pc1

RNA-dependent RNA polymerase

2919 amino acids

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped.

336.877 kDa

MTTPPLVIPLHVHGRSYELLAGYHEVDWQEIEELEETDVRGDGFCLYHSILYSMGLSKENSRTTEFMIKLRSNPAICQLDQEMQLSLMKQLDPNDSSAWGEDIAIGFIAIILRIKIIAYQTVDGKLFKTIYGAEFESTIRIRNYGNYHFKSLETDFDHKVKLRSKIEEFLRMPVEDCESISLWHASVYKPIVSDSLSGHKSFSNVDELIGSIISSMYKIMDNGDQCFLWSAMRMVARPSEKLYALAVFLGFNLKFYHVRKRAEKLTAKLESDHTNLGVKLIEVYEVSEPTRSTWVLKPGGSRITETRNFVIEEIIDNRRSLESLFVSSSEYPAELCSQKLSAIKDRIALMFGFINRTPENSGRELYINTYYLKRILQVERNVIRDSLRSQPAVGMIQIIRLPTAFGTYNPEVGTLLLAQTGLIYRLGTTTRVQMEVRRSPSVISRSHKITSFPETQKHNNNLYDYAPRTQETFYHPNAEIYEAVDVKTPSVITEIVDNHIVIKLNTDDKGWSVSDSIKQDFVYRKRLMDAKNIVHDFVFDILSTETDKSFKGADLSIGGISDNWSPDVIISRESDPQYEDIVVYEFTTRSTESIESLLRSVEVKSLRYKEAIQERAITLKKRISYYTICVSLDAVATNLLSLPADVCRELIIRLRVANQVKIQLADNDINLDSATLLAPDIYRIKEMFRESFPNNKFIHPITKEMYEHFVNPMISGEKDYVANLKSIIDKETRDEQRKNLESLKVVDGKKYTERKAETALNEMSQAEEHYRSYFENDNFRSTLKAPVQLPLIIPDVSSQDNQFSNKELSDRIRKKPIDHPIYNIWDQAVNKRNCSIALGHLDELEISMLEGQVAKKVEESYKKDRSQYNRTTLLTNMKEDIYLAERGINAKKRLEEPDVKFYRDQSKRPFHPFVSETRDIEQFTQKECLELNEESGHCSLINVEDLVLSALELHEVGDLEHLWNNIKAHSKTKFALYAKFISDLATELAISLSQNCKEDTYVVKKLRDFSCYVLIKPVNLKSNVFFSLYIPSNIYKSHNTTFKTLIGSPESGYMTDFVSANVSKLVNWVRCEAMMLAQRGFWREFYAVAPSIEEQDGMAEPDSVCQMMSWTLLILLNDKHQLEEMITVSRFVHMEGFVTFPAWPKPYKMFDKLSVTPRSRLECLVIKRLIMLMKHYSENPIKFMIEDEKKKWFGFKNMFLLDCNGKLADLSDQDQMLNLFYLGYLKNKDEEVEDNGMGQLLTKILGFESAMPKTRDFLGMKDPEYGTIKKHEFSISYVKDLCDKFLDRLKKTHGIKDPITYLGDKIAKFLSTQFIETMASLKASSNFSEDYYLYTPSRRLKNQEQSRSKHVIDAGGNISASVKGKLYHRSKVIEKLTTLIKDETPGKELKIVVDLLPKAMEVLNKNECMHICIFKKNQHGGLREIYVLNIFERIMQKTVEDFSRAILECCPSETMTSPKNKFRIPELHNMEARKTLKNEYMTISTSDDASKWNQGHYVSKFMCMLLRLTPTYYHGFLVQALQLWHHKKIFLGDQLLQLFNQNAMLNTMDTTLMKVFQAYKGEIQVPWMKAGRSYIETETGMMQGILHYTSSLFHAIFLDQLAEECRRDINRAIKTINNKENEKVSCIVNNMESSDDSSFIISIPNFKENEAAQLYLLCVVNSWFRKKEKLGTYLGIYKSPKSTTQTLFVMEFNSEFFFSGDVHRPTFRWVNAAVLIGEQETLSGIQEELSNTLKDVIEGGGTYALTFIVQVAQAMIHYRMLGSSASSVWPAYETLLKNSYDPALGFFLMDNPKCAGLLGFNYNVWIACTTTPLGEKYHEMIQEEMKAESQSLKSVTEDTINTGLVSRTTMVGFGNKKRWMKLMTTLNLSADVYEKIEEEPRVYFFHAATAEQIIQKIAIKMKSPGVIQSLSKGNMLARKIASSVFFISRHIVFTMSAYYDADPETRKTSLLKELINSSKIPQRHDYLQEPHTLKPTKVEVDEDSWEFKSAKEECVRVLKQRIKIHTGREERSISLLFENMAKSMIGRCTDQYDVRENVSILACALKMNYSIFKKDAAPNRYLLDEKNLVYPLIGKEVSVYVKSDKVHIEISEKKERLSTKLFNIDKMKDIEETLSLLFPSYGDYLSLKETIDQVTFQSAIHKVNERRRVRADVHLTGTEGFSKLPMYTAAVWAWFDVKTIPAHDSIYRTIWKVYKEQYSWLSDTLKETVEKGPFKTVQGVVNFISRAGVRSRVVHLVGSFGKNVRGSINLVTAIKDNFSNGLVFKGNIFDIKAKKTRESLDNYLSICTTLSQAPITKHDKNQILRSLFVSGPRIQYVSSQFGSRRNRMSILQEVVADDPTLHWPDQDTSQKQLEDKFRELAHKELPFLTEKVFHDYLEKIEQLMKENTHLGGRDVDASKTPYVLARANDIEIHCYELWREYDEDEDEAYQAYCSEVEAAMDQEKLNALIERYHVDPKANWIQMLMNGEIETVEELNKLDKGFESHRLALVERIRVGKLGILGSYTKCQQRIEELDGEGNKTHRYTGEGIWRGSFDDSDVCIVVQDLKKTRESYLKCVVFSKVSDYKVLMGHLKTWCREHHISNDEFPTCTQKELLSYGVTKSSVLLYKMNGMKMLRNMEKGIPLYWNPSLSTRSQTYINWLAVDITDHSLRLRNRTVENGRVVNQTIMVVPLYKTDVQIFKTSPVDLEQDVQNDRLKLLSVTKAGELRWLQDWIMWRSSAVDDLNILNQVRRNKAARDHFNAKPEFKKWIKELWDYALDTTLINKKVFITTQGSESQSTVSSGDSDSAVAPLTDEAVDEIHDLLDKELEKGTLKQIIHDATIDAQLDIPAIESFLAEEMEVFKSSLAKSHPLLLNYVRYMIQEIGVTNFRSLIDSFNQKDPLKSVSLSILDLKEVFKFVYQDINDAYFVKQEEDHKFDF