Protein
Serine/threonine-protein phosphatase 2A catalytic subunit A
Organism
Dictyostelium discoideum
Function
Plays a role in activating the myosin contractile function. Dephosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr-2029' in the C-terminal tail region of myosin II heavy chain (mhcA). Drives the assembly of dephosphorylated myosin II filaments to allow myosin recruitment into the cytoskeleton.
Similarity
Belongs to the PPP phosphatase family. PP-2A subfamily.
Sequence
MGEFQDVDKYISILKECKPLSESEVRDLCEKAREILSKESNVQPVRCPVTVCGDIHGQFHDLMELFKIGGNCPDTNYLFMGDYVDRGFYSVETVTLLVALKVRYKDRVTILRGNHESRQITQVYGFYDECLRKYGNPNVWKLFTDLFDYLPLTALIENQVFCLHGGLSPSIDTLDHIENLDRVQEVPHEGAMCDLLWSDPDDRLGFGYSPRGAGYTFGKDISEQFNHNNGLTLVARAHQLVMEGYNWCHDQNVVTIFSAPNYCYRCGNLAAIMEIDEKMKHTFLQFDPAPRRGEPHVTRRTPDYFL