Protein
Polyadenylate-binding protein, cytoplasmic and nuclear
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
Similarity
Belongs to the polyadenylate-binding protein type-1 family.
Sequence
MAATSTAAVDQLAADLGNTSLDNKAAAPAPIDTSAVPEAQAEGAEAAPTPTAAPHPQASASLYVGELDPSVTEAMLFELFSQIGSVASIRVCRDAVTRRSLGYAYVNYNTTADGEKALEELNYTLIKGRPCRIMWSQRDPALRKTGAGNIFIKNLDAAIDNKALHDTFAAFGNILSCKVAQDEHGNSKGYGFVHYETDEAASQAIKHVNGMLLNEKKVYVGHHIPKKDRQSKFEEMKANFTNVYVKNINNEVTDEEFRELFAKFGEVTSSSLARDQEGKSRGFGFVNFTTHEAAAQAVDELNGKDFRGQDLYVGRAQKKHEREEELRKSYEAARLEKANKYQGVNLYIKNLGDDVDDDKLRAMFSEYGPITSAKVMRDSLIEGSEEKDEKDKENKKEGETKEEEQNEGSEKKTEKKGDRKLGKSKGFGFVCFSNPDDATKAVTEMNQRMVDGKPLYVALAQRKDVRKSQLEASIQARNQLRMQQAAAQAGMPQQYMQAPVYYAGQQPGFMPAPGGRGVPFPQGGIVPGVQGGRPGQYPYQQGGRGGVPPQQMPPMGYPINQFGPGAFPPNTPQYMAAMGQVGALGGGRGGPAGRGPQGIPAGIPQGLQGGPAVPGYPPAGRPQNGGGRGTPRGNANFMAAGRGASPIPGAPADLSAGSFLQAQLATTQDPQAQKQIIGENLFPKIQAIQPALAGKITGMLLEMDNAELINLFEDDNALNVKVQEALAVYDEYLKTQGQQPTQQPAEANGEQPKAEEQKPEEQKA