Protein
Phosphonoacetaldehyde reductase
Organism
Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)
Function
Catalyzes the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate, a step in the biosynthesis of phosphinothricin tripeptide. Phosphinothricin tripeptide is both a natural-product antibiotic and potent herbicide. Can use both NAD and NADP but the preferred substrate is NAD.
Similarity
Belongs to the iron-containing alcohol dehydrogenase family.
Sequence
MTAVFPGELLLAEGIHEIARVTALLSGPLRRAPRVAQVVGPGFAGRPWAPRLTDALRPLDPTVVVHDGPTTPDSVAALARQLRAIRADVAVAIGGGTVMDAAKAAAALADGGPPDADRVRQACAAGPAAGDTPPAVRVVAVPTTAGTGAEATPFATLWDLKHRRKLSLTGPRVRPSAAVLAPELLAGLGRRALATGILDALCQGAEASWSIRSTPESIRWGTSAVTLAAEALDQVQDDAPDAAARLALQRAAHHSGRAIALAQTSSCHAISYPLTLRLGLAHGHACGVTLGRLLRYNHAVPAGDCADPRGTGHVRRVLDALAAPLGGTPARAALRVERFITACGLTPYDALDVDHRSLAAEAVTYPRCHDNPRRLDRESLGRLLGERSEMEETCG