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oxyT

Gene
oxyT
Protein
N,N-dimethyltransferase OxyT
Organism
Streptomyces rimosus
Length
344 amino acids
Function
Involved in the biosynthesis of the tetracycline antibiotic, oxytetracycline. Catalyzes the dimethylation of 4-amino-4-de(dimethylamino)anhydrotetracycline (4-amino-ATC) to yield anhydrotetracycline (ATC) (PubMed:1134373, PubMed:18422316). Also able to catalyze the dimethylation of 7-chloro-, 6-demethyl-, 2-decarboxamido-2-nitrile-, and 4-methylamino-derivatives of 4-amino-4-de(dimethylamino)anhydrotetracycline (PubMed:1134373).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Mass
37.376 kDa
Sequence
MTTTPLAPVAQARSLLQLTTAYHQAKALHSAVELGLFDLLADGPATAEEVKDRLRIVHPLAKEFLDALVALELLEADGDRYRNSPAAQAFLVSGASEYLGGTVLQHARKHYHVWAGLTTALQEGEAGSGAEAHGPEAYPKHYEDPERARQVMAHFDTFSSFTAEELARRVDWSGYGSFIDIGGARGNLATRVALAHPHLHGAVFDLPALAPLAGELIRERGLEGRVRFHGGDFLTDPLPSADAVVTGHVLPDWPVPQRRKLLARIHEALPSGGALVVYDLMTDPATTTVHDVLQRLNHGLIRGDSSSSSVEEYRAEIEEAGFRVRQAERIDNLLGDWLIVAVKP