orcA

Origin recognition complex subunit 1

631 amino acids

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).

Belongs to the ORC1 family.

72.401 kDa

MTDESSSSISYPPIKKYKKSLKLNNNTNNNNKNNNNHNNRDIVMQPNSTDEESSDNEKIGFSDPENEKINKHKASFKDSNDENNNNSTYYEDTDDDDYEDEDEDENHKIKDESDNSEDFNNHTKNTTDLDEGFKSTVNGSESEEEEEEEEYEEEEEEDEEGKFNLDQYDEFYEDDDDGDDDDDDDENAQDKVEILQIEHQNLDNDNDNDNDYANDNIYTKAKEALHLSAVPDKLPGREKEKATIASFIRAKLKANESGGCLYIAGMPGTGKTATVKEIIKELQAKKKQQGGGGGLNFQFIEINGMQLSDPHQLYHILYNKMQKTRKSLEPKKISSQDALRLIQRNFELKNKKKQFRVILVDEFDSLITKKQTVIYNLFEWPNKPNSKLIIIAIANTMNLPDTLLPRVKSRMGLQKVPFTPYNIEQLETIIKYRLQDLDAFDEESIQICSKRVAAVCGDARRALEICRKAATIANQEYQKKLLIFNNSNNNKSLSGSQKLPIPGPITADHIEEVFEQFSSPLLKKLNQLSFYEKLFLLCICRENQFSNVPEVKYGTISTRMRIITKKINVSCPNPTQLFQLAGNLLGCKFIIIQDDKPINWDHQIKLNLPLEDLSFGLEQDPDLKNLEISNN