Protein
Deoxyribonuclease Tat-D
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis (By similarity).
Similarity
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Sequence
MASIRQAFVKSLRFYDIGYNATDPVFRGIYHEKLKHPDDFDSIISRAKAVGVEKMMITGDNVENSEEALNLATNYECFTSTVGVHPCQAQCFLRHSEGPEDYLVKLEALANKGKASGKVVAFGEFGLDYDRLHYAPADVQKMYFEEQLKVAVRVQLPLFLHSRNAENDFFAILEKYLPELPKKGVVHSFTGSIDEMRRCIEHGLYVGVNGCSLKTEENLEVVRAIPLEKMLLETDAPWCEVRPSHAGHQFLKTKLPFDSCKKERFKEGCMIRGRNEPCNTYIVAEIVAALKDISLEELSEQIWENSINLLSK