orfC

Antigen Lp49

456 amino acids

May be involved in virulence. Binds human plasminogen (PLG) and stimulates its proteolytic cleavage to enzymatically active plasmin in the presence of an urokinase-type PLG activator in vitro. Activated plasmin has proteolytic activity which may help the bacteria to spread throughout the host by degrading extracellular matrix components, facilitating tissue penetration and invasion.

51.845 kDa

MNSNPKKKFLKLIKIKSDIILLIPIFLFLVCCKSGDFSLLSSPINREKNGTEIVKFSIHPYKGTVIRLGEEILPFKVLEMDKNIALVEMAIPVYKDEKEIELKLSSPGFQNSSYRIRKPEELNEKLIALDKEGITHRFISRFKTGFQPKSVRFIDNTRLAIPLLEDEGMDVLDINSGQTVRLSPPEKYKKKLGFVETISIPEHNELWVSQMQANAVHVFDLKTLAYKATVDLTGKWSKILLYDPIRDLVYCSNWISEDISVIDRKTKLEIRKTDKIGLPRGLLLSKDGKELYIAQFSASNQESGGGRLGIYSMDKEKLIDTIGPPGNKRHIVSGNTENKIYVSDMCCSKIEVYDLKEKKVQKSIPVFDKPNTIALSPDGKYLYVSCRGPNHPTEGYLKKGLVLGKVYVIDTTTDTVKEFWEAGNQPTGLDVSPDNRYLVISDFLDHQIRVYRRDGF

ORFC

Uncharacterized protein ORFC

372 amino acids

40.626 kDa

MNKILGLRRAKSAPLVPGAEKGKEKSVEETGFMTLAGRLRRGMQRLSRRGYGDNRRSRGSENNEQDPQPGDKIASPQRRDYTKSEASCRPGSGKTSPCGSSGTPCSDDAGGGRNGQENSGTRDTPCWMYKDSKSRYRVGVTPDLIPTIFGVSEVAASGLPRCRDKAAKRQPQSLLSPGVEALLVTIAESLETNGKRVSGRTAGKLWSWRVRDKAPERDYRNVTPTMFEGSCFGKPIRAGVFNAPRAYLDDLLGDHYFVPYLRRLPRDFTREETLSLRVATEAAVFANMLWEARHKNNFGAGVSYYPGALASATGTAPDFTDRGRSSLDSPYFASTFLPGIFVILPPGELPIDFMRLAVLLAVSAIETCVTTV

orfC

Protein ORF-C

120 amino acids

Induces alteration of mitochondrial function that results in apoptosis contributing to tumor regression.

14.2 kDa

MAWYHQHRWHLDYSIPRQNLQAFLTTITFIDPQFKIQENGLTEGEYKTQIVKQIIPQLCRIPNQNSPPPIWVQGPRIKGDPTWLKINAKFITELIPKQKGTKNISTKTYLSRLFVIWLQN