Protein
Puromycin-sensitive aminopeptidase
Organism
Caenorhabditis elegans
Function
Aminopeptidase (PubMed:12930831). Required for the exit from meiosis, probably upstream of cyclin cyb-3 (PubMed:17021038). Involved in the establishment of the anterior-posterior polarity at the embryonic 1-cell stage by regulating the dynamics of sperm-donated centrosomes (PubMed:17021038, PubMed:20599902, PubMed:28065742). Plays a role in oocyte maturation (PubMed:24663498). Required for embryonic development (PubMed:12930831).
Similarity
Belongs to the peptidase M1 family.
Sequence
MLGRLAVRQAVRCSKASIKPVNTHQLCLRNFSAIRRLSFVAGAQCRPYHTTANMLHRTARGEHGMAACGNPSAAVKFERLPTFAEPTHYNVRLSPCLNQFSFDGHATIDVTIKEATDVLKVHAQSLLIQSVSLITQPGDASKSLETSYDDKLNILTIKLPTTMQPQKVQLDFKFVGELNDKMRGFYRSQYKDKNGTEKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISETPTADGKRKAVTFATSPKMSSYLVAFAVGELEYISAQTKSGVEMRVYTVPGKKEQGQYSLDLSVKCIDWYNEWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVALVVAHELAHLWFGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIWLHFLNDELASGMGLDALRNSHPIEVEIDNPNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQDLWTALSEASGQNVNELMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFISDGGEDPKNSQWQVPITVAVGSSPSDVKARFLLKEKQQEFTIEGVAPGEWVKLNSGTTGFYRVEYSDEMLTAMLPDIASRRMPVLDRFGLINDLSALLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAREMSEDTLKSAKQLVVKMFEQTGAELGFAEQAGEDSQKMMLRSLVQARLARAGHQPTIDKFTQMFNDFLEKGTPIHPDIRLATFGVVARYGGKEGFDKLMNLRETTTFQEIERQTMVAMSQTPEESLLAQLFEYGFEKNKVRPQDQLYLFLGTGATHMGQQYAWKYFCEHIKEFLDKYGGANSSLFQRCLKFAGESFGNEKRAVEFQDFFCNCNVLSDTDRQTLARPIGQTVEAIRLNARLLESNRQIIENLLKQSNV