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pam-b

Gene
pam-b
Protein
Peptidyl-glycine alpha-amidating monooxygenase B
Organism
Xenopus laevis
Length
875 amino acids
Function
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
Similarity
In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
Mass
97.085 kDa
Sequence
MDMASLISSLLVLFLIFQNSCYCFRSPLSVFKRYEESTRSLSNDCLGTTRPVMSPGSSDYTLDIRMPGVTPTESDTYLCKSYRLPVDDEAYVVDYRPHANMDTAHHMLLFGCNVPSSTDDYWDCSAGTCNDKSSIMYAWAKNAPPTKLPEGVGFQVGGKSGSRYFVLQVHYGDVKAFQDKHKDCTGVTVRITPEKQPLIAGIYLSMSLNTVVPPGQEVVNSDIACLYNRPTIHPFAYRVHTHQLGQVVSGFRVRHGKWTLIGRQSPQLPQAFYPVEHPLEISPGDIIATRCLFTGKGRMSATYIGGTAKDEMCNLYIMYYMDAAHATSYMTCVQTGNPKLFENIPEIANVPIPVSPDMMMMMMMGHGHHHTEAEAETNTALQQPKREEEEVLNQDVHLEEDTDWPGVNLKVGQVSGLALDPKNNLVIFHRGDHVWDENSFDRNFVYQQRGIGPIQESTILVVDPNTSKVLKSTGQNLFFLPHGLTIDRDGNYWVTDVALHQVFKVGAEKETPLLVLGRAFQPGSDRKHFCQPTDVAVDPITGNFFVADGYCNSRIMQFSPNGMFIMQWGEETSSNLPRPGQFRIPHSLTMISDQGQLCVADRENGRIQCFHAKTGEFVKQIKHQEFGREVFAVSYAPGGVLYAVNGKPYYGDSTPVQGFMLNFSNGDILDTFIPARKNFEMPHDIAAGDDGTVYVGDAHANAVWKFSPSKAEHRSVKKAGIEVEEITETEIFETHMRSRPKTNESVGQQTQEKPSVVQESSAGVSFVLIITLLIIPVVVLIAIAIFIRWRKVRMYGGDIGHKSESSSGGILGKLRGKGSGGLNLGTFFATHKGYSRKGFDRLSTEGSDQEKDDDDDGSDSEEEYSAPPIPPVSSS