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panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Yersinia pestis
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.844 kDa
Sequence
MKITVLGCGALGQLWLSMLHQQDHDVQGWLRVPQPFCSVNVIMLNGESFNRNLTTNDPKHLLQSELLLVCLKAWQVSSAVTALLPKLNPECKILLLHNGMGTQEELPLNEHVFLHGVTTHAARRDGNTIIHVASGMTHIGPTSSVIIDDNHLADTLHQALPDVAWHNDISAACWQKLAVNCVINPLTGLYNCRNGDVQRYPELIERLCAEVASVMEMEGYHTSTESLLSYVNNVIRSTADNTSSLLQDLRSQRHTEIDYITGYLLRRARSHGMALPENARLYELIKRKESDYERIGAGLPGSW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
Probable 2-dehydropantoate 2-reductase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.062 kDa
Sequence
MTWHILGAGSLGSLWAARLGRAGLPVRLILRDRQRLRRYQQAGGLSLVEDGQASLYPIAAETPDGGQPIQRLLLACKAYDAEEAASSVAHRLAGNAELLLLQNGLGSQQAVAARLPRSRCLFASSTEGAFRDGDFRVVFAGRGHTWLGDPRDTNAPAWLTQLSQAGIPHSWSDDILERLWRKLALNCAINPLTVLHDCRNGGLRQHPEEIAALCDELGQLLHASGYDAAARSLLEDVRAVIDATAANYSSMHQDVTRGRRTEIGYLLGYACQHGQRLGLPLPRLGTLLARLQAHLRQRGLPDR
Protein
Probable 2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Salmonella typhi
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.842 kDa
Sequence
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAVRTLASTLPVTSPILLIHNGMGTIEELQSIQQPMLMGAITHAARRDGNIIIHVANGTTHIGPAREQDGDYSYLAEILQGVLPDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLCYYVEQVIDSTAENISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMPRPW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Has a strong preference for NADPH over NADH as the electron acceptor. Pantoate, ketoisovalerate, oxaloacetate, pyruvate, 3-hydroxypyruvate, alpha-ketoglutarate, alpha-ketobutyrate, and acetaldehyde cannot serve as substrates for reduction.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.938 kDa
Sequence
MKITVLGCGALGQLWLSALCKHGHDVQGWLRVPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAVRTLASTLPVTSPILLIHNGMGTIEELQNIQQPMLMGTITHAARRDGNIIIHVANGTTHIGPAREQDGDYSYLADILQGVLPDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEVAAVIEREGYHTSADDLRYYVEQVIDSTAENISSMLQDVRAMRHTEIDYITGYLLKRARVHGLAVPENSRLFEMVKRKESEYERSGTGMPRPW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Shigella flexneri
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.871 kDa
Sequence
MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGMGTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYSYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIRALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYERIGTGLPRPW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Escherichia coli O157:H7
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.848 kDa
Sequence
MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGMGTIEELQNIQQPLLMGTTTHAACRDGNVIIHVANGITHIGPARQQDGDYSYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIRTLRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYERIGTGLPRPW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Escherichia coli (strain K12)
Length
303 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.871 kDa
Sequence
MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNGMGTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDYSYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDIRALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYERIGTGLPRPW
Protein
2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
Probable 2-dehydropantoate 2-reductase
Organism
Bacillus subtilis (strain 168)
Length
298 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
33.287 kDa
Sequence
MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIRLYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGHIHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHNHSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEACRILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLDAVHLEFLYGSIKALERNTNKVF
Protein
Probable 2-dehydropantoate 2-reductase: panE

Gene
panE
Protein
2-dehydropantoate 2-reductase
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
296 amino acids
Function
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Similarity
Belongs to the ketopantoate reductase family.
Mass
32.201 kDa
Sequence
MNIVVLGPGAVGSLWALHLHSAGHQVALWSRQAQPTITLQLDEEAPISFRNQNLDTLIHADLLLITVKAWQVEAALQPLLPHLNRETILLFMHNGMGAVEAISESLTHFPVLFATTTHGALKATLNQVSHTGFGQTQVGPFNALGARCDFIADVFNHALAPVTWNPEIQQALWRKLAVNCAINPLTAIHQCANGALVAPEFTPIITAILDEVTAVMQAEAISGEAEALRDGVYQVIQATAANLSSMHQDVFHRRPTEIDFITGYVVRKGEQHGIATPVNSALYQQIKTLEQSWSKA
Protein
2-dehydropantoate 2-reductase: panE