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piki-1

Gene
piki-1
Protein
Phosphatidylinositol 3-kinase piki-1
Organism
Caenorhabditis elegans
Length
1607 amino acids
Function
Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes.
Similarity
Belongs to the PI3/PI4-kinase family.
Mass
185.305 kDa
Sequence
MSDDEELQLAIEISKKTFKDEQKLRSNDLDLIRFESPDEPARQRKINQIKQLYEANSPGPSSYSGSLATSPIDFRPVYNEPRAGPIPHSQSYPRNYFQDWSAIASTSQPPAFPPPPRPPKPEQYKFPPAPSVPLLHDRYFVPPPPPVPPRHSRVQQSPPVPIHPTPPVSSTPLRHSAPSFASDSQQFLSPIKPFEISFNSTVDTSSNQTGSHDHSIQYQPLTHLYVPYVMHSLNSSYGALLNGDLIDLSAFEDSSNASQDEIRKEFDPLFISTYSTDTPSPDNSMPAVNAYFSKPIDEPECVGGAKLIQENIEFPSSSFCLIDCPNGIEEQVKKLCKRNLIRKDMTPDFFIAPTVDYMVTTASTVKVVVYKDHSWKANKSNGKAMICAIDEKMDIITTQALSLFDSELPTDKEYGLKIYGLNQFLSSDSLLGSNLYTGHCLLNGDDVKLDLGVFAPNSRIYEQTLESWNLMKSQVKYSTVVDKEDVENTLGHLASEMSQYEIAFNDGSTLKLSSSSQRVKQVIMLLCKCLHGIVPEKLYNEMQKYLASTTEDQLVHHRNDFLREIHSFLELYCRCTVSRYNIPPLQIITKPKVEVLSKMDFLQIMLNSVHSIPEHWQSQYSEFYMSLDLYHGTQVLDGFSNKVPKTIKNDHFFPRIPLDLYAKFKRLNLCQYPRETRIVVSISGTVRNSAQAANEYNPDIVMLGYCSVPLYDENLFMRQGPLFLPLTLLKKQPMLKPFGPYPYIKDARDPILIMSFKIWDTEIYFPNVVIDMQCIPQDFATLDIETQEYLLELIENQDTSTLETDDQDLIWQKRLHLTNQPEALPLVLSSLQDWSFGFVMRVYQILEEWAPLRPEIAMEFLLPKYPDERIRAHAVQSLARGSTDFLYHTIPQFIEALRFELYEKSALADFILELSFVSLDFTFEIYWQLQQRVDHCAVDDLPYAIRCQNLQQKMIDEHENPNLKTDIKLQHELLNELDSIQDDLRSKSGDSEIERLHRLRTRLGILDSKLLQNKVRLPICPAFDCTGVRIEECSVFNSNAKPLKIVFRGLNMNYSIIHKRDDDMRQDAFVMKMLNEMDRIWKSNGLDLRMITFRIMPVGYRRGMGELVLNCATLMEIQKEEGLRGVLNDEILRKWLMKHNSDEFAYKEAQENFIRSCAGWCIVTYVLGIGDRHNDNILFTKNGHVFHIDFGKYMGDWQMAAGFRRDRVPFVFTTEMFHVINNGRAPTQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDIPGINMDSLAFVENNLMLDLSDTDATVQFTAMIQNSLGSAFVRLNFVAHTVAQFISSRPSFSKQDPNKLSFVPELYTENSDGRISRVTVLKFEKHCIPNKIYMYKVEVHRKNVAVSSFIYRSFAEFEELHTKLRARFPMMAVSLNTISNLRSNVRAVAQKRIIHVQKFLIYLFNQVDEICHCDLVYTFFHSILRDNKCDTYIDESLDMPSQCQIYLKIEYNSVKETLSVFIGHAKYLALLQNNQQPDPYVKTYVRPDLRNQSKQKTQVVRGTRHPTFNQDLNYTEFPIEILSTRVLEVSIWNNGGYLVKHKMYMLCIPLLKVKKLAESRKNCRTLEGWFNCEKCV