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pemK

Gene
pemK
Protein
Endoribonuclease PemK
Organism
Escherichia coli
Length
133 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Probably functions as an endoribonuclease. Responsible for the stable maintenance of the plasmid during cell division by postsegregational killing of plasmid-less daughter cells. Neutralized by coexpression with cognate antitoxin PemI. Both PemI and PemK proteins bind to the promoter region of the pem operon to autoregulate their synthesis.
Similarity
Belongs to the PemK/MazF family.
Mass
14.822 kDa
Sequence
MLKYQLKNENGWMHRRLVRRKSDMERGEIWLVSLDPTAGHEQQGTRPVLIVTPAAFNRVTRLPVVVPVTSGGNFARTAGFAVSLDGVGIRTTGVVRCDQPRTIDMKARGGKRLERVPETIMNEVLGRLSTILT