per

Period circadian protein

1271 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

135.42 kDa

MEGESTESTQNTKVSDSAYSNSCSNSQSQRSGSSKSMLSGSHSSGSSGYGGKPSIQTSSSDMAIKRNKEKSRKKKKAKCTQAQATISSSLEGAEEQPHSSGTTCDQKILHVLATTQQLGDQPSSLDHKLGEQLEARHNCGVGKAEQPQSFSLPCPLSVSTLMPGIGVCHGGNAPGGKWEKTFESCKLDTGPAKTERVKEDSFCCVISMHDGIVLYTTPSITDVLGFPRDMWLGRSFIDFVHTKDRATFASQITTGIPIAESRCSMPKDARSTFCVMLRQYRGLQTSGYGVIGRSVNYEPFRLGMSFREAPEEERSDNYMVANSSNMLLVICATPIKSSYRVPEEIHSQRSPKFAIRHTAAGIISHVDSAAVSALGYLPQDLMGRSIMDLYHHDDLPVIKEIYESVMKKGQTAGASFCSKPYRFLIQNGCYILLETEWSSFVNPWSRKLEFVVGHHRVFQGPKICNVFETPPNSEPKIAEELQNKNTRIKEEIVNLLAEKVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSIETPPSYNQLNYNENLLRFFNSKPVTAPVEVDPPKVGSSDVSSTREDARSTLSPLNGFEGSGASGSSGHLTSGSNIHMSSATNTSNAGTGTGTVTGTGTIIATSGTGTVTCASGNMDANTSAAFNIAANTSAADNFGADTSAADTSGADTSAADNYAVDNYGPGNFGAENSCADNSGAENSCADNSGVDNSRPGNSGADNSAADNFGADNSGPDNSGADNSGPDNTGPDNSGAENSRAENSRADNSRPDHPRPDISGASNSRPDKTGPDKSGAENSASGSGSGTSGNEGPSSGGQDTRTTAGTPDSPPVSLTESLLNKHNDEMEKFMLKKHRESRGDRRTVEKNKNKTTNTIDSLKILEYSSTGPGHGTKRGGSYSWEGEGNKPKQQPTLNSVGVGTGAPEAPIPPVHPTHTTHTAIAQSSFSAQQSLFPTFYYIPATPLAASTPAPGALSPTPRNQKHHHHAHQHAPKVPDQASTSQQAAGPAAIPLQYVTGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGIANAMQLPEQPSTSQSNYSKTVFSVIVAPPTITTTTATTTPKTQGAFHSITPAQLQRPSSQDTSVKTEPASNATPSHSSNKKKANSSIASGIGDYNSNQACSRNRANVKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDNDKEAKHRKLKNITRLSSKIMEHPEEDQTQHGDG

per

Period circadian protein

1224 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).

127.852 kDa

MEGGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGTASSSKGGTAAIPPVTLTESLLNKHNDEMEKFMLKKHRESRGRTGEKSKKSANDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKEVPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEHPEEDQTQHGDG

per

Period circadian protein

1208 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

126.82 kDa

MEGGESAESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAGQSLISASTSLEGGAEEKPRPSGSGCGVEQQSCRELLQDQQHGEDHSEPKATEQLQQEEGDRSGSESEAERVENAAKSEAAQSFPIPSPLSVTIVPPSMGGCAGVGHAASLDSGLAKLDKTWEAGGPGKVEPVPGVPGTAAAGTGQRGERLKEESFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDTKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKIPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHQEDLSVMKETYEMVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKSCNVFEAAPTCKLKMSEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKLELPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGSASSNYRGGSVAIQPVTLTEALLNKHNDEMEKFMLKKHRESRGRSGEKSKKSATDTLKMLEYSGPGHGIKRGGSHSWEGEANKPKQQLTLGTDAIKGVVGGSGGVVGTGGGAGVAGGGGTGTGLAGTSDGRLTMSSGAGGVVGGPGGAAAAAGVISSVGSSMPGPSSYPTCTQNINLWPPFSVGITPPVHSTHTAMAQSSFSSAGLFPTFYYIPASLTPTSPTRSPRMHKHPHKGGPEMPTTSQQAAAAAAQAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFTGMTNALQIPERPLGSQSAYNKSMYTTTPPSMAKKVPGAFHSVTTPSQVQRSSSQSASVNAEPGCSASVSDPCKKEAPGSSPIPSVMGDYNSELPCSSSNPANNKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDIEKDPKHRKLKSMSPSDSKIMEHPEEDQTQHGDG

per

Period circadian protein

1093 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

115.896 kDa

single

NKDKSRKKKKPKCIALATATAVSLEGTRESPLPASGSCEKVLQELQDTQQLGEPLVVTETQLSEQLLETEQNEDQNKSEQLAQFPLPTPIVTTLSPGIGPGHDCVGGASGGAVAGGCLVVGAGTDKTSELIPGKLESAGTKPSQERPKEESFCCVISMHDGIVLYTTPSISDVLGFPRDMWLGRSFVDFVHHKDRATFASQITTGIPIAESRGCMPKDARSTFCVMLRRYRGLNSGGFGVIGRAVNYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKDTYETVMKKGQTAGASFCSKPYRFLIQNGCFVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKLCNVFETSVSAKPKISEEAQNRNARIKEDIVKLLAETVSRPSDTVKQEVSRRCQALANFMETLMDEITRADLKLDLPHENELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGADGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGDKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTGGGGGGGGGGGGGGGGGLPLFLDVTHTSSSSQNKGPTGVAAGGAGGGVGGGGGSCSGLGGNGNVGSGNGNNSQPSTNQYTQSGLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSSTNTNPNRPHKHAHVHSSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMVYQPVPFAGVANPMQLPEQASKNVYTTQPVMVAPPTATNKTQGAFHSITPAPPQRPSSQATSVKAETGSNVAPSDTSKKEVPDSPITPTMGDFTLDQPCNNNATTLKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPENDKDAKHRKLKSLDQSDNKIVEHPEEDQTQHG

per

Period circadian protein

1087 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

118.081 kDa

MEGESTESTHNTKVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMAVKRNKDKSRKKKKAKSPAQATAATTTTIKSLEQTEEPLLVKPNNGSCEQQLELQDAQQLGAPTPSDAHDAHGDKPQLDVDEQQDDPQAEQIQQLETATAATISPDTMSASVTVTIDGCTSMEKTCEWTDRPGRLEAHAACIGKQHVQQQQHDRVKEDSFCCVISMHDGVVLFTTANLNEMLGYPREMWLGRSFIDFVHIKDRATFASQITTGIPIAESRCSQSKDARTTFCVMLRRYRGLASGGFGIIGRPVSYAPFRLGLTFREAPEEVQPDGCTLSNATSMLLVISATPIKSCYKEPDEFLSPKGPKFAIQHTAAGIISHVDTAAVSALGYLPQDLIGRSILDFYHHEDLSDIKDIYEKVVKKGQTVGATFCSKPFRFLIQNGCYILLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCDVFEMSPNVTPNIPEDEQNRNACIKEDILKMMTETVTRPSDTVKQEVSRRCQALASFMETLMDEVARGDLKLDLPHETELTVSERDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNENLLRFFNSKPVTAPVDTDPPKMDSSYVSSAREDALSPVHGFEGSGGSGSSGNLTTASNVRMSSVTNTSNTGTGTSGGENSASGSSNPLPVNMTLTEILLNKHNDEMEKCMLKKHRESRGRTGDKTKKSVIEKMPEYSGPGHGQTMKRGGSHSWEGDANKPKQQLTLSAVVVAPTVSVSPAEDSQTTAKWQAPMTGSHLFQSSYNFPQSINLWPPFSLGLTTPTVHTTHTSMAQKSFSPQHNLFPAFYYIPAPLATATAGSAAAQTSVSSASAAQHSPKSSENPSTSQPEATAATAMPMPYMAGVMYPHPSLFYAYQPMPFPSVSGAVQMSVQSSGSQSNNNNKSIYTMAPASTTTQKPGAFHSITPAELNKPDAPDTLLHTETSPKISVQEAPKKELSDLPSTSARRGSSSDQRNNSNNPKKYTDSNGNSDDMDGSSFSSFYSSFIKTTDGSESPPDNEKETKVHKLKPIVEHPEEDQTQHGDG

per

Period circadian protein

893 amino acids

Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

97.174 kDa

MEETATHNTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPSVTKRNKDKEHKKKKLKSSVTTAATATVTSVVTTVSEYTEHENGTSHMSLGVSGTVVPLSGTVAEETEITEAGSEGSVISSHAGVALGAAGVVPATTPGPENEAHQMASLTQTLNSIKKMKKMKDLSTDIPEETEGHSFSLPMVAEEKEEHIRNSFDAEPPAHNEGEFCVVVSMQDGVVVFTTPSITDVVGFPKDMWLGRSFIDFVHPRDRTAFANHITSGVITPLSNSNPKGGSHPGKNSFYCCLRRYRGLKSTGYGVTEKEVSYLPFQLNMTFRELLPHSNPLEVEGNTSPESVPGGCNSMFLVITAKLICSAYKHAGETCASPKFVTRHLATCKLNYVDPECMPYLGYLPHEMLGNSVLDFYHPEDLPFLKEVYQIVMQENGAPFRSKPYRFRSHNGGYILLETEWSSFVNPWSKKLEFVVGQHRVLKGPENADVFMAPVEDDTLQISEEVLKESKIIQEEIRSLLSEMVKNNGHLEKQQMSKRCRDLATFMESLMDDITKPDLKLELPQEEHSFSEHDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNDNIQRFFESKPKTTLSDESGESKIEANRSLMSTDEEGKSGPAADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYKPPLLTEALLCRHNEDMEKKMVQKHREQRNKGSERESKLKKCVHDKLLQEQCHGVKRSGSHSWEGEVYKASKHPHVEGGKELNPGSGGSGGGGVTSGLSQCLGVAATGKQYSGVGSVPPIFQGGTNVNLWPPFSVTVTPLQPTPPCSTHGFATNNIPTPPHMASMIPVYYIEKRAPNFKNN

per

Period circadian protein

849 amino acids

Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity). Expression exhibits prominent circadian variation in adult heads and in particular in the photoreceptor nuclei.

94.799 kDa

MNNMDGSENNAKVSDSAYSNSCSNSQSRRSHSSKSTHSGSNSSGSSGYGGQPSTSSSSNDLSDQKKEKELKKKKQVETLMPDTQIEVECRPEEDVINIPSEEGGAADDVLVPSPKQTLQTDNDIADIEVAIPDTNNDKEEAIVYNTSLINPGTACPFGRPALSNCNGFSCVISMHDGVVLYATASLTSTLGFPKDMWVGRSFIDFVHPRDRNTFASQITNELAIPKIVSLTEETDQTMENPGSTMVCRIRRYRGLSCGFSVKNTTTAYLPFLLKFKFKNVNEDKGNVIYLVIQAVPFFSAFKTSNEVLAKTVSFVIRHSADGNLEYIDAESVPYLGYLPQDITNRDALLLYHPGDLGYLQEIYGSLVKEGNVTRSKTYRMMTQNGHYMKVETEWSAFINPWSKKLEFVTGKHYIIEGPANPDVFQNPENVLKLTEEQKNQAKMYRDSIIRIMKDVLTKPAEIAKQQMSKRCQDLAHFMEMLIEEQPKPVDDLRLEIQDADHSYYERDSVILGGISPHHEYDSKSSTETPLSYNQLNYNDNLQRYFNSHQSNAFVDNNLLPSRNPLYLSAPHFSESIKNVPSAMEYSGDVIDLTGPGETSGVIVFNKSPTMGLKTGKPIRLTESSLTKHNAEMEKELMKIHREHRCYSKGDRVKVSNEARQKKKEHLARCNAGFQTISAANNTPSVYEKPHNLKRSSKQMESEPIANKHHCPSSRQFRRKQTTCSGGFAQPPSATNPVSTSSQWSSSPVNNVNPFILGVRMQPPMPILSPLPVVSGMFPMYYTPVTATVTTSEGRPSEPNYHRNNMNNNQFQQPLGNSRLPTTICVIQCGTSRIIHSFRGTRTTGGTRYT

per

Period circadian protein

676 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

71.004 kDa

multiple

KVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQATEQLQQEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSCTGTGTTSSSRGGSAAIPPVTLTESLLNK

per

Period circadian protein

661 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

69.678 kDa

multiple

KVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQAAEQLQQEEDQSGSESEADRVEGVAKSEAVQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTTSSSRGGSAAAPPVTLTESLLNK

per

Period circadian protein

656 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

69.118 kDa

multiple

KVSDSAYSNSCSNSQSQRSGSSKSRLSGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGTGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCVEQQICRELQDQQHGEDHSEPQATEQLQQEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVTIVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKEDSFCCVISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSVPKDAKSTFCVMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRCQALASFMETLMDEVSRADLKSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGTNSGTGTGTTSSSRGGSTAIP

per

Period circadian protein

396 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

40.198 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGANGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTIGGGGGGGVGGGMPLFLDITHASSSSQNKGLAGVGVGGAGGVVGGGGSGTGLGGNGNVGSGNGNNNQPSTNQYTQSRLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSSTNTNPNRPHKHAHVHNSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

396 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

40.214 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGANGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTSGGGGGVGVGGGMPLFLDITHASSSSQNKGLAGVGVGGAGGVVGGGGSGTGLGGNGNVGSGNGNNNQPSTNQYTQSRLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSSTNTNPNRPHKHAHVHNSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

395 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

40.062 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGADGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTSGGGGGGGGGGGMPLFLDMTHASSSSQNKGLAGVGVGGAGGVVGGGSGTGLGGNGNVGSGNGNNNQPSTNQYTQSRLPCTQNINLWPPFSVGITTPTSVLSSHTAVPPSSFSPQHSLFPTFYYIPASIAASSPSGTNTNPNRPHKHAHVHNSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

391 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

39.76 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGADGPGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANDAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNTGGGGGGMPPFLDIQHTSSSTQNKGLAGVGVGGAGGGVVGVGSSAGGNGSGTGNNNGNGNNNQPTTNQFTQSGLSCTQNINLWPPFSVGITTPTSVLSSHTAVAQSSFSPQHSLFPTFYYIPASIAASSPSGTSPNPNRPHKHAHVHSSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

390 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

39.544 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVESSYVSSARGEDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGGADGTGSGAAPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANEAMKMLEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNPSGGGGGMPLLLDITHTSSSTQNKGLAGVGVGGAGGGVGGGGSGTGLGGNGNVGSGNGNNNQASTNQYTQSGLPCTQNINLWPPFSVGITTPTSVLSSHTAVAQSSFSPQHSLFPTFYYIPASIAASSPSGTNPSPNRPHKHAHVHSSSEKPSTSQAAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

385 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

39.104 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVPVELDPPKVESSYVSSAREDARSTLSPVQGFEGSGGSGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGDGGGGGAGDGPGSGAVPPVTLTESLLNKHNDEMEKFMLKNDRESRGWSGEKNKKSANDTLKMVEYSGPGPGHGHGIKRGGSHSWEGEANKPKQQLTLNAGGMPPLVDIHASSSSLSKCQTSVAGGGGGGGAGSASGTCGTGNNGAGGGGGSNAQSSTNQYTQSGLSCTQNINLWPPFSVGITTPTSVLSTHMAVAQSSFSPQHSLFPTFYYIPASIAASSPASGTSPNPRPHKHTHVHPSSEQPSTSQGAAATMPLQYMTGVMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

375 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

38.368 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVEPSYVSSAREDAHRTLSPVQGFEGSGGTGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGGGGGGGGGGGPGNGAVTPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANDTLKMVEYSGPGPGPGHGHGIKRGGSHSWEGEANKPKQLLTLNTGGMPPLLDIHTSSASLSKCQASGAGGGGSGSVGGTGNIGSGGSNAQPSTNQYAQSGLSCTQNINLWPPFSVGITTPTSVLSTHTAVAQSSFSTQHNLFPTFYYIPASIAASSPSGTSPNPRPHKHTLVHKSAEQPSTSQAAAATMPLQYMTGLMYPHPSLFYTHPAAAAATAMV

per

Period circadian protein

375 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

38.358 kDa

single

SSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKVEPSYVSSAREDARSTLSPVQGFEGSGGTGSSGNFTTGSNLHMSSVTNTSNAGTGTSGTGNSGGGGGGGGGAGPGNGAVPPVTLTESLLNKHNDEMEKFMLKKHRESRGRSGEKNKKSANDTLKMVEYSGPGPGPGHGHGIKRGGSHSWEGEANKPKQLLTLNTGGMPPLLDIHTSSASLSKCQASGAGGGGSGSVGGTGNIGSGGSNAQPSTNQYTQSGLSCTQNINLWPPFSVGITTPTSVLSTHTAVAQSSFSTQHNLFPTFYYIPASIAASSPSGTSPNPRPHKHTLVHKSAEQPSTSQAAAATMPLQYMTGLMYPHPSLFYTHPAAAAATAMV

per

GDP-perosamine synthase

371 amino acids

Catalyzes the synthesis of GDP-perosamine from GDP-4-keto-6-deoxy-D-mannose and L-glutamate. Can use only L-glutamate as amino donor. In vitro, can also use GDP-4-keto-3,6-dideoxymannose to produce GDP-3-deoxyperosamine. Involved in the formation of S-LPS, which is required for attachment of the protein S-layer to the outer membrane surface.

Belongs to the DegT/DnrJ/EryC1 family.

40.637 kDa

MSDLPRISVAAPRLDGNERDYVLECMDTTWISSVGRFIVEFEKAFADYCGVKHAIACNNGTTALHLALVAMGIGPGDEVIVPSLTYIASANSVTYCGATPVLVDNDPRTFNLDAAKLEALITPRTKAIMPVHLYGQICDMDPILEVARRHNLLVIEDAAEAVGATYRGKKSGSLGDCATFSFFGNKIITTGEGGMITTNDDDLAAKMRLLRGQGMDPNRRYWFPIVGFNYRMTNIQAAIGLAQLERVDEHLAARERVVGWYEQKLARLGNRVTKPHVALTGRHVFWMYTVRLGEGLSTTRDQVIKDLDALGIESRPVFHPMHIMPPYAHLATDDLKIAEACGVDGLNLPTHAGLTEADIDRVIAALDQVLV

per

Period circadian protein

358 amino acids

Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

40.93 kDa

single

GVVMYTTSSITATLGFPKDMWIGRSFIDFLHPKDANTFASQITNGLAIPKIVNDTQEKAQIFGTQGSTMVCRIRRYRGLSSGFGVKDTSVSYMPFLLKFRFRNISDDKGLVVYLVIQTVPFFSAYKTPNEILTQEVSFIMRHSANGNLEYIDPDCVPYLGYIPQDITNRNALVLYHPGDLPFLQEVYQAIVKEGSVTRSKSYRMVTQNGHFIKVETEWSAFINPWSRKLEFVNGKYYIIEGPANPDVFESPDPEKTPKLTEERKNQAQICRDDIIRIMNEVLTNPAEIAKQQMSKRCQELALFMEILQEEQPKAEEEFHLQTQDVDHTYYERDSVMLGGISPHHEYNDIKSSAETSLS

per

Period circadian protein

354 amino acids

Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

40.303 kDa

single

GIVMYTTSSLTTTLGFPKDMWIGRSFIDFVHPRDRNTFASQITSGLAVPKIVNGQSPGNPASTMVCRIRRYRGLTTGFGVKDRVVTFMPFLLKFTFKNVSDEEGKVIYLVIQATQFFSAFRIPSEVVSKAVPFVMRHAANGNLEYIDPESVPYLGYLPQDVTDKDALQLYHPEDLDYLQQVYETIVKEGGVPRTKAYRMMAQNGDYLKLETEWSSFINPWSKRLDFVIGKHHIIEGPSNPDVFQSPDPEKAVAMSEEEKAKEQKYRRDIIRTMNEVLTKPAEVAKQQMTKRCQDLASFMESLMEEQQPKVDEDLRLDIQDPDHSYYQRDSVMLGGISPHHDYNDSKSSTGTPLS

per

Period circadian protein

143 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

14.46 kDa

single

SKSSTETPLSYNQLNYKENLQRFFNSKPVTAPTQLDPVNRDSSYASTSREDACSAISPDHGGECSGGSGSSGNCTTNSNIRMSSFTNTSITGTGTSGCGNSGGKLSESGPVEVGGAAADAGPSLAADNSIPPISVTLTESLLN

per

Period circadian protein

141 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

12.325 kDa

single

EGSGGSGSSGHFTTGSNVHMSSVTNTSNGGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTASGTATGTASGTATGTANGTGTGKGTDTHTAGSGSGSGTGTGTGTGTTTTTTTGNNSSSSTPPVTLTESLLNK

per

Period circadian protein

131 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

13.059 kDa

single

SKSSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKLESSYVSSAREDARSTLSPVHGFEGSGGSGSSGNFTTGSNVRMSSVTNTSNAGTGTSGGGNSAGGASGGVGAVGVAANAPLVTVTLTESLLN

per

Period circadian protein

125 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.117 kDa

single

EGSGGSGSSGNFTTGSNVHMSSVTNTSNAGTGGTGTNTGTNTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGKGAGAGTGTATNETAGPGTTTTTTTRSTTTAATAASPPVTLTESLLNK

per

Period circadian protein

124 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

12.529 kDa

single

SKSSTETPPSYNQLNYNENLLRFFNSKPVTAPVELDPPKGESSYVSSAREDARSTLSPVHGFEGSGGSGSSGNFTTGSNVRMSSVTNTSNAGTGTSSAGGNGNGGSGASHAPPVTVTLTESLLN

per

Period circadian protein

114 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

10.246 kDa

single

GGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGGTGTGTGTGTGTGTGTGTGTGTGTDTGTGTGTGTETGTGTGTGTRNGTNSGTKTGTASSYRGGGVAIQPVTLTESLLNK

per

Period circadian protein

110 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

9.85 kDa

single

GGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGGTGTGTGTGTGTGTGTGTGTDTGTGTGTRNGTNSGTNSGTRTGTASSYRGGGGGAGGGGGVTIQHLTLTESLLNK

per

Period circadian protein

109 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.6 kDa

single

SKSSTETPPSYNQLNYNENLQRFFNSKPITAPVDVDPHEVEQSYDASTDARSFRSPLRHFEGSGGSGSSGNFNSGSNLHIGSITNTSNTGTGTSSGSVQLITLTESLLN

per

Period circadian protein

109 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.435 kDa

single

SKSSIETPPSYNQLNYNENLQRFFNSKPVTAPVETDPIKMEQSYSTPANTGSNLSPMQCFEDSGGSGSSRNCTSGSNLNMGSVTNTSNTGTGTSSGSAPLVTLTESLLK

per

Period circadian protein

109 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.417 kDa

single

SKSSTETPPSYNQLNYNENLQRFFNSKPVTAPVEVDPMKNEQSYSISADARNTLSPVQCFEGSGGSGSSGNFTSGSQIHMSSITNTSNAGTGTSSGSAQLVSLTESLLN

per

Period circadian protein

109 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.525 kDa

single

SKSSTETPPSYNQLNYNENLQRFFNSKPATAPVEFDPIKMDQSYNEPAEAECTVSPVQCFEGSGGSGSSGNFTSGSNLNMRSVTNTSNTGTGTSSESVPLVTLTEALIS

per

Period circadian protein

107 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

11.407 kDa

single

SKSSTGTPPSYNQLNYNENLMRFFKSKPVTVGKEESMAVEQSYNDVELQRDPSPDQCCDYSGESGSAGNLSSGSNVQMEIITNGSNTGTGTSSGSFQPPLLTEALLN

per

Period circadian protein

88 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

7.961 kDa

single

EGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNGSASSNYRGGGVAIQPVTLTESLLNK

per

Period circadian protein

86 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

7.746 kDa

single

EGSGGSGSSGNFTTGSNIRMSSVTNTSNAGTGTGTGTGTGTATGTGTATGTGTSAGGTSAGGNASGNSGNPPPAFAITLTETLLNK

per

Period circadian protein

66 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

5.929 kDa

single

EGSGGSGSSGNFTTGSNIHMSSVTNTSNAGTGTSGTGNSGGGSGGGTGPGSGAIPPVTLTESLLNK

per

Period circadian protein

65 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

6.04 kDa

single

EGSGGSGSSGNFTTGSNVRMSSVTNTSNAGTGTSAGDNSAGGNGSGNSNSAPAVTVTLTESLLNK

per

Period circadian protein

63 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

5.82 kDa

single

EGSGGSGSSGNFTTGSNVRMSSVTNTSNAGTGTSGGGNSAAASGASVNAPPVTVTLTESLLNK

per

Period circadian protein

63 amino acids

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

5.943 kDa

single

EGSGGSGSSGNFTTGSNVRMSSVTNTSNTGTGTSGGGNSAAASGARHNAPPVSVTLTESLLNK