par-6

Partitioning defective protein 6

309 amino acids

Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis (PubMed:8898226). Required for localizing/ maintaining par-3 at the cell periphery (PubMed:9834192, PubMed:8898226). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841). Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Plays a role in endosome and Golgi body positioning (PubMed:22634595).

Belongs to the PAR6 family.

34.219 kDa

MSYNGSYHQNHHSTLQVKSKFDSEWRRFSIPMHSASGVSYDGFRSLVEKLHHLESVQFTLCYNSTGGDLLPITNDDNLRKSFESARPLLRLLIQRRGESWEEKYGYGTDSDKRWKGISSLMAQKPPKRSYSISNPEDFRQVSAIIDVDIVPEAHRRVRLCKHGQERPLGFYIRDGTSVRVTERGVVKVSGIFISRLVDGGLAESTGLLGVNDEVLEVNGIEVLGKTLDQVTDMMVANAHNLIITVKPANQRNTLSRGPSQQGTPNASEMSAATAAATGGIQRPMKMNGSSDGSYHPKQHDANDSDSGED