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phactr4b

Gene
phactr4b
Protein
Phosphatase and actin regulator 4B
Organism
Danio rerio
Length
754 amino acids
Function
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
Similarity
Belongs to the phosphatase and actin regulator family.
Mass
84.195 kDa
Sequence
MENRDDEVEHQHSTMGSEGGTAGDGTPPPKRKGKFSTLGKIFKPWKWRKKKSSEKFKETSEVLERKMSMRRPRQELIEQGVLKELPDNESGEAHGHKAPYVKNGHTLPVGVGGSLALEQVHSPSESEFRINPVWLPQPEDRRARAPSDGDHRGALGPRASNQDDGRRGGWSVGTEDWKNNLAWHGEDIRRGGRAHAEMDKRPGLMKAPSEDGRRTRPEPDWKPTLPRHSSVEEGRGRRESDSSQYLPNSEMMRDTLREPLPPKQSIMPPKWLMTSTPEPGSDSLPRTPVHNPAAPSFCSSNSSSSSSAGKPLRNVSSAGANTAPPGGAPLTTSSAPCSMGTIPNHPSKQPPMPPPKPINRSNNPAIMAELTQGGMNLVPAKPSPPMPPKRTTPVTKRNPEDSPLTIASLPSILSEDMRANIPGGYQLPPPPPSPPLPTHIPPSPPRAHTHHLLHQHSYPYPLPQPLPVHFDPPSPPEDPPARDEDDYSDEEEEEEDDEDDEEPPPDHLPSPQSQPELEPRSRRCLVGELSVSVIPEGNNSSEEEEDEEDQHPEESDSDGPVLYKDDESDEDEEDDSPPSALASRVKRKDTLALKLSSRPSAPDRQAPERQAKSEHSGLSWQSKEQWEAIRTQIGTALTRRLSQRPTAEELEQRNILQPKNEADRQAEVREIKRRLTRKLSQRPTVAELQARKILRFHEYVEVTSAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESRIYTRFHRP