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otx2

Gene
otx2
Protein
Homeobox protein OTX2
Organism
Danio rerio
Length
289 amino acids
Function
May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.
Similarity
Belongs to the paired homeobox family. Bicoid subfamily.
Mass
31.594 kDa
Sequence
MMSYLKQPPYTVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPAREASSESGASGQFTPPSSTSVPAISTTTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLTGPGSTLSPMSSNAVTSHLNQSPASLPTQGYGASGLGFNSTADCLDYKDQASSWKLNFNADCLDYKDQTSSWKFQVL

Gene
OTX2
Protein
Homeobox protein OTX2
Organism
Homo sapiens
Length
289 amino acids
Function
Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Similarity
Belongs to the paired homeobox family. Bicoid subfamily.
Mass
31.636 kDa
Sequence
MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Gene
Otx2
Protein
Homeobox protein OTX2
Organism
Mus musculus
Length
289 amino acids
Function
Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Similarity
Belongs to the paired homeobox family. Bicoid subfamily.
Mass
31.622 kDa
Sequence
MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Gene
otx2
Protein
Homeobox protein OTX2
Organism
Xenopus tropicalis
Length
289 amino acids
Function
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity).
Similarity
Belongs to the paired homeobox family. Bicoid subfamily.
Mass
31.596 kDa
Sequence
MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPSKKKPSPAREVSSESGTSGQFSPPCSTSVPVISSSTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGAGATLSPMGTNAVTSHLNQSPAALSSQAYGASSLGFNSTADCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL

Gene
Otx2
Protein
Homeobox protein OTX2
Organism
Rattus norvegicus
Length
70 amino acids
Function
Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Similarity
Belongs to the paired homeobox family. Bicoid subfamily.
Mass
7.139 kDa
Fragment
single
Sequence
MTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGAS