pepD

Dipeptidase

533 amino acids

Hydrolyzes a wide range of dipeptides. Highest activity against Ala-Gln.

Belongs to the peptidase C69 family.

59.751 kDa

MACTTILVGKDASYDGSTIIARNEDSANGEFNPKRFIVVKPEEQPREYKSVISHLTITLPDDPLQYTAVPNADLKEGIWGEAGVNEANVAMSATETLTTNERVLGADPFVEYTPAKGDEPEVPGGIGEEDFLTIVLPYVKTAREGVQRLGALLEEFGTYEMNGVAFSDSNEIWWLETVGGHHWIAKRVPDEAYVTMPNQLGIDEFDLEDALGDQEAHMCSEDLAEFIETNHLDLAVENTTPFNPRDAFGSHSDSDHVYNTPRAWYMQRFLNPYDEVWDGPDADHKPTSDDIPWARQPERKVTIEDIKYVLSSHYQGTPFDPYGQLGDERTRHMYRTIGINRQSQLAVMQIRPYRPQASRAIQWMAYGSNPFNTLVPFFPNVDTTPAYLEDTTTRVTSENFYWANRIIAALCDGAFRSTSNAVERYQEKTGAMGHRLVAATDEQIARLGLTAAEEAAQSAAEEEFEADNVDGDVQPMTPDETIAALRNPEVREILAAANQTMADQLKEETEKLLDSVLYTRSMEMKNGFHMSDF

pepd

Xaa-Pro dipeptidase

501 amino acids

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position.

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

56.426 kDa

MSVHPRNQGKDDCCEKTHLDSQYSPGYYWLGNNTLKVPLVLHKENRQRLVSQILSKHKDQVKENSFILLESGKSTMQYDTDHEPLFKQERYFFWTFGSDIPDCFGIVGLDEQATSILCIPKLPAEYATWMGEIRSKEYYKSIFLVDQVLYVDEMMDYLKSKNASTIYTILGTNTDSGSTFVEPQYPGLRETFNVNNTLLFPEIAECRVIKSPKEVEVIRYCVDASVSAHKHVMRKVKVGLKEYQCESEFLHHVYNEWGCRNVGYTCICAANKNSAVLHYGHAGEPNSATISENGFCLFDMGAEYHSYTADITCSFPATGKFSPEQRVVYQAVLDASVAVMEAMRPGVSWVDMHKLAERCILAALLKAGILVGDLQDLIANKIGSVFFPHGLGHFLGLDTHDVGGYLGDCQPKVHSLRTTRTLKAGMVITSEPGCYFINHLLTQALSNPETAKFFNLTELDKYRNIGGVRIEDDILVTETGCDNLSKNLPRTIDEIEAFMLK

PEPD

Xaa-Pro dipeptidase

493 amino acids

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

54.548 kDa

MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK

Pepd

Xaa-Pro dipeptidase

493 amino acids

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen.

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

55.029 kDa

MASTVRPSFSLGNETLKVPLALFALNRQRLCERLRKNGAVQAASAVVLQGGEEMQRYCTDTSIIFRQESFFHWAFGVVESGCYGVIDVDTGKSTLFVPRLPDSYATWMGKIHSKEYFKEKYAVDDVQYTDEIASVLTSRNPSVLLTLRGVNTDSGSVCREASFEGISKFNVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSRGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTEDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELARIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVPRTVEEIEACMAGCDKASVPFSGQK

PEPD

Xaa-Pro dipeptidase

493 amino acids

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen (By similarity).

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

54.701 kDa

MAAVTGPSFWLGNETLKVPVALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETLRYCTDTEVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASYATWMGKIHSKEHFKEKYAMDDVQYTDEIDSVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMRRLADRIHLEELAHTGILSGSVDAMVQAHLGAVSMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPAHACFFNREVLQRFRGFGGVRIEEDVVVTDSGMELLTCVPRTVEEIEACMAGCDKAFTPFSGPK

Pepd

Xaa-Pro dipeptidase

492 amino acids

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen (By similarity).

Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

54.751 kDa

MASTVRPSFSLGNETLKVPLALFALNRQRLCERLRKNGAVQAGSAVVLQGGEEMQRYCTDTSIIFRQESFFHWAFGVIESGCYGVIDVDTGKSTLFVPRLPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTSRNPSVLLTLRGVNTDSGNVCREASFEGISKFTVNNTILHPEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCSGENAAVLHYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELTRIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGVERIDEPGLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQALADPAQACFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLTCVPRTVEEIEACMAGCDKALAPSGPK

pepD

Cytosol non-specific dipeptidase

485 amino acids

Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source.

Belongs to the peptidase M20C family.

52.915 kDa

MSELSQLSPQPLWDIFAKICSIPHPSYHEEQLAEYIVGWAKEKGFHVERDQVGNILIRKPATAGMENRKPVVLQAHLDMVPQKNNDTVHDFTKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADENVVHGPLEVLLTMTEEAGMDGAFGLQGNWLQADILINTDSEEEGEIYMGCAGGIDFTSNLHLDREAVPAGFETFKLTLKGLKGGHSGGEIHVGLGNANKLLVRFLAGHAEELDLRLIDFNGGTLRNAIPREAFATIAVAADKVDVLKSLVNTYQEILKNELAEKEKNLALLLDSVANDKAALIAKSRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDNNVEIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGHYWTLLTELLKEIPAK

pepD

Cytosol non-specific dipeptidase

484 amino acids

Dipeptidase with broad substrate specificity.

Belongs to the peptidase M20C family.

52.888 kDa

MSEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKPATKGMENHTPVVLQAHLDMVPQANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGLASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWLQSEILINTDTEEIGEIYIGCAGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQNQPHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLFVESAEKAPTVFTAQSTQTVINALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKSTILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQPVNDSTILDVTRKHYAEVLGEQPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLADIPAK