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parE

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
695 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
76.164 kDa
Sequence
MSSSDKIPSLFGDDDALAPVPAAPFKASVEPRVEPTPRPIPPPPPSKTASAPGEYSAADIEVLEGLEPVRKRPGMYIGGTDERALHHLFAEVLDNSMDEAVAGFAKTIEVKLDADGFLSVKDDGRGMPVDPHPKYPGKSALEVIMTVLHAGGKFTGKAYETSGGLHGVGASVVNALSERVEVTVWRDGFEHLQVFSRGKPLGPIQQVAPSKKKGTMVRFKPDDEIFGEGTNFKPARLYRMARSKAYLFRGVQIKWSCDPSRIHDQTPPEATFHFPNGLADFLAERTKGLTTITPESFAGRIERQGEAGAVEWAVTWTPQGFGEHDGFMQSYCNTVPTPEGGTHESGFRAALTRGLKAYAELKGEKRGTIITADDVVAQAGALISVFIKNPEFQGQTKEKLSTSEAQRFVEASLRDPFDLWLSSSPKNAQALLEFVIERAEERLKRRKDKEVSRASATRKLRLPGKLADCAGSAVDGAELFIVEGDSAGGSAKQARDRKYQAILPLRGKILNVASASGEKFTANKELSDLMLALGAQAGAKYREEDLRYERIIIMTDADVDGAHIASLLITFFYRTMPELIRGGHLFLALPPLYRLAHGGKSEYARDDAHKEELLATVFKGKKPEIGRFKGLGEMMASQLKETTMDPKKRTLARVTLPRHEESVEDLVETLMGRKPELRFRFIQENAEFASADLDL

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)
Length
692 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
77.446 kDa
Sequence
MSNDNKDLFSVLNHAQSRIDRKENTQYTSAHSEIVVPAVPLSSPHHHKEDSTYNASSIRILEGLEPVRLRPGMYIGGTDSKALHHLFSEIIDNAMDEAVAGYADLIDITLDSNNYLTVTDNGRGIPIENHPQIPDKSTLEVIMTHLHSGGKFDGKAYQTSGGLHGVGISVVNALSDDMEVEVARERKLYRQRFSRGIPQSGLEELGDVYNRRGTRVCFHPDSQIFGENTAFDPEKIYKIARSKAYLFNGVKIRWNCDPAALKDAKNIPEKDVFYFPDGLKDYLSLSLKNKHLVTAEIFSGKTQQLSGHGSVEWAIAWHNGDAYIQSYCNTIPTEEGGTHETGLRQTLLRGLKAYAELIGNKRASIITSDDVMASTVVMLSVFIKDPQFVGQTKDRLATTEAQRIVENAIRDPFDHWLANSPHEATKLLNWVIERAEERLKRRQDREINRKTAVRKLRLPGKLADCSQNSAAGAELFIVEGDSAGGSAKQARNRTNQAILPLRGKILNVASAAREKMSSSQTIADLILALGCGTRSKYREEDLRYERIIIMTDADVDGAHIASLLITFFFQEIPDLIRAGHLYLAVPPLYRISQGGKVAYARDDSHKDELLKTEFTGKGKIEIGRFKGLGEMRAEQLKETTMNPKKRTLLRVSIDTFEMQETKETVQNLMGTKPEERFRFIQESSTFANNLDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Length
685 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267). Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
76.257 kDa
Sequence
MAKKINNEYNDASIQVLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNAVDEALSGYGNEINVTIQKDNSICVADSGRGMPTGMHASGIPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSKWLEVHIVRDGVEYMERFEDGGKPVGTLKKIGKTKKRNGTSVTFLPDDTIFSTTNFSYEILAERLRESAFLLKGVKITLTDERGEEPKEEVFHYEEGIKEFVAYLNEEKDTLTPVVYFSGAKEGIEVELAYQYNDGYSENVLSFVNNVRTKDGGTHEVGMKTSMTKAYNEYARKVGLLKEKDKNLEGSDFREGLAAVLSIRVPENLLQFEGQTKGKLGTPLARTVVDNVVGEQMGFYLQENSEMSQSLIRKAIKAREAREAARKAREESRNGKKRKKGESLLSGKLTPAQSRNPKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTIGAGVGPEFSIEDCNYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVYIALPPLYKVSKGTGKKSVIEYAWTDGELAEVIDKVGKGYMLQRYKGLGEMNAEQLWETTMDPETRTLIRVRIDDAAQAERRVTTLMGDKVEPRRKWIEQHVQFTLEEDGSILDRSEEDTSAPTGESLLDAEKTKEAEQTDDTEISLFDIE

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
664 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.47 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEVVDNSVDEVLNGYGDAITVTINQDGSISIEDNGRGMPTGIHASGKPTAEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYTQNFKNGGIPATGLVKTGKTKKTGTKVTFKPDSEIFKSTTTFNFDILSERLQESAFLLKDLKITLTDLRSGKEREEIYHYEEGIKEFVSYVNEGKEVLHDVTTFAGHSNGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNEYARRINELKDKDKNLDGNDIREGLTAIISVRIPEELLQFEGQTKSKLGTSEARSAVDSVVSEKLPYYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTDKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRIIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKNKKVEYAWTDEELENLQKQLGKGFILQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVAPRREWIEKHVEFGMQEDQSILDNKEVQILENEKYIEEETN

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
664 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.47 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEVVDNSVDEVLNGYGDAITVTINQDGSISIEDNGRGMPTGIHASGKPTAEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYTQNFKNGGIPATGLVKTGKTKKTGTKVTFKPDSEIFKSTTTFNFDILSERLQESAFLLKDLKITLTDLRSGKEREEIYHYEEGIKEFVSYVNEGKEVLHDVTTFAGHSNGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNEYARRINELKDKDKNLDGNDIREGLTAIISVRIPEELLQFEGQTKSKLGTSEARSAVDSVVSEKLPYYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTDKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRIIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKNKKVEYAWTDEELENLQKQLGKGFILQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVAPRREWIEKHVEFGMQEDQSILDNKEVQILENEKYIEEETN

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain MSSA476)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.422 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQADRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.364 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain MW2)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.364 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
74.507 kDa
Sequence
MSDLFSFNNKEKKNKIIYTNYSAKDIEVLDGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEAVAGFASIIMIKMHQDHSITIFDNGRGIPIDNHPKFPNKSALEVILTTLHSGSKFSNNVYHTAGGLHGVGISVVNALSKHLKIEVYQQGKLYSQSYSKGEKLTDLISTEVSKRLRGTSINFTPDPEIFSETLHFNPKKIYEIARSKAYLYRGVSIEWECEVEVPSDIPKKALINFPNGLKDYLSSKISLDNLVIPEIFSGNIESTMDAIKLEWAICWQNNDTSAFMKSYCNTVPTPQGGTHEQGLKSAILRGLKAYSEMIGNKKSANLTIEDIFETASVVLSVFIVEPSFQGQTKEKLVSNGVSKLVENIIKDHFDHFLSSDKVLATHLLEHVIAISEFRRNKKNERNISRKNATQKLRLPGKLADCTRTSAEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIINNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPQLVKEGHLYLAKPPLYRLTQSNKIYYACDEEEKIKLTYKLSKTSKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLKVTLEDVQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDQIINKLDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.364 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain COL)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.364 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.337 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain N315)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.337 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGSIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Staphylococcus aureus (strain MRSA252)
Length
663 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
74.398 kDa
Sequence
MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEIDVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKASTSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLHDVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYARRINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADKLPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKNTDKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTIGAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLYKLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTLIRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHFEFGMQEDQSILDNSEVQVLENDQFDEEEI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Rickettsia bellii (strain RML369-C)
Length
662 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
73.986 kDa
Sequence
MSDLFSFNKEKKTKIINNTYSAKDIEVLEGLEPVRKRPGMYIGGTDLNAMHHLVSEVLDNSMDEAVAGFASIITIKMHQDHSITISDNGRGIPIDNHPKFPNKSALEVILTTLHSGGKFSSNVYQTAGGLHGVGVSVVNALAEHLEIKVYKQGKLYKQSYAKGEKLTELICEEAPKRLKGTSINFIPDPEIFGDKIHFNPKKVYELARSKAYLYRGVTIEWECEIEASSDVPKKALINFPNGLKDYLSSKITPDDLITTEIFSGNVESEQDGIKLEWAICWQNNDSSAFIQSYCNTVPTPLGGTHEQGLKSALLRGLKAYGEMVGNKKTANLAIEDILETASVVLSIFIAEPTFQGQTKEKLVSQGVSKPAENIIKDHFDHFLSSNKTIANNLLEHFIAIAEFRLNKKNEKTISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIVNNQAIQDLEIALACGSMKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEDGHLYLAKPPLYRLTQSNKTYYANDEEEKAKLTDKLSKSSKAKIEVGRFKGLGEMMPMQLKETTMHPEKRSLLKVTLEDFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIINELDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Length
662 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
73.827 kDa
Sequence
MSDLFSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEAVAGFASIITITMHHDHSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFSNNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSYSKGEKLTDLICEEASKRLRGTSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWACEVEVQSDIPKKALISFPNGLKDYLSSKITLDNLVIPGIFAGNIESKSDRIKLEWAICWQNNDSSAFVQSYCNTVPTPQGGTHEQGLKSAILRGLKAYGEMIGNKKAANLTIEDILETASVVLSIFIAEPSFQGQTKEKLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVISIAEFRISKKNEKNISRKNATQKLRLPGKLADCTRTSPEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIVNNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQSNKTYYAGDEEEKAKLMDKLLKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLKVTLADFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIISELDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Length
662 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
73.954 kDa
Sequence
MSDLFSFNKEKKNKLVDNNYSAKDIEVLEGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEAVAGFASIITIKMHQDHSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGGKFSNNVYHTAGGLHGVGISVVNALSKHLEIKVYKQGKLYSQSYSKGEKLTDLICEEASKRLRGTSINFTPDPEIFSEKLHFNPKKIYELARSKAYLYRGVTIEWECEVEVPSDIPKKALINFPNGLKDYLSSKITLDNLIIPEIFSGNIESTPDEIKLEWAICWQNNDNSAFIQSYCNTVPTPQGGTHEQGLKSAILRGLKAYGEMIGNKKAANLTIEDILETASVVLSIFIAEPSFQGQTKEKLVSNGVSKPVENIIKDHFDHFLSSDKALATNLLEHVIAIAEFRISKKNEKNISRKNATQKLRLPGKLADCTRTTPGGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIVNNQAIQDLEIALACGSLKNYKEENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQSNKTYYAGDEEEKAKLTDKLSKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLKVTLEDFQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDKIINELDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Rickettsia prowazekii (strain Madrid E)
Length
662 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
74.252 kDa
Sequence
MSDLFSLNKEKKNKIVYTNYSAKDIEVLDGLEPVRKRPGMYIGGTDSNAMHHLVSEVLDNAMDEAVAGFASIIMIKMHQDHSITIFDNGRGIPIDNHPKFPDKSALEVILTTLHSGSKFSNNVYHTSGGLHGVGISVVNALSKHFKIKVYKQGKLYSQSYSKGAKLTDLISAEASKRLRGTSINFTPDPEIFSEKLHFNPKKIYEIARSKAYLYRGVSIEWECEVEVPSDIPKKALINFPNGLKDYLSSKISLDNLVIPEIFSGNIESTVDDIKLEWAICWQNNDTSAFMQSYCNTVPTPQGGTHEQGLKSAILRGLKAYSEMIGNKKAANLTIEDILETASIVLSIFIVEPSFQGQTKEKLVSNGVSKLVENIIKDHFDHFLSSDKVLATHLLEHVIAIAEFRRNKKNERNISRKSVTQKLRLPGKLADCTRTSAEGTELFIVEGDSAGGSAKQARNRETQAVLPLWGKVLNVASSTLEKIINNQAIQDLEIALACGSLKNYKKENLRYEKIIIMTDADVDGAHIASLLMTFFFLRMPKLVEEGHLYLAKPPLYRLTQSNKIYYACDEEEKIKLTYKLSKASKAKIEVGRFKGLGEMMPAQLKETTMHPEKRSLLKVTLEDVQNVDKIVDDLMGKKPEKRFQFIYEQALVKMDQIINKLDI

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Bacillus subtilis (strain 168)
Length
655 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
73.007 kDa
Sequence
MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKIGKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVFYYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
647 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
71.664 kDa
Sequence
MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTNEAIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEETTVF

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
Length
643 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
72.352 kDa
Sequence
MAENKKYDESAIQVLEGLEAVRKRPGMYIGSTDNKGLHHLVWEIVDNAIDEALAGYCTQIDVILEKDNSITVIDNGRGIPTGMHKTGKPTPEVIFSVLHAGGKFDSTAYKSSGGLHGVGSSVTNALSKRFKAIIYRDKKIHEIEFKNGGKLEKPLTFINTTYKTGTTINFLPDDTIFSNAKFNFSLISERLKESALLNSGLKITLSDLISNRYVEYQFQDGLVEFVKELVDDKTPVTDIITINNESKNIIVEIALQYTEDDNEIILGFANNVKTIDGGTHLVGFKSGLIRAINDYAKDQKILKDKTKLDSNDLREGLVAIVTVKIPENLIEYEGQTKSKLGTSDAKTVVEQIVYEFMSYWLIENKVLANKVIENALNAQKARIAAKQARQAIKSVKGKKNVNKLMLGKLTPAQGKKRELNELYLVEGDSAGGSAKSGRDRNFQAILPLRGKVINSEKAKLVDLLKNEEIQSIINAIGAGVGKDFDISDINYGKIIIMTDADTDGAHIQTLLLTFFYRHMKDLIIHKKVYIALPPLYKITFNDKSFIYLWDEEELNKFNKTNTKKYEIQRYKGLGEMNADQLWQTTMDPKNRKIIQVTISDGLLAERMFKTLMGDDVEKRKLWIQENVKFTLEDDQIQIIEMEK

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
635 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
72.413 kDa
Sequence
MKNNYSEANIKILKGLDAVKKRPGMYIGSTDSRGFHHLLWEILDNCVDEVLSGFANTIAVVLHAENQITVSDNGRGIPFETHSDSKISTIDTVFTYLHAGGKFDNDSYKIAGGLHGVGASVVNALSDQLQVTVKRQGKVYRSVYENGGKIKQKAHCIGNAKIDEHGTSVTFRPDPKVFKKIHFDSELIRARLKELAFLFKKLQLTFVDETGSGEKEVFFTEAGISQYLDELNADSKQIAQKIFVSGTEDDIELEAVFQFIDGEDEKLLSFANSIRTSEGGSHEASFRQSVGDVINNYCRKYNFLKERDKNFEASEIREGLNGIIKVNLPEKIIAFEGQTKSKLFSKEVKAVVQKLTQKHFFQFLERNSVDAKLIVEKLFYNRKLRQELKQQRQIKKNLSNPKAERILFGKLAPAQSKKVAERELFVVEGDSAGGTAKMGRDRFLQAILPLRGKVLNVEKINNKKEAINNEELLTLIFCIGTGIGNNFTIRDRKYDKIIIMTDADNDGAHIQILLLTFFYRYMKPLIEKGHIYLALPPLYKFEGRDKKARYLWTEQELEQYRAKHSHFNVQRYKGLGEMNADQLWETTMNPMTRKLIQVKLDNFIQAEKQINVFMGDKTELRKSWIEANINFSSEN

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Length
633 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
71.373 kDa
Sequence
MVSNYNEKHIKVLKGLEPVRKRPGMYIGSTDTRGLHHLVWELFDNAVDEALNGSANKIEVVHKKDGSIIVTDNGRGIPVGKNLATNLSTVDTVYTVLHAGGKFDDQAYKVSGGLHGVGASVVNALSRKLIVTVHRDGGMYESIYQDGGKIIQPLKKVGNSTKHGTIVQFWPDPTIFKNIQFNPYMIKERLHESSFLFKGLKIVFVDENNPELSQTFIAKDGILEYLKYVNENKKSISKIIPFKGDYEKIVVDGCFQYTDNESELIISFANSVKTSEGGSHENGFKQAMLETINDYSKKYKLINNKDKGFDWSDLKEGLSVVLSVQVPEKIIAYEGQTKNKLFTQEVKVAVAKILTQQLFYFLEENQADAKQLIERFKLIKEAKEAAKKAKENTKKLKSAKSERVLYGKLTPAQQKNPLQNEIFLVEGDSAGGTAKSGRDKRFQAILPLRGKVVNVEKSRLQDLLKNEEILSIISCLGCGIGNNFNIKNLKYHKIIIMTDADTDGAHIQVLLLTFFYRYMKELIEQGKVYIALAPLYKISAKNSNKSAFAWDDYQLDELRTKYGSYEVQRYKGLGEMNSEQLWTTTMDPSKRQLIQVSIQNAAQAERKVSILMGDDASIRKNWINENVDFSIEE

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
633 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 2 subfamily.
Mass
71.569 kDa
Sequence
MKSNYSATNIKILKGLDAVKKRPGMYIGSTDSKGLHHMLWEILANSVDEVLAGYATNITVTLDLNNTITVSDDGRGIPYEIHQDSNISTIDTVFTFLHAGGKFDDQSYKLAGGLHGVGASVVNALSDHLEVTVKRNGQIYQSVYQAGGKIIQKAKKIGDTTSHGTTVSFHADPKVFKKAQFDSNIIKSRLKELSFLFAKLKLTFTDQKTNKTTVFFSTSGLVQFLDEINNTVETLGQKTLIKGEKDGIEVEVVFQFNQSDQETILSFANSIKTFEGGSHENGFCLAISDVINSYCRKYNLLKEKDKNFQLSEIRQGLNAIIKVNLPEKNIAFEGQTKSKLFSKEVKNVVYELVQQHYFQFLERNNNDAKLIIDKLLNARKIKEQIKQQRELKKSLSSPQKEKILFGKLAPCQTKKTSEKELFIVEGDSAGGTAKMGRDRIFQAILPLRGKVLNVEKINNKKEAITNEEILTLIFCIGTGILTNFNIKDLKYGKIIIMTDADNDGAHIQILLLTFFYRYMQPLIELGHVYLALPPLYKLETKDRKTVKYLWSDLELESVKLKLNNFTLQRYKGLGEMNADQLWDTTMNPTTRKLVQVKLDDLINAEKQINIFMGEKSDLRKHWIEANINFSVEN

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
632 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
70.173 kDa
Sequence
MTTNYSAQEITVLKDLEPVQIRPGMYTDTTRPNHLAQEVIDNSVDEALAGFATKIEVILHPDQSIEVTDNGRGMPVDIHPTEGVSGVEVILTKLHAGGKFSNKNYEFAGGLHGVGISVVNALSERVDIQVKRNGEIYKIAFENGSKVEELEIIGTCGRRTTGTIVHFKPNPKYFDSAKFSVSRLRHLLRAKAVLCSGLEIKFIDKVNNTQDIWLYEDGLSDYLIEAVNGFETLPKKPFVGEFKGANEAVSWALLWLPEGGELIGESYVNLIPTIQGGTHVNGLRQGLLDAIREFCEFRNLLPRGVKLTADDIWDRCSYILSLKMQDAQFAGQTKERLSSRQSAVFVSGVLKDAFSLWLNQNVQDAEKLAEIAISSAQRRLRAAKKVVRKKLVSGPALPGKLADCGSQDLEKTELFLVEGDSAGGSAKQARDREYQAILPLRGKILNTWEVSPDQVLGSTEIHDIAVALGIDPDSNDLSQLRYGKVCILADADSDGLHIATLLCALFLRHFPKLVQDGHVYVAMPPLYRIDLNKEVFYALDENEKEAILDRLKNKKGKPNVQRFKGLGEMNPSQLRETTMDPNTRRLVQLTYDLGEDQGSDTLELMDMLLAKKRSEDRKNWLQAKGDQVDLSV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Escherichia coli (strain K12)
Length
630 amino acids
Function
Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed:9334322). It relaxes supercoiled DNA (PubMed:15105144, PubMed:21300644, PubMed:23294697, PubMed:23352267). MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed:20921377).
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
70.244 kDa
Sequence
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIGNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQNVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALTEEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTDAMMDMLLAKKRSEDRRNWLQEKGDMAEIEV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Salmonella typhi
Length
630 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
70.089 kDa
Sequence
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDESFFDSPRFSVSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIGNFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALTEEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTNAMMDMLLAKKRSEDRRNWLQEKGDLADLDV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
630 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:22916023). Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
70.089 kDa
Sequence
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDESFFDSPRFSVSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIGNFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQNVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALTEEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTNAMMDMLLAKKRSEDRRNWLQEKGDLADLDV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
629 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
69.179 kDa
Sequence
MATYNADAIEVLSGLDPVRKRPGMYTDTTRPNHLAQEVIDNSVDEALAGHAKSVQVILHQDNSLEVIDDGRGMPVDIHPEEGVPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVRVKRDANEYRMTFADGFKDSDLEVIGTVGKRNTGTSVHFWPDPKYFDSAKFSVSRLKHVLKAKAVLCPGLSVVFEDKNTGERVEWHFEDGLRSYLTDAVAELPRLPDEPFCGNLEGSKEAVSWALLWLPEGGESVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNEHAEIGLQLAELAISNAGRRLKAGKKVERKKITQGPALPGKLADCAGQEPMRAELFLVEGDSAGGSAKQARDKEFQAIMPLRGKILNTWEVDGGEVLASQEVHDIAVAIGVDPGASDLAQLRYGKICILADADSDGLHIATLLCALFVRHFRPLVEAGHVYVAMPPLYRIDLGKDIYYALDEAERDGILERLAAEKKRGKPQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTLEDATGTLEIMDMLLAKKRAGDRKSWLESKGNLAEVLV

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Francisella tularensis subsp. holarctica (strain LVS)
Length
627 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.
Similarity
Belongs to the type II topoisomerase family. ParE type 1 subfamily.
Mass
70.355 kDa
Sequence
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYEDNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIRFWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDNFSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLSVKNIKITANDSFAQLNYVISVKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQNPDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGKLTDCISSDVNSTELFIVEGDSAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISALRYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALDENERDTILTKNSKLPGKVNIMRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEMLDMLLAKKRAKDRRDWLENYGDRASVE

Gene
parE
Protein
DNA topoisomerase 4 subunit B
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Length
599 amino acids
Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule (By similarity).
Similarity
Belongs to the type II topoisomerase family.
Mass
68.775 kDa
Sequence
MKTQNYDESKIITLSSLEHIRLRSGMYIGRLGDGSNIDDGIYVLIKEIIDNSIDEFIMGYGNEIFIKKENNLISIRDYGRGIPLGKVIESVSVINTGAKYNDDVFQFSVGLNGVGTKAVNALSSKFLVRSTRNGKSFEALFSKGKLLESREIKSSDKDGTYVEFLADSEIFGKYSYSEDFLKRRFFHYACLNKGLIINYNDQIFESKNGLLDFLNSEIKSDDLLYDIVYYSSKTLEFAFSHTNNYGETYFSFVNGQYTNDGGTHQTGFREGFVRAINDFLKKTYSSTDIREGLVATLSVKIKDPIFESQTKNKLGNIETRGNVAKEVQKIISEILYKDKILAKLIEKKVVDNERLRKELSSVRKEARERAKKISFKIPKLKDCKFHFNDSSKQSEQTMIFLTEGDSATGSMVSCRDVYTQAIFSLRGKPQNMFEKNKSEIYKNEELYNMMVALGIEESIENLRYNKVVIATDADFDGFHIRNLLLTFFLTFFEDLILNGHMYILETPLFRVRNKKITTYCYSEEEKQKAILELKGGCEVTRFKGLGEISPNEFKGFIDINSIKLTKVDLFNIKEIKEKLGFYMGQNTPERRNFIMENLI

Gene
parE
Protein
2-deoxy-scyllo-inosamine dehydrogenase
Organism
Streptomyces rimosus subsp. paromomycinus
Length
339 amino acids
Function
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily.
Mass
35.458 kDa
Sequence
MKALMFKAPLQAVLTERDVPEPAPGEALVKLAYNSICGSDLSFYKGVWHGFTYPVVPGHEWSGTVVEAGGGAADLVGQNVVGDLTVACGSCRHCTVGKPTLCADLQELGFTRDGACAEYMTVPTGNLHRLPEGLSLREATQVEPLAVALNAVDRLAVTAGEKVAITGAGGIGLLLAQAVRLRGAEVTVLAEPVTERRQAAHALGVPHTVGGDPGELVGFVEKHPELTPDVVLEASGYPLAVQEAVEAVRSGGRIGLIGYRIEEAATMAPHHIVVKVLSLQASMGPGDRFGEAIELLAAGAVDVDALLSHEFGLADHDRALDVALRRADGNTRSYFNLRA

Gene
parE
Protein
Toxin ParE
Organism
Escherichia coli
Length
103 amino acids
Function
Toxin component of a type II toxin-antitoxin (TA) system involved in plasmid partition. Acts by inhibiting DNA gyrase, converting supercoiled plasmid DNA into a singly cleaved linear form in an ATP-dependent fashion. To do so it probably interacts with one of the gyrase subunits. Gyrase inhibition is prevented by antitoxin ParD, and is reversed in vitro by incubation with ParD. In cells that have lost the plasmid filamentation and growth inhibition occur; this is suppressed when ParD is supplied in trans. The parDE operon alone is capable of stabilizing an RK2-derived minireplicon under defined growth conditions in several different Gram-negative bacteria. It does so by the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system.
Similarity
Belongs to the RelE toxin family.
Mass
11.716 kDa
Sequence
MTAYILTAEAEADLRGIIRYTRREWGAAQVRRYIAKLEQGIARLAAGEGPFKDMSELFPALRMARCEHHYVFCLPRAGEPALVVAILHERMDLMTRLADRLKG