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perR

Gene
perR
Protein
HTH-type transcriptional regulator PerR
Organism
Escherichia coli (strain K12)
Length
297 amino acids
Function
Apparent regulatory gene involved in peroxide resistance in stationary phase.
Similarity
Belongs to the LysR transcriptional regulatory family.
Mass
33.639 kDa
Sequence
MKLLAKAPLNLLRAFEAAGRTGAFALAASELELSPSAISHAIRKLENLLDVRLFQRSTREITLTKEGEILLEHIQRGFNELQQGLALVTADESRPLRLHTAPSFAHQWLLPRLGKFIRENPSIDLRLSASTEYARFEQDDFDLDIVYGEPRPSPYEKIPLAVEELTPLCSPQLAERLKKPEDLYALTLIQCDVQLYQWKGWFEANKMTPPNNYGLRFDRSFMAIAAAVDGLGVVLESKLLAEREIASGKLVCPLVNSTSEIHYIGHYLVFPQHQHMHSALDVFKTWLLNELNLGKIR

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
150 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.28 kDa
Sequence
MSAELESIDHELEESIASLRKAGVRITPQRQAIMRYLISSHSHPTADEIYQALSPKFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEKCGKIVDFHYPQLDEVEQLAQHVTDFDVTHHRMEIYGVCKECKEEGN

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
150 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.28 kDa
Sequence
MSAELESIDHELEESIASLRKAGVRITPQRQAIMRYLISSHSHPTADEIYQALSPKFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEKCGKIVDFHYPQLDEVEQLAQHVTDFDVTHHRMEIYGVCKECKEEGN

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
150 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.301 kDa
Sequence
MSAELESIDHELEESIAALRRAGVRITPQRQAIIRYLIASHSHPTADEIYQALSPDFPNISVATIYNNLRVFKSIGIVKELTYGDASSRFDFNTHNHYHVICEKCGKIVDFHYPQLDEVEQLAQHITEFDVTHHRMEIYGICKECKDKEE

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain USA300)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection.
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain COL)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.197 kDa
Sequence
MSVEIESIEHELEESIASLRQAGIRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain N315)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.197 kDa
Sequence
MSVEIESIEHELEESIASLRQAGIRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain MRSA252)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain MSSA476)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus aureus (strain MW2)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.183 kDa
Sequence
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK

Gene
perR
Protein
Peroxide-responsive repressor PerR
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
148 amino acids
Function
Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity).
Similarity
Belongs to the Fur family.
Mass
17.043 kDa
Sequence
MSAELETIEHQLEDSITSLRNNGVRITPQRQAILKFLIASHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELPYGDSSSRFDFSTHNHYHVICEQCGKIVDFHYPQLDEVEQLAQHVTDFNVTHHRMEIYGLCKDCQDK

Gene
perR
Protein
Peroxide operon regulator
Organism
Bacillus subtilis (strain 168)
Length
145 amino acids
Function
Hydrogen and organic peroxide sensor. Represses the expression of a regulon of peroxide-inducible genes such as katA, ahpC, ahpF, the heme biosynthesis operon (hemAXCDBL), fur, perR, zosA and mrgA.
Similarity
Belongs to the Fur family.
Mass
16.424 kDa
Sequence
MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIYKALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKIVDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH

Gene
perR
Protein
Transcriptional regulator PerR
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
138 amino acids
Function
Represses the expression of most of the genes involved in oxidative stress response, such as rbr3A-rbr3B, dfx, rd, nror, fprA1 and fprA2, coding for reverse rubrerythrins, desulfoferrodoxin, rubredoxin, NADH-rubredoxin oxidoreductase (NROR), and oxygen-reducing flavoproteins, respectively. Thus, by controlling primarily oxygen and reactive oxygen species (ROS) scavenging, PerR plays an important role in the oxidative stress defense system in C.acetobutylicum, an obligate anaerobic bacterium. Probably acts as a peroxide sensor.
Similarity
Belongs to the Fur family.
Mass
15.672 kDa
Sequence
MNDISTIFKEKKLKLTPQRIAVYKYLKSTHEHPSAETIYKAIQSDYPTMSLATVYKALKTLAEVHLIQELNVGEGNFRYDANSSSHPHIQCLSCGKVDDIMGITFDNLNKDVSSHTDYDVISNKLYFYGICKDCKDKA