Protein
Phenylalanine-4-hydroxylase
Organism
Dictyostelium discoideum
Function
Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.
Similarity
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Sequence
MESNTNSQGQGIIPQSYHSSIFFSISKGSDKIGGLLEYLEIIKKHNINITRIESRPSKTEKKDYDFFLDLEYPTENNKEVEKVIKDLEEKGVKATTLQESSNQTYAPWFPRKISDLDLFANKVLEMGSDLTSDHPGASDPVYRERRREIAKIASTYKHGDEIPRIDYTEEEIKTWGVVYNRLKELFPTNACHQHAYIFPLLEQNCGYSPDNIPQLQDISNFLQECTGWRIRPVQGLLSARDFLNGLAFRVFHATQYIRHPSVPLYTPEPDCCHELLGHVPLLADPDFADFSQEIGLASIGASDEDIQLLSTCYWFTVEFGLCKEGDTIRAYGAGILSSTGEMEHFLTDKAKKLPFNPFDACNTEYPITTFQPLYYVAESFQKAKEQMRQFADSFKKPFSIRYNPYTQSIEILDNKDKLLNICNDIRNQSEILADAISKLKA