Protein
Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1
Organism
Caenorhabditis elegans
Function
Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
Similarity
Belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
Sequence
MRASTACLVALLAPFYISALPVEYFYGDEQQPIEEGAENSAVFEQDRELIGLFNPSKEIGQVSGLAVNKNGHIVAFHRSGRVWDEKSFNDHETFNKDLGVINNKTIAIISREKKVIDEFGAGLFYMPHGLTIDNNGDYWVTDVGSHQVHKIDAKTQKIVMSLGEKMVPGEDQAHFCKPTDVAVAKNGHIFVADGYCNSRILKFDAKGNLMAQINAATEENQPSEFVVPHSLSLIEDMNIVCVADRENQRVQCFSAGLSEGDRTLPTGIPITSATDIGRVFAIREREHYLIGVTGNSEDVEAQMFSIDMQTGKTETFAKGVRNTHALAIAADGVMFVSQLEPSRILEIRLL