKYSMEDAKATYELGKEFLPMEIQLSRLVGQPLWDVSRSSTGNLVEWFLLRKAYERNEVAPNKPSEEEYQRRLRESYTGGFVKEPEKGLWENIVYLDFRALYPSIIITHNVSPDTLNLEGCKNYDIAPQVGHKFCKDIPGFIPSLLGHLLEERQKIKTKMKETQDPIEKILLDYRQKAIKLLANSFYGYYGYAKARWYCKECAESVTAWGRKYIELVWKELEEKFGFKVLYIDTDGLYATIPGGESEEIKKKALEFVKYINSKLPGLLELEYEGFYKRGFFVTKKRYAVIDEEGKVITRGLEIVRRDWSEIAKETQARVLETILKHGDVEEAVRIVKEVIQKLANYEIPPEKLAIYEQITRPLHEYKAIGPHVAVAKKLAAKGVKIKPGMVIGYIVLRGDGPISNRAILAEEYDPKKHKYDAEYYIENQVLPAVLRILEGFGYRKEDLRYQKTRQVGLTSWLNIKKS

pol

DNA polymerase

775 amino acids

Belongs to the DNA polymerase type-B family.

89.781 kDa

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLGRPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFDIETLYHEGEEFGTGPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFTLGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERVARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYAGGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQKIKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYADTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGLGAWLKVKGKK

pol

DNA polymerase

773 amino acids

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

89.812 kDa

MILDTDYITEDGKPVIRIFKKENGEFKIDYDRNFEPYIYALLKDDSAIEDVKKITAERHGTTVRVVRAEKVKKKFLGRPIEVWKLYFTHPQDVPAIRDKIKEHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFDIETLYHEGEEFAEGPILMISYADEEGARVITWKNIDLPYVDVVSTEKEMIKRFLKVVKEKDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGREGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWETGEGLERVARYSMEDAKVTYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRKAYERNELAPNKPDERELARRRESYAGGYVKEPERGLWENIVYLDFRSLYPSIIITHNVSPDTLNREGCEEYDVAPQVGHKFCKDFPGFIPSLLGDLLEERQKVKKKMKATIDPIEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGRQYIETTIREIEEKFGFKVLYADTDGFFATIPGADAETVKKKAKEFLDYINAKLPGLLELEYEGFYKRGFFVTKKKYAVIDEEDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIYEQITRDLKDYKATGPHVAVAKRLAARGIKIRPGTVISYIVLKGSGRIGDRAIPFDEFDPAKHKYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTRQVGLGAWLKPKT

pol

DNA polymerase

773 amino acids

Thermostable DNA polymerase. In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.

Belongs to the DNA polymerase type-B family.

89.989 kDa

MILDADYITEDGKPVIRVFKKEKGEFKIDYDRDFEPYIYALLKDDSAIEDIKKITAERHGTTVRVTRAERVKKKFLGRPVEVWKLYFTHPQDVPAIRDKIREHPAVVDIYEYDIPFAKRYLIDRGLIPMEGDEELRMLAFDIETLYHEGEEFGEGPILMISYADEEGARVITWKNIDLPYVESVSTEKEMIKRFLKVIQEKDPDVLITYNGDNFDFAYLKKRSEMLGVKFILGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLETVYEPVFGQPKEKVYAEEIARAWESGEGLERVARYSMEDAKATYELGKEFFPMEAQLSRLVGQSLWDVSRSSTGNLVEWFLLRKAYERNDVAPNKPDERELARRTESYAGGYVKEPEKGLWENIVYLDYKSLYPSIIITHNVSPDTLNREGCREYDVAPQVGHRFCKDFPGFIPSLLGDLLEERQKVKKKMKATVDPIERKLLDYRQRAIKILANSYYGYYAYANARWYCRECAESVTAWGRQYIETTMREIEEKFGFKVLYADTDGFFATIPGADAETVKNKAKEFLNYINPRLPGLLELEYEGFYRRGFFVTKKKYAVIDEEDKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSRHEVPPEKLVIYEQITRDLRSYRATGPHVAVAKRLAARGIKIRPGTVISYIVLKGPGRVGDRAIPFDEFDPAKHRYDAEYYIENQVLPAVERILRAFGYRKEDLRYQKTKQAGLGAWLKPKT

pol

Pol polyprotein

581 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

65.158 kDa

single

LEILAETHGTRPDLTDQPIPDADHTWYTDGSSFLQEGQRKAGAAVTTETEVIWARALPAGTSAQRAELIALTQALKMAEGKRLNVYTDSRYAFATAHIHGEIYKRRGLLTSEGREIKNKSEILALLKALFLPKRLSIIHCLGHQKGDSAEARGNRLADQAAREAAIKAPPDTSTLLIEDSTPYTPAYFHYTETDLKKLRELGATYNQSQGYWVFQGKPVMPDQFVFELLDSLHRLTHLGYQKMKALLDRGESPYYMLNRDKTLQYVADSCTVCAQVNASKAKIGAGVRVRGHRPGTHWEIDFTEVKPGLYGYKYLLVFVDTFSGWVEAFPTKHETAKIVTKKLLEEIFPRFGMPQVLGTDNGPAFVSQVSQSVAKLLGIDWKLHCAYRPQSSGQVERMNRTIKETLTKLTLATGTRDWVLLLPLALYRARNTPGPHGLTPYEILYGAPPPLVNFHDPEMSKFTNSPSLQAHLQALQAVQREVWKPLAAAYQDQLDQPVIPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGISAWIHAAHVKAATTPPIRPSWRVQRSQNPLKIRLTRGAP

pol

5'-3' exonuclease

302 amino acids

5'-3' exonuclease acting preferentially on double-stranded DNA.

34.883 kDa

MIIYKKNVNYLLIDGTSYLYRAYYAFLKFKNNFNKPCGAIYGMLNMLRSMLLKYPYSNIVVIFDSPQKTFRNELFIPYKKNRPKMPNDLKEQILPIHHIIKHIGIPIISIPHVEADDIIGTLATKLYKKKYFILISTNDKDLAQLVNIHIHVLIGTSNIVLDESKVKKKYGIIPKLIPDLLGLMGDNSDNIPGVPTVGKKTALILLKTFGSLENIYNNIEKIPKCLIKKAKTIYNNLHTYKKLAFLSQKLATIKTDINVNITTKKIKMLPPCTTEISNFFLHYKFYNWNKLLKQGLWLKNCK

pol

5'-3' exonuclease

302 amino acids

5'-3' exonuclease acting preferentially on double-stranded DNA.

34.883 kDa

MIIYKKNVNYLLIDGTSYLYRAYYAFLKFKNNFNKPCGAIYGMLNMLRSMLLKYPYSNIVVIFDSPQKTFRNELFIPYKKNRPKMPNDLKEQILPIHHIIKHIGIPIISIPHVEADDIIGTLATKLYKKKYFILISTNDKDLAQLVNIHIHVLIGTSNIVLDESKVKKKYGIIPKLIPDLLGLMGDNSDNIPGVPTVGKKTALILLKTFGSLENIYNNIEKIPKCLIKKAKTIYNNLHTYKKLAFLSQKLATIKTDINVNITTKKIKMLPPCTTEISNFFLHYKFYNWNKLLKQGLWLKNCK

pol

5'-3' exonuclease

287 amino acids

5'-3' exonuclease acting preferentially on double-stranded DNA.

33.047 kDa

MPYTKKKPIIIVDGSLYLYRSYFTFQNFNSNEENPSGAIYGMLKTIQNILNKNYNSKKIIIIFDSSKKNFRNTIFKEYKSNRSAMPNKLYVQIQPLFKILEEIGIKTLSILGIEADDIIGSLAYKLEQKGEQVLIVSHDKDMIQLITDNINVLNISKNSILTPEKIQEKYGIYPKEFIDLLALMGDSSDNIPGVPKIGIKTALFLLKKFSNIKNIYNNIEKIQSLPFRNAKNAAIQLKNYKKTAFLSYQLAKIKLDVPINITSEEITLKKTCFKKLSNLIRWYSFNE

pol

5'-3' exonuclease

287 amino acids

5'-3' exonuclease acting preferentially on double-stranded DNA.

33.047 kDa

MPYTKKKPIIIVDGSLYLYRSYFTFQNFNSNEENPSGAIYGMLKTIQNILNKNYNSKKIIIIFDSSKKNFRNTIFKEYKSNRSAMPNKLYVQIQPLFKILEEIGIKTLSILGIEADDIIGSLAYKLEQKGEQVLIVSHDKDMIQLITDNINVLNISKNSILTPEKIQEKYGIYPKEFIDLLALMGDSSDNIPGVPKIGIKTALFLLKKFSNIKNIYNNIEKIQSLPFRNAKNAAIQLKNYKKTAFLSYQLAKIKLDVPINITSEEITLKKTCFKKLSNLIRWYSFNE

POL

Retrovirus-related Pol polyprotein

246 amino acids

26.354 kDa

multiple

SAQPVRAFTPWVELLSLLLSKARTSAFRDFGKDLDIVHLPRFFRDSQILPDEILLALHGFGGKLRYAGSLPIFELARPLRVSLRLRVVASPLDGPTVFTDASSSTGQGAVVLTARTAPAAVLHVRSHSDVPGFFTTGNALADQHAGHKVLTVREADLHSTLHLGARALSRTCSIPMAVAREVVQACPHCNSAPALSAGVNPRGIAPLDVWQTDFTLEPRLAPRSWLAVTVDTASTVIVATQHGRAN

POL

DNA polymerase

214 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

23.869 kDa

single

EWKCIAQEYVKLNIAAKEKADKEKNQTIRSIAKLLSNALYGSFATKLDNKKTVFADQLDSSTAKGIANGEFSVKSSSFIETDCLSAEIMSELVVAYSPDTLLHPQQEGATEANTQETPTFIGPTDHVTYTYKPITFLEAEEDEICLQTIEKNSPLIPNDRYPSHIASFVLAWTRAFVSEWASLLYSEDLGTPMERRCLKSVYGDTDSLFLTEEG

POL

DNA polymerase

214 amino acids

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.

Belongs to the DNA polymerase type-B family.

23.869 kDa

single

EWKCIAQEYVKLNIAAKEKADKEKNQTIRSIAKLLSNALYGSFATKLDNKKTVFADQLDSSTAKGIANGEFSVKSSSFIETDCLSAEIMSELVVAYSPDTLLHPQQEGATEANTQETPTFIGPTDHVTYTYKPITFLEAEEDEICLQTIEKNSPLIPNDRYPSHIASFVLAWTRAFVSEWASLLYSEDLGTPMERRCLKSVYGDTDSLFLTEEG

Pol

Retrovirus-related Pol polyprotein

120 amino acids

13.302 kDa

single

PSLQAHLQALQAVQREVWKPLAAAYQDQQDQPVIPHPFRVGDTVWVRRHQTKNLEPRWKGPYTVLLTTPTALKVDGIAAWIHAAHVKAATTPPAGTASGPTWKVQRSQNPLKIRLTRGAP

pol

Pol polyprotein

116 amino acids

Integrase: Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions.

13.029 kDa

single

AHLHALYLVHHEVWRPLAAAYQHQLDRPIVPHPFRLGDTVWVRRHQTNNLQPRWKAPYTVLLTTPTALKVDGIAAWIHAAHVKAATTPPAGTASGPTWKVQRSQNPLKIRLTRGAP

pol

Pol polyprotein

100 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

11.075 kDa

single

AGLLAGSWIPDWTFVSVPPLVTLWYTLTKEPIPGEDVYYVDGACNRNSREGKAGYITQQGKQRVEKLENTTNQQAELTAIKMALEDSGPRVNIVTDSQYA

pol

Pol polyprotein

100 amino acids

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Belongs to the retroviral Pol polyprotein family.

12.024 kDa

single

KEALVIWGELPTLELPVEREVWEQWWADYWQVSWIPEWDFVSTPPWLKLWYTLTKEPLAKEDVYYVDGACNRNSREGKAGYITQYGKQRVEKLENTTNQQ