Protein
Serine/threonine-protein kinase pakA
Organism
Dictyostelium discoideum
Function
Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells.
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Sequence
MEEKPKSTTPPPSVSSLRQKFEQFLDKTDKGFNATRNNYRGPVSSSTGIINDKEKKSHSYFKVREEGSNKRPSSFSASNPITPSSPQSTHSSPIYRGVGYHQYSSVNSGNSYSGSGNNINNIINNSNNSNSNNLYGNNSNNQSSGSLGNFLIDKLEYSAATVTASDLKRERQQLFRNKEEFTMESSSYGGSTIGDDDLDSLNGSSSQQFNHRNSSWADRRERFIKKVMNGQFNEVQMRDELNRLRDIEADKIRAEERRTPSMNMDEFKAIEIERLRKKIYQEELVIFRQEEIEKIQREERIKIEKEYDDKSIISSQERQHIVQQIINQKEDEKGSSPPFPIPLVVNNNNNENNENDNNNNNNNNNNNNNNNNNNNNNNNKNIDLTSFNNNININSNNNEIKNNVIVDSDDEEELERLEQLRRQREIERLREEEEENEDRVERELASRRRQEEDRIKREEEEEEEEQRNYLRRLKELERIKQIEEEEEEERERQSQLQSSQQQQKSSSTQRSSNTVTSTSSSSTGGDSNPSTSQKPTNLLNLMGSNNNISNINTNILSHSIVNSSGGLPPPPPTASHVDNRSRSHTLAGESHSSENTPLVSSIDNNGVNNKMSRSHSGGALSGLALPTAPPLPNQPNVNNSNNNNNNNNINNNHNHSHNHSNNLHQSALKNSSSMSTPSISPSQAGNSATSTVPSSPISASTSMSSPTLVVSPRKDELTTSTGSTRKGSISEREDKKKVSSSSTSSSSSSNGGLSSSGKDHKKDHSSEEKEKEKKSFFNKLFSKEKKDHHSSSKSPSSGSSGGGEVDEKKKKKLSPRVGTPFNVKHDVHVNFNADTGFEGLPKEWEVLIKSNFQEPEVMQHPEEVLDVVKFHAQYQGLASAPAMHAPSIPLTDEPPVTLNDLISLDDPKKIYYNINKIGEGGAGEVFEAINSRTNQTIAIKKMKLKAQNLKTVINEIGMMKNSNHENIVQYIDSYIVADELWVAMEFMSGGCLTEVLDQYRDIQLNESQIAFVCQEVLRGLEYIHKFNRIHRDIKSDNILIGANGEIKLADFGYAAQLTQIRQERNSVVGTPYWMAPELIRGNNYDFKVDVWSLGIMTREMAEGEPPYLEFPPLRALFLLTTQGLPPIRDAHKWSKEFNDFLALCLEKDTEKRASSSSLLHHPFLKRACSGPEFYKAVDAARIEKENQLQNFANLTAI