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pdsA

Gene
pdsA
Protein
Protostadienol synthase A
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
738 amino acids
Function
Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secondary metabolite which promotes virulence.
Similarity
Belongs to the terpene cyclase/mutase family.
Mass
83.217 kDa
Sequence
MTTDSSMPATVIGKAEFSNTKAASEFGTNLSRWRLNVDNGRHMWEYLESEDEARKRPQSILEKYWLGLPYELPARPRATRALEAVENGWEFFKRLQTADGHWGCNDDGPLFVTSGMVIARYIVGIPIDSHMKQEMCRYLLNVVNEDGGWGLFIQSPSTVFGTVMNYCMLRILGLGPEHPAMARARNTLHRLGSASATPTWGKFWLCVLGVYEWEGMIPLPPEPLLVPASLPFNPGKWWVHTRNVYISMSYLYGHRFSMPPNKLVQALRDELYDIPYEQINWPAQRTNVSAADRLTDPTWIQRSFTSALTTYETFKIPFLRRRALNEALFQIETETRNTHYLCIAPVSFASNMLALYHAHGRDSHWIRGMRDRFIDPMWLCREGLAASGTNGTSLWDTALTVQATIDAGLAARPENQAILRKALEFIDNSQIREDPLGVHHVYRQPTRGAWPFSTRDQSYAVSDTTAEAVKVVVLLQQIEGFPSRISDERLQQAIDLILGMENAGGGFSAYEPVRGPKFLELLNITELYENVMTDNLYPECTSSVIMSLTTFAREYPTYRARDIQACVSRSVDYLLRSQYPNGGWFASWGVCFTYATMFALQGLACMGRNESNCAACQRACSFLLQHQNPDGGWGESLDTVRFKQYLPHPDGSQVTNTAYAVIGLLAARCGNHEAIRRGVAYLMKEQQDTGEWLPGALEGVFAPPGGMRYPNYKFHFTLMALGRYAAVHGDECLAAQLV
Protein
Protostadienol synthase A: pdsA

Gene
PDSA
Protein
Protostadienol synthase A
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)
Length
735 amino acids
Function
Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secondary metabolite which promotes virulence.
Similarity
Belongs to the terpene cyclase/mutase family.
Mass
82.905 kDa
Sequence
MPVADIEMVTGSAGHVDSKAASEYGTDLRRWRLKVHEGRHMWEYVDEDVAQTQQQTFAENYWLGQEYELPKMSTPIFAQDALDNGWAFFKRLQTQDGHWGCHDDGPLFVTSGIVISSYICGITLPDAMKNEMIRYLLNFVNEDGGWGLWINSPSTVFGTTMNYTMLRILGVPSTHPALLDARDTLLKMGSARALPTWGKFWMCALGAYEWDGMIPLAPEPLLAPGFLPLNPGNWWVHTRNVFVSMSYLFGHRFSAPMTPLIQELREELYDMPYHKIDWFAQQTNISDYDRLHPPTMLQKGLANALCYYEYVKVPYLRRKALDEALFQVEMEVHNTSYLCIAPVSFASNMLVMFHAHGANSHWVKGMADRIIDPMWMCREGMAASGTNGTSVWDTALTVQAALDGGLAQRPENHNTMLEALKFIEVSQITENPLGVSQGYRQPTKGAWPFSTRDQAYAVSDTTAVTVRAVIQLQALKSMPKLVSDERLAEAVDLIIGMENKCDGYSAFEPLRGPKALELLNITELYDNVMTESLYPECTSSVLLCLDTFTKAYPHHRPVEIQSIMARCARYLIKAQFPCGGWLASWGVCFTYATMFALQGLETVGLRESNSETCRNACSFLLQYQNDDGGWGEDLISIREKRYIQDPAGSQVTCTAYALMGLISAHCSNRDALRRGIRWLMRAQQATGEWLPGSLEGIFACPGGMRYPNYKFHFTLSAIGRYIERYGDEALYLKEQ
Protein
Protostadienol synthase A: PDSA

Gene
pdsA
Protein
Protostadienol synthase A
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
735 amino acids
Function
Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secondary metabolite which promotes virulence.
Similarity
Belongs to the terpene cyclase/mutase family.
Mass
83.091 kDa
Sequence
MATDSSMPGTVIGKAEFSDTKAASEFGTDLSRWRLNVDNGRHMWEYLESEDEARKRPQSFLEKYWLGLPYELPARPRATCALEAVENGWEFFKRLQTADGHWGCNDDGPLFVTSGMVIARYIVGIPIDSHMKQEMCRYLLNVVNEDGGWGLFIQSPSTVFGTVMNYCMLRILGLGPEHPAMAKARNTLHRLGSARATPTWGKFWLCVLGVYEWEGMVPLPPEPLLVPASLPFNPGKWWVHTRNVYISMSYLYGHRFSMPPNKLVQALRDELYDIPYQQINWPAQRTNVSAADRLTDPTWIQRSFTSALTMYETFKIPFLRRRALNEALFQIETETRNTHYLCIAPVSFASNMLALYHAHGRDSHWIRGMRDRFIDPMWLCREGLAASGTNGTSLWDTALTVQATIDAGLAARPENQAILRKALEFIDNSQIREDPLGVHHVYRQPTRGAWPFSTRDQSYAVSDTTAEAVKVIVLLQRIEGFPSRISDERLQQAIDLILGMENAGGGFSAYEPVRGPKFLELLNITELYENVMTDNLYPECTSSVIMCLTTFAREYPTYRPRDIQACLSRSIDYLLRSQYPNGGWFASWGVCFTYATMFALQGLACMGWNESNCAACQRACSFLLQHQNPDGGWGESLDTVRFKQYLPHPDGSQVTNTAYAVIGLLAARCGNHEAIRRGVAYLVKEQQDTGEWLPGPLEGVFAPPGGMRYPNYKFHFTLMALGRYVAIHGNECLAI
Protein
Protostadienol synthase A: pdsA

Gene
pdsA
Protein
cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A
Organism
Dictyostelium discoideum
Length
452 amino acids
Function
Phosphodiesterase which displays a preference for cAMP over cGMP. Involved in the degradation of extracellular cAMP. Maintains the responsiveness of cells to the chemoattractant cAMP during the aggregation phase of development.
Similarity
Belongs to the cAMP phosphodiesterase class-II family.
Mass
51.093 kDa
Sequence
MALNKKLISLLLLIFIILNIVNSHQQEDCDDDDEDIGISAERSERRSVKNSNDGSNFYNLNDYYTPENWNYYSGSFATKDCRDASYITIPLGTTGGLDEGNLSSFLLTKKGSNLFIALDAGTVWQGVRRLTTFKYFNTLFNITYPSWAVLPEQRTSWFLKNHVMSYFIGHSHLDHVGGLILVSPEDYLAKNWIDVQPPINNGIMGLIRKLGFKPTDFTSSSILQKKTIMGLPSTINSISTNLFNNQVWPNLPSFGRYQYFSLASGIEYPFTELVPYNATTMSLVANEFPFSVKVKPFELCHDNLISTSFLFTDSISGEQIAFFSDTGVPSSVACDWEGKIYAVWKQIKIDKLKAIYIETSFPNNTPDSAMFGHLRPRDVMKLMDQLLVQSIQTSPPMTNLKHVKLIIEHIKPQVAEDPNGWTTQRVIYQQLKEANNNGVRIIIPNQGDPICI
Protein
cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase A: pdsA