Protein
Pentalenolactone F synthase
Organism
Streptomyces arenae
Function
Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent oxidation of pentalenolactone D to pentalenolactone F in the biosynthesis of pentalenolactone antibiotic. Also able to catalyze the oxidation of pentalenolactone D to pentalenolactone E.
Similarity
Belongs to the TfdA dioxygenase family.
Sequence
MEVTPIPGAPLGAVVHGARVTGDMDKTHLEEIWSALDTYLVLVLRGHETPSYEEFLAFGRRFGHIPKTGLTSGAHPEHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYSFRPRVSQVGFLEAVEVPYSGGGETLFTDMYALYESLSPEERRRLHSFRVRHALRTGYEETIEEELQREVTLGEGADRIQPEDGTSTVHPLIARNPRTGRRSVYISTLNTERIVDLAPDDSRELLDGLLAHAGKPQYTYAHTWQPGDLVVWDQLGTVHAKQAFDPAERRVMRQVVSIFDDPAGPWRAEAAA