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plk-1

Gene
plk-1
Protein
Serine/threonine-protein kinase plk-1
Organism
Caenorhabditis elegans
Length
649 amino acids
Function
Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca (PubMed:10660671). In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes (PubMed:10660671). Zygotic role in the development of the germline and nerve cord (PubMed:10660671). In mitotic cells, plays a role in spindle organization and centrosome maturation (PubMed:20823068). Involved in asymmetric nuclear localization of cdc-25.1 during embryogenesis which affects cell division timing (PubMed:18305005, PubMed:18316412, PubMed:20823068). Together with plk-2, regulates cytoplasm polarity in early embryos (PubMed:18199581, PubMed:18316412, PubMed:18305005). May play a minor role in chromosome pairing and synapsis during oocyte meiosis I (PubMed:22018922).
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Mass
73.633 kDa
Sequence
MNRLPNIAKPPQKSNQRKEKAPPEVPALIADKDRGTYYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKVDNERILIHRELGHINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFFKSGFMPTRLPVSCLTMVPKFGGHETSMMEENVAPRGVDARSQRPLNGRAGLSALPQHIVSNNADRERAQQQAAEATFREPEDAYLSQLFHQVAVLLEQRIPGLEEEEAALDGYQSPECLPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDQAGNELTYIEKSNKEHYFSMHSGEMPGLLNKKVTLLKYFRSYMNDHLVKAGEGSEQRAGDDLARLPTLRVWFRTKSAIVLHLSNGTVQINFFNDHVKMMMCPLMQAVTFIDQNKRMLTYKLNNLQRNGCPEKFLHRLKYAKTMIERLMSDANVVSQNPARQPDMPRSMAAARSASAGSRGPNQAASHLPQSASGSNIHPRR