Protein
Trans-4-hydroxy-L-proline dehydratase activating enzyme
Organism
Clostridioides difficile
Function
Catalyzes activation of the trans-4-hydroxy-L-proline dehydratase under anaerobic conditions by generation of an organic free radical on a glycine residue, via a homolytic cleavage of S-adenosyl-L-methionine (SAM). Is involved in the anaerobic degradation of 4-hydroxyproline.
Similarity
Belongs to the organic radical-activating enzymes family.
Sequence
MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYTKQVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVGQEYSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAIDTCGYAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGANINIRIPLIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEELQRPSEEKLEEIKRLFEASNFNTKIGG