Protein
Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Last enzyme in penicillin biosynthetic pathway, which converts isopenicillin N (IPN) to penicillin G, using phenyl-acetyl-CoA or phenoxyacetyl-CoA as acyl donors.
Similarity
Belongs to the peptidase C45 family.
Sequence
MLHVTCQGTPSEIGYHHGSAAKGEIAKAIDFATGLIHGKTKKTQAELEQLLRELEQVMKQRWPRYYEEICGIAKGAEREVSEIVMLNTRTEFAYGLVEARDGCTTVYCKTPNGALQGQNWDFFTATKENLIQLTICQPGLPTIKMITEAGIIGKVGFNSAGVAVNYNALHLHGLRPTGLPSHLALRMALESTSPSEAYEKIVSQGGMAASAFIMVGNAHEAYGLEFSPISLCKQVADTNGRIVHTNHCLLNHGPSAQELNPLPDSWSRHGRMEHLLSGFDGTKEAFAKLWEDEDNYPLSICRAYKEGKSRGSTLFNIVFDHVGRKATVRLGRPNNPDETFVMTFSNLDTKSAIQANI