Protein
3'-5' exoribonuclease parn-1
Organism
Caenorhabditis elegans
Function
Involved in transcriptome surveillance. Required for piwi-interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.
Similarity
Belongs to the CAF1 family.
Sequence
MVIVTDSNFLDAAGTLRKGLLYCDFVAIDFEFLGLDVSAISLHDTVESRYQILRDNVIKYRPCQLGLTLFKQKSNRAYKADTYSVPLFQRFGDNDTSISLPSMRFLVKNKFNLNQVFMDGVEFCTRKEFKKFERALLAGTAASYLSREVKSQIELLKVMVHEKCYQSTSYHITHRTDEPMQKIPLKMKPNSSVSLRMPRNLSSVEKYMIIYELTKAFPQFLFTCDEKQQNLHVKNISDDYLKEKDNLERARARCSESVKGVSAILQVVHMTGKLVVGHNSLLDAMYMYHYFFSHLPANYQMFKDKFNALFPRIMDTKLLAQALRFELPGVGDSLENLGDYFGSDKSDKTVPPELRGFIEPWMNPLEDESENVYHNAGFDSYVTGEVFLKLAHIYINRRNNFKNEILDFDRIYQYLEAPILNRLPFQLMDVGCCYLTGDDSKGFRPDVITIVRRDRVAIEEDEFRYLEKALGTLMATYQFDIEWSKNKKELFLATNSPGSYAFLCEKFSNDSSLAPLDELDSGKKWTFEQRQTAWRSFKNRGVGIGINAKRIRAQNQATKIQRAMEI