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papA5

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium leprae (strain TN)
Length
423 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.595 kDa
Sequence
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGWNLVADDLLHPGICVVDANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELVLYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQATPLSMEAVLQQRGVKKHALSGAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINAVVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTDIVDLATDIVATLRADLANGVVQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDLAIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEPAKALEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
422 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.429 kDa
Sequence
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Length
422 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.429 kDa
Sequence
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Length
422 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.429 kDa
Sequence
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
422 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.429 kDa
Sequence
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
422 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Is also able to catalyze acyl transfer using various nucleophiles as acceptors and several acyl-CoA thioesters as donors in vitro; preference is observed for saturated medium chain alcohols and long chain acyl-CoA thioesters.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.429 kDa
Sequence
MFPGSVIRKLSHSEEVFAQYEVFTSMTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGWNLVADDLLHSGICVIDGTAATNGSPSGNAELRLDQSVSLLHLQLILREGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTPLSMEAVLAQRGIRKQGLSGAERFMSVMYAYEIPATETPAVLAHPGLPQAVPVTRLWLSKQQTSDLMAFGREHRLSLNAVVAAAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEATNLLGAASYLAEIGPNTDIVDLASDIVATLRADLANGVIQQSGLHFGTAFEGTPPGLPPLVFCTDATSFPTMRTPPGLEIEDIKGQFYCSISVPLDLYSCAVYAGQLIIEHHGHIAEPGKSLEAIRSLLCTVPSEYGWIME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Length
416 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.667 kDa
Sequence
MFPSSGIRKLARSEEMFAETHNFIGLAAHVKGSMDADALSDAFDLLLQAHPVLGGHLEQLPDGKWEIVLDDLMHPGIEVVELTGDEPAPPLIFDQTVSLVHLRLTIRDGQAQPTLYIHHSLADGHHQFSLVEELFSTYTDLVTTGTTKPVEVHPAPEPLEVILANRGVEKRTRSGLERLLAAMFVYDLPPSRRAPSDVNPVLPQLVPMAYCTLSEQDTEKIIAFCRANKLGLNSLLSAAVLMAEWNVRRTPNIPVPYVYPVDLRYLLSPPVSATESTNPVGIATYLAEIEKGTDIAELARDINDTYKKDIAEGVIQQSFLHFSPQYVGNPPGLPDVVMFTDNGIVPPLRTPPDMEVAASHGEFYFAVGAGIEIYTSKIFNGQLMIEYHSHGPDREKSVAAIEEQLRAVVARQSGVG

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium ulcerans (strain Agy99)
Length
414 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
45.394 kDa
Sequence
MFPGAVIRKLAFSEEIYARYQAFTSFTAHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNHHIVANDLLHSGLVVIDGRRAENPHVQLDQRDSLFRLQLTLGESENLVTAYVHHSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAPQPAEDLLKRRGIKQSALTGFERFLPLLFAYDLPPIAEEMRKFEAPEPVPVTRCRLTSQETADLVSFSRDNGLSFNAVLAAAILLAEWRLRETPHVPIPYCYAVDLRFLLSPPVGATESTNPVGLATYLAEIGPDTDITELAADIVATFRADLSDGMIHQSALRSGRILEGTPPGLPPFILCTNVSTLPPIRTPEDVELVDFHSRIHCAMDVPFGFYACSIATDRLSIELHGSIPAPQLLLDAIRDILCSVPSEYGLFME

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium sp. (strain JLS)
Length
410 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
44.501 kDa
Sequence
MAYSTSVIRRLAPSEKFFAETQTFTSITVLLDGTVDIDAMADAFDALLEAYPVYAGHLEPDSDGGFELVADDLLHPGLWVQFEGDPAPTDQLDQGVALIYLLVKPDSTPVEVTLFIHHSLADGTHMAGLLFELFARYTEVVTTGSAGPVSPNPAPEPIETVLEQRGIRKQQRSGLDRFIPAMFAYELPPKRVTTRSAAERPAAVPTTRCRLSKAETSSLVKYGRVNRLFVNNLISAAILLAEWQVRRTPHIPIPYVYNVNLRALVEPPVSATGCTLAIGVATYLAHITPQTTMVELARGIADMFQADLADGVVQQSLLHFNMQYEGAIPGLPDVVLSTNLGNAVAMSTPPGLEVVGVQSQFYRASSAVIDVYSFGVVGGELLIEHHVDAAETTIDLIRSLLRSVVSEHQH

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium sp. (strain KMS)
Length
410 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
44.501 kDa
Sequence
MAYSTSVIRRLAPSEKFFAETQTFTSITVLLDGTVDIDAMADAFDALLEAYPVYAGHLEPDSDGGFELVADDLLHPGLWVQFEGDPAPTDQLDQGVALIYLLVKPDSTPVEVTLFIHHSLADGTHMAGLLFELFARYTEVVTTGSAGPVSPNPAPEPIETVLEQRGIRKQQRSGLDRFIPAMFAYELPPKRVTTRSAAERPAAVPTTRCRLSKAETSSLVKYGRVNRLFVNNLISAAILLAEWQVRRTPHIPIPYVYNVNLRALVEPPVSATGCTLAIGVATYLAHITPQTTMVELARGIADMFQADLADGVVQQSLLHFNMQYEGAIPGLPDVVLSTNLGNAVAMSTPPGLEVVGVQSQFYRASSAVIDVYSFGVVGGELLIEHHVDAAETTIDLIRSLLRSVVSEHQH

Gene
papA5
Protein
Phthiocerol/phthiodiolone dimycocerosyl transferase
Organism
Mycobacterium sp. (strain MCS)
Length
410 amino acids
Function
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
Similarity
Belongs to the acyltransferase PapA5 family.
Mass
44.501 kDa
Sequence
MAYSTSVIRRLAPSEKFFAETQTFTSITVLLDGTVDIDAMADAFDALLEAYPVYAGHLEPDSDGGFELVADDLLHPGLWVQFEGDPAPTDQLDQGVALIYLLVKPDSTPVEVTLFIHHSLADGTHMAGLLFELFARYTEVVTTGSAGPVSPNPAPEPIETVLEQRGIRKQQRSGLDRFIPAMFAYELPPKRVTTRSAAERPAAVPTTRCRLSKAETSSLVKYGRVNRLFVNNLISAAILLAEWQVRRTPHIPIPYVYNVNLRALVEPPVSATGCTLAIGVATYLAHITPQTTMVELARGIADMFQADLADGVVQQSLLHFNMQYEGAIPGLPDVVLSTNLGNAVAMSTPPGLEVVGVQSQFYRASSAVIDVYSFGVVGGELLIEHHVDAAETTIDLIRSLLRSVVSEHQH