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phpC

Gene
phpC
Protein
Phosphonoacetaldehyde reductase
Organism
Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)
Length
395 amino acids
Function
Catalyzes the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate, a step in the biosynthesis of phosphinothricin tripeptide. Phosphinothricin tripeptide is both a natural-product antibiotic and potent herbicide. Can use both NAD and NADP but the preferred substrate is NAD.
Similarity
Belongs to the iron-containing alcohol dehydrogenase family.
Mass
40.987 kDa
Sequence
MTAVFPGELLLAEGIHEIARVTALLSGPLRRAPRVAQVVGPGFAGRPWAPRLTDALRPLDPTVVVHDGPTTPDSVAALARQLRAIRADVAVAIGGGTVMDAAKAAAALADGGPPDADRVRQACAAGPAAGDTPPAVRVVAVPTTAGTGAEATPFATLWDLKHRRKLSLTGPRVRPSAAVLAPELLAGLGRRALATGILDALCQGAEASWSIRSTPESIRWGTSAVTLAAEALDQVQDDAPDAAARLALQRAAHHSGRAIALAQTSSCHAISYPLTLRLGLAHGHACGVTLGRLLRYNHAVPAGDCADPRGTGHVRRVLDALAAPLGGTPARAALRVERFITACGLTPYDALDVDHRSLAAEAVTYPRCHDNPRRLDRESLGRLLGERSEMEETCG