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pgal-1

Gene
pgal-1
Protein
Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1
Organism
Caenorhabditis elegans
Length
350 amino acids
Function
Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
Similarity
Belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
Mass
38.593 kDa
Sequence
MRASTACLVALLAPFYISALPVEYFYGDEQQPIEEGAENSAVFEQDRELIGLFNPSKEIGQVSGLAVNKNGHIVAFHRSGRVWDEKSFNDHETFNKDLGVINNKTIAIISREKKVIDEFGAGLFYMPHGLTIDNNGDYWVTDVGSHQVHKIDAKTQKIVMSLGEKMVPGEDQAHFCKPTDVAVAKNGHIFVADGYCNSRILKFDAKGNLMAQINAATEENQPSEFVVPHSLSLIEDMNIVCVADRENQRVQCFSAGLSEGDRTLPTGIPITSATDIGRVFAIREREHYLIGVTGNSEDVEAQMFSIDMQTGKTETFAKGVRNTHALAIAADGVMFVSQLEPSRILEIRLL